5J5C


Conserved Protein Domain Family
DCB

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pfam16213: DCB 
dimerization and cyclophilin-binding domain of Mon2
DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.
Statistics
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PSSM-Id: 465072
Aligned: 22 rows
Threshold Bit Score: 148.943
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5J5C_B         29 HHSQLRKACEVALEEIKAETEKQS-PPHG------EAKAGSSTLPPVKSKT--------NFIEA-----------DKYFL 82   human
EFA78841       15 NGLGLLTVLQTELRSISQEARSKFpAIKE------ASERGILKLKYIEEQStsietlivAL-SKs----------EDVLK 77  
EGC38554        3 KLKSLLSVIVSDLRTISQEGRNKFqNIKD------VSERVILTIKYLEEQSttseqlmqNLKIKs----------EEIIK 66  
Q55BA7          4 NKSALLSFLEMDLRNISSEARNKLlNIKE------ASERGILYIKYLQEQSatpeillqNLKSKs----------DEILK 67   Dictyostelium...
EGG13164        5 asSSSLALLVSDFQALASETKRKHaDVREvnttpsTSSKFSIALNLLRSTPd------qVLASFrkkttppstyvEDIIK 78  
CCH58575        8 QFFTLQKLLNNDLHNLVSESRRKNsEVKH------TSDKALEILKTCHSNL--------DLKRH-----------PDFII 62  
CCF56269        7 QFSSLYKQLDTGLHSLSSEAKRRNsEVKH------ASEKSLKILKTVHDSG--------DFLRH-----------PDFVV 61  
XP_003668010    5 kfTSFRKQLDQELHSLSSESKRRNsTIKH------ASDKSIDILKTIQNIE--------ELVRH-----------PDFVT 59  
XP_001745931   24 RGRQLVEALKSDLNLMATEARKKAtPLRL------AVERALVRLSTVGSLPp------tSILPEml-------raKDLMQ 84  
KJE91042        5 LGRQLLEVLQTDLRTISAEAKKKHpTVKD------AAEHGILRLRSVASASsssk-pfnEVLAEt----------DEVLA 67  
5J5C_B         83 PFELAC-QSKCPRIVSTSLDCLQKLIAYGHLT---------GNApdsttpgkklIDRIIETICGCFQGpqTDegvQLQII 152  human
EFA78841       78 PFLMSC-DTKNQKMVSIAIGSILKLISQSAVS---------ITT----------LPLILSKMSMLIDIg-SEepvQLKVL 136 
EGC38554       67 PFLMAL-ETKNQKMISIAIGSILKLISHSSIS---------INS----------LPLILNKMQMLIDVg-SDesvQLKVL 125 
Q55BA7         68 PFLMAL-ESKNQKMISLAIGSVLKLISHSAIS---------NSS----------IPSILSKMQLLIDVg-SDesiQLKVL 126  Dictyostelium...
EGG13164       79 PIFMGC-GTKNVKVVAIALGSLQRLISMDVMPpvnkwtylkSFK----------IPQIVAILTSVLPLg-VEi--QLRIL 144 
CCH58575       63 PLIKAC-SSKSAKLTTIAMQCLQRMSSVDCIP---------DSR----------ISQVLDSFIEATLLa-SDi--QLKVL 119 
CCF56269       62 PFVLAC-SSRSAKLTTIGLQGLQNLSSTNCIP---------KDR----------LIEVLDGFIDATHLa-MEi--QLKVL 118 
XP_003668010   60 PLVLAC-SSRNAKLTSIAMQCLQGLASVPSIP---------ESR----------IPEVLDGFIEATQLa-MEi--QLKVL 116 
XP_001745931   85 SFLLGLeETKNPRVVQLSMACIHRMIDTDAID---------HES----------KLVVLERLQQLASTg-QE---EIKIL 141 
KJE91042       68 PLLMAC-DSKAPKLVQVAINSVHKLISHNAIS---------QSM----------VGPVINTLWQLMEEs-LE---EVKIL 123 
5J5C_B        153 KALLTAVTSQHiEIHEGTVLQAVRTCYNI--YLASKNlINQTTAKATLTQMLNVIFARM 209  human
EFA78841      137 QGLLILITTLH-DLHDDLLAQCLVLCFRL--HCSKNT-SIQKTSSATLPQITRIIFDRV 191 
EGC38554      126 QGLLVLITTMG-DIHDDTLSQCLVLCFRL--HCSKNI-SIQSTSSATLPQIIRIIFDRV 180 
Q55BA7        127 QGLLVLITTVP-DIHDEELSQLLVLCFRL--HGSKNT-SIQSTSSATLPQIIRIIFDRV 181  Dictyostelium discoideum AX4
EGG13164      145 QTLPSLFTRCSlYLHDTLLADALLLCFRL--QDSRIG-VVSSTSAATLRQLVMVVFEGV 200 
CCH58575      120 QIVPIFFKTYGkYIYGPLCAKLLTCCSNLlqVPNKSP-MVIGTASATMQQLIDEIFERL 177 
CCF56269      119 QVVPIFFKTYArYIHGQVCMKLLQCCSVLlqLPQKSS-IVASTASATLQQLVDEIFERL 176 
XP_003668010  117 QIVPIFFKTYAkYIVGPQCKKLLQCCSSLlqLPNKAP-VVFGTASATLQQLIDEVFERV 174 
XP_001745931  142 QCVLSLVTTSP-DIRGDDLAQAVALCFRL--HFVKDV-MTAAIAAASLRQLVAAVFERV 196 
KJE91042      124 QCCLSFITSSL-LLHDETLSKVIVVCFRL--YFKKDA-LTTNTAAATLRQILTVVFDRV 178 
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