Conserved Protein Domain Family
TFP_LU_ECD_Ly6A_like
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cd23541: TFP_LU_ECD_Ly6A_like 
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins
The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).
Links
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Statistics
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PSSM-Id: 467071
Aligned: 21 rows
Threshold Bit Score: 105.105
Created: 27-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q63317        25 QGLNCYNCTMipfGNTCSstaTCPyp---dGVCTIQVAEVVvssv------------rlkvKSNLCLPgCPKSpqtpe-- 87  Norway rat
XP_004454839  23 QGLRCHQCYTnpdLSPCTp-dTCSlpddagGFCASQLVSTTvgta------------evqvEHKFCLSaCPQEfrdlsq- 88  nine-banded arm...
XP_005354102  19 QGLSCYQCIGaakPETCQp-aTCSyt---nGVCVTQEMESTvesy------------kmtlISKFCSPtCPDKeypetl- 81  prairie vole
XP_007938745  19 QGLRCYQCYAapyLGPCRe-eTCDyp---aGVCVSQEVIISlnse------------eikaENKLCLPsCPRNnlpllg- 81  Orycteropus afe...
XP_008571767  25 QGLKCYQCIAasnMNSCHp-aVCSfp---dGVCVSQEVTTIvese------------kvslENKFCLPsCPDRidiqda- 87  Sunda flying lemur
XP_012608394  19 QGLRCYHCTQlvpGDSCPv-vTCTyp---nGVCVTQKVTAIvesq------------evkvENKLCLPtCPPEdsvipq- 81  gray mouse lemur
XP_012880611  19 QSLQCYQCVGatqDSTCKq-sTCPfp---kGVCVTQEVGMAmgs--------------rkmKNKFCLPtCPKGknmsikn 80  Ord's kangaroo rat
XP_020026008  25 QGLRCYKCFGslrGKSCQp-tTCSsp---nSVCVTQVLETIvlsk------------kvklRNKFCLPfCPEKytsikn- 87  American beaver
ELW63421       1 QGLHCYECLItsdFSSCRl-rTCYfp---dSFCISQEVVAVmggqsvlsslspagseteklQRKFCLPtCPKDsyqlks- 75  Chinese tree shrew
XP_005000995  25 QGLHCYRCLNytsGKFCDq-vMCSfpg-gkEVCVSQEQSFTlgsk------------ivkrEDKLCFPdCPKDtdfrs-- 88  domestic guinea...

Q63317        88 --vlgtVVHVNTDCCNTDLCNA 107 Norway rat
XP_004454839  89 -ermgrVLKSRVTCCQEDLCNA 109 nine-banded armadillo
XP_005354102  82 -evlgfTVNSKIFCCNTDLCNA 102 prairie vole
XP_007938745  82 dhqagmKVDTTVSCCNTDLCNR 103 Orycteropus afer afer
XP_008571767  88 -htlglVVSSKTSCCKGDLCNA 108 Sunda flying lemur
XP_012608394  82 -lvpnfTMSYKISCCKEDLCNA 102 gray mouse lemur
XP_012880611  81 ipligkMIHSKTSCCSEDLCNL 102 Ord's kangaroo rat
XP_020026008  88 mpvmgtILNTQTSCCTDDLCNG 109 American beaver
ELW63421      76 mnilgaVVNSTLSCCKGDLCRA 97  Chinese tree shrew
XP_005000995  89 -tfsgfHTTVKIMCCNRNLCNA 109 domestic guinea pig
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