3ESH


Conserved Protein Domain Family
YtnP-like_MBL-fold
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cd07728: YtnP-like_MBL-fold 
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Bacillus subtilis YtnP and related proteins; MBL-fold metallo hydrolase domain
Bacillus subtilis YtnP inhibits the signaling pathway required for the streptomycin production and development of aerial mycelium in Streptomyces griseus. Members of this subgroup belong to the MBL-fold metallo-hydrolase superfamily which is comprised mainly of hydrolytic enzymes which carry out a variety of biological functions.
Links
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Statistics
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PSSM-Id: 293814
Aligned: 28 rows
Threshold Bit Score: 410.497
Created: 9-Jun-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
3ESH_A      6 ISIHYLNGgntkxdggaxfgvvpkplwskqynanernqinlpTHPILIQTaqYNLIIDAGIGngklsekqlrnfgvdees 85  Staphylococcus aur...
BAH45032   11 FQLSWLRGgltkldggamfgvvpkplwskrypsndlnqiplrADPILVQAhgKRILIESGMGndrltekqkrnfgleees 90  Brevibacillus brev...
ADH98769   12 VTMTWLDGgvthldggamfgvvpkplwskrypvndnnqielrSDPILLQVdgKHMLIESGIGngkfsekamrnygitses 91  Bacillus selenitir...
EFR96749    9 ITIYWLRGgythfdggamfgvvpkplwekkypaneknqlanvTDPMFFQYegKNYLIDTGLGnnrltekqkrnygvtees 88  Listeria ivanovii ...
EIA21127    6 LDIHWLSGgkmafdggamfgvvpkalwfkkypaneqnqiatdTDPMYFNIegKHVLIDAGIGvnrftekqkrnfavekes 85  Listeria fleischma...
EIT85504    9 LTFTWLNGgvthmdggamfgvvpkplwskkyavnelnqielrTEPILIQGlgKNILIDAGIGfgkltdkqkrnygvnees 88  Bacillus macauensi...
EUJ37168    9 IEIHWLRGgvthfdggamfgvvpkalwskkyqpneknqircvTDPMYFHYqgKHYLIDAGLGngrltekqkrnfgvtges 88  Listeria weihenste...
EXJ22926    9 ASITWLDGgktrmdggamfgpvpkklwsrrypanadnqielpTDPMLLEIngKHYLLDAGIGrgrlsnkqkkifgatees 88  Alkalibacterium sp...
KGX89416    9 AKLTWLQGgvthmdggamfgvvpkplwskkypvndrnqielrTDPILLELsgKRYLIDAGIGndkltekqlrnfgvcees 88  Pontibacillus halo...
AKF93511    9 CKLTWMRGgmtqldggamfgvvpkalwskrypsneqnqiplrSDPILVQVhgKNILIESGMGtnrlnekqkrnfglvees 88  Brevibacillus late...

Feature 1                           # # ##                                                    
3ESH_A     86 hiiaDLANYNLTPKDIDYVLXTHXHFDHAAGLTDQAgha----ifeNAIHVVQQDEwhefiapnirskstywdknkgdys 161 Staphylococcus aur...
BAH45032   91 qvveSLAAKGLTPADIDIVIMTHMHYDHANGLVSIRdgqlv-stfpQAVIYVQEQEwaemrepnvrskntyweenwrpie 169 Brevibacillus brev...
ADH98769   92 kvkeNLAELGLTPADIDAVLMTHMHFDHVSGLTEPVdgkqq-pvfpNAVIYVEEKEwaemrqpnirskntyfrenweaie 170 Bacillus selenitir...
EFR96749   89 fvleDLARLGVSPEEIDYVLMTHLHFDHVLGLTGVSeegny-sifkNAEIWTSKMEwdemrnpnirskatywkenweqie 167 Listeria ivanovii ...
EIA21127   86 fviqDLAKLGITPLDIDYCLMTHLHFDHATGLTSVQngelv-stfpNAKIITSSTEweemkkpnirskatywkenweqie 164 Listeria fleischma...
EIT85504   89 silsSLEECHLTPADIDLVLMTHLHFDHASGLTAKKqdtfv-svfeNATIYVSEVEwkemqhpnirskntyweenwqpia 167 Bacillus macauensi...
EUJ37168   89 fmieDLATLGVKPEDIDVILMTHLHFDHVVGLTNAAges----ifsNAIIYTTATEwdemqhpnirskatywpenwpgia 164 Listeria weihenste...
EXJ22926   89 rieeDLKKLNLKPSDIDGILMTHLHFDHVTGLVKRCgdkll-slfpKAAIFIERREweavrfpskrtqgtywadnwqpie 167 Alkalibacterium sp...
KGX89416   89 sidrSLSQLGLSTASIDAVLMTHMHFDHASGLTKWDgeelv-ptfeNATIYVSQVEweevtepnmrsvntywednwrpik 167 Pontibacillus halo...
AKF93511   89 elseSLQEVGLQFEDIDLVLMTHMHYDHANGLVSVAedgslystfpNAAIYINEIEwnemrspnirskntywednwrpie 168 Brevibacillus late...

Feature 1                            ##                   #                                   
3ESH_A    162 NKLILFEkHFEPVPGIKXQHSGGHSFGHTIITIEsqgdKAVHXGDIfpttahknplwvtayddypxqsireKERXIPYFI 241 Staphylococcus aur...
BAH45032  170 KQVKTYGaSHEVVPGITLHHTGGHSQGHAIVRMEtegqLLLHLADImpthahqnplwvmayddypmtsiyaKEEWIINGI 249 Brevibacillus brev...
ADH98769  171 HQVKTYAgQIEVAPDVRMIHTGGHSYGHAIIHIScgnaNIWHMADLmpthvhlpslwvlayddypmtsihqKEQYIQANL 250 Bacillus selenitir...
EFR96749  168 SQVHTFDrEVKINDVVKMEHTGGHSAGHSIIWFHlngeKAVHMADIfptfahqnvlwvtayddypmtsiaaKQEIFKQTF 247 Listeria ivanovii ...
EIA21127  165 KQVTTFSkKMEVLPGVSMYHTGGHSAGHCIIEIEskgeRAVHLGDIfpthahlnplwvtayddypmdsifaKERLFQKWM 244 Listeria fleischma...
EIT85504  168 HQVTTFQeKISPLEGITMIHTGGHSDGHCIIEIEeageKLYHLGDImpthahknplw----vlayddypmtSIAAKEQWI 243 Bacillus macauensi...
EUJ37168  165 SQIKTYEqELLLNEAITLRKTGGHSLGHAVIEINsggqSAIHMADIfpthahknvlwvtayddypmdsifaKERLIKEID 244 Listeria weihenste...
EXJ22926  168 AQVRIFDdTIEVEEGIQMGHTGGHSPGHCFVKITqgfeTAVYLSDVfpthahlnplwvtafddyplesieaKEKWITEGI 247 Alkalibacterium sp...
KGX89416  168 HQVKTFShHMKIDEGLGMWHTSGHSNGHAIIRYIdeehQFIHMADLmpthahrnplwvlayddypvtsvheKKRWLDEAI 247 Pontibacillus halo...
AKF93511  169 KQVCTYTgQKEVVPGIKMVHTGGHSDGHAIILFEskgeKACHMADImpthahqnplwvmayddypmtsiyaKEKWLKEMI 248 Brevibacillus late...

Feature 1              #
3ESH_A    242 QQQYWFLFYH 251 Staphylococcus aureus subsp. aureus Mu50
BAH45032  250 KQGAWFTFYH 259 Brevibacillus brevis NBRC 100599
ADH98769  251 PNSPVFTFYH 260 Bacillus selenitireducens MLS10
EFR96749  248 GENYWFLSYH 257 Listeria ivanovii FSL F6-596
EIA21127  245 DGQTWFLFYH 254 Listeria fleischmannii subsp. coloradonensis
EIT85504  244 KPHTWYVFYH 253 Bacillus macauensis ZFHKF-1
EUJ37168  245 GKKKWLLFYH 254 Listeria weihenstephanensis FSL R9-0317
EXJ22926  248 EQDWTFLYYH 257 Alkalibacterium sp. AK22
KGX89416  248 KEGAWLTFYH 257 Pontibacillus halophilus JSM 076056 = DSM 19796
AKF93511  249 AQQAWFTFYH 258 Brevibacillus laterosporus

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