Conserved Protein Domain Family
OGFr_N

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pfam04664: OGFr_N 
Opioid growth factor receptor (OGFr) conserved region
Opioid peptides act as growth factors in neural and non-neural cells and tissues, in addition to serving in neurotransmission/neuromodulation in the nervous system. The Opioid growth factor receptor is an integral membrane protein associated with the nucleus. The conserved region is situated at the N-terminus of the member proteins with a series of imperfect repeats lying immediately to its C-terminus.
Statistics
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PSSM-Id: 461383
Aligned: 14 rows
Threshold Bit Score: 315.419
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_016080819  14 EGESDMVNLRFYKNEIPFQPNGLHINEILKNWKNDYDILEDNHSYIQWLFPLREQGVNWYAKPLTAREIQEFKSSDEVMK 93 
XP_019477766  46 DEEEDMWNLSFYKNEIAFMPHGLHIEDLLESWWDNYEVLEENHSYIQWLFPLREHGMNFRAKPLTCQEIEALKKSEEVME 125
XP_008108379 124 VEEAEMWNLSFYKNEIRFMPNGLHIDDLLEKWQNDYGILEENHSYIQWLFPLREQGMNWRAKLLTCQEIEAFKKSKEVME 203
NP_001298278  65 CPEERMTNLKFYLNEIKSSPDDVSIETFHTEWRTDYKRLERVHSYIQWLFPLREPGVNYMAAELTKKEIQAFRESEEAKS 144
XP_015220427  74 YSRGKMFNLKFYLNEIGTEPDGIMIKEFLQNWKQDYKKLERNHSYIQWLFPLREPGMNYMAYELTREEIEEFHKNEVAKQ 153
NP_001068572  68 FQINPLYHLKFYRGEIKAAPVAIHIDGFHKEWWGQYDLLEKAHYYIQWLFPIQRKVNNWRIHCLRKKEIMLFRRDEDVKH 147
XP_040060379 175 STRRDKLNLQFYLGMTRSVPDGVSIDGFHQDWYKDYDRLESVHSYIQWLFPLQEPGMNRDASILTTEEIEEFLQSNIAKE 254
XP_014723955  49 RYQNDLSNLRFYKNKIPFKPDGVYIEEVLNKWKGDFEKLEHSHTYIQWLFPLREQGLNFYAKELTTYEIEEFKKTKEAIR 128
NP_001314975 100 RQPNEYRNLRFYLNKIPLVPDGIYIEEILTKWRGDYDKLEHNHTYIQWLFPLREQGLNFYAQELTQDEIKEFQSTREAKR 179
XP_029691670  95 HQPNEYRNLRFYLNKIPLVPDGIYIEEILTKWRGDYDKLEHNHTYIQWLFPLREQGLNFYAHELTQDEIKEFQSTREAKR 174 torafugu
XP_016080819  94 RFVQAYELMLGFYGIELVDPELGVVKRANNYPKRFQNLNWHSHNNLRITRILKCLGEMGYEHYQAPLVKFFLEETLVKHR 173
XP_019477766 126 RFIRAYQLMLRFYGIILVNQETGELKRAENWAERFLNLNRFSHNNLRITRILKCLGELGYEHYQVHLVKFFLTETLVNET 205
XP_008108379 204 RFVRAYKLMLGFYGIEMINEETGELRRAENWCERFENLNRYSHNNLRITRILKCLGEMGYEHYQVRLVQFFLTETLVHQK 283
NP_001298278 145 RLLDSYELMLGFYGLQLLNRETGEVKRADNWRERFANLERNMHNNLRITRILKSLGELGFEHFQAPLVRFFLEETLVRKT 224
XP_015220427 154 TLIQSYELMLGFYGIELVNKETGEVKRAWNFEDRFDNLDRNMHNNLRITRILKCLGELGFEHYKAPLVKFFLEETLVNKE 233
NP_001068572 148 KLIKSYKVMLDFYGIRLADEKTGKVERAENWKQRFNNLNRNTHNNLRITRILKCLGTLGLEHYQAPLVKFFLHETLFQGQ 227
XP_040060379 255 NLLKSYKLMLDFYGIELSDEKTGEVRRACNWRDRFNNLNRRTHNNLRITRILKCLGTLGYRHYQAPLVHFFLKETLVHRE 334
XP_014723955 129 RFLLAYKMMLEFFGIKLTD-KTGNVARAANWQERFQHLNESQHNYLRITRILKSLGELGYESFKSPLVKFILHEALVENT 207
NP_001314975 180 RFLLAYTIMLDFFGIKLLD-KNGNVSRASNWQDRFQHLNESQHNYLRITRILKSLGELGFESFKLPLVRLLLEEALVEGT 258
XP_029691670 175 RFLVAYSLMLDFYGVKLLD-KSGNVARAPNWQERFRHLNESQHNYLRITRILKSLGELGYESFKAPLVRLFLEESLCHST 253 torafugu
XP_016080819 174 LQNVKQSALDYFVFTVKNKHLRRELVYYAWKNFKPPNKFVWGPLQKLQ 221
XP_019477766 206 LPNVKRSALDYFLFTIRSKRKRRELVHYAWQHYKPQGSFVWGPHDKLL 253
XP_008108379 284 LPNVLMSALDYFMFTVRSKQKRRDLVHFAWQHYKPRREFGWGPHKKLR 331
NP_001298278 225 LSSVKRSVLDYFLFAVRDKRERRKLVRFAFQHFEPKDKFVWCP-RKIQ 271
XP_015220427 234 LSSVKRSVLDYFLFSIRDKRKRRELIEYAYQHFEPKDKFVWCP-RRVQ 280
NP_001068572 228 LKNVKQSVLDYFMFAVLDKSKRRELIRYAYLYFKPRKDFVWGSKKILE 275
XP_040060379 335 LPQVRDSVLHYFVFAVLDKRERRRLLKFAYLSYDRREEFVWCP-KKIQ 381
XP_014723955 208 IPNIKQSALEYFVYTIRDRRERRKLLRFAQKHYTPSENFIWGPPRKEP 255
NP_001314975 259 LPNMRHSALEYFVFTLRQHAQRRALLRFARRHYQPPENFIWGPPKKKR 306
XP_029691670 254 LPNMQHSILEYFVYTIRLPATRRRLLRYARQHYRPAHAFLWGPLPKRQ 301 torafugu
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