1ZP3


Conserved Protein Domain Family
fadh2

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TIGR00676: fadh2 
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5,10-methylenetetrahydrofolate reductase, prokaryotic form
The enzyme activities methylenetetrahydrofolate reductase (EC 1.5.1.20) and 5,10-methylenetetrahydrofolate reductase (FADH) (EC 1.7.99.5) differ in that 1.5.1.20 (assigned in many eukaryotes) is defined to use NADP+ as an acceptor, while 1.7.99.5 (assigned in many bacteria) is flexible with respect to the acceptor; both convert 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. From a larger set of proteins assigned as 1.5.1.20 and 1.7.99.5, this model describes the subset of proteins found in bacteria, and currently designated 1.7.99.5. This protein is an FAD-containing flavoprotein. [Amino acid biosynthesis, Aspartate family]
Statistics
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PSSM-Id: 273212
Aligned: 21 rows
Threshold Bit Score: 354.247
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1ZP3_A               25 VSFEFFPPRTSEMEQTLWNSIDRLSSLKPKFVSVTYGANS-GER--DR-TH--SIIKGIKDRTGLE--AAPHLTCIDATP 96  Escheric...
AAQ58640              8 FSFEFFPPKTPEGVAKLRTTRQQLAQFKPQFFSVTFGAGG-TTR--DG-TL--STVLEIH-SEGQA--AAPHLSCIGSTR 78  Chromoba...
lhbprmlnih:CBU_2047   8 LSFELFPPKTLTGFENLKSVWRTLQDKTPDYFSVTFGAGG-GNQ--DK-TM--RVVRALR-QDFIE--VAPHLTCIGLSK 78  Coxiella...
AAF64321             16 YSFEFFPPKTPEGDSKLMETVKELSLLNPDFVTVTYGAGG-STR--DK-TV--QILSQISKDYSFP--TVSHFTCVGANK 87  Leptospi...
AAN85549             15 FSFEFFPPRTEAGSRMLWQAIRRLEALSPTFVSVTYGAGG-SSR--DR-TV--EVTKRIAAQTTLR--PVAHLTAVGHSV 86  Streptom...
AAM75976             26 LSFEFFAPRSHAGSIRLMCAQQVLSRFVPRFVSVTRSTSL-G-------QQ--AHIDTIASTLSVFprTAPHVLFCQCPR 95  Candidat...
WP_002858469          4 FSFEVFPPRKDENIKNLHAILDDLGQLSPNFISVTFGAGG-SIN--SQnTL--EVASLIQEEYQIP--SIVHLPCIHSSK 76  Campylob...
WP_000089968          8 LSFEVFPPNPAVGNDNIISALQDMQELAPHFISVTASNNKfNIK--ET-TV--RLADFIQNDLAIP--TIAHLPAIYLTK 80  Streptoc...
WP_007056260          6 FTLEVFPPKRNAPVGTIYDTLDGLEGLNPDFISVTYG-HG-THS--DR-TAtaRIAHTISKEYGIP--AVAHLTALYSDK 78  Bifidoba...
WP_003130232          8 LSFEVFPPTTQIGSTNLVKTLDSLRTLSPDFISVTCSNNN-YDNigDT-TI--KFADYVNNTLDIP--AVAHLPAAYLDK 81  Lactococ...
1ZP3_A               97 DELRTIARDYWNNGIRHIVALRGDLPP-G------SGKPEMYASDLVTLLKEV---A-DFDISVAAYPEVHPEAKSAQAD 165 Escheric...
AAQ58640             79 ENIAAILNEYRGNGIRHLVALRGDIP--Sgm---vAAGEFRYANELVEFIRAEhgdH--FHIEVAAYPEFHPQARSAEDD 151 Chromoba...
lhbprmlnih:CBU_2047  79 TAIFDLLNNYRLLGIKRIVALRGDLP--Lee--diAGGDFNHANELVAYIRKLtgdY--FHIEVAAYPEFHPETRTVQEA 152 Coxiella...
AAF64321             88 NQILETLKGIRSSGILNLMALRGDPPK-GegefkkVENGFGNATELVSFIRSEk--L-DFCIGGGCYPEKHPNAKTLEED 163 Leptospi...
AAN85549             87 AELRHIIGQYADAGVRDVLVLRGDPPGdPnapwtpHPQGFTHAHELVRLVRn---lG-GFSVGVAAFPERHPRSADWDSD 162 Streptom...
AAM75976             96 ALAREL-RAYELLGIRHLVLLRGDNG---------IAPGSIGAPELVSMVRRSy--GeAFYIDVAAYPDGHPMSSTIFED 163 Candidat...
WP_002858469         77 EKITQILQKCKEKNLNQILALRGDICE-Nl----kKSKDFSYASDLISFIKKQe----YFEIYAACYPEKHNESKNFIED 147 Campylob...
WP_000089968         81 DKVAETIADLDKVGVQKILALRGDIIP-Dv----ePQKDFRYATDLIEFIKEQt--P-HFDIIGACYPEGHPDSPNQISD 152 Streptoc...
WP_007056260         79 AKIDEALDMFEEAGVSAVLALRGDYID-Ge----qLVGEFNHASDLVSYIRSVk--P-DFKVFGACYPEGHYQADSLDQD 150 Bifidoba...
WP_003130232         82 AQVIEILERLKDKQIKKILALRGDISDe------pMKDDFKFASDLVKFIKDYd--D-SFEVLGACYPDIHPESVNRVSD 152 Lactococ...
1ZP3_A              166 LLNLKRKVDAGANRAITQFFFDVESYLRFRDRCVSAGIDVEIIPGILPVSNFKqAKKFADmTN-VRIPAWMAQMFDGLDD 244 Escheric...
AAQ58640            152 LANFVRKVRAGADSAMTQYFFNADSYFRFVDEVRARGVDIPIVPGIMPISNFGqLCRFSD-MCgAEVPRWLRLRMQSYYD 230 Chromoba...
lhbprmlnih:CBU_2047 153 LKNFQQKIAAGANGAITQYFYNRDAYFNFVDACRNVGIEAPIVPGIMPISDFDkLVRFSK-TCaTEIPRWLYKRLESYKN 231 Coxiella...
AAF64321            164 VENLKLKVDAGTDFLVSQLFFVNSIFENFLNLVRKVGIQVPVIPGIMPITSFSqIDRFRSmAG-CEFPSSLIQDLQEVEH 242 Leptospi...
AAN85549            163 ISHFVAKCRAGADYAITQMFFDVEDYLRLRDRVAAAGCDTPIIPEIMPATDVRqIRRFAE-LSnARFPAALADRLEAAAG 241 Streptom...
AAM75976            164 VRALARKVRCGANSAITQCFYNPDAYYRLQDELQRLGVSLPVTPGIMPVLSHDyMSRFIL-PSgVDVPAWILKRLEALRY 242 Candidat...
WP_002858469        148 IHHLKTKVNAGTDKLITQLFYDNEDFYTFKQNCALADIDIPIYAGIMPITNKRqVLKISQ-LCgAKIPPKFVKILEKYEN 226 Campylob...
WP_000089968        153 IQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNqALRLLKtCEnIHLPRKFKAILDKYEH 232 Streptoc...
WP_007056260        151 IENLKIKVDAGVTHLISQLFYDNEDFYRFLDKARAAGITVPIEAGIMPVRGAKsVRRMAE-RNaSRIPDRLNTLLNKWGD 229 Bifidoba...
WP_003130232        153 FHYLKEKVDAGCDRLITQLFFDNDSFYDFQERCAIAEINTPIFAGIMPVINRNqILRLLKn-CnTPLPAKFIRILEKYEH 231 Lactococ...
1ZP3_A              245 daETRKLVGANIAMDMVKILSREGVKDFHFYTLNRAEMSYAICHTLG 291 Escherichia coli
AAQ58640            231 dtASIRALGLDVVTELCDRLLQGGAPGLHFYTLNQAGLVSTIWQRLG 277 Chromobacterium violaceum ATCC 12472
lhbprmlnih:CBU_2047 232 dkASLKAYGVEVVTKLCEDLIAYGVPGLHFYTLNQCEPTQTIIENLQ 278 Coxiella burnetii RSA 493
AAF64321            243 rpEEFYRRSLNFSVKQCRELLAMGVPGIHLYTLNQSHASYDIVRELK 289 Leptospira interrogans
AAN85549            242 dpAEGHRIGVEYATSMAERLLAEGAPGLHYITLNRSTATLEIHENIQ 288 Streptomyces atroolivaceus
AAM75976            243 csASVLEFGTDVALSLCESLAARGASDFHLYTMNDHRAVWRVCEHVL 289 Candidatus Tremblaya princeps
WP_002858469        227 ntLALEDAGIAYACDQIVDLITSGVDGIHLYTMNKSKAAIKIYEAVK 273 Campylobacter jejuni
WP_000089968        233 dpESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQATH 279 Streptococcus pneumoniae
WP_007056260        230 diQSLRAAGILYASEQIADLVAHDVDGVHLYSMNHPATTRRIWRNAE 276 Bifidobacterium
WP_003130232        232 nlIALRDAGIAYAIDQIVDLVTEDVAGIHLYTMNNANTAHSIHASIS 278 Lactococcus lactis
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