Conserved Protein Domain Family
Lys_Orn_oxgnase

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pfam13434: Lys_Orn_oxgnase 
L-lysine 6-monooxygenase/L-ornithine 5-monooxygenase
This is a family of Rossmann fold oxidoreductases that catalyze NADPH-dependent hydroxylation and are involved in siderophore biosynthesis. This family includes L-ornithine 5-monooxygenase, which catalyzes the hydroxylation of L-ornithine at the N5 position, and L-lysine 6-monooxygenase, which catalyzes the hydroxylation of lysine at the N6 position (EC:1.14.13.59).
Statistics
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PSSM-Id: 433204
Aligned: 31 rows
Threshold Bit Score: 409.282
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001595607            49 ESLDLVCVGFGPASLAIAIALHDAYsksslppPKVLFLERQPEFAWHAGMQLPGARMQISFLKDLATPRDPRSKFTFINY 128
PRJNA212797:N288_03730   2 nIYNLIGIGIGPYNLSLAVMLKKVPg------LTGLFFDKTPEFSWHPGMLIEGSEMQVPFLDDLVTLADPTSPYTYLNY 75 
jgi:Ndas_1073           15 RVHDFAAVGIGPFNLGLACLTAPIPg------LDGLFLDEKPEFSWHSGMLLEEAELQTPFMSDLVTLADPTSPFSFLNY 88 
CBG72818                 2 RTYDFIGIGLGPFNLGLACLTEPIAe------LDGIFLETKPNFEWHSGMFLDGAHLQTPFMSDLVTLADPTSPYSFLNY 75 
jgi:Strop_2550           2 TTHDFIAIGLGPYNLGLACLTEPISe------LDGLFLEARADVSWHPGMLLESTRLQTPFLADLVTFADPTSPYSFVNY 75 
jgi:Micau_2597           2 sTHDFIAVGLGPYNLGLACLTAPIDd------LDGLFLEARDSFDWHPGMLLESTRLQTPFIADLVTLADPTSPYSFLSY 75 
P65199                   4 EIYDFVAIGIGPFNLSLASLSAPLRg------VRTLFLDKKSGFDWHPGMLIETSTLQNPFLADLVSLADPRSEYSYLNY 77  Borde...
WP_013183778             4 KIYDFIAIGIGPFNLGLACLVQPIQe------INSLFIDQNPSFNWHPGMMLESSTMQTPFMADLVTLASPTHPLSFLNY 77  Xenor...
WP_011914714             3 KIYDFIGIGIGPFNLGLACLAQPIDg------LDCLFLDRAEGFNWHPGMMLDSATLQTPFMADLVTLADPTSRFSFLNY 76  Pseud...
EFG06283                11 QPHDLVGIGIGPSNLSLAALAHGVPg-----gLATAFFEQSPRFGWHPGLLIDGAVLQVPFLADLVTLADPASPWTFLNY 85 
XP_001595607           129 LHCKGRLNTFINLSTFLPSRMEYEDYLRWCASHFEKegcVKYGANVESVVPSSpsaEDgkipsFTISSssp--sgELI-- 204
PRJNA212797:N288_03730  76 LHEHDRLTQFSYFHRLEIPRKEYNHYCQWAASNLDN---CRFGMEVADVRDRE---ENge-rfFEVTVlnm-dngQEE-- 145
jgi:Ndas_1073           89 LKETGRLYPFYIRERFYPLRAEYDDYCRWAARRLGDa--VRFGQRVESVEYDP---DRal-ylLHSTeta---tgARH-- 157
CBG72818                76 LKDSGRLYSFYIRENFYPLRVEYDDYCRWAAGRLTN---VRFGTTVTEVTYED---ADe---vYAVRTa------AGD-- 138
jgi:Strop_2550          76 LKETGRLYPFYIRESFFPLRVEYDAYCRWAAARLSN---LRFGHTVTTVEYDE---ADge-yvVTAETad-----gPV-- 141
jgi:Micau_2597          76 LKETGRLYPFYIRESFFPLRAEYNDYCRWAAGKLPN---LRFRHSVTAVEYDE---SDd---rYVVHAdtp---dgPV-- 141
P65199                  78 CKLTNRIYSYYMRENHYLSRAEYTRYCQWVAARLPN---LRFGCDVQGVLHDP---EShs---ylVTGqht-msgQRF-- 145 Borde...
WP_013183778            78 IKKKGRIYSFYIRESFFLMRKEYNQYCQWAAEQLSN---LRFNTQVESITHDA---AAs---lYTLHCldt-rtgEKH-- 145 Xenor...
WP_011914714            77 AKQIGRLYAFYIKEDFFLMRREYNQYCQWVVEQLDS---LRFGHFVQHVDYLD---ERr---cYRVRGvha-rsgEGF-- 144 Pseud...
EFG06283                86 LRGRERLFPFYFAQTFHVHRSEYDAYCRWVSDSLPG---LHFGHRVDAVRWNP---ERa---lFEVDFtrfgpegEAQap 156
XP_001595607           205 -THSARHVVIAVGGKPIIPPVLQn-----KPCVLHSSQFATNiGKieklqkeRRKPLRFAVIGSGQSAAEIYNDLWER-- 276
PRJNA212797:N288_03730 146 -TYFAYNLILGTGNEPLVPGHIKdf---lgEDCIHSSRYLQYkDK-------LVEGGSISVIGSGQSAAEIFYDLLQC-- 212
jgi:Ndas_1073          158 -THRARRLVLGTGTPPYLPEPCRdl----pGDAVHSSGYLPAaRR-------LRDKRSVTVVGSGQSAAEIFHDLLQDld 225
CBG72818               139 -VLRARHLVLGTGTPPYVPETVRdl----dGDWIHNSRYLTHkRE-------LQRKKSITVVGSGQSAAEIYRDLLGEid 206
jgi:Strop_2550         142 -THRARRLVLGTGTPPELPAVCQgl----gGDAIHNSRYLEHrDA-------LRSKRSITIVGSGQSAAEIYYELLTD-- 207
jgi:Micau_2597         142 -THRARHLVLGTGTPPYLPPACAgl----gGDMIHNSRYLEHrEA-------LRAKDSITVVGSGQSAAEIYHDLLCD-- 207
P65199                 146 -MFRCRKLVLGLGSQPYLPACCDr----rAAPFIHSADYLRHkYE-------LQGRASITIVGSGQSAAEVFHDLLREsg 213 Borde...
WP_013183778           146 -QFSCKKLVLGTGPSSYIPKCCRpf----sDQMVTSGEYLKNkAA-------LQQKKSITVMGSGQSAAEIFYDLLED-- 211 Xenor...
WP_011914714           145 -EFLTRRLVLGTGTTPYLPSCCEgl----aEHVSHSGNYLQDkPR-------LQGKRSITVVGSGQSAAEIYYDLLQDid 212 Pseud...
EFG06283               157 gRTHARHIVLGVGTEPYVPDALRpltaapGAPVLHSADYLAHrDR-------LLAAGHITVVGSGQSGAEVFLDLLRHrp 229
XP_001595607           277 FG--EetgVTVKLLVKGQSLRPSDDSPFVNEIFDPDRVTPHYNRPSHLRAAGIVLDrATNYGVVRLELLEHLYEKLYIQR 354
PRJNA212797:N288_03730 213 QK--Th-dFQLNWLARSAGFLQLESTKLGQEFFSPEYVNYFHSLPYEERIQSLDTLnG-LRNGIEPGLLDLIYKELYHQT 288
jgi:Ndas_1073          226 EH--G---YQLNWVTRSPRFFPLEYTKLTLEMTSPEYADHFHALPAPTRDRLVASQkN-LYKGIDSDLINAIYDLLYVKS 299
CBG72818               207 VH--G---YQLNWVTRSPRFFPLEYTKLTLEMTSPEYIDYFHALPEPTRHRLTREQkG-LYKGIDGDLVDEIFDLLYQKS 280
jgi:Strop_2550         208 ID--Ty-gYQLTWVTRSPRFFPLEYTKLTLEMTSPDYVDYFHGLPEETRYRLEGEQkGL-LKGINSDLINSIFDLLYARS 283
jgi:Micau_2597         208 ID--Ty-gYQLTWVTRSPRFFPLEYTKLTLEMTSPDYVDYFHALPEPTRYALEAAQk-PLFKGINADLINDIYDLLYAKS 283
P65199                 214 RH--D---YSLAWITRSPRFFQMENTKLTLELISPDYTEYFHDLPEARRQEILTQQn-SLYKGINASLINQIYDLLDEKV 287 Borde...
WP_013183778           212 IDtyN---YQLNWVTRSPRFFPLEYTKLTLEMTSPEYVDYFYDLPENKRDALNRTQkS-LYKGINSSLINEIFDLMYTKR 287 Xenor...
WP_011914714           213 RH--D---YQLNWITRAPRFFPLEYTKLTLEMTSPEYIDYFHSLPRSTREKLIDSQkG-LYKGINGTLINAIYDELYNQS 286 Pseud...
EFG06283               230 AG--A---EGIHWISRSESFAPMEYSKLGLEHFTPDYTHYFHSLPEQTRDRLIPRQwQL-HKGIDARTIAAVHEELYRRT 303
XP_001595607           355 IKCertgaEPR-AAIIINRRVTSATASPs-QdslRLKIVTEDGDEKVEEELDVDYIFTATGYRR 416
PRJNA212797:N288_03730 289 IGG-----ESSlARIQPHAELQGMERTSs-----GFALQLQQKQAETPFKLDSDKVVLATGYRp 342
jgi:Ndas_1073          300 RLG-----RPP-VRLMTGTEVTGARHDAasG---AYTLDLRNTDQGRDFALDTEGLVLATGYQY 354
CBG72818               281 LGG-----PLP-TRLLTNSALHSAGHEN--G---TYTLGLRQEEQEKDFELHTQGLILATGYRY 333
jgi:Strop_2550         284 TDG-----PVR-TRLLTNTELVSAAHDA--G---TYTLGLRHHEQGRDFTLDTEGLVLATGYRF 336
jgi:Micau_2597         284 LHG-----PAP-TRLLTNTELVEAAYTD--G---RYRLGLRHTEQDRAFTLDTEGLVLATGYHY 336
P65199                 288 HDG-----DNR-YTLLTNSELRACRYDPlqE---RFQLDFQHLDCDRPFSHATDGLVLATGYSH 342 Bordetella pertussis ...
WP_013183778           288 LNG-----ELN-VGLYTNSELQQIHQVTe-G---KFVLDLFQQEQEAAFSLETEGVVLATGYQY 341 Xenorhabdus nematophila
WP_011914714           287 LKG-----EVP-TQLLTNAELRRCQRLAd-G---TLELEFFQHELQQSYRHRCEALVMASGYQY 340 Pseudomonas stutzeri
EFG06283               304 LDG-----GWPqTVLTPGVTVRTAGRLAt-T---KVELHLEHAQQGTRSRLTTEAVVLATGYRE 358
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