1P0K


Conserved Protein Domain Family
IPP_isom_2

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TIGR02151: IPP_isom_2 
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isopentenyl-diphosphate delta-isomerase, type 2
Isopentenyl-diphosphate delta-isomerase (IPP isomerase) interconverts isopentenyl diphosphate and dimethylallyl diphosphate. This model represents the type 2 enzyme. FMN, NADPH, and Mg2+ are required by this form, which lacks homology to the type 1 enzyme (TIGR02150). IPP is precursor to many compounds, including enzyme cofactors, sterols, and isoprenoids. [Biosynthesis of cofactors, prosthetic groups, and carriers, Other]
Statistics
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PSSM-Id: 273999
Aligned: 18 rows
Threshold Bit Score: 441.705
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1P0K_A   5 ERKRQHINHALSIGQKRE---TGLDDITFVHVSLPDLALEQVDISTKIGELSSSSPIFINAMTGGGGKlTYEINKSLARA 81  Bacillus subtilis sub...
Q8EST0   7 QRKTEHIRLCLTGNVEGVnksTGLEGINFIHNALPEIDFADISLESSFLGKQLKAPFLVSSMTGGSEL-ATKINQNLAIA 85  Oceanobacillus iheyen...
Q8DJ26  16 QRKAEHLKLCLQGDVNHQeitTGFEKYRFRHCALPELDFAEIDLRVEFLGWRLAAPLLISSMTGGTPQ-AGEINRRLARV 94  Thermosynechococcus e...
Q9ZD90  10 ERKQEHIEINLKQNVN-StlkSGLESIKFIHNALPEINYDSIDTTTTFLGKDMKAPILISSMTGGTAR-ARDINYRLAQA 87  Rickettsia prowazekii...
Q9RVE2  12 TRKLRHLEACLRPESQYQkvkTGLDSVPWPYRALPESNLEEMRLDTVFLGRRLKAPVLIGAMTGGAEK-AGVINRNLATA 90  Deinococcus radiodura...
Q8TT35   7 RRKIEHLKLCAESPVEARgvsAGFEDVTLIHRALPELNMDELDLTVDFLGKRMQAPFLIASITGGHPD-TLPVNAALAAA 85  Methanosarcina acetiv...
Q8TX99   3 ERKWEHVLACIWEDVESEe-sPLFDCVKIVHRALPELDFDDVDMEIELFGKRLSFPLIIAGMTGGHPK-TGEINRKLARV 80  Methanopyrus kandleri...
Q96YW9   8 NRKIEHVEICLYENVEFGs--TLFEDVTLIHQSLPGFSLADVSTTTNFLGKKMSAPIIITGMTGGLPE-LGKINETIAEV 84  Sulfolobus tokodaii s...
Q8ZYF6   5 KRKDDHIYLASSELSQIGs--AWFEEVVLIHNALPEIDLSEVDLTTRFLGAPVKAPFGIGAMTGGTEL-AGKINAELAKA 81  Pyrobaculum aerophilu...
O51627   9 ENKKRHIEICLNKNDVKGg-cNFLKFIKLKHNALSDFNFSEINIKEEIFGYNISMPVFISSMTGGSKE-GNDFNKSLVRI 86  Borrelia burgdorferi B31
1P0K_A  82 ASQAGIPLAVGSQMSALKDPSERLSYeIVRKENPNGLIFANLGSEATAA--------QAKEAVEMIGANALQIHLNVIQE 153 Bacillus subtilis sub...
Q8EST0  86 AEEKGWALAIGSTRAFLESDQHKESF-LIRNQAPTAPLIVNIGAVQLNYgyg---peECQRIIDKTNADSIVLHLNSLQE 161 Oceanobacillus iheyen...
Q8DJ26  95 AQQKGIVMGVGSQRVLLEHPEVATTF-AIRREAPTIPLLANLGAVQLNYgcg---vsECQKIVDLLEANALILHLNPLQE 170 Thermosynechococcus e...
Q9ZD90  88 AQKSGIAMGLGSMRILLTKPDTIKTF-TVRHVAPDIPLLANIGAVQLNYgvt---pkECQYLIDTIKADALILHLNVLHE 163 Rickettsia prowazekii...
Q9RVE2  91 ARNLGLGMMLGSQRVMLEHPDAWESF-NVREVAPEILLIGNLGAAQFMLgyg---aeQARRAVDEVMADALAIHLNPLQE 166 Deinococcus radiodura...
Q8TT35  86 AEELGVGIGVGSQRAAIDDPAQEDSFrVVRDKAPNAFVYGNVGAAQIRQyg----veGVEKLIEMIDADALAIHLNFLQE 161 Methanosarcina acetiv...
Q8TX99  81 ARELEIGIGVGSQRAGVKDPEVRWTFeVVREEYPDGLVLANIGLPQLREng----pdLALEVVDMVDADALAVHVNVLQE 156 Methanopyrus kandleri...
Q96YW9  85 IEELGLGMGVGSQRIAIEKKETKETFsIVRKKAPNSPIIANLGAPQFVKgys---leQVEEAIQMIEADAIAIHFNSAQE 161 Sulfolobus tokodaii s...
Q8ZYF6  82 AEEFGIPIYVGSQRIALVKPEVKWTFeVVKQNAPHVPKVANLGAPQLAElgereleeWVVQAIDMIDAYAIAIHLNAAQE 161 Pyrobaculum aerophilu...
O51627  87 ANYLKIPIGLGSFKLLFKYPEYIRDF-TLKRYAHNIPLFANVGAVQIVEfg----isKIAEMIKRLEVDAIIVHLNAGQE 161 Borrelia burgdorferi B31
1P0K_A 154 IVMPEGDRSF-SGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSKIENLR-RQRQI--- 228 Bacillus subtilis sub...
Q8EST0 162 AVQDGGDLNF-KDLLPKIEQVCKQVKAPVGVKEVGFGIDGEVARRLYDAGISYIDVAGAGGTSWSQVEKLR-SKDPLnka 239 Oceanobacillus iheyen...
Q8DJ26 171 AVQTGGDRNF-KGLLTKIGVLCRALPVPVIVKEVGNGISAEVAKQLVDVGVAAIDVAGAGGTSWAKVEAAR-AQDASqry 248 Thermosynechococcus e...
Q9ZD90 164 LTQPEGNKNW-ENLLPKIKEVINYLSVPVIVKEVGYGLSKQVAKKLIKAGVKVLDIAGSGGTSWSQVEAYR-AKNSMqnr 241 Rickettsia prowazekii...
Q9RVE2 167 ALQRGGDTRW-QGVTYRLKQVARELDFPVIIKEVGHGLDAATLRALADGPFAAYDVAGAGGTSWARVEQLV-AHGqv--- 241 Deinococcus radiodura...
Q8TT35 162 AIQPEGDRDA-TGCLDMIAEICSMVRIPVIAKETGAGISREDALLLHKAGVSAIDVGGVGGTSWAGVEVYR-AKESKdpv 239 Methanosarcina acetiv...
Q8TX99 157 AVQLEGEADA-AGFVDVLAEVCETVDVPVVLKETGAGVSAEDAKLVRDI-VDGIDVGGAGGTNWAVVEAVR-SKAHGeip 233 Methanopyrus kandleri...
Q96YW9 162 VFQPEGEPNYsIEILYKLIDISKSLKVPIIIKESGSGLSMEVTKMFYENGIKYFDTSGTGGTSWVSVEMYRgLRRNNwka 241 Sulfolobus tokodaii s...
Q8ZYF6 162 VVQPEGEPRF-KGVLEKLKIVKRAAGKPLIVKETGNGISKEVAARLSG-IADAIDVGGFGGTSFVAIEGAR-AKESPlqk 238 Pyrobaculum aerophilu...
O51627 162 LMKVDGDRNF-KGIRESIAKLSDFLSVPLIVKETGFGISPKDVKELFSLGASYVDLAGSGGTNWILVEGMK-SNNLNi-- 237 Borrelia burgdorferi B31
1P0K_A 229 -----SFFNSWGISTAASLAEIRs-EFPASTMIASGGLQDALDVAKAIALGASCTGMAGHFLKALTdSGEEGLLEEIQLI 302 Bacillus subtilis sub...
Q8EST0 240 ---aaEAFNNWGTPTKDCLVSVRg-ELPEAPLVASGGMKTGVDAAKAITIGADVVGFARHLLKAAM-ETPEDVIRTMEQL 314 Oceanobacillus iheyen...
Q8DJ26 249 ---lgDAFAEWGIPTAHCLEQVHt-ALPDTPLIASGGLKDGIDVAKALALGAGLAGLARPFLQAAH-QSEEALAQRIDLL 323 Thermosynechococcus e...
Q9ZD90 242 ---iaSSFINWGITTLDSLKMLQe-ISKDITIIASGGLQSGIDGAKAIRMGANIFGLAGKLLKAAD-IAESLVLEEIQVI 316 Rickettsia prowazekii...
Q9RVE2 242 ---hsPDLCELGVPTAQALRQARk-TLPGAQLIASGGIRSGLDAARALSLGAEVVAVARPLLEPAL-DSSEAAEAWLRNF 316 Deinococcus radiodura...
Q8TT35 240 serlgELFWDFGIPTVASLIESR----VSLPLIATGGVRTGLDIAKSIALGASAASAALPFVGPSL-EGKESVVKVLSCM 314 Methanosarcina acetiv...
Q8TX99 234 ---lgYAFSDWGVPTAASILEVRsvVGNDLAIIGTGGVRTGMDVAKVLALGADCAGMALPVLRKVLaEGVRGCVRFLKSI 310 Methanopyrus kandleri...
Q96YW9 242 --esaKLFLDWGIPTAASIVEVRs-iAQDGTIIGSGGVRNGLEVAKAIALGADIGGFALPALKAAV-KGKESLMNFLKKV 317 Sulfolobus tokodaii s...
Q8ZYF6 239 --rlaETYKWWGIPTAASICEVKs--AYAGYLIASGGIRSGLDGAKAIALGANFFTMSQPLLKAAL-DGR--LREEIAMI 311 Pyrobaculum aerophilu...
O51627 238 ----aSCFSDWGIPSVFTLLSIDd--SLKANIFASGGYETGMDIAKGIALGARLIGVAAVVLRAFYdSGEDAVFGLFSDY 311 Borrelia burgdorferi B31
1P0K_A 303 LEELKLIMTVLGARTIADLQKAPLVIKG 330 Bacillus subtilis subsp. subtilis str. 168
Q8EST0 315 ELELKMTMFGIGAVNLEELKNTSRVSIM 342 Oceanobacillus iheyensis HTE831
Q8DJ26 324 LEELKTVLFCTGSATPQALYQRRCLERI 351 Thermosynechococcus elongatus BP-1
Q9ZD90 317 IEQLKITMLCTGSCTLKDLAKAEIMw-- 342 Rickettsia prowazekii str. Madrid E
Q9RVE2 317 IQELRVALFVGGYRDVREVRGG------ 338 Deinococcus radiodurans R1
Q8TT35 315 LDEFRAAMFLCGCANIQALHNSPVVVTG 342 Methanosarcina acetivorans C2A
Q8TX99 311 AREVKIAMLMAGCSSVEEMSSVPIVVYG 338 Methanopyrus kandleri AV19
Q96YW9 318 IFELKVAMFLSGNKTIGELKKTPIVIGK 345 Sulfolobus tokodaii str. 7
Q8ZYF6 312 IAELKTAMFLTGARTVQELALVPRVYGP 339 Pyrobaculum aerophilum str. IM2
O51627 312 EHILKMSMFLSGSKSLLEFRNNKYFLSS 339 Borrelia burgdorferi B31
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