4Z2M,6GEJ,1ZLA,3A6N,4JJN,6IQ4,1EQZ,5B40,2IO5,5BSA,6FTX,2HIO,5BS7,5WCU,5KDM,4H9N,5AY8,6UPH,5ZBX,6KXV,7BXT,3R45,6XWS


Conserved Protein Domain Family
HFD_H3
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cd22911: HFD_H3 
histone-fold domain found in histone H3 and similar proteins
Histone H3 is a core component of the nucleosome, which wraps and compacts DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called the histone code, and nucleosome remodeling. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Links
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Statistics
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PSSM-Id: 467036
Aligned: 107 rows
Threshold Bit Score: 112.633
Created: 22-Feb-2021
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
Download Cn3D
 
Conserved site includes 45 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1ZLA: Xenopus laevis histone H3 forms a heterodimer with histone H4; contacts at 4A
  • Structure:4JJN: Saccharomyces cerevisiae histone H3 forms a heterodimer with histone H4; contacts at 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1             #  #  ##  ## # # ##   ## ### ## # #        ##### ##  ##  ### ### ###  #    
4Z2M_G         6 HRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKt------DLRFQSSAVMALQEACEAYLVGLFEDTNLCAI 79  human
1ZLA_A        39 HRYRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKt------DLRFQSSAVMALQEASEAYLVALFEDTNLCAI 112 African clawed ...
XP_001584219  38 KQRRKRNSWLREIHFYQKTTNLLIRKLPFCRLVKEITQSVSi-----gEFRYTTGAMEALQEASEAFLIKLLEDGQVCAI 112
Q8IDZ1        72 HRYRPGVLALKEIRAYQASTQLLIPKIPFVRVVKEITRLFElp---deQFRYTPEALLALQTASEAYLVSLFEDAYLCSL 148 Plasmodium falc...
Q2N2K6        79 RRFRPGDNALKQLRQYNQTPSLLIRKLPFQRLIREISTRMTee----dSLRWTSFALVLLQTVVEDYMVSFFEDANACAL 154 Tetrahymena the...
XP_013904860  70 ARHGAKALKASEIKKYQKTGDLLIPKAPFMRLVKEVTQNVAds----kDLRYKLTAVQAIQEAAEQYLTGLMEDAQLCAI 145
OSX75622      47 TRYRPGTRALREIRKYQASTKPVLPRAPFVRLVREVAQEVRp------DFRFTKKCLVLLQEAAEGHVVEVIQDAYACAR 120
EFX66448      55 KRYRPGSKALKEIRHYQRGTGLLIPRSPFTRVIKQISQELTgnsapliRLRFTSEALECLQVASEAMVIQLFEDSVWTMV 134
EFX86522      97 KKYRPGTKALREIRKYQKGTEFLLHKAPFQRLVREVSDSLTd-----sTSRFTADALECLQTASEAFVIQLFEDSVLAMV 171
P34440       162 RRYRPGQKALEEIRKYQESEDLLIPKAPFARLVREIMQTSTpf---ssDLRIRSDAINALQEASEALLVQMFDGSSLISA 238 Caenorhabditis ...

Feature 1            #####   #  #    
4Z2M_G        80 HAKRVTIMPKDIQLARRIRG 99  human
1ZLA_A       113 HAKRVHIMPKDIQLARRIRG 132 African clawed frog
XP_001584219 113 HARRITLMNRDLQLAQRLRG 132
Q8IDZ1       149 HANRVTLMPKDIHLARRIRG 168 Plasmodium falciparum 3D7
Q2N2K6       155 HAKRVTLMSKDLALAARIRG 174 Tetrahymena thermophila SB210
XP_013904860 146 HARRITLFVKDIQLARRIRG 165
OSX75622     121 HARRVTLMPKDLLLAQRIRG 140
EFX66448     135 NAKRLTLMVQDIQLVRRIRG 154
EFX86522     172 HAKRVTLMLRDIQFIRRLRG 191
P34440       239 HSKRATLTTTDVQLYRRLCL 258 Caenorhabditis elegans

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