Conserved Protein Domain Family
Det1

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pfam09737: Det1 
De-etiolated protein 1 Det1
This is the C-terminal conserved 400 residues of Det1 proteins of approximately 550 amino acids. Det1 (de-etiolated-1) is an essential negative regulator of plant light responses, and it is a component of the Arabidopsis CDD complex containing DDB1 and COP10 ubiquitin E2 variant. Mammalian Det1 forms stable DDD-E2 complexes, consisting of DDB1, DDA1 (DET1, DDB1 Associated 1), and a member of the UBE2E group of canonical ubiquitin conjugating enzymes and modulates Cul4A function.
Statistics
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PSSM-Id: 462868
Aligned: 32 rows
Threshold Bit Score: 435.152
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015795436 133 RECSLFTFDSRYVIVASSAP-----IIDM--PNYYDVLRNNESVsvnvkffcEDYIIYLIDIKNGKKCDQIVLKTDNISL 205
XP_002049492 150 REFSVFLEDSRYVLLAGMCIlqgcnLAVSdyERYPDVFDKVDPF---------SYIFYVVDLQQGVVTDEVRLPQDAISL 220
EDW00670     148 REFSVFLEDARYVLLAGMCIlqscnVSVSdyENYADIFDKVEPF---------SYIFFVVDLQQGIVTDEVHLAQDVISL 218
XP_002014308 150 REFSVFLENGRYVLLAAMCIlh-gaLATAdyISYPDLFDKLDAF---------SYIFFVVDLVLGVVTDRLFLPQDSIVI 219
XP_001963225 148 REFSVFLENGRYVLLAAMSVlr-naLPTMsyVLYPDLFDKLDAY---------SYVFFVVDLEKDCVTHRLFLSQDSIVI 217
Q658D0       123 KDFFLYMECHQFGLFATSTA-----QSNDs-SATEGAIHGVPSI--------EKITFYLVRLDDGAILDEKAFRNDFINL 188 Japanese rice
EEF43016     158 KDFFLYVESSQFGVFATSTA-----QFHDt-PAIGGAIQGVPSI--------ERITFHLLRLEDGEILDEKVFQNDFINL 223
KRH77746     121 KDFFLYMESNQFGLFATSTA-----QIHDa-PAVGGAVHGVPSI--------EKITFHLLRLEDGEILDKKVFSNDFVNL 186
Q9ZNU6       121 KDFFLYMESNQFGLFATSTA-----QIHDa-PPTGGAIQGVPSV--------EKITFHLLRLVDGAILDERVFHNDYVNL 186 tomato
P48732       122 KDFFLYHQTRRFGLFATSTA-----QIHDssSPSNDAVPGVPSI--------DKITFVLLRLDDGVVLDERVFLHDFVNL 188 thale cress
XP_015795436 206 PHNQGLYLYDDILAILSVQHQTIYLYRLDDckiVGKtFIEVN-SIGRFCYDDDPFVSTLHNTETRplsps---------- 274
XP_002049492 221 SHNHGISVHGHTIAILSRLRQSIYIYELV----NGR-LIKQEhEIGPR--PLHCAFQDVSSMFMVm-------------- 279
EDW00670     219 SHNQGISVHGSTIAILSLLRQAIYIYELV----NGR-LIKQEhEIGPT--PANCAFEDLSPVEAVtfdv----------- 280
XP_002014308 220 GHNHGISVHDSLVAIMSRLYQCIYIYEVV----AGR-LVKRE-TIGPR--PRG--FIDEVSSDIGvlda----------- 278
XP_001963225 218 AHNHGISVFGSTIAIMSRLHQCIYVYELV----EGR-LVEQE-TIGPR--PRD--FIENASMDVGnlda----------- 276
Q658D0       189 AHSIGAYLYEDLLCIVSLRYQTIHVLQIRD---SGN-LVEVR-KIGAFCQEDDELFLHSHG------------------- 244 Japanese rice
EEF43016     224 AHNMGVFLYDDLLAIVSLRYQTIHILQIRE---SGN-LVDVR-AIGAFCREDDELFLNSSAQFTVipdkskmh----qps 294
KRH77746     187 THNMGVFLYDDLLAIVSLRYQTIHILQIRD---SGN-LVDVR-AIGEFCREDDELFLNSNAQGMAfsdknkql----qlp 257
Q9ZNU6       187 AHSIGAFLYDDLLAIVSLRYQRIHILQIRD---SGD-LVDVR-AIGEFCREDDELFLNSNSQVLVnh------------- 248 tomato
P48732       189 AHNMGVFLYDDLLAILSLRYQRIHLLQIRD---SGH-LVDAR-AIGYFCREDDELFLNSSSQAMMsqdkskqqslsgske 263 thale cress
XP_015795436 275 -ssdsSNASASSYldsqfdtptHPYHE-VSFCAMKHRILAFFYRQAQSQak--ekSNPELLLTFYRKFDEYCGLRMSKMQ 350
XP_002049492 280 -----L----------------DVNTL-LPITHIKQRVLSFLYRQIQPDs----pQASQKYQDFYKNFDFIENMIIEKMQ 333
EDW00670     281 -------------------------ntlLPITHIKQRVLSFLYRQIQPGs----pEAIESLKEFYKNFEYIENMIIEKMQ 331
XP_002014308 279 -------------------------ntiLPITHIKQRVLSFLYRQIDANs----sRSSQRYQDFYKNFDFLEHMIMEKMQ 329
XP_001963225 277 -------------------------ttvLPITHIKQRVLSFLYRQINVEa----pGAKQKLQDFYKNFEFVEYMIMERMQ 327
Q658D0       245 ----------------------QAARGvSFLPGIKQRLLSFIFRKTWNEesdqtlRVQHLKKKFYFHFQDYVDLIIWKVQ 302 Japanese rice
EEF43016     295 rnhieNNVPS--T---------QPTSDnSFLSGIKQRLLSFIFRGIWNEdrhkttRVQCLKKKFYFHFQDYVDLIMWKVQ 363
KRH77746     258 gnhieNHMHQ--G---------QPNLGnSFLSGIKQRLLSFIFQGLWNEerddtlRIQRLRKKFYFHFQDYVDLIIWKVQ 326
Q9ZNU6       249 ---vgNGFHH--S---------LPQSEtSFLSGIKQRLLSYIFRGIWNEadq-tmRVQCLKKKFYFHFQDYIDLIIWKVQ 313 tomato
P48732       264 ddtgeNGLRHSLS---------QPSGSnSFLSGVKQRLLSFIFREIWNEesdnvmRVQSLKKKFYFHFQDYVDLIIWKVQ 334 thale cress
XP_015795436 351 LLDRDHLLIKYE-----FGELVAQRLGDQT-GFT-SYFVFYQISKAKILDIYSNTSNELAQLFENYCDYFRNT--HTlYN 421
XP_002049492 334 LIDSDFLLLRYEer-pkDSDVTPILVTGEP-QPPrRLYVFYAMSSEEVLGVYHDDSVDLLQIVVQFYDKLCNVrsLQ-TG 410
EDW00670     332 LVDNDLLLLRYEer-pkD---TPNLITGEQfEPRrRLYVFYDISKEQVLGVYHDDSVDLLRIVVQFYDKLCNVrsLQ-TG 406
XP_002014308 330 LVNSDLILLRFEer-pkDNDITPLLTLGEI-PTPrRFYVFYTILGEQVMGVYQDDSVELLQIILQFYDQMRNVrsLH-TG 406
XP_001963225 328 LVNKELLLLRYEernrtDSDVTPLL------PSPrRLYVFYNIASEEVVGVYHDDSVDLLQIILQFYDQMSNVrsMQ-TG 400
Q658D0       303 FLDRHHLFIKFG-----SVDGGVSRSTE---QNS-AFFAVYNMETTDIVSLYQNSSEELYSLFEYFYDHFHTNpqNSsHG 373 Japanese rice
EEF43016     364 FLDRHHLLIKFG-----SVDGGVSRSAD---HHP-SFFAVYNMDTTEIVAFYQNSADELYLLFEQFCDHFYATsrNSlHM 434
KRH77746     327 FLDRHHLLIKFG-----SVDGGVSRNAD---HHP-AFVAVYNMDTTEIVSFYQNSADELYLLFEQFCDHFHATsrNSmYM 397
Q9ZNU6       314 FLDRHHLLIKFG-----SVDGGVSRNAD---IHP-SFFAVYNMETTEIVAFYQNSADELYFLFELFSDHFHVSskSSlHM 384 tomato
P48732       335 FLDRQHLLIKFG-----SVDGGVTRSAD---HHP-AFFAVYNMETTDIVAFYQNSAEDLYQLFEQFSDHFTVSs-STpFM 404 thale cress
XP_015795436 422 QAICSSTNNFYARECLHrFKN--I--TNRDHGSEETTRRVLSLLPLSAQSYTPSPYLDLSLFKYDDRWISPLERPKVCSE 497
XP_002049492 411 DAPSSPSSHYF-------MQQncInpNKSAPFMRQAALRYNPTVPVSTQSFSTSPYLNYNVFSYDDKLISPLERPKACSV 483
EDW00670     407 DAPSS--SHHF-------MQRycTnpNKTALIMRQAALRYNSTVPISTQSFSTSPFLNYNLFKYDDRLVSPLERPKACST 477
XP_002014308 407 DAPSLP-PQFF-------LKQnfVdaNKTINFMRQAALRFNPSVPVSTQSYSPSPYLKYNEFSYDDRLISPLERPKPCSA 478
XP_001963225 401 DAPSLP-LHFF-------LKQnfAdaSESIPFIRHAALRFNSSVPVSSQSLSPSPYLQFNEFSYDDRHISPFERPNPCST 472
Q658D0       374 NFISSHSNNVHALDQLRt-----I--KNKANSTSQFVKKMMASLPYTCQSQSPSPYFDLSLFRYDEKLISAIDRHRHCTE 446 Japanese rice
EEF43016     435 NFISSHSNNIHAFEQLRt-----I--KNKASSFSQFVKKMLASLPFSCQSLSPSPYFDQSLFRFDDKLISATDRHRPSTD 507
KRH77746     398 NFISSHSNNIHALEQLRs-----I--KDKASSSAQFVKKMLASLPFSCQSQSPSPYFDQSLFRFDDKLISATDRHRQSTD 470
Q9ZNU6       385 NFMSSHSNNIHALEQLRc-----T--KNKATNFSQFVKKMMASLPCSCQSQSPSPYFDQSLFRFDEKLISAIDRHRQSTD 457 tomato
P48732       405 NFVTSHSNNVYALEQLKy-----T--KNKSNSFSQFVKKMLLSLPFSCQSQSPSPYFDQSLFRFDEKLISAADRHRQSSD 477 thale cress
XP_015795436 498 YAIQFFS-RSDGSFRFQIHADRQHIEASlVTLRLVAYTFHPTDPFALSIQRTS--SDIAVHLHFRY 560
XP_002049492 484 EPIVFRD-RATNLIKFRFNTKAHRPPSQfTPRELCAFICHPFEPLVLSIQKCM--HVYSYKLHIYN 546
EDW00670     478 EAIVFRD-PETNLIKFRFDVKARR--STlTPRELCAFIYHPFEPLVFSLQKCM--HVYACNVHIYY 538
XP_002014308 479 EPIVFRD-RTTKLVKFRLSAKARRQNNPlAPRELCAFICHPFEPLILSIQKYS--HIYAYNIHLYN 541
XP_001963225 473 EPIVFRD-RMTKSVKFRLYAKARRPVSSlSPRELCAFIWHPFEPFVLSIQKCM--NSYAYHVHLYN 535
Q658D0       447 HPIKFISvKQPNVVKFKIKPGSDSGASDsRAKRISSFLFHPFFPLALSIQQTYm-QPTVVNLHFRR 511 Japanese rice
EEF43016     508 HPIKFISrRQPCVLKFKIKPGPEAGSIDgRTKKVSSFLFHPFLPLALSIQQTLfmQPS-VNIHFRG 572
KRH77746     471 HPIKFILrRYPYSLKFKIKPGPEAGSMDgRAKKISSFLFHPILPLALSVQQTLflQPSVVNIHFRR 536
Q9ZNU6       458 HPIKFISrRQPNILKFKMKPGPEAGSTDgRTKKICSFLFHPILPLALSVQQTLflQASVVNIHFRR 523 tomato
P48732       478 NPIKFISrRQPQTLKFKIKPGPECGTADgRSKKICSFLFHPHLPLAISIQQTLfmPPSVVNIHFRR 543 thale cress
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