2FUL,2IU1,3JUI,1UG3


Conserved Protein Domain Family
W2
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cd11473: W2 
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C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon
This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.
Links
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Statistics
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PSSM-Id: 211395
Aligned: 23 rows
Threshold Bit Score: 55.9455
Created: 4-Apr-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2FUL_A         11 TQLDEYGEWILEQAGedke--------------nlpsDVELYKKAAELDvln------------------------dpKI 52   baker's yeast
2IU1_A          7 ERVNILFDFVKKKKEegvi---------------dssDKEIVAEAERLDvk--------------------------aMG 45   human
XP_003380194  215 TLDDLMREVLINEEVtvahgttladg-rvicgkklddDIESVPASQCKYddsspalelragnpgeesrksfwpawfplVV 293  Trichinella s...
NP_187972      24 DSMDKIRNQLERMSEt---------------------LAESVPHSKYAE-----------------------------AI 53   thale cress
XP_001706394  252 TWEQKIIQFMQKDPEg---------------------EEETLEALREDAlrqvkqck-------------eecgmsaeES 297  Giardia lambl...
XP_001032762  128 NWNKLFRKFVHSDEDslifiseiev---klhtindyqNVQSLHLQKSQT-----------------------------LI 175  Tetrahymena t...
XP_001624139 1030 DVNQSIGKALLESALhdnn---------------mdnQAQSVNLKKTMMhlkpvfenyvk--------daegqrdligAI 1086 starlet sea a...
EET02383      101 ACSNPETSYILKEKGlsmvcaacgqarplaadrftryVIKIIEQKTRAEqgktgasdrpea------srvrspvilypRI 174  Giardia intes...
XP_002364706  571 THKEDEIVSLVQALEq--------------------gLDQVEKDPSKKLgvddiva----------------vlkdedEL 614  Toxoplasma go...
XP_002119720  493 EHNKKLQDHLLDVDGsese--------------tssmDSADEDEQDPIMddd------------------------ltTF 534  Ciona intesti...

2FUL_A         53 GCVLAQCLfd-------------------------------------edIVNEIAEHNAFFTKILv----tPEYEKNFMG 91   baker's yeast
2IU1_A         46 PLVLTEVLfn-------------------------------------ekIREQIKKYRRHFLRFChn---nKKAQRYLLH 85   human
XP_003380194  294 VKAAPLALvneldetdadfsmdleknmgaeekvpsenmileinsskhayNVTMEQVYQAVVNGLFqlpleqANCQLSAVD 373  Trichinella s...
NP_187972      54 VKGMLLAVrrrvnlne--------------------------rlsiqetIDLVFDAYGPILIPYAt----sNTTQIQIIE 103  thale cress
XP_001706394  298 VMFMWRCIvslsk-------------------------------tmskdIVGALKKWGPCLYTLVgd---dLVMQGKLLS 343  Giardia lambl...
XP_001032762  176 TLLILIILqnyshqldinlfvknyk--------fayqlaylicltkkkqFCITHKDFYDFLHIFLqi--qiPKNHYGKIL 245  Tetrahymena t...
XP_001624139 1087 EDFFLDSAvarckpklg------------------------cvliqdffLDSAVARCKPKLGCVLiqdfflDSAVARCKP 1142 starlet sea a...
EET02383      175 KKIMRYDItpsakagelqeiadeavksrilredeivffymaalfdtdrpTLNYIKECIPVLREILt-----KDDGLSLLH 249  Giardia intes...
XP_002364706  615 ASIVPSAVvaavvikrs------------------------mgkenmegVLEVVKSVQDVWKVLLdn--sqVKDKDQVLI 668  Toxoplasma go...
XP_002119720  535 QREVKESLcggiee-----------------------------niqsdnLVLEINSSKYAYNMSVkd---vVQTVTKSLL 582  Ciona intesti...

2FUL_A         92 GIERFLGleh-----kdLIPLLPKILVQLYNNDIISEEEIMRFG 130  baker's yeast
2IU1_A         86 GLECVVAmhq-----aqLISKIPHILKEMYDADLLEEEVIISWS 124  human
XP_003380194  374 YWKALMPnlav--qndcIQSALVRIVHSLFEMDILEEDQILNWY 415  Trichinella spiralis
NP_187972     104 SVEKICLep------qsPFSPVFGIIIQTLSRHCVNVEAIVDWE 141  thale cress
XP_001706394  344 TVQTTCYnn------pnIINSFKPIVVQLYDLEILEADVIIAWA 381  Giardia lamblia ATCC 50803
XP_001032762  246 VIKKINTqdkq---ninFILASQQEKKLLFQNEILTKEYILNWV 286  Tetrahymena thermophila
XP_001624139 1143 KLGCVLIqdffl-dnawRRDTLQVCLHLLYEMDVLDEAVILHWH 1185 starlet sea anemone
EET02383      250 SLDCITRkyeee-mlssKTNLLSAILLELYGSELIDKNAVNAWI 292  Giardia intestinalis ATCC 50581
XP_002364706  669 KEMVNMIkaikcprlspCTAVIEAVWDSMVATGILSDSAFIRWF 712  Toxoplasma gondii ME49
XP_002119720  583 EIATEKTand----ptqYFTNLKMVLMFLYENDVLSEEVILHWN 622  Ciona intestinalis
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