Conserved Protein Domain Family
AKR_AKR9A_9B
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cd19080: AKR_AKR9A_9B 
AKR9A and AKR9B families of aldo-keto reductase (AKR)
The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.
Links
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Statistics
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PSSM-Id: 381306
Aligned: 29 rows
Threshold Bit Score: 371.937
Created: 13-Mar-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    ###                                 #    #                       
P25612     17 FLSETAAIKVSPLILGEVSYDgarsdflksmnKNRAFELLDTFYEAGGNFIDAANNCqneQSEEWIGEWIQsrrlRDQIV 96  Saccharomyces cere...
EME30873   37 TQVGSFGLRVSPLCLGCMGYGkswqd--imgeHVENEAILDTYVEAGGNFLDMANKYnegETEEIIGEWMKkrgnRERMV 114 Galdieria sulphuraria
EJT46271   64 VLSPTASVRVSPLCLGAMNLGnqwaglgskmsTADAFAFLDAFYDAGGNFIDTANSYqaeQSERLIGEWMQarqnRDSIV 143 Trichosporon asahi...
Q00049     18 ILSSSAGVRVSPLCLGTMSFGngwkgvmgecdQATSFNMLDTFYESGGNFIDVANFYqggDSERWVGEWMAqrqnRDEIV 97  Aspergillus flavus...
KPJ94433    4 RLLGRSGLRVSELALGAMTFGeewg---wgatKKESKAMFDAYANAGGNFIDTANRYtegTSEKYVGEFVKa--dREHFV 78  Gemmatimonas sp. S...
EEF59590    4 RLLGNSGLRVSEMALGTMTFGedwg---wgapKEEAQKVYNAFREAGGNFIDTANVYtngSSESFLGEFMKg--hRESIV 78  Pedosphaera parvula
OQW30516    4 KLLGKSGLRVSELCLGTMTFGedwg---wgsnKEESRKIFDAFLNAGGNFIDTANLYtngTSESYLGEFMEg--rRECVA 78  Nitrospira sp. SG-...
OGR88718    4 KLFGRSGLKVSEVCLGTMTFGedwg---wgasKDESRAIFDAFTAAGGNFFDTADGYtngTSEKFLGEFIKg--sRERSV 78  Elusimicrobia bact...
KER09077    4 TLLGKSGLRVSELCLGTMTFGtewg---wgadKDESKKIFDAYANAGGNFLDTANRYtegTSEKFLSEFIAs--dRDHFV 78  Chlorobium sp. GBChlB
OJU80674    4 CILGKSGLRVSQICLGTMTFGeefg---wgnsRQESRKVFDYFLDMGGNFIDTANHYtkgTSEKLLGEFIEh--kRNQIV 78  Chlamydia sp. 32-24

Feature 1        #                                                 ##                         
P25612     97 IATKFiksdkkyka--gesntanyCGNHKRSLHVSVRDSLRKLqTDWIDILYVHWWDYmSSIEEFMDSLHILVQQGKVLY 174 Saccharomyces cere...
EME30873  115 VATKFsigmrk--------ndpnaVGNHRKNMVSAVKDSLRRLqTDYIDLLYVHFWDFtTPIEEVMSSFHDLISAGKVHY 186 Galdieria sulphuraria
EJT46271  144 LATKFswfyhyrmdrvdpgvnvnfQGNSAKSLHVSFEASLRKLqTDYVDILYVHYWDWsASIPELMGALNDLVRQRRVLY 223 Trichosporon asahi...
Q00049     98 LSTKYtmgytmfg---pqkiksnyQGNHTKSLRLSVKASLQKLqTDYIDLLYVHMWDFtTSVEEVMRSLNHLVANGKVLY 174 Aspergillus flavus...
KPJ94433   79 VATKYtlftgr--------ddpnkCGNHRKNMVQALDASLQRLdTDYVDLYWLHAWDFtTPVDEVMRALDDMVCAGKVLY 150 Gemmatimonas sp. S...
EEF59590   79 LATKYtnampg--------tdpnaAGNQRKNMMQAVEASLKRLqTDYIDLYWVHIWDQiTPVEEVMRGLDDLVRQGKILY 150 Pedosphaera parvula
OQW30516   79 LATKYtnsapg--------ndpnaGGNQRKNMMQSVEASLKRLkTDYIDLYWMHIWDGmTPVEEVMRAFDDLVRQGKVLY 150 Nitrospira sp. SG-...
OGR88718   79 IATKYsfnmrp--------gdpnaGGNHRKNMIQALEGSLKRLgTDYVDIYWVHAWDElTPSDEVMRGLDDLVRQGKVLY 150 Elusimicrobia bact...
KER09077   79 LATKYtlydkp--------adpnyCGNHRKNLMRSVRESLKRLnTDHIDLLWLHMWDStTPVDEIMRGLDDLVSRGIVHY 150 Chlorobium sp. GBChlB
OJU80674   79 LATKYtlntsp--------kdpnaGGNHRKNMVRSLEDSLKRLqTDYIDLFYLHIWDEtTPIEEILRAFDDLVKSGKILH 150 Chlamydia sp. 32-24

Feature 1        ##                        #                           #######                
P25612    175 LGVSDTPAWVVSAANYYAtsygktpfsIYQGKWNVLNRDFErDIIPMARHFgMALAPWDVMGGGRFQSKKameerrknge 254 Saccharomyces cere...
EME30873  187 VAFSDTPAWVVAKANTIAefrgwprvaAYQGRYSLSDRTMErELIPMLRSEkIAHVPWGVLGQGKLTGKYqrgtqpki-- 264 Galdieria sulphuraria
EJT46271  224 LGASDMPAWVVAACNEYAkar---gmaQFVVLFSLADRAVEeEVIPMLRHQgMALAPFGVLGSGKFKSPEalreqevrg- 299 Trichosporon asahi...
Q00049    175 LGVSDTPAWLVVKCNAFArangltpfsVYQGHWSCAFRDFErDILPMCESEgMGLAPWGVLGRGQFRSAEdfsregr--- 251 Aspergillus flavus...
KPJ94433  151 IGVSDTPSWIVSQANTLAdlrgwtrfvGLQIRYSLIDRTAErDLLPMAREFdMAVTPWSVLGAGVLSGKYnkdkaatgr- 229 Gemmatimonas sp. S...
EEF59590  151 VGISDAPAWWIAQANTLAslrgwspfvGLQIEYSLVERTVErELIPMAQALnLGVTAWSPLSGGILTGKYhgqgsaegsr 230 Pedosphaera parvula
OQW30516  151 VGVSDAPAWWVAQANTIAnlrgwtpfvGLQVEYSLIERTPErELLPMAQALgLTVTAWSPLAGGVLTGKYltqngqagks 230 Nitrospira sp. SG-...
OGR88718  151 VGVSNTPAWVVSYCNAISeirgwsrftGLQVEYSLLERTPErEFLPMAKALgLAVTAWSPLCGGLLTGKYgagagigeek 230 Elusimicrobia bact...
KER09077  151 IGISDTPAWIVSQANMLAdlrgwtqfvALQIEYSLLQRSPErDLLPMAKALeLTVTPWGAIAGGALTGKYlkgengrv-- 228 Chlorobium sp. GBChlB
OJU80674  151 VGLSDTPAWIIAKGDTLAsfrgyspivAMQLEYSLIERSIErEYFDMSKSLdIPIVAWSPLGMGVLSGKYnerkgnqtke 230 Chlamydia sp. 32-24

Feature 1                                            #                ######  #  ##           
P25612    255 g-----irsfvgaseqtDAEIKISEALAKIAEEHGtesVTAIAIAYVRSkaknFFPSVEGGKIEDLKENIKALsiDLTPD 329 Saccharomyces cere...
EME30873  265 ---------rggitqmtEKDFQLQDVVTDIAKQLNv-sNSQIVLAWMLNhqpgTIPIVGCRTTAQLKEHIQALniRLNAE 334 Galdieria sulphuraria
EJT46271  300 ---------tkatdaeiKLAEVLQGVADELSTSDMkvtVPGVALAWSRQkyehSIPLIGGHKIEHLKSNIEMLriKLTPE 370 Trichosporon asahi...
Q00049    252 -----------kmgpqdEKHRRLGEKLDQMAQQKNt-kATSIAQAYVMHkapyVFPVIGGRKVEHLKENIEALglVLSEE 319 Aspergillus flavus...
KPJ94433  230 ---------aqegaatiERNLEIAAAVIEMADQIGc-tPSQVAVSWTRQqpgvVIPIIGARNTEQLEDNLRALdvVLTEQ 299 Gemmatimonas sp. S...
EEF59590  231 ms----sdmmkefmpeeKRAAAIVAAVKAIAQETGr-sMAQVALAWLRYrsvpVIPIIGARKLSQLNDNLASLelSLSAV 305 Pedosphaera parvula
OQW30516  231 dgarldlpdmqqffsygNRTTAIVQEVMAIAQEVGr-tPAQVALAWLRQrfqpIIPIIGAKKLHQFKDNLANLdlILEPK 309 Nitrospira sp. SG-...
OGR88718  231 r------ldksafveidERKLKIVDTVKSVAAELGr-sPAQVALAWTRKr---SIPILGARTLGQLHDNLKCLefLLSYE 300 Elusimicrobia bact...
KER09077  229 ---------patsarrsEKATELAKVVMRLAEKIGa-tPAQVAFQWTRQraqsIVPIIGARTAAQLHDNLGILnlTLPDD 298 Chlorobium sp. GBChlB
OJU80674  231 arf--qvnptwgesylkEKNMQIAKKVVKIAKDAAr-sPTQVALNWILQksplMIPIIGAKTQSQLEENLGCLdfVLTSQ 307 Chlamydia sp. 32-24

Feature 1           
P25612    330 NIKYLE 335 Saccharomyces cerevisiae S288C
EME30873  335 QMERLN 340 Galdieria sulphuraria
EJT46271  371 QMATID 376 Trichosporon asahii var. asahii CBS 2479
Q00049    320 EIREID 325 Aspergillus flavus NRRL3357
KPJ94433  300 QLAELG 305 Gemmatimonas sp. SG8_17
EEF59590  306 QVKALD 311 Pedosphaera parvula
OQW30516  310 LLDRLT 315 Nitrospira sp. SG-bin1
OGR88718  301 QESRLN 306 Elusimicrobia bacterium RIFCSPLOWO2_01_FULL_60_11
KER09077  299 AMHELD 304 Chlorobium sp. GBChlB
OJU80674  308 QMKELD 313 Chlamydia sp. 32-24

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