2L02,2L01


Conserved Protein Domain Family
DUF2582
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pfam10771: DUF2582 
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Winged helix-turn-helix domain (DUF2582)
This family is conserved in bacteria and archaea. The function is not known. The structure of two proteins in this family were solved using NMR and shown to adopt a winged helix-turn-helix fold. Structural analysis shows that these proteins form an unusual dimeric conformation. This dimer was shown to be similar to that found in the FadR and TubR wHTH domains. It was suggested that these proteins are not very likely to bind to DNA.
Links
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Statistics
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PSSM-Id: 431486
Aligned: 16 rows
Threshold Bit Score: 72.3189
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2L02_B         1 MDKKI---VGANAGKVWHALNEa--DGISIPELA---RKVNL-SVESTALAVGWLARENKVVIE-----RKNGLIEIYN 65  Bacteroides thet...
Q8ABX5         1 MDKHI---IGENAGKLWRLLSTdvhRKWTLQEVK---DATGF-NDLEAASAIGWLAREDKIQFElehhsTKDKNVFLYL 72  Bacteroides thet...
Q602J4         1 MHDDIattVGNAAGKIWHFLDQn--GEASASRLA---DETGL-DRNEVQRAIGWLAREGKLVTE-----RRGRYEFFRL 68  Methylococcus ca...
jgi:Maeo_0009  1 MDNIVn-kIGEIAGEIYHILKE---GEKNMSGLKkplKEKGY-TDSLITMAIGWLARENKIDIY-----KQERQTIVKL 69 
Q59003         1 MEDMWg-kIGETAGKIYHLLEG---GEKSLSQIEkilRKEGY-NSNIVKMAIGWLAREDKIFVL-----KDDKKWVIKL 69  Methanocaldococc...
Q8TM49         1 MTEYMnfkIGEAAGALYHRLEE---GECSLNQIKnylSSNGF-DSQMALMAIGWLAREDKIVLN-----RGSNRWSVRL 70  Methanosarcina a...
2L01_A         3 MLKEK---AGALAGQIWEALNGt--EGLTQKQIK---KATKLkADKDFFLGLGWLLREDKVVTS-----EVEGEIFVKL 68  Phocaeicola vulg...
Q8A6Q7         1 MDRKQ---IGVYAGKVWQLLSNn--EKWGYGTLK---RKSGL-KDKELGAALGWLSKENKIEFD-----QCDEELYVYL 65  Bacteroides thet...
Q5LAG2         1 MDKNE---IGLNAGKVWQLLSNn--DKWSYGNLK---KKSGL-KDKDLGAALGWLAREDKIEFE-----QEEEELYVYL 65  Bacteroides frag...
WP_005854120   1 MTKGS---IGLNAGAIWNLLSDg--QHWSFEALR---AKSAL-TDADLWSAIGWLARENKIEID-----NTSSHPIFCP 65  Parabacteroides
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