3K2Y,2L1I


Conserved Protein Domain Family
HIRAN
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smart00910: HIRAN 
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The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p.
HIRAN is found as a standalone protein in several bacteria and prophages, or fused to other catalytic domains, such as a nuclease of the restriction endonuclease fold and TDP1-like DNA phosphoesterases, in the eukaryotes. It has been predicted that this protein functions as a DNA-binding domain that probably recognises features associated with damaged DNA or stalled replication forks.
Links
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Statistics
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PSSM-Id: 214906
Aligned: 51 rows
Threshold Bit Score: 45.3518
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3K2Y_A         11 VTVVGERYVddivatL-------TTLRVG---MAVLLQR---ESG-----NQ---------------------------- 44   Lactobacillus...
Q6BIP2        180 lNVQAWATRp----tT-------KPLKYL---EKLELRR---LMP-----KKlnvgkptke------------------- 218  Debaryomyces ...
NP_001117447  163 TFIVGRKFSd-----V-------QDLEIG---GDIFLLR---HPE-----NV---------------------------- 191  thale cress
XP_001382790  158 VDVQAWATRp----tM-------QPLQYS---DRLIIKR---LIP-----RK---------------------------- 187  Pichia stipit...
EGA81788      179 lQVTGMATRp----tV-------RPLKYG---SQMKLKR---SSEeisatKV---------------------------- 213  Saccharomyces...
XP_444917     170 lQVTVMVTRp----tM-------RPVPYG---TPLIFKR---SNN-----NV---------------------------- 199  Candida glabr...
XP_455865     182 iHTMGFATRp----tV-------KPVPIG---SRLGFKK---SVP-----KDlplgk----------------------- 216  Kluyveromyces...
NP_985767     151 TQVNAMATRp----tA-------QPLKYG---SELLIRRtsgQPN-----NSgl-------------------------- 185  Ashbya gossyp...
XP_756718     274 GLPASLTYNg----tIdqeppvdPNFSREnwpRASRFWT---ESG-----YRpimlqlsqptglsasmrtlpngwaypst 341  Ustilago mayd...
XP_962010     193 GTTINCHRVp----aPkpg--mvSLLGDGywpQIKILLR---KRV-----DD---------------------------- 230  Neurospora cr...

3K2Y_A         45 -------------YD----DN--------------A--------ISVWTLq---------HAKLGYIARYQNQPYATLMD 76   Lactobacillus...
Q6BIP2        219 ----ktkfgdssiIR----IY--------------T--------IPKYTEe--------sGREIGRIPEDITRILVPLID 260  Debaryomyces ...
NP_001117447  192 -------------KD----RN--------------A--------IKVISg---------dSEMLGYLPKDISQCLSPLID 223  thale cress
XP_001382790  188 -------------ST----IN--------------NssiirlctVPKNTMd--------tGREIGRIPEDLTRIFAPLID 228  Pichia stipit...
EGA81788      214 -------------YDsrgrKK--------------Asma---slVRIFDIq--------yDREIGRVSEDIAQILYPLLS 255  Saccharomyces...
XP_444917     200 -------------PL----KKiyeqlnkkktglaaF--------VKIYSAn--------dEREIGRVPEDIARIVFPLLH 246  Candida glabr...
XP_455865     217 --------slqhqHC----SH--------------L--------VRLIDTs--------qDRELGRMPEDVARILYPLLD 254  Kluyveromyces...
NP_985767     186 -----------rsRK----KP--------------G--------FSQYVRfcd----atsSRELGRLPEDISEILHTLLQ 224  Ashbya gossyp...
XP_756718     342 aaqrpdikvsvvvPP----RA--------------R--------FPQLSVeqaarygpapEPAFGSLAEKYVSSMEPLLR 395  Ustilago mayd...
XP_962010     231 -------------TE----TN--------------R--------IPAYDCt---------rVVFGYLDAKTSYCLGNLLT 262  Neurospora cr...

3K2Y_A         77 --QGQRLYGIVTVL-D-Q-Q---KqHLELMLWRL 102  Lactobacillus plantarum
Q6BIP2        261 --LDISSFYTTVMI-DtE-Kr--LsTGDSFYIQI 288  Debaryomyces hansenii CBS767
NP_001117447  224 --DYDLKFEGTITS-V-P-Kk--Ss--EAVLIKV 248  thale cress
XP_001382790  229 --LDIAFFEATVLE-T-T-Kr-rLsTGDSFIIQI 256  Pichia stipitis CBS 6054
EGA81788      256 --SHEISFEVTLIF-C-DnKr--LsIGDSFILQL 283  Saccharomyces cerevisiae Lalvin QA23
XP_444917     247 --RNEVHFKLTMIYpG-D-Kr--LsIGDNIIIQM 274  Candida glabrata CBS 138
XP_455865     255 y-SEQVSLEPYLLI-N-NgKr--FsVGDNIYIRI 283  Kluyveromyces lactis NRRL Y-1140
NP_985767     225 --TPGVEFKATMIF-C-NsKr--LsVGDLFVVRL 252  Ashbya gossypii ATCC 10895
XP_756718     396 --NNKVRCEARCRM-V-P-IgraQnFLHHLEILV 424  Ustilago maydis 521
XP_962010     263 saMGIRTDCRIPPR-R-K-SgpnEkIGESISAAV 293  Neurospora crassa OR74A
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