1GOJ,1T5C,3HQD,3H4S,2NCD,3BFN,3DC4


Conserved Protein Domain Family
KISc

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smart00129: KISc 
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Kinesin motor, catalytic domain. ATPase.
Microtubule-dependent molecular motors that play important roles in intracellular transport of organelles and in cell division.
Statistics
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PSSM-Id: 214526
Aligned: 61 rows
Threshold Bit Score: 302.954
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1GOJ_A       7 SIKVVARF--RPQNRVEIES-GGQPIVTFQG-----PDTCTVDSKEAQ------G----------SFTFDRVFDMSCKQS 62   Neurospora crassa
XP_647667  453 RIRVCVRK--RPLNKKEIAK-SEKDIIEVLPk-----KDLIVNEPKTKldlskfIek-------hKFTFDGVFDESANNY 517  Dictyostelium di...
NP_032468  195 RICVCVRK--RPLNKKETQM-KDLDVITIP------SKDVVMVHEPKQ------KvdltrylenqTFRFDYAFDDSAPNE 259  house mouse
BAA33063    42 RVRVAVRL--RPFVDGTAGA-SDPPCVRGMDs-----cSLEIANWRNH------Qet-------lKYQFDAFYGERSTQQ 100  human
NP_511125    8 AVRIAVRE--APYRQF-LGR-REPSVVQFPPws--dGKSLIVDQN--------------------EFHFDHAFPATISQD 61   fruit fly
Q39493      95 NICIAVRK--RPISDKERQKlDHDSVSCFQNkvwihSAKLKVDGITKY------Lth-------nSFQLDHTFGEDSTTE 159  Cylindrotheca fu...
1808299A    27 HIEVILRA--IPEKGLQNNE-STFKIDPYEN-------TVLFRTNNplhett--------kethsTFQFDKVFDANATQE 88   baker's yeast
NP_567426   48 PVEVIGRIrdYPDRKEKS-----PSILQVNTd----nQTVRVRA---D------Vgy-------rDFTLDGVSfSEQEGL 102  thale cress
3BFN_A      22 RVRVAVRL--RPFVDGTAGA-SDPPCVRGMDs---cS--LEIANWRNH------Qet-------lKYQFDAFYGERSTQQ 80   human
3DC4_A      23 AVRIAVRE--APYRQF-LGR-REPSVVQFPPws--dGKSLIVDQN--------------------EFHFDHAFPATISQD 76   fruit fly
1GOJ_A      63 DIFDFSIKPTVDDILNGYN-G-TVFAYGQTGAGKSYTMMGTsi--ddPD------GRG--VIPRIVEQIFTSILSsaa-- 128  Neurospora crassa
XP_647667  518 QVYLHTAYPLVDSIFHKGK-A-TCFAYGQTGSGKTHTQMGQ-------Q------GDG--LYALAARDIFHRLETyf--- 577  Dictyostelium di...
NP_032468  260 MVYRFTARPLVETIFERGM-A-TCFAYGQTGSGKTHTMGGD------FSgknqdcSKG--IYALAARDVFLMLKKpny-- 327  house mouse
BAA33063   101 DIYAGSVQPILRHLLEGQN-AkVVLAYGPTGAGKTTHAGQP------RA------TWGdpAGSHGPPAAHKGGGCrgp-- 165  human
NP_511125   62 EMYQALILPLVDKLLEGFQ-C-TALAYGQTGTGKSYSMGMTppgeilPE------HLG--ILPRALGDIFERVTArqen- 130  fruit fly
Q39493     160 QIYLATTLPLVDHVVSTQGrA-TVFCYGQTGSGKTYTMNGI---------------QQ--ILA---YDLYGQLAEht--- 215  Cylindrotheca fu...
1808299A    89 DVQKFLVHPIINDVLNGYN-G-TVITYGPSFSGKSYSLIGS------KE------SEG--ILPNICKTLFDTLEKneet- 151  baker's yeast
NP_567426  103 EEFYKKFIEERIKGVKVGN-KcTIMMYGPTGAGKSHTMFGC------Gke------pG--IVYRSLRDILGDSDQd---- 163  thale cress
3BFN_A      81 DIYAGSVQPILRHLLEGQN-A-SVLAYGPTGAGKTHTMLGS------PE------QPG--VIPRALMDLLQLTREegaeg 144  human
3DC4_A      77 EMYQALILPLVDKLLEGFQ-C-TALAYGQTGTGKSYSMGMTppgeilPE------HLG--ILPRALGDIFERVTArqen- 145  fruit fly
1GOJ_A     129 -niEYTVRVSYMEIYMERIRDLLAPQ-N-DNLPVHEEKN---------RGVYVKGLLEIYVSSVQEVYEVMRRgGNARAV 196  Neurospora crassa
XP_647667  578 -kdQLQVCISFFEIYGGKLFDLLNE--R-KKLACRENEL---------QNVVIVGLSEKHVTSPQELMNCIIDgNKIRST 644  Dictyostelium di...
NP_032468  328 kklELQVYATFFEIYSGKVFDLLN-R-K-TKLRVLEDGK---------QQVQVVGLQEREVKCVEDVLKLIDIgNSCRTS 395  house mouse
BAA33063   166 -amGLSVTMSYLEIYQEKVLDLLDPA-S-GDLVIREDCR---------GNILIPGLSQKPISSFADFERHFLPaSRNRTV 233  human
NP_511125  131 nkdAIQVYASFIEIYNEKPFDLLGST-P--HMPMV--------------AARCQRCTCLPLHSQADLHHILELgTRNRRV 193  fruit fly
Q39493     216 --dDLEITVAFFELYSGNVLDLLHGC-Q-RC-KLLEDGN---------GEVNITGLREVPAPTPEAFLQVIEEgHSLRTT 281  Cylindrotheca fu...
1808299A   152 kgdSFSVSVLAFEIYMEKTYDLLVPLperKPLKLHRSSSkmd--------leIKDICPAHVGSYEDLRSYIQAvQNVGNR 223  baker's yeast
NP_567426  164 --gVTFVQVTVLEVYNEEIYDLLSTNsS-NNLGIGWPKGastkvrlevMGKKAKNASFISGTEAGKISKEIVKvEKRRIV 240  thale cress
3BFN_A     145 rpwALSVTMSYLEIYQEKVLDLLDPA-S-GDLVIREDCR---------GNILIPGLSQKPISSFADFERHFLPaSRNRTV 213  human
3DC4_A     146 nkdAIQVYASFIEIYNEKPFDLLGST-P--HMPMV--------------AARCQRCTCLPLHSQADLHHILELgTRNRRV 208  fruit fly
1GOJ_A     197 AATNMNQESSRSHSIFVITITQ--KNVETGSAKSGQLFLVDLAGSEKVGKT-G-ASGQTLEEAKKINKSLSALGMVINAL 272  Neurospora crassa
XP_647667  645 GSTGVNSDSSRSHAILQISLKNikTN-----KLHGKFSFIDLAGSERGSDT-YdNDKQTRKEGADINKSLLALKECIRAL 718  Dictyostelium di...
NP_032468  396 GQTSANAHSSRSHAVFQIILRRkgK-------LHGKFSLIDLAGNERGADTsS-ADRQTRLEGAEINKSLLALKECIRAL 467  house mouse
BAA33063   234 GATRLNQRSSRSHAVLLVKVDQr-ERLAPFRQREGKLYLIDLAGSEDNRRT-G-NKGLRLKESGAINTSLFALGKVVDAL 310  human
NP_511125  194 RPTNMNSNSSRSHAIVTIHVKSk--------THHSRMNIVDLAGSEGVRRT-G-HEGVARQEGVNINLGLLSINKVVMSM 263  fruit fly
Q39493     282 QKTEANDASSRSHAICQVFLRDygGN------LRGKLGLVDLAGSERGSDT-KqHNSQRRTESADINTSLLALKECIRAL 354  Cylindrotheca fu...
1808299A   224 MACGDKTERSRSHLVFQLHVEQr--NRKDDILKNSSLYLVDLHGAEKFDKR-TeSTLSQDALKK-LNQSIEALKNTVRSL 299  baker's yeast
NP_567426  241 KSTLCNERSSRSHCIIILDVP----------TVGGRLMLVDMAGSENIDQA-GqTGFEAKMQTAKINQGNIALKRVVESI 309  thale cress
3BFN_A     214 GATRLNQRSSRSHAVLLVKVDQreR-LAPFRQREGKLYLIDLAGSEDNRRT-G-NKGLRLKESGAINTSLFVLGKVVDAL 290  human
3DC4_A     209 RPTNMNSNSSRSHAIVTIHVKSk--------THHSRMNIVDLAGSEGVRRT-G-HEGVARQEGVNINLGLLSINKVVMSM 278  fruit fly
1GOJ_A     273 TD---------GKSSHVPYRDSKLTRILQESL-GGNSRTTLIINCSPSSYNDAETLSTLRFGMRAKSIKNKAKVN 337  Neurospora crassa
XP_647667  719 DQs--------SK--HTPFRQSTLTQVLKDSF-VGNSRTVMIANISPNQSSSEHTLNTLRYADRVKELGTSesns 782  Dictyostelium discoid...
NP_032468  468 g----------RNKPHTPFRASKLTQVLRDSFiGENSRTCMIATISPGMASCENTLNTLRYANRVKEFGISPSDi 532  house mouse
BAA33063   311 n----------QGLPRVPYRDSKLTRLLQDSL-GGSAHSILIANIAPERRFYLDTVSALNFAARSKEVINRPFTN 374  human
NP_511125  264 AA----------GHTVIPYRDSVLTTVLQASL-TAQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNPMqv 327  fruit fly
Q39493     355 GQ----------KSAHVPYRGSKLTLILKDCF-SPDSKTTMVATVSPGASAADHSLNTLRYADRIKEQRVSSngq 418  Cylindrotheca fusiformis
1808299A   300 SmkerdsaysaKGSHSSAYRESQLTEVLKDSL-GGNRKTKVILTCFLS--NVPTTLSTLEFGDSIRQINNKVTDN 371  baker's yeast
NP_567426  310 AN----------GDSHVPFRDSKLTMLLQDSFeDDKSKILMILCASPDPKEMHKTLCTLEYGAKAKCIVRGSHTP 374  thale cress
3BFN_A     291 n----------QGLPRVPYRDSKLTRLLQDSL-GGSAHSILIANIAPERRFYLDTVSALNFAARSKEVINRPFTN 354  human
3DC4_A     279 AA----------GHTVIPYRDSVLTTVLQASL-TAQSYLTFLACISPHQCDLSETLSTLRFGTSAKaaalehhhh 342  fruit fly
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