Conserved Protein Domain Family
AKR_EcYajO-like

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cd19079: AKR_EcYajO-like 
Escherichia coli YajO and similar proteins
Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.
Statistics
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PSSM-Id: 381305
Aligned: 37 rows
Threshold Bit Score: 368.065
Created: 13-Mar-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Conserved Features/SitesClick to see Conserved Features Help
 
putative activecatalytic
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structure evidence that Rattus norvegicus voltage-dependent K+ channel beta subunit (3EAU) in complex with cortisone and cofactor NADPH.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      ###                                    #    #                  
P77735      2 QYNPLGKtdLRVSRLCLGCMTFGepdrgn--hawtlPEESSRPIIKRALEGGINFFDTANSYSDGs----------SEEI 69  Escherichia coli 5...
ABW01275    2 EYVNLGNsgLKISRICLGAMQFGntap------wmvELEDARKVWKKAWDLGINCIDTANVYSRGr----------SEEI 65  Caldivirga maquili...
EGC92767    2 EYTKLGTtdITISRLCAGCMSFGdsntnf--hswtlNKEESENLVKRALDLGINFFDTANVYSAGt----------SEEY 69  Turicibacter sp. HGF1
EHL70831    2 EYTKIGVsdMPVSRLCLGCMSFGandtnf--ldwtlDYEESEKIMKHAFGLGINFFDTANCYSSGt----------SEEY 69  Synergistes sp. 3_...
BAC44303    2 EYIKLGNsdLKVSRICLGCMGFGdnksgv--hkwilDYQQTKEIIKLALDKGINFFDTAPVYAEGt----------SEEF 69  Mycoplasma penetrans
AMD17739    2 KYVKLGNsnLKVSKVCMGCMGFGdpnngm--htwtlPERESIEIISQGMDSGINFFDTAIGYQNGt----------SEQY 69  Methanobrevibacter...
CCA90043    2 EALRLGRsgLKVSQLALGTASFGdtdra----awnvGADMAWNLVRHAFDRGITLFDTGSTYGGGl----------AEDR 67  Novosphingobium sp...
APZ95691    2 EYQKLGHseLVVSRLGLGCVTFGre----------iDAAQAMLIMDHAIENGITLFDTAEAYGGGa----------SETV 61  Fuerstia marisgerm...
OVZ58410    1 MASRTGPtlPRMSRLCLGMMSYGdpawa----pwvvGQDAARVLFRQCLENGITCFDTANYYSDGe----------SERI 66  Pigmentiphaga sp. ...
AAK43116    9 KYVNLGEsgVKVSQVAIGTWFLPrlqekdelgiykvDKETTLKILKRAYDEGVNFIDTANRYHGAmapvdlphvgnAERI 88  Sulfolobus solfata...
Feature 1                       #                                        ##                   
P77735     70 VGRALRdfarREDVVVATKVFHrvgd--lpeGLSRAQILRSIDDSLRRLGmDYVDILQIHRWDynTPIEETLEALNDVVK 147 Escherichia coli 5...
ABW01275   66 VGELVKg--mREDVVIATKVFGqmgngpnarGLSRKHIMWQVRESLRRLNtGYIDLYQIHRFDydTPIEETLSTLTDLVH 143 Caldivirga maquili...
EGC92767   70 LGRAIKhnvpRDQVVLASKVYFne------gHLKKEAIHREIDGTLKRLGtDYLDLYLIHRFDyeTPMEETMEALNELVT 143 Turicibacter sp. HGF1
EHL70831   70 VGRAIKknfpRSDIFLATKVFFnadl--srgGLSKEAVNREIDNSLKRLGtDYVDLYIIHRFDraTPVEETMEALHGLVR 147 Synergistes sp. 3_...
BAC44303   70 LGRAIQeltkRENVVIATKFFPrsreayekgITGQQWVQQNLEQSLKRLNtDYVDLYILHLWDynTPIEDILEGLNNAVK 149 Mycoplasma penetrans
AMD17739   70 LGKAIRenavRDDIVVATKFLPrseeeiknnVSGQRHIHNFVEKSLENLGlDYIDLYIYHMWDynTPMYDILEGLNEVID 149 Methanobrevibacter...
CCA90043   68 LGQAVErlghRDEIVLTSKVYFptgpdanarGLSRKHIVAALDRSRARLRtDYVDVLMLHRWDahTPIEETLTALDILVR 147 Novosphingobium sp...
APZ95691   62 VGDWLTsrrmRGNVVLATKVNG---------RLTREHVRSSVDKSLRRLQtERIDLLQLHVWDeeTPLEETLEALTSVVD 132 Fuerstia marisgerm...
OVZ58410   67 LGRLVRehggRHELTLATKVGLpva---dgrGLSAAQIARQAEASLRRLEtDYIDLYQVHSWDdaVPVEETLGALEALVD 143 Pigmentiphaga sp. ...
AAK43116   89 VGEFLKtv-dRESVVISTKVRGkmgdfvngeGLSRKHILWQIKESLKRLGtSYIDVYFIHWPDpdTPKLETLRTLNSLVN 167 Sulfolobus solfata...
Feature 1              ##                        #                           #######          
P77735    148 AGKARYIGASSMhASQFAQALELQKqhGWAQFVSMQDHYNLIYREEErEMLPLCYQEGVAVIPWSPLARGRLTRPWGETt 227 Escherichia coli 5...
ABW01275  144 QGLVRYIGASSMwTWQFAKMIYTAEmkGYEKFVSMQNVYNLLYREEErEMIPFCKAHGIGIIPWSPTAAGILSGKYYKDg 223 Caldivirga maquili...
EGC92767  144 SGKVRAIGASAMyGYQFHNLQLVAEknNWAKFQSMQNHYNLLYREDEhELIPICKQMNVSLTPYSPLAAGRLSRLEWKSd 223 Turicibacter sp. HGF1
EHL70831  148 AGKVLNLGASAMyGYQFHNMQAAAEnnGWTKFAVMQNHYNLLYREDErEMIPICEQYGTARTSYSPLASGRLSRRAWHTd 227 Synergistes sp. 3_...
BAC44303  150 SKKVRAIGISNCyAWQLQKANDIAKanGWSQFVSIQGHYNLIFREEErEMIPFCEENNVALTPYSVLASGRLVKESNETs 229 Mycoplasma penetrans
AMD17739  150 EGKVRYIGISNCfAWQLAKANALAEseGFAKFVSVQGHYNLIFREEErEMIPLCKTDNIATTPYSSLASGRLSRLPGTEs 229 Methanobrevibacter...
CCA90043  148 SGRVLYTGASSMsAWRMMKVLGLQRasGMAPFIAMQGLYNLLYREEErEMMPLCREEGIGCMAWSPLARGRLAGAAGDPv 227 Novosphingobium sp...
APZ95691  133 EGKVRYVGCSNYsATQLTAALAMSDqkHFSRMTSVQPPYNLVQRDIEtDLLPLCEAENVGVISYSPLAAGFLTGKYRPNq 212 Fuerstia marisgerm...
OVZ58410  144 AGKIRAYGCSNLdHLQIGQAARAAAalGARGYASAQLQLNLLYQEELrATVPACARHGLHIMAYSPLARGYLAGPAAGDa 223 Pigmentiphaga sp. ...
AAK43116  168 NGLVYYLGVSNHsAVDVMEFLQLSErhNLEKFIVMQEKYNMLERDIEkDKAIIAKRFGLAIMAYSPLAQGFLTGKYVDKn 247 Sulfolobus solfata...
Feature 1                                                  #                    ######  #  ## 
P77735    228 arlvsdev-------gknlykesdENDAQIAERLTGVSEELGAtRAQVALAWLLSKp----gIAAPIIGTSREEQLDELL 296 Escherichia coli 5...
ABW01275  224 kiivpetetrvrpgsgdyriyvepPENAEILRRVIEVANNKGAtPTQIAYAWLLHKg-----VTAPIIGTTKPEHVEEAV 298 Caldivirga maquili...
EGC92767  224 slrsqtdki------avskydstaEKDHEIVLRVHELAQQHEAsMTQIALAWQLAKg-----VASPIIGATKEKYFDDAV 292 Turicibacter sp. HGF1
EHL70831  228 tkrsqtdra------aekkydafeSHDCNIVARVYEVAERHGAtMTQVALAWQFAKn-----VASPIIGVSKLSHLDDAA 296 Synergistes sp. 3_...
BAC44303  230 arlesdyi-------aklkydsskEVDEIIINRVKELAKKKGLsNTQIALGWLLNKg-----VHSPIIGATKIKHIEEAV 297 Mycoplasma penetrans
AMD17739  230 krlnedfy-------aklkyesseSKDLEIIKRVDELAQNYGVsMTEVSLAWLLTK------ITSPIVGATKTHHVEGAV 296 Methanobrevibacter...
CCA90043  228 rlaqdpl----------aasrftpDLDAPVLAALDAASVRTGLpHAQLALGWLAAR------QAIPVIGAASAEQIDVAI 291 Novosphingobium sp...
APZ95691  213 pvppgtrfdv----ipghqniyftDHGYQVLEQLDELAERTGQtHIQLALSWVLHQp----nIASVLVGARTKAHIDQAL 284 Fuerstia marisgerm...
OVZ58410  224 eaaarlasd------akgqrlyggPRGARVRAEQLRIAAELGAePAAVALAWVLAQp----gVRSVIVGASQSSHLDVAL 293 Pigmentiphaga sp. ...
AAK43116  248 gwkieelsras--itedlkkryftEANLRILLGLKDVASELGItLSQLAISWLLKRgeqlgiTVIPLIGASKIEHLEDNL 325 Sulfolobus solfata...
Feature 1                     
P77735    297 NAVDITLKPEQIAELE 312 Escherichia coli 53638
ABW01275  299 NAISIKLTDDEVKYLE 314 Caldivirga maquilingensis
EGC92767  293 GAFNVKLTHHDIAYLE 308 Turicibacter sp. HGF1
EHL70831  297 DAFKLCLPDEEIRYLE 312 Synergistes sp. 3_1_syn1
BAC44303  298 SAVGIKLSEEEIAYLS 313 Mycoplasma penetrans
AMD17739  297 NSVDLELSDDDIGYLE 312 Methanobrevibacter sp. YE315
CCA90043  292 AAVSSRPDAVTCAAME 307 Novosphingobium sp. PP1Y
APZ95691  285 EAIHVNDVFTDISQTL 300 Fuerstia marisgermanicae
OVZ58410  294 RGRDLRLPAQALDRLA 309 Pigmentiphaga sp. NML030171
AAK43116  326 SALNINLRDDYMKRIE 341 Sulfolobus solfataricus P2

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