Conserved Protein Domain Family
PH-GRAM_GRAMDC4

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cd13221: PH-GRAM_GRAMDC4 
GRAM domain-containing protein 4 (GRAMDC4) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
GRAMDC4 is a membrane protein. Nothing is known about its function. Paralogs include: GRAMDC1A, GRAMDC1B, GRAMDC1C, GRAMDC2, GRAMDC3, and GRAMDC-like proteins. It contains a single PH-GRAM domain at its N-terminus. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.
Statistics
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PSSM-Id: 270041
Aligned: 13 rows
Threshold Bit Score: 140.553
Created: 25-Jan-2012
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003198332 456 LPICENGWRCClinrdrkmptdYIRNGMLYVTeNYLCFESss--srSGSSKKNKVIKLVDITDIQKYKVLSVLPGSGMGI 533 zebrafish
XP_003640385 461 LAVCENGWRCClinrdrkmptdYIRNGILYVTeNYLCFESs----kSGSSKRNKVIKLTDITDIQKYKVLSVLPGSGMGI 536 chicken
Q6IC98       460 LAVCENGWRCClinrdrkmptdYIRNGVLYVTeNYLCFESs----kSGSSKRNKVIKLVDITDIQKYKVLSVLPGSGMGI 535 human
A2RV80       461 LPACETGWRCClinrdrkmptdYIRNGILYVTeNFLCFESs----rSGSSKRNKVIKLTDITDIQKYKVLSVLPGSGMGI 536 African clawed ...
XP_003420939 462 LAVCESGWRCClinrdrkmptdYIRNGVLYVTeNYLCFESs----kSGSSKRNKVIKLADITDIQKEFGPGRLALSGTAE 537 African savanna...
NP_001192282 490 LAVCENGWRCClinrdrkmptdYIRNGVLYVTeNYLCFES------SKSGSSKRNKVIKLMDITDIQKEESVLDEWGLAS 563 house mouse
XP_800124    510 LPGWKEGKRCTliskn--tvtgAFKNGRFYLTkSFLCFEKs-----RLTKEGNMLIPLKDILRIEKAKPFNFLPGNGMSI 582 purple urchin
XP_002613676 171 QQEWEDGRHCVlidrdkgltsgGIKHGRLYLTkNFLCYERs-----KSNPSKNVKIQLGDIVGLEKAKALPFMPGNGMSL 245 Florida lancelet
XP_001628208 532 LPSWEEGRHCFlvdkd--kpftNSKQGKLYLTqSYLCFEKa-----KSSSSKHITIKLESIVRLSKFKPIGIMPGTGMSI 604 starlet sea ane...
XP_002741611 663 LPDWQGGKRCTliske-kpltgAFKNGKLFLTrSFLCFERs-----KNPTPKNLVIPLTDITSCEKAKPYGFLPGGGMAI 736 Saccoglossus ko...
EFW42087     422 ENVELIDWRCAllnka--skytGHRQGKLYLTaRHLCFDPasgffsSASEKDKLLIDLADIVTIRKAKPISFSPGDGFSI 499 Capsaspora owcz...
XP_002404537 194 VPGWEQGRKCTlikke-rsltsAFRNGRLYLTnNYLLFLRy-----KSQHPKNVAIPLTRIMKLEKGRPYSWIPGDGMSL 267 black-legged tick
EFX82058     401 LSGWQNGLRATlvnrd-ksltsSFKSGRLFLTtSYLCFERs-----KTQPGKNVVIPLDRIIRLEKGNQYSWIPGGGMII 474 common water flea
XP_003198332 534 SIatpSTQKPLVFGamihrdEAFETIFTQY 563 zebrafish
XP_003640385 537 AVstpSTQKPLVFGamvhrdEAFETIFNQY 566 chicken
Q6IC98       536 AVstpSTQKPLVFGamvhrdEAFETILSQY 565 human
A2RV80       537 AVstpSTQKPLVFGamvhrdEAFETIFSQY 566 African clawed frog
XP_003420939 538 LAsrdRGEGEATSGwvwvcpLNPSPFADEG 567 African savanna elephant
NP_001192282 564 PLslgEAGGPVAMVvlfhfsIKSCLSSLAQ 593 house mouse
XP_800124    583 EIhlsSADKPVLFGgmlrrnLIYDQLVETW 612 purple urchin
XP_002613676 246 EVkvnNAEKPYLFGaminrdEVYDQVLVAS 275 Florida lancelet
XP_001628208 605 EVevkNVDKPYIFGammgrdEVYDSIMNTA 634 starlet sea anemone
XP_002741611 737 EInvvGSTQSCYLFgaminrDESFESIMRA 766 Saccoglossus kowalevskii
EFW42087     500 EVilsDSHSILFGAlvrrdvTFETIAKQGA 529 Capsaspora owczarzaki ATCC 30864
XP_002404537 268 VVttsTGDVFTFGAvnnredTFRSIVDLGL 297 black-legged tick
EFX82058     475 EVfvqGLDRERGWMdgfdryISFVCLALFL 504 common water flea
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