Conserved Protein Domain Family
TBD
?
pfam12845: TBD 
TBD domain
The Tbk1/Ikki binding domain (TBD) is a 40 amino acid domain able to bind kinases, has been found to be essential for poly(I:C)-induced IRF activation. The domain is found in SINTBAD, TANK and NAP1 protein. This domain is predicted to form an a-helix with residues essential for kinase binding clustering on one side.
Links
?
Statistics
?
PSSM-Id: 463729
Aligned: 10 rows
Threshold Bit Score: 64.3767
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_005993776 215 QKSEEFLQRAYWELKKEMSNLHLVTKVQSEVLRKLRAtLTAANKDSLSFPAQCVED 270
XP_008997060 132 LHERDNIEKTFWDLKEEFHRICMLAKAQKDHLSKLNI-PDTATETQCSVPIQCTDK 186
1_pfamImport   1 GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQeQARSGG-QRHSPLSQRHS 55 
3_pfamImport   1 GDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQeQARSGG-QRHSPLSQRHS 55 
XP_542751    214 SISSDNMQNAYWELKREMSNLHLVTQVQAELLRKLKIpTTIK---KACSPVGCMED 266
XP_008119738 227 DIHSVNVQHAYWELKKEMSNLHLVTEVQAEMLKKLKLiPLGTRKVPSCTPLQCVED 282
XP_015214543 136 DDKSKEILEAFQEIQGKFHVIQNLTRKQKDHLNKLCRaNDTAQEQQFSMPIQCTDV 191
XP_007494316 181 FNKREEIEKTFYEMKEEFHRICMLARAQREHLNRLNI-QEPIPEIQFSMPIQCTDE 235
XP_001511169 193 SHERADLEKTFLEMKEELHRICMLTRMQTDHLSKFNLkNETAREIQFSMPIQCTDK 248
2_pfamImport   1 GHARENLETIFQEMKEECHRICMLAREQTDQLSKFKIkPEPETEIQFSMPIQCTDK 56
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap