4H9S


Conserved Protein Domain Family
DAXX_histone_binding
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cd13150: DAXX_histone_binding 
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Histone binding domain of the death-domain associated protein (DAXX).
DAXX is a nuclear protein that modulates transcription of various genes and is involved in cell death and/or the suppression of growth. DAXX is also a histone chaperone conserved in Metazoa that acts specifically on histone H3.3. This alignment models a functional domain of DAXX that interacts with the histone H3.3-H4 dimer, and in doing so competes with DNA binding and interactions between the histone chaperone ASF1/CIA and the H3-H4 dimer.
Links
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Statistics
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PSSM-Id: 240523
Aligned: 20 rows
Threshold Bit Score: 200.541
Created: 1-Feb-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Histone H3.3Histone H4
Conserved site includes 58 residues -Click on image for an interactive view with Cn3D
Feature 1:Histone H3.3 interface [polypeptide binding site]
Evidence:
  • Structure:4H9S: Human DAXX contacts histone H3.3 as it wraps around the H3.3/H4 dimer, contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     ##  #  ## #######   #### #### ##  #  ##  #            ###           
4H9S_F          1 GSRRQIQRLEQLLALYVAEIRRLQEKELDlseLDDPDSAYLQEARLKRKLIRLFGRLCELKDCSSLTGRVIeq-----rI 75   human
XP_002427969   67 EYTSSQHFKNFVKKLLAKKIRELEETEVDl--SDEENSTYVKLQRHRKRFCTIYKKLCKYTNENPDANRIYlr-----kI 139  human body louse
EFN83096      250 DKKRKIKTILMAMKKCDLRIKKFETAEVDf--NEDADSNYIKMERYKQRMVELYSKLCELTDDNADAGRSYlr-----pK 322  Harpegnathos ...
XP_002109841  129 QTLQKLKKYETDLRKYNKLINKHEYDDMSledLDNSGSIYILISKLKKKSVAIVEKINKLVRSRSVLEPPF--------R 200  Trichoplax ad...
XP_003427694  249 QDMKKVKKIEKAIRICLKRIRELEEKEVDf--DAEENSAYLQEDRYKRKLVELCNSLSDIVGDRMLKKEIYkkqirrkdI 326  jewel wasp
AAV30852     1230 RRDERIRHFYRTLHAITKRIKMLEEAEVD---LNDEDSSYLQLERFKKRACQIYEKICDLKGESKSVRRQLkk-----pI 1301 fruit fly
EHJ67426      222 PQAERIKKIEKEIARCKSVIAKLDELEVD---DDSVNSPYIRSEKLKAKIVSLYRELCELTGSSPVKKRQIh-------L 291  monarch butte...
EFR27895      612 RKDQQIARLNRTLYCLKKRIQMLEEAEVDf--NHDANSAYMMVQRYKKRAFDVYKKLCDITGESKDAHRLVkk-----pI 684  Anopheles dar...
EHJ76041      495 KKMIQIRKLEKTIKKLHRAIQKLEQQEVDf--DDDEDSVYLLTERYKERMVRVHKKFCQLTNTKMPSEPRIh-------I 565  monarch butte...
NP_001189467  275 DTETRIKEIEITIANYKEKIVKLEQQDVC---DDSLYSPYIQSEKLKQKIVDLYKELCSLTGDEPIKRREVr-------L 344  domestic silk...

Feature 1                                                         #####  #                        
4H9S_F         76 PYRGTRYPEVNRRIERLINKPgp-----------------------dTFPDYGDVLRAVEKAAARHSLGL---------- 122  human
XP_002427969  140 CFSGSKYPNVNKIIENWLNETk-------------------------RFPDFTDIVKLLENQSSYLDLSTndpdkirlig 194  human body louse
EFN83096      323 HISTTQIVAVDQAISNFINSKiskqnrlkk---------rgaftnnlIFPDYRDILECVNRCNIKRNLGL---------- 383  Harpegnathos ...
XP_002109841  201 QFCNTRYRDINKEVTKFLKAQyyrnhnstiksrakhrkqqallvqslCMPDFVDIKDIVTSANRKYKLGL---------- 270  Trichoplax ad...
XP_003427694  327 PGEMTGISTVDEAIISFINTNikqvnklkhi------khpyaiadylLVPDYPDILDCIVKCDKEKDLEL---------- 390  jewel wasp
AAV30852     1302 HFKDSDYPHFNNSLSAFVNRMq-------------------------DFPDYHDVLQILEKCNKEKELGL---------- 1346 fruit fly
EHJ67426      292 KVVEGHPDGPVRCLEAFLNDNigsd-------------------gdpPFPDFSDVVQCVSEANEKDKLGW---------- 342  monarch butte...
EFR27895      685 YFQGTSYTEFNRTIQLFVNRTd-------------------------SFPDFRDVLKCLQHCDQKYGYNL---------- 729  Anopheles dar...
EHJ76041      566 ESRPGRPTGPAKRVEKWINKKvpig-------------------aplPFPDFHDVLHCVRDANDDDRLGW---------- 616  monarch butte...
NP_001189467  345 QVAKDHPPAPVQKLEQFLNENigsn-------------------gepPFPDFHDVMMCVAEANATESLGW---------- 395  domestic silk...

Feature 1                     #   ##  #  #  ##  ## ### #                          #  ##  ## ##  ##
4H9S_F        123 PRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFgCHLTDdyrpgVDPALSDPVLARRLRENRSlAMSRLDEVISKYAMLQD 202  human
XP_002427969  195 NWYNKLYQTTEIFQQVGVMLQERRKYDLWDSFcGFLKDs----SDPAEDNPELKKIFKENFDnRVKKEQEIFAHYSEIQT 270  human body louse
EFN83096      384 DKRKLKHMAKKAFTELGEYLQRARRNDYWDTFsLYLENa---eEDPALKDKELASKLAVNRSeGDKRLAAVFEKYRKKQE 460  Harpegnathos ...
XP_002109841  271 TQRQHDDIAKEAFREVCHKIRKRRLEELNLEIrHHLKPn---eQDPAINNPTLKEDLDKSLKiGQEREKEVILKFSKIQD 347  Trichoplax ad...
XP_003427694  391 TKKKMEQLAKTAFKSIGSYLKKQRVLESEEYI-SSFIDat-tePDPAAKDPELNKRLQNNKKeGDKKLEEIFKKYVDKQE 468  jewel wasp
AAV30852     1347 AKYEMKRIAYDAFNKVGRMLQSRRKNDLYETV-THYTAn---gKDPASSDPELLAKLKENNK-KQTKISDILEKYALEQD 1421 fruit fly
EHJ67426      343 TRPEILREARVLFTQCGRALQKRRQNREWRDL-LHKVKlercdTDPADSDPALLQRLEDNRRaAVKKESEILERYTMMQT 421  monarch butte...
EFR27895      730 RREQMDRVAQDAFLQVGKLLQKRRKTDLYETV-SYYANd---aTDPALADQKLQEKLDQNRK-YYNKVGELIDRFAKAEA 804  Anopheles dar...
EHJ76041      617 NEYEIMEEARDLFTRCGKKLQRRRQENEWRLAvSRITQv----LDPAEENIDLKKRLEENEAlATSKELELFKKFVDKQN 692  monarch butte...
NP_001189467  396 NAVQVMSEANALFTQCGRALQKRRQQREWRDLlCRVRSed--lRDPADDDPELLARLEENRRtAAKKERDLMERFTNIDC 473  domestic silk...

Feature 1           #
4H9S_F        203 KSE 205  human
XP_002427969  271 KQG 273  human body louse
EFN83096      461 DLK 463  Harpegnathos saltator
XP_002109841  348 DIR 350  Trichoplax adhaerens
XP_003427694  469 GLS 471  jewel wasp
AAV30852     1422 LNA 1424 fruit fly
EHJ67426      422 APS 424  monarch butterfly
EFR27895      805 NNE 807  Anopheles darlingi
EHJ76041      693 QLK 695  monarch butterfly
NP_001189467  474 DVP 476  domestic silkworm

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