Conserved Protein Domain Family
ligA

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PRK07956: ligA 
NAD-dependent DNA ligase LigA; Validated
Statistics
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PSSM-Id: 236137
Aligned: 438 rows
Threshold Bit Score: 916.435
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
122879187   4 GVIERARELRRRIENADHRYYDLADPEITDAQYDQLFRELQELEQKYPELVTADSPSMRVGGAVRKSFVKVRHSIPMLSL 83 
33864448    7 TPPKRAAELRQLLNQAAHSYYVLDTPTMEDAVYDRLYRELLNLEAKDSSLLTPDSPTQRIGGAPAQGFASVQHRIPLLSL 86 
33866919    3 EQQQRAAELRSLLNRAAHAYYVLDAPVMEDTLYDRLYRELQQLEQADPSLLSADSPTQRVGKAPATGFHSVEHRIPLQSL 82 
124024594   7 TPPERAAELRQLLNQAAHSYYVLDTPTMEDAVYDRLYRELLDLEVKDSSLLTPDSPTQRIGGAPAQGFASVPHRIPLLSL 86 
148240764   6 GLQERAAELRQLLNRAAHAYYVLDAPDLEDSVYDRLYRELLDLEAAHPELVEADSPTQRVGGSPAEGFRSVTHRIPLFSL 85 
148243508   6 QQQLRAAELRQLLNRAAHAYYVLDAPEFEDAVYDRLYRELLDLEQQHPDLLSADSPTQRVGGPPAEGFSSVEHRIGMLSL 85 
159904348   7 NLSKRSFELRKLLNRANHAYYVLDTPLMEDTVYDRLYRELLNIEKNHPSLITADSPSQRLGSTPAKEFVKVEHKIPLMSL 86 
78185772    3 DQSERATELRNLLNTAAHAYYVLDTPTMEDAVYDRLYQELLELEQNTPSLKTADSPTQRVGGAPAEGFTSVEHRIGLLSL 82 
78214056    3 DPHERAAELRHLLNRAGHAYYVLDAPEMEDTVYDRLYRELLELEQNDPGLQRPDSPTQRVGGAPAEGFTSVEHRVGMLSL 82 
113954059  12 SSQERAEELRRLLNRAAHAYYVLDAPDMEDPVYDQLYRELQDLEHQDSTLVSADSPTQRVGGRLADGFRSVSHRISLFSL 91 
122879187  84 ANAFDEVEVKNFVDRIfRRmgssnPLE--------FSVEPKFDGLAISLRYELGKFVQGVTRGDGDVGEDVSENIRTIRS 155
33864448   87 DNAFNVDELTGWYVRLaKLlg-hqTNPktpqpdlsMVGELKIDGNALALSYEHGVLIRAATRGDGANGEEITANVRTIAS 165
33866919   83 DNAFDHGELKAWHERLlKVld-raDDSpl-----pLVGELKIDGNALALSYRHGVLERAATRGDGSSGEEITANVRTISS 156
124024594  87 DNAFNVDELTGWYVRLvKLlg-yqTNPktpqpdlsMVGELKIDGNALALSYEHGVLIRAATRGDGANGEEITANVRTIAS 165
148240764  86 DNAFSAEELRGWYTRLlKVld-rePPSgsplpalaMVGELKIDGNALALSYDNGVLVRAATRGDGDQGEDITANVRTIAS 164
148243508  86 DNAFNAEELQAWDARLgRQle-dnPERqr-----eYVCELKIDGNALALSYADGVLVRAATRGDGSRGEEITANVRTIQA 159
159904348  87 DNAFNFEELQDWDLRIrKLln-qkNNFgilktsidFACELKIDGSALALSYANGVLVQAATRGDGVAGEEITANVKTITS 165
78185772   83 DNAFNRDDLSAWNERLlRAid-rpLGSpl-----dLVSELKIDGNALALSYRNGVLERAATRGDGQRGEEITANVRTISA 156
78214056   83 DNAFNRDDLRAWHERLlKVld-rpSDSrl-----pLVGELKIDGNALALSYRNGVLERAATRGDGSRGEEITANVRTISS 156
113954059  92 DNAFNRDELHGWYSRLlKAld-rtPAAgsppptlpMVGELKIDGNALALSYENGVLVRAATRGDGEQGEEITANVRTISS 170
122879187 156 VPLKLkgnNVPAILEVRGEVYMPRDGFSEFNKRAMARGEKLLANPRNGAAGSLRQLDSRISAQRPLSFFAYGVGliqveq 235
33864448  166 IPLRLqlvHPPAWLEVRGEAFIPNSTFADINTARGKRGDVAFANPRNACAGTLRQLDPKVVASRQLDFFAYTLH------ 239
33866919  157 IPLRLqidDPPEWVEVRGEAFIPDDTFAAINNERAAHGDALFANPRNACAGTLRQLDPKVVAARRLDFFAYTLH------ 230
124024594 166 IPLRLqlvHPPAWLEVRGEAFIPNSTFADINTARGERGDVAFANPRNACAGTLRQLDPKVVASRQLDFFAYTLH------ 239
148240764 165 IPLRLhldPPPAWVEVRGEALIPDNTFAAINSERAARDEPLFANPRNACAGTLRQLDPKVVAARRLDFFAYTLH------ 238
148243508 160 VPLRLqlkQPPAWVEVRGEAFIPDDTFEAINAERQQRGEALFANPRNACAGTLRQLDPKAVAARRLDFFAYTVH------ 233
159904348 166 IPLSLdieNPPSWLEVRGEAFLPKQTFDGINLLRKQQREALFANPRNACAGTLRQLDPQIVASRQLDFFAYKMY------ 239
78185772  157 IPLRLrldNPPEWVEIRGEAFIPDNTFAEINAERESRGEALFANPRNACAGTLRQLDPKVVAARRLDFFAYTLH------ 230
78214056  157 IPLRLqieNPPEWVEVRGEAFIPDATFAAINAEREQRDEALFANPRNACAGTLRQLDPKVVAARRLDFFAYTLH------ 230
113954059 171 IPLRLhlePVPAWVEVRGEAFIPDATFHAINNERLSRDESLFANPRNACAGTLRQLDPSVVAARRLDFFAYTLH------ 244
122879187 236 dlfEEi-------pQSIASTHSAMLAQLRAWGFPVSSLVEVVQGSDGLLAYYQRIGEARDGLPFDIDGVVYKLDDLAGQR 308
33864448  240 ---LPdnwqakahdPARPMNQWAALQWLQAIGFKVNPNTALLADLTAVENFFKLWDEDRHQLPYATDGVVVKLNDLQLQE 316
33866919  231 ---LPsdh------snsPECQWDVLAWLEQAGFRVNPNRELCDGLNGIERFCDRWEQQRHQLTYATDGVVVKLNDLRLQD 301
124024594 240 ---LPdnwqakaddPASPMNQWAVLQWLQAIGFKVNPNTALLTDLTAVEHFFKLWDEARHQLPYATDGVVVKLNDLQLQE 316
148240764 239 ---LPedw-----sgeRPTSQWESLRWLEDAGFRVNPNAALLPDVDSVEQFFGDWDSRRHDLNYATDGVVVKLNDLRLQD 310
148243508 234 ---LPad-------emGPKSQWDALQWLETAGFRVNPHRERTSGADGVVAFYDRWEEQRHQLPYATDGVVVKLDALERQQ 303
159904348 240 ---LPkdwdpqgenIHQPEAQDAALKWLKKAGFKVNPNTKIFKSLHEVQSFFDIWEKKRHKLPYTTDGVVVKVNNFKLQE 316
78185772  231 ---LPtq--------eqPASQWDALTWLENAGFRVNPNRALCADLADINRFSDHWEQARHDLPYATDGVVVKLNNLVLQD 299
78214056  231 ---LPgd--------aqPPGQWAALEWLNSAGFRVNPNRELCGDLAAIQRFCDHWEQGRHDLPYATDGVVVKLDDLQLQD 299
113954059 245 ---LPdew-----qerRPLTQWDALQWLGDAGFKVNPNAGLLPDLQAVEQFFDTWDTERRQLDYATDGVVVKLNDLRLQD 316
122879187 309 EMGFVSRAPRWALAHKFPAQEQSTTVEAIEIQIGRTGAATPVARLKPVHVAGVIVTNATLHNADQIARLDVRVGDTVIVR 388
33864448  317 TAGFTQKAPRWAIALKYAAEEAPSKLLRLTCQVGRTGAVTPVAEFEAIPLAGTSVSRATLHNANRVSELDLHSGDTIVVR 396
33866919  302 EAGTTQKAPRWAIALKYPAEEAPSKLLKLAVQVGRTGAVTPVAEFEPVALAGTSVSRATLHNADRIAELDLHLGDTVVVR 381
124024594 317 TAGFTQKAPRWAIALKYAAEEAPSKLLRLTCQVGRTGAVTPVAEFEAIPLAGTSVSRATLHNANRVSELDLHSGDTIVVR 396
148240764 311 AAGFTQKAPRWAIALKYPAEEAPSRLLKLTCQVGRTGVVTPVAEFEPVSLAGTSVSRATLHNADRLQELDLHSGDTIIVR 390
148243508 304 LAGFTQKAPRWAIALKYAAEEAPSRLLRLVAQVGRTGVVTPVAEFEAVPLAGTSVSRATLHNADRLEELDLHSGDTIVVR 383
159904348 317 MLGVTQKSPRWAIALKYPAEEAPTKLINLSYQVGRTGTVTPVAEFEPIPLAGTIVRKATLHNADRLQSLDLHNEDTIVVR 396
78185772  300 EAGFTQKSPRWAIALKFPAEEAPSRLLRVVVQIGRTGVITPVAEFEPVALAGTSVSRATLHNADRIAELDLHLGDTIVVR 379
78214056  300 EAGFTQKAPRWAVALKYPAEEAPTRLLRVGAQVGRTGAITPVAEFEAVPLAGTSVSRATLHNADRIAELDLHLGDTIVVR 379
113954059 317 AAGFTQKAPRWAIALKYPAEEAPSKILRISYQVGRTGVITPVAEFEPVGLAGTSVSRASLHNADRLVELDLHDGDTIVVR 396
122879187 389 RAGDVIPEVAAVVADQRPPATQSWQMPTQCPVCGSEIvrEEGQAVWRCSGeLtCPAQRKEAFRHFVSRRAMDVDGLGEKF 468
33864448  397 KAGEIIPEVIGVLRELRPAGAQTLKLPHICPECRSDLvrEEDEAATRCVNsS-CPAILRGTLRHWVSKGALDVDGLGSKL 475
33866919  382 KAGEIIPEVVRVLPELRPTGAVPLELPDHCPECGSNLvrDDSEAATRCINsS-CPAILRGGLRHWVSKGALDVDGLGNKL 460
124024594 397 KAGEIIPEVIGVLRELRPAGAQTLKLPHICPECRSDLvrEEGEAATRCVNnS-CPAILRGTLRHWVSKGALDVDGLGSKL 475
148240764 391 KAGEIIPEVLRVLPELRPEGALPLELPQQCPSCGSDLvrESGEAATRCVNsS-CPAILSGALRHWVSKGALDVDGLGSKL 469
148243508 384 KAGEIIPEVLRVLPELRPEGAEQLELPSHCPECGSLLvrESGEAATRCVNsS-CPAILRGALRHWVSRQAMDVDGLGGKL 462
159904348 397 KAGEIIPEVVCVLKELRPQNSTRLYLPSNCPECDEKLvrGTDQAATKCVNnL-CPAIIQGALRHWVSKKAMNIDGVGSKV 475
78185772  380 KAGEIIPEVVRVLPELRPSSATPVQLPEHCPECGSNLvrEGDEVATRCVNsS-CPAILRGGLRHWVSKGALDVDGLGSKL 458
78214056  380 KAGEIIPEVVRVLPELRPSDATPVQLPQQCPECGSNLvrEGDEAATRCVNsS-CPAILRGGLRHWVSKGALDVDGLGSKL 458
113954059 397 KAGEIIPEVVRVLPELRPALAQPLEITKTCPACGSTLvrESNESATRCINsS-CPAILRGALRHWVSKGAMDIDGLGSKL 475
122879187 469 IEVLVDSGVVQGVADLYLLTVDQLLQLrmistaesphaflrearehlasgayaqleatlvgigvdlagerevpqtwqadl 548
33864448  476 IEQLVNRGLVQSIADLYALEASLLASM----------------------------------------------------- 502
33866919  461 IQQLVERGLVRSIADLYRLDAALLASL----------------------------------------------------- 487
124024594 476 IEQLVNRGLVQSIADLYALEASLLASM----------------------------------------------------- 502
148240764 470 IEQLVERGLVRSIADLYRLDTALLTSL----------------------------------------------------- 496
148243508 463 IEQLVDRGLVRSIADLYRLDAALLASL----------------------------------------------------- 489
159904348 476 IEQLVNKGIVKSIPDLYELNYQMLFGL----------------------------------------------------- 502
78185772  459 IEQLVDQGLVRSIADLYRLDAALLGSL----------------------------------------------------- 485
78214056  459 IEQLVDRGLVGSLADLYRLDAALLASL----------------------------------------------------- 485
113954059 476 IEQLVDRGLVQSIADLYRLDMALLGSL----------------------------------------------------- 502
122879187 549 lraglptfdwnrKKIATKWAENLIEAIETSRDTTLERFLFALGIEHVGESTAKALSAWFGdLDLIRHLp---WPLFKRVP 625
33864448  503 ------------DRMGSKSTANLITALQASKSKPWHKQLYGLGIHHVGEVNAKALAKKFPsAATLATAackaPEQITSVF 570
33866919  488 ------------ERVGEKSAANLVAALEQSKQQPWHRQLYGLGIRHIGEVNAKALAAAYPnSASLAAAe---PESIAALH 552
124024594 503 ------------DRMGNKSTENLITALQASKSKPWHKQLYGLGIHHVGEVNAKALAKKFPsAATLANAackaPEQITSVF 570
148240764 497 ------------ERMGEKSAGNLVAALAQSRTQPWSRQLYGLGIHHVGEVNAKALASAFAdAHSLADAavqrPEAITDLH 564
148243508 490 ------------ERMGEQSASNLIEALAASRQRPWHRLLYALGIHHIGSVNAKTLAAAFPsWEALQSAs---EEALNELY 554
159904348 503 ------------ERMGEKSAHKVIESIEKSKTQPWNKQLYGLGILHIGEGNAKLLANAFAsEDELSHAainsPERIAKIH 570
78185772  486 ------------DRMGERSANNLIEALKLSRQRSWARQLYGLGIHHIGEVSAKAITAEFSdSNSLMEAactaPERITAIY 553
78214056  486 ------------DRMGDKSATNLVEALKASKQQPWHRQLYGLGIRHIGEVNAKALAAAFFsIDSLATAaleaPEQIAELH 553
113954059 503 ------------ERMGSKSAENLIQALNASRSQGWAKQLYGLGIHHVGDVNAKAITTAFPnADSLNQAachaPESITAIF 570
122879187 626 DIGGEVARSLGHFFDQPGNQKAIDHLLarkvrigdthppspklrgelrlanlledleipkvtpiraaqiatafgsidalr 705
33864448  571 GVGNEIAQSLQQWFATPANQQLLAKLKql--------------------------------------------------- 599
33866919  553 GIGPEISSSLQQWHANPPNQRLLEDLRav--------------------------------------------------- 581
124024594 571 GVGNEIAQSLQQWFATPANQELLAKLKql--------------------------------------------------- 599
148240764 565 GIGPEIAQSLQQWFNTSANQDLLQQLRav--------------------------------------------------- 593
148243508 555 GIGPEISQSMQQWCSTEANQSLMAELAal--------------------------------------------------- 583
159904348 571 GIGNEMVESLQEWFEDESNQRIISRLKel--------------------------------------------------- 599
78185772  554 GIGTELAQSLQQWFSNPANQHLLDDLRsq--------------------------------------------------- 582
78214056  554 GIGPEISASLGQWLHTPANQQLLQDLRsv--------------------------------------------------- 582
113954059 571 GVGKEIAQSLQQWFSSPANQRLLDELRsl--------------------------------------------------- 599
122879187 706 nggpeplveagVPqsvaeslatwllvpandtlavkaqkklsallamMPE-------------AGEEKtg---------pL 763
33864448  600 ----------gIS---------------------------------LEA-------------NEDELahdtdqnqrtvsL 623
33866919  582 ----------gLS---------------------------------LEAntselnanstgegNSSGA------------L 606
124024594 600 ----------gIS---------------------------------LEA-------------NEDELahdtdqkqrtvsL 623
148240764 594 ----------gLT---------------------------------LAAsdqerqala-------------drnngkghL 617
148243508 584 ----------eLP---------------------------------LAS-------------DDSSAesag----aigaL 603
159904348 600 ---------------------------------------------gVQLkstandsgai----------ksvinssnkeV 624
78185772  583 ----------gFR---------------------------------FALddndpg--rlgaaASEQH------------L 605
78214056  583 ----------gFS---------------------------------LEAstseqeaasqagaDADGV------------L 607
113954059 600 ----------gFS---------------------------------LSLneeeqsra--------------ttaaanhhL 622
122879187 764 DGQTVVITGTLAAlTRDAAKQRLEALGAKVAGSVSKKTAFLVAGEEAGSKLDKAQSLGVEIWDEARLLAFLGE 836
33864448  624 EGQTFVLTGTLPTlSRSEAQALIEASGGKVNNSVSKNTSYVVAGVAAGSKLNKAEKLEVTVLNQEELLKLLAS 696
33866919  607 LGKTLVLTGTLPNlSRSDAKTLIEGAGGKVSGSVSKKTDYLVAGEAAGSKLSKAESLGVEILTEAELQKLLST 679
124024594 624 QGQTFVLTGTLPTlSRSEAQALIEAAGGKVNSSVSKNTSYVVAGAEAGSKLNKAEKLRVTVLNEEELLKLLAS 696
148240764 618 NGQTFVLTGTLPSlSRSQAQALIEGAGGKVSGSVSKKTSFVVAGDEAGSKLDKANTLGVSVLDEAALMLLIQN 690
148243508 604 TGQTLVLTGTLPNlSRLEAQALIEAAGGKVTGSVSKKTNYVVAGSEAGSKLQKAEKLGVAVIDEAELKALLS- 675
159904348 625 LGKRFVLTGTMESiNRDVAQEMIEKAGGKVNSSISSKTTYLITGSNPGSKLSKAKELGIKIINEEDFFNLLSK 697
78185772  606 KGLTFVLTGTLPTlSRSEAKERIETCGGKVSGSVSKKTDYLVAGEEAGSKLTKATTLGIKILDEDRLQAMLKD 678
78214056  608 QGKTLVLTGTLPNlSRSEAKALIETAGGKVSGSVSKKTDYLVAGEAAGSKLTKAESLGVTVLSEADLTALLQP 680
113954059 623 TGSTFVLTGTLPTlTRSQAKEQIEACGGKVSGSVSKKTSYLVAGEEAGSKLTKAQELGVSILDEEALQNMLRG 695
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