6U42


Conserved Protein Domain Family
CFA20_dom
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pfam05018: CFA20_dom 
CFA20 domain
This domain is characteriztic of cilia- and flagella-associated protein 20 (CFA20). CFA20 is a cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. In Chlamydomonas reinhardtii, it stabilizes outer doublet microtubules (DMTs) of the axoneme and may work as a scaffold for intratubular proteins, such as tektin and PACRG, to produce the beak structures in DMT1. Other proteins contain a domain with homology to CFA20. WDR90/POC16 contains such a domain in its N terminus, followed by a large C-terminal domain with multiple WD40 repeats. This domain is also present in the N terminus of uncharacterized protein C3orf67.
Links
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Statistics
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PSSM-Id: 461521
Aligned: 34 rows
Threshold Bit Score: 170.075
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6U42_3W         1 MFKNAFQsgFLSVLYSIGSKPLEIWDK-QVSNGHIKRITDADIQS-SVLEIMG--QNVSTTYITCPaDPNK--------- 67  
EEB11006        1 MFSKVYQpgLICIFDADNEKPLKIWEK-KIQDGSVKRILSDEIRG-LVLEISS--KMPMSNYIYCPsNIKQ--------- 67  
EEB11007        1 MTDFYMSpgFTCIFHSVNKHSLAKWEK-KIRNGTIKKLRDDELCS-QVLEINA--PKMAATYIMCPaDPNQ--------- 67  
4_pfamImport    1 MFAQTCQsgFISLLYSIGARPLQLCEKhEETPGSIRRVLDDEVQS-SVVELLA--DNLVHTWIRFPsASDEdqeqqqlss 77  
XP_011153412    8 G--------YISLLYSVAGKPLDLWSKhVSLGGKIRRVSDDMLHGdRVIEIVGphDSIVSTSITAPaEVVN--------- 70  
EGD74896        1 MSGKAWQlpLVDVFKHFGAGDWKQCSR----SGEVNRVMDKILRT-NVYRISG--SVPASNYMQFPkATSQ--------- 64  
A0E0P2          1 MN---WQhpFVDVFKQFGVFEIAHTQS----KGQVSVVQDNSIGR-KIIRLLG--AISANNMVQIPdPCQGi-------- 62   Paramecium te...
A8JAN3          2 SLAPEWQhpFVNIFKLCDVDTMREFET----KGDVTEHIDKIIGK-KVFKIRG--MIPAGNYLRVPrTKLQ--------- 65   Chlamydomonas...
XP_001613256    1 MYRNKFQpnILSLLLSAGSKPLDLWKT-KTKKGCVRKVLDDTIKL-SAIEIVS--ENTSDSYIYTApEKFS--------- 67  
EGI71076        1 MLKNTFR--YMPLLYSIANKPLHLWSKhVSFGGKVRRVSDNQLHGdKVIEITGphDNTIPTNITIPaKALD--------- 69  

6U42_3W        68 -----TLGIKLPFLVLIIK-NLNKYFSFEVQV-LDDKNVRRRFRASNY--QSTTRVKPFICTMPMRLDSG--WNQIQFNL 136 
EEB11006       68 -----SLNIYYPYLHLTVKlSYSSIFAFDVLI-IDDENVKRRFRISTI--QTFVDIQPFMCKLPLSLESG--WNEITVPL 137 
EEB11007       68 -----VLKIKNPILNMTVK-NLNKYFAFDVQI-LDDKGVKRRFRASTH--QNVTEVKPFYTKLPLTLEEG--WNQINFPL 136 
4_pfamImport   78 mpwntSLHIRLQHLVLVLK-NLGQHISLEVQM-ADDQGTRRRFRFSTF--QTKTAVHPQITLLPLRLDEG--WNQLQLDL 151 
XP_011153412   71 -----TLNIRLPVLVLIIK-NLKSHFKLEVQI-TDKNQYRKRFSFMTYnlEKLPSINASTACIPLKLEEC--WNILEINL 141 
EGD74896       65 -----SLGLVGRFVYIQYRpaRDKPFVIHLEA-AVKGGVVIRVSFSNL--YKEFKATSTWLQFPV-VNMPlqWTLFVIDL 135 
A0E0P2         63 ----kQLGLTGRYIYIEFIpiKGRYFTIHFDLqIKDRDPLIKLTVSNM--YDVHKVQQSQLLIPYPKNAPnkWTILILDV 136  Paramecium te...
A8JAN3         66 -----TLGLTGRLLYIQLKvtPIKVFAIHIEV-VTEDHNIHRISISNMynPESMKRKSNGVQLPFPKPSHr-WCVLAVDL 138  Chlamydomonas...
XP_001613256   68 -----SLGISLPFIVLIVK-NMNKYFSFRISI-MDDKRCRRTFRISNF--QTVTRLSNKWCTMPMILNEG--WNIIQINL 136 
EGI71076       70 -----ILNIKLPILILIVK-NLNLWFKLEVQI-IDKQQYRRRFSFMTYnvEKLPSINASIARIPLRLDDC--WNFLEINL 140 

6U42_3W       137 SDFTRRA--Y-GTNYI------ETLRVQVHANCRIRRIYFSDRLYSEEELPAEFKLFL 185 
EEB11006      138 HHYVKSI--Y-GTNYS------KTQRVAIYSNCFLKKIYFSDKEYSDEDIPLEFHIED 186 
EEB11007      137 QDFTMRC--F-GTNHV------QTLRIQIYASCRLKRIFFSNKILQEQDIPLEFRLNS 185 
4_pfamImport  152 VDLALCC--Y-NARYA------HTISVQLHASCRVRRIYFAEQMFSEAQLPAEFRLYK 200 
XP_011153412  142 QTLCRMV--Y-GTDYE------ALQRMIVYSDCRLRRVYLQDRHYGHDETPIELCNAF 190 
EGD74896      136 TMLLSL---YlNRKFV------YLKSIKLCANMSVRGVFTSDQFFKHTSLPRPMRMFT 184 
A0E0P2        137 EYFLGSFglLpSSLYKsfkgihSLKSFQICSSMNIRGIYTSDNLYDWDTMPKQMLFKL 194  Paramecium tetraurelia
A8JAN3        139 REALRG---YtSSPFA------SVKAVQTCSWMTVRTMFASDYKFSLQSLPGDMALSH 187  Chlamydomonas reinhardtii
XP_001613256  137 QEYTQKA--F-RTKYQ------ETIEMQINASIRIRCIYFCDRLYSNDELKDEYKIFC 185 
EGI71076      141 QTLCHQV--Y-KTDYE------ALQRVTIYQNCHLRRVYLQNRHYNDDELYRTFFNMY 189
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