4KXR,6VHR,5XKL,4RCL


Conserved Protein Domain Family
ESX-1_EspG

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pfam14011: ESX-1_EspG 
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EspG family
This family of proteins contains the the EspG1, EspG2 and EspG3 proteins from M. tuberculosis. These proteins are involved in the ESAT-6 secretion system 1 (ESX-1) of Mycobacterium tuberculosis which is important for virulence and intercellular spread. Proteins in this family are typically between 254 and 295 amino acids in length.
Statistics
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PSSM-Id: 433641
Aligned: 125 rows
Threshold Bit Score: 65.0332
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4KXR_C                16 GFWMLQALLDIRHvaP---ELRcrPYVS--TDSNDWLNEHPGMA---------VMREqGIVVND-AVNEQVAARMKVLAA 80  Mycobac...
UANL:O3I_023780       15 AALLLRDMVGIDAy-PlvlALM--PNIYr-IEDRDRVRERVHEQ---------LTAA-GVIDDG-RVHPVVVHWLHCLDR 79 
WP_013138286          15 TLEYVRKLAKTESv-PtvlACY--QGFYvdVEQRRKEWDLMNAE---------LNEK-GILRGE-AVHPELQAWLEALDH 80  Segnili...
goetting:GPOL_c35050  15 VLRRLGQRCGVTTw-PvvlDLWt-PAADg-AHSETGADTRGPADhddatldraITEA-GLVDSSg-PTLWADLVLGVLAH 89 
jgi:Gbro_3645         18 VLRGLGQRFGAQTw-PvvlDIEgvLDIDd-AAAARPALSHAELHq-------rIAET-GLVCSDgEPTTLCDTVIRVLCA 87 
goetting:GPOL_c32920  14 EILTLADRLGVDTl-PdtlALW--PTQPt-VGELQHVRDRCVGQ---------LSDR-ELIVDg-EIDPDLAHVLTTMRR 78 
UANL:O3I_004665        8 ALLAVADRAGVQTl-PlalAVG--PQQDs-FEEWQRAQESAVAS---------LIDG-GLIDAHgEVDPELADVLFTLAH 73 
WP_025347265           8 AVLAVSELLGVQTl-PlvlGVG--PQQDs-IDAFTAARADALRG---------LRGG-GLVDSYdDVEPDLGAALSILAQ 73  Nocardi...
Q5Z1M5                 8 GVLALAERLGIQTm-PlvlGIG--PRQQt-YDAWTAAQRRAVAD---------LTGA-GLIDGYgEVDPELADAMYVLAQ 73  Nocardi...
WP_014349132           8 GLLAVAERLGVQTl-PqvlSVA--PQHDs-YDEWARAQNRAVTE---------LTGA-GVIDSYgEVEPNLADALFTLAQ 73  Nocardi...
4KXR_C                81 PDLEVVALLSRgkllygviddenqppgsrdipdnefRVVLARRGQHWvSAVRVGNDITVDDVTVsds---asIAALVMDG 157 Mycobac...
UANL:O3I_023780       80 PDSELVARIVDtnalae--------------tptmlRFSLVRRAEDHvLAVRYDDHVVIQSVFPtgra-mdsIASALSAA 144
WP_013138286          81 PDRELSGRVKRges--------------------mlRMALVRRGDVHaLAIRYGDEVVIQNFEYdaqkssgqLARAALVV 140 Segnili...
goetting:GPOL_c35050  90 PDRELEIRGFAtds--------------------tvRACVARRGHDHvLAVRRGDHLDLALLDVrdt---naLAGVVRAT 146
jgi:Gbro_3645         88 PERMIEMRTIAdag--------------------frRICLARSGNDHvLAVRDGARIELSVVSPtgv---geLGALLRAR 144
goetting:GPOL_c32920  79 PERELSIRIITsdg--------------------llRASVLRVKRSHvVATRRGDTVRVRGFEAegs---erVVAEVARL 135
UANL:O3I_004665       74 PEQELAARIYTgng--------------------srRVCVVRRAHMHaVAVRSGDDFDVRPVWTdgs--aadLVRPVLAA 131
WP_025347265          74 PERELAARIVTaag--------------------vhRVCVARRGMGHaAGVRIGDAIEVRTIWAded--gaaLARPILDV 131 Nocardi...
Q5Z1M5                74 PDRELVARVYPgdg-------------------aptRLCLALRGERHaLALRRGDDIRIEPAWSdes--gsaLVAALLRA 132 Nocardi...
WP_014349132          74 PDRELVARVFTgaa--------------------pvRICLARRGEQHaLAVRTGDDYDITTVWSdgs--gatLARPVLAA 131 Nocardi...
4KXR_C               158 LEsihhADPAAINAVNVPMEEMLEATkswqesgfnvFSGGDLRRMGISAATVAALGQALSDPAAEVAVYARQYRDDAkGp 237 Mycobac...
UANL:O3I_023780      145 LGc---WPALEFDSLVAPMTQLDSIPae------pdQRRQALRELGATPRTAAALGRELGTVLRRAE--IVMIEHRD-Gs 212
WP_013138286         141 LGe---GVIPDFNRVSAPTQSIVDAMprnv---dldAVYTSLLRVGASQKDAKVLATIMATVEVQSE--FVVYERGD-Gp 211 Segnili...
goetting:GPOL_c35050 147 CGp---HDALDFTETSVPTRELTERFghca---dtaGVVAALRAWGATAADAIRVADALLSCDVRWE--IVATSRAD-Ga 217
jgi:Gbro_3645        145 LPe---RAPCVFDAISHPAAELLDRLgrcr---sglDMTDALHAMGASPGDAMVVSAAFASCRVQTE--IVAVAHDA-Gv 215
goetting:GPOL_c32920 136 LPk---AIDVDCGSVSAPAVDVAEHLaglr---aatPIADELHALGADSRTAIVLGAVLADYRAAVEMRVAALDPHV-Dr 208
UANL:O3I_004665      132 MDa---CPPAEIPNFSVPAAELAERLdsat---nssELTDALYALGATDRDATTLGLTFGATHAYAE--IVACAHED-Gv 202
WP_025347265         132 LGp---AEPADIVSFSAAADELAERMdaaa---rstEFAEALHGLDVEERAAIEFGMAMAQCHAHAE--IVAYAHSD-Gi 202 Nocardi...
Q5Z1M5               133 LGp---AEPADVAPFSAPAAELAERLsaar---tsaDFTDAVYALGVAERDAPRYGLAFESCRAYAE--IVAYAHVD-Gv 203 Nocardi...
WP_014349132         132 LGp---ATPADVAVFSAPATELSERLeaaq---tsaEYADALYALGVADQDAPRYGLAFASCHAYAE--IVAYAHIV-Gv 202 Nocardi...
4KXR_C               238 s---asVLSLKDGSGGRiaLYQQARTAGsGEAWLAICPATPQLVQVGVK 283 Mycobacterium tuberculosis H37Rv
UANL:O3I_023780      213 faqpelCTNVLDTPSGR--IVVVPHCALdGEVWSTYLPGDVSAVRAGVE 259
WP_013138286         212 rargkgAVSVFDSPKGR--FVSSPSVASdGEIWSTMTPGTDHRISQAfn 258 Segniliparus rotundus
goetting:GPOL_c35050 218 ftqtsgAIGIIDSRAGR--ILMGLSRSPdDRLWTTITPGTGHRIGAAVD 264
jgi:Gbro_3645        216 ltqssgAVAILDTDKGR--IVSSPSKSPdGRVWTTLSPGSGHRIAQAIG 262
goetting:GPOL_c32920 209 sivadgALAVFYAARGC--VLSAPSTSPdGQLWCSLKGGSDHRIAQAVA 255
UANL:O3I_004665      203 ttrapgAVAVYDTARGR--IVAAPMVSPdQQVWSTVTPGTDHRVAQAVA 249
WP_025347265         203 ttrssgAVAVYDTARGR--IAASPGAAPdLRVWSTFTPGSDHRVAQAIT 249 Nocardia nova
Q5Z1M5               204 ttrppcAAVVYETGRGR--IVVAPGIAPdQQVWSTVTPGTDHRVAQAIS 250 Nocardia farcinica
WP_014349132         203 ttrppaAVAVYDTGHGR--LVAAPGFAAdQQVWSTVTPGTDHRIAQAIS 249 Nocardia cyriacigeorgica
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