4ROC,5N9G


Conserved Protein Domain Family
CYCLIN_BRF2
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cd20555: CYCLIN_BRF2 
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cyclin box found in B-related factor 2 (BRF-2) and similar proteins
BRF-2, also called transcription factor IIIB 50 kDa subunit (TFIIIB50), or BRFU, is a general activator of RNA polymerase (Pol) III transcription and is required for Pol III transcription of genes with promoter elements upstream of the initiation sites. It recruits Pol III to type III gene-external promoters, including the U6 spliceosomal RNA and selenocysteine tRNA genes. BRF-2 contains one cyclin box. The cyclin box fold is generally a protein binding domain, but binds DNA in BRF-2.
Links
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Statistics
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PSSM-Id: 410258
Aligned: 16 rows
Threshold Bit Score: 123.157
Created: 12-Apr-2019
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
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DNA binding
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:DNA binding site [nucleic acid binding site]
Evidence:
  • Structure:4ROC; Homo sapiens BRF2 in complex with TBP binds DNA, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        # #                                      # ##### ##            #      ##        
4ROC_A         7 SRSQQRGLRRVRDLCRVLql-pPTFEDTAVAYYQQAYrh-sGIRAARLQKKEVLVGCCVLITCRQHnWPLTMGAICTLLy 84  human
XP_013414364  76 SEGKKIGEKRIKEISAAMnl-sSDMKESALDMYNKLIhrsgPFRGILLANKLVLASAAVYVVCRQRgWPVTLNSTASLCq 154 Lingula anatina
XP_002734942  73 SCGHKAGLKEISELCKLMkm-sSELQKRSTELFEKAYni-dCFKNYMTKKKHVLNGCCVYISCRQEnWPVTIAFICDLIq 150 Saccoglossus ko...
XP_007909877  66 CRNQIHGLKRVRDVCRVLrl-rAVLEETASGLYREAYeh-eELLQARLCKKEALVGCCVYISCRQHsWPLTLGTVCSLLh 143 elephant shark
XP_002590253  72 SKARRDGALRVEEISAMLrvtsDVMVEEAKTLFTQAFnl-kVLNKAKREKKRVLPGCVVYIVCRQHdWPILLSDMWDLLq 150 Florida lancelet
A8KBY2        64 CRNLVSGFSRLRALCRIFrl-sSSMEDASANLFERAYnh-pNFLHISLSKKQILAGCCMFHICRQNsWPVFMGTIGYLLd 141 zebrafish
XP_022091682  78 SRNLKPWMSYLKEVCSMMgl-sAEMEKGVVDIFSQACk--gILKCKQRLKKQALCGAAVFTVCRQNdWPVVLSDVSTVVq 154 crown-of-thorns...
XP_009061290  65 SESLHQGRMKTGELCDKLhl-dCGMKEAATQKYVQLFkh-nDFRTILKVFKMALVSVCVYIEARQNnIPILMYDVTSILg 142 owl limpet
ELT90726      82 SRGKKQGLSRMKDVAQTLkc-sSALRKQASEIFEKMFhs-pKVISERIETKITIAMVCLYLVCRNAmWPITVSDVCDIAn 159 Capitella teleta
XP_021347697  66 RPAVRQCKAKMRSLCAKLty-sYAMIEAANNLFDRAYay-gEFKRMHSFNKNMLSHCCVYITGRQFnFPVTIKEFCAITr 143 Yesso scallop

Feature 1            #  #  ##   #    
4ROC_A        85 a-dLDVFSSTYMQIVKLLGL 103 human
XP_013414364 155 c-sVFDLGKYYKEILKVLNI 173 Lingula anatina
XP_002734942 151 c-sRQDFNSVYKSLLSQLDI 169 Saccoglossus kowalevskii
XP_007909877 144 t-dPSLVSSLYLRLLVLLHI 162 elephant shark
XP_002590253 151 c-rDSVFYSVYKVILAELDI 169 Florida lancelet
A8KBY2       142 a-dNYQMGTIYQELTKSLNL 160 zebrafish
XP_022091682 155 c-sVSDLFAMKKLLTSEFNI 173 crown-of-thorns starfish
XP_009061290 143 feeKKKFQKVLHKAKAILGL 162 owl limpet
ELT90726     160 c-dVGKFVRWSREVTTEMNL 178 Capitella teleta
XP_021347697 144 q-pVSDVAKLYHKLITKLHI 162 Yesso scallop

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