Conserved Protein Domain Family
DUF6583

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pfam20224: DUF6583 
Family of unknown function (DUF6583)
This family of proteins is functionally uncharacterized. This family of proteins is found in bacteria, mainly in Firmicutes. Proteins in this family are typically between 454 and 596 amino acids in length. There are two highly conserved residues, a Tyr and an Asp.
Statistics
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PSSM-Id: 466375
Aligned: 16 rows
Threshold Bit Score: 225.337
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CDA16142   1 MKNKKILIIPIVIIILLVALAGV-SAFLYFKTDLFKSPKQLFFKYLGESVSSTKN-FNYDKSLANYKELSQKSSKSTGei 78 
CCZ17322   1 MGNKKLIKGLIITLVILLIIGGA-LAYIYFGTDLLKTDAELFAKYGGRATSALGQfLESGNTKTYYQKKQNQNYENDTk- 78 
CDA58416   1 MKNKKALIVIIVLLIILAVCGGA-FAYVYFATDLLKSNSQMFSKYGTMLDMELYNfFYDENIKTYYTNKSANNYENTG-- 77 
CDD36476   1 MKKK--IALTLLIVVILLGIGGV---YAYFATNAFKTDKELFFSYMT--SDWLSD-LKDENLKEYIKKQENNAYTNKG-- 70 
CDC06908   4 KKNTKILLILIIIIVIIILAG---VGILVFATDIFKSDKEMFFKYMADIGDSKKG-FIDDGLKQYFEKKNNTPYNDEG-- 77 
CDE84094   1 MKKNKGLKITIIILAILIILSVIaFALIYVFTDLFKSNKELFAKYAVSMMQEKTA-FLPSNLKEYINKKSTTPYENNG-- 77 
CDE11348   4 RKKRNLIIVLSIITGLILIIGGI-LIYLNIATDIFKSPDEVFYKYLYQNGSIADV-FDTELLDRYYQRIENNAYNGTG-- 79 
CDE84715   1 MQKRKKALIITLMIVTIIITILItFAVVYFTTDIFKNGQQAFIYAMSKNVETFAT-LANTNTNIQEEFRKNYSYNSTG-- 77 
CDD15870   1 MKKKGLSLWIIILIVILILGAGAaGGYLYFYTDLFKKPQELFWKYLSQEKELLKI-FENEYDAQQTEAWKNSSYVSSG-- 77 
CDD15873   1 MKKK---LVIILPISIIIITATV-LCILYFCTNIFKSGEQLFWGYIIKNSGILNT-FENENEKEQQQVKKVNNYTATG-- 73 
CDA16142  79 tgSITDNSsn--tsSSSKSIE-DAINNSKIEYSIESIPSKNkyHASIKPNYNDSEITNLELLADNDSYGAKCTDLYDKYV 155
CCZ17322  79 -lNVKLNI----------GND-NPQYETILALKGAVDHDNKkaEQNIDLNYSNSQKFSFNLIKNDETYAFGSKEVVDKYV 146
CDA58416  78 --VLRVKS---------GGNT-DINTDLNLTIKGATDVDNDnfEQEITINYSDSEKFAFKLVKNNQMIALGSDEVANKYV 145
CDD36476  71 --SIALEVqd--dgSISDETL-QMIKNSKITFEGKTDNSKKiaEQTLTMELAQGINIPVKVRRDGETLGIQSNLLNTKFI 145
CDC06908  78 --EFSVNIs----sDNEQKKF-ENVNNFNISFSGQVDTANSkaAQNISLNYSNDVKFPINYKQIENKIGLQTKYVGSKFV 150
CDE84094  78 --SLTANIssn-snEQINNMF-NFANNARINFSGKVDAANNrdEQNINIFYTNDVSLPFNYKHVEDIYALQADFALPNYV 153
CDE11348  80 --EITIKTgmnddsESDTKEFdNLMNNLKLSYTTKSNLPEKkqETEATIAYNDQEQFKFSVVQDNNNYGIKSDEVVYKYL 157
CDE84715  78 --TINGNI----------SQE-NVNQNVTLKTTARRDKNSGryYADITLQNASQDILKYSYINDNDIYAIKCDDILPNYI 144
CDD15870  78 --SLTTLI----------QKG-TEKKNINVTTATRHDNTTGrtYAEANLKNGQDSILTFSYINSGNVYAIKCEDILKYYI 144
CDD15873  74 --TLNICV----------EKN-EEMQNINVITNTSHEAETGrtYTKATLKNEETELLKLFYINSDDVYAIKCEELLKYYI 140
CDA16142 156 YFENNNLKTLVSKFGId---SKYi-----pDKLEKVDIYELLNISADSRTQIVDRYQKLLDSKLTKDMFTSNKKVTTSVN 227
CCZ17322 147 AIENSNLKDFAKKVGIt--dLDKi-----pNKIDIEN--YKNTLTPEQLKELRTKYLEVVKAKLSDADFSKEKG------ 211
CDA58416 146 GIKNENLDELSNKLGId--eEMKv-----pNNIKLDK----SSITVQNIKSLVTKYIGKLAGQLSESNFTKN-------- 206
CDD36476 146 AVRNENLKNLLERLGAd---AEDv-----pDKIDFEE----STFTESEIKELKEKYFSILDENLDEELFSKEKEN----- 208
CDC06908 151 AIETEKLNKLSEDLd----dVESy-----gEMVDKLQKMGKVELTEDEKSHIKDTYITVINQQLEKDKFSKVKES----- 216
CDE84094 154 GIENNNIPELLQKLGVnidsSVEi-----pNKIEGQDLE-SIKFSDEEMKGLYNNYLMPAINNLTDDKFSKMENSDGSVD 227
CDE11348 158 KIKNENLRDIYTKLGVq--nSESi-----pNQFNKIDYNIYKNMNAEDKAKILSTYQNVLNKGILSNHYTKQADVNLNFN 230
CDE84715 145 GVKNSNLKEYAKNMGIseetVSNi-----pDQIDFEVFKGAFNVTKEEKEHLSSIYVNTISNSISKENFQKNGKENITVN 219
CDD15870 145 GIRNENLNELINKLSd----GITlpegllgEKIEIKN---EKIITAEEQQQLLNTYLNIVKQNISEENYSKSKSN----- 212
CDD15873 141 GIRNSDLKDFARKMGVdelnIQYi-----pDNINFEN---ILNITEKEKNQIIKTYLNIIVQNIQKNNYTKLGKNTIEIE 212
CDA16142 228 GTNVKANAYTLTINGEHAYDILLSFFQTLKDDDQTLDLIIEKceksgvtkayetqeniqssiysissdnnddeiqitftk 307
CCZ17322 212 ----ENNKYILSLSGDKVKTILMTVLKEMRSEQVMLNMLETSdn-----------------------------------i 252
CDA58416 207 ----NNTSYTLTIEKDNLKNIMIYCLNEAKNDSEIIKMLGMSdd-----------------------------------i 247
CDD36476 209 ----DQTIIKLSMTEEKAKDVLIKIFQTIRDDETLLKKFSGVid-----------------------------------r 249
CDC06908 217 ----DMSGYKLSLTGTDLQNVLVKLLETLKNDQTTVDKLNEYlkiq------------------------------knsa 262
CDE84094 228 --------YAITLTVEDLKNILIQMLQNLSQDTSLISKINSIyqeis----------------------------ngtet 271
CDE11348 231 GQSVVANAYSLTLTEEEISSLKISLLETLMKDELTLKYLVQFlqld------------------------------ssyt 280
CDE84715 220 NINCNASKYTLTLNGEEIKTLLINLLNTAETDETSMNILAKLqnalt----------------------------tnvdt 271
CDD15870 213 ----NVNTYTLKLEMDNIKQILSNCLENAKTDTTILNTIKES-------------------------------------- 250
CDD15873 213 ENIYETKAYLLKLNGNELKDIIIKCLENSKSDNTVLDILERNg------------------------------------i 256
CDA16142 308 DSLKD-DIQTLIESLQDSkdNFSADESVQIIVYSYKGKTA-------KIEF------KNGSDEtsaFSIEITHNKSEEII 373
CCZ17322 253 REYQD-DIDSSINELED---TDFSEFTMQISVGEDNTATVeikegdqKILV------NLAITNsdeIAIKAEVTMPSNDI 322
CDA58416 248 STYQD-NIDQEINDLNE---QDFSNTSIKITLTSTENGVE--------------------------ADVEVNTDEDNVGL 297
CDD36476 250 DDLKQ-QIDDLVDELKDI--EPDEKTTFEMKLSIKSKKVE-------KVEM------NIKEGEn--ITANILIENSQNKL 311
CDC06908 263 KITAS-QIDDAIKSIKDD--TDFSDKNFEIAVYQKNRDVC-------KLVI------ETTEGT---IAIEKKIEGNQQNI 323
CDE84094 272 IITAD-DVNDMISNLQE---TKVNDGDLTVTITQFNGKVN-------KVDI---------------TIISSSESNSNSV- 324
CDE11348 281 VQIKQ-LIQEKIDDLKRE--QIEKNENVRITVYESNMQLL-------TTIV------EMPEAN---YTINNNVSETNQKV 341
CDE84715 272 TQINS-NIENTIAKIQND--EIIANTTFVMELYYYKGNTI-------KTII------DISSIGk--VTINTDKNTQNIVF 333
CDD15870 251 NLLTEtDFAQLISILKESinNNNSNIQTVITVYEKDGNTI-------KTDIiislkdELGATLqyvVTINNISTQQELKA 323
CDD15873 257 SDYTE-ALDNIILNIQ----NKEINKNLEITIYVNEEKII-------RTAI------NILDILk--LNIDNISELNNIKA 316
CDA16142 374 TLNSDDttyi------------kanySSSKKEKKATIVLYEDNDTEFANLYIEHkkdkn----------------kinfk 425
CCZ17322 323 TIVGSDn-------------------QSGLQTETINVKLTKQITDNECQYIANVnvgdstii----------atldinnm 373
CDA58416 298 SVILERgknitikqtgsfdtadvlteETTATPNNIEYTISKEKSASKSKY------------------------------ 347
CDD36476 312 SIK-----------------------AYDEGDSILELQIEKETNENDVAYKIDIktdldteladqekaeihltvqyknla 368
CDC06908 324 VVSYEM-----------------------KEDKKSKISFSANFENLE--------------------------------- 347
CDE84094 325 --------------------------DSSTEETEANFTIIKEETSSNLTYDISLnmlsgeteit------gglemsytni 372
CDE11348 342 TIVKQ---------------------SNDGNNINTTVTLERNTSDNSNSFKMEQist---------------------tg 379
CDE84715 334 LIEKYD--------------------DIGNINMTSQITISKGNYNDNVVYNLEIi------------------------p 369
CDD15870 324 EVLLEKtdk--------------tdaTSENMISSTKIEVSKIIEESAITNKYEIm------------------------p 365
CDD15873 317 IISVQTs------------------eVISEIPYNSKIVLSKVVEENYITNNIKIm------------------------p 354
CDA16142 426 INDSSNSVLELNIDsngqigkgtietvcnlKFKEEDDLEINLN------LNN---STTY------TDDI-NIDDLSSNNG 489
CCZ17322 374 LSSNVNESYKIEL-------------------LENSETQLAIE------LKN---SITF-------KTV-NVTELNDSNA 417
CDA58416 348 TITSSEENCSLEIGfeldgisdngatekvyVSYDANDVQFNVE------YNN---AITF-------KDV-TVTELNGENS 410
CDD36476 369 TLDNVEENYELKL-----------------STQDYDESNTDLK-------------LNYtnvkqfSSNI-KVEGINSENS 417
CDC06908 348 SLQNIKENYELIMSlpev--------aessTTTDVDSEVVVYK------FSN---DVNF------TDSA-TVEDFSSDNS 403
CDE84094 373 NTSSVVENYAITVNv-------------------nDMTNLKYS------FSN---NVVF------ANSV-GIADFDLNNT 417
CDE11348 380 ETTTDRNAITINL------------------NGNVDTGNLELNvklenlIGNklnEINYtdkkefSSSV-NIEGLNDDDS 440
CDE84715 370 DTLNINQNINIMAQfgnttesg-ytnsyevTIQNSEKSSMNFQ---------------YnvetlaSENVeEIQEITDSNS 433
CDD15870 366 NVSKQNKTYSIESKigklvng--satntfiTTINDENSTIKAT---------------YnkninkVEQVeEIMELKNNNT 428
CDD15873 355 DVSRPTYEYSLTTKmgklqnnn-idnltvtTVTNENNLKISAT---------------YnkniqiGTEVeKIMELKNSNA 418
CDA16142 490 ELLNTISNTKMNDLYKEIYSNLQKVLPEKAKLLGID 525
CCZ17322 418 VVFNKLKTEEIQSLVPAIIEEIQKVNQNKMEKILED 453
CDA58416 411 VALNDYSQEELSPLLQQLLAQIITVNSQKIQNANVF 446
CDD36476 418 ITLNDATDDEIDELLITIY-----------KNLGLY 442
CDC06908 404 LMLTDYDSDQVSNFLNAVVERISEVNEQQMGQLGLE 439
CDE84094 418 IVLNNYQTADIQTFLNQLGTIITNKNEEQMKKIGYP 453
CDE11348 441 VSLNDMTLEEINSLYKSIVERIQYLYNEKLQNIGFD 476
CDE84715 434 IIFNNYKIEQLVPFITAYMQQNSALINNKLLSIDST 469
CDD15870 429 IIINNYSKEQLKPFIEKNVLSKRDKITNKINQVVTE 464
CDD15873 419 VIVNNYTVKQLQPFIEKNIINKFDNVTKKLESIGIN 454
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