3U1Y,4MQY,1XXE


Conserved Protein Domain Family
LpxC

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pfam03331: LpxC 
UDP-3-O-acyl N-acetylglycosamine deacetylase
The enzymes in this family catalyze the second step in the biosynthetic pathway for lipid A.
Statistics
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PSSM-Id: 460886
Aligned: 286 rows
Threshold Bit Score: 268.49
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3U1Y_A           4 QRTLKNIIRATGVGLHSGEKVYLTLKPAPVDTGIVFSRtdldpvvE--I-PARA--ENVGE---TT--MSTTLVkgDVKV 73  Pseudomonas a...
WP_015756737     2 QKTISCSARCTGISIDGRVPSTVTFMPALPGTGIVFIRqd---------lPGSPriECCTQyarTDsrWTSLVKn-ELRI 71  Desulfofarcim...
WP_014435966     4 QKTIAEPVGIAGKGLFHGKDAELTFRPAPENHGIVFRRtd----lGnaTvPALV--DHVVK---RS--RRTALKlgEAVI 72  Phycisphaera ...
Q7UGZ2           7 EHTIASCCEISGRGYWSGKDVRVTCCPAPAGTGIVLVRad---lpGqpEcPATT--QYATG---IS--FRTNLAngPATF 76  Pirellula sp.
WP_012912116     2 QRTVARAVNVAGFGYWSGRDVNVDFRPAAAGTGIVFVRhd---ldRprRiPATV--NHRIE---TP--RRTTLSadGAQV 71  Pirellula sta...
jgi:Plim_0919    7 QRTLERAVEMSGIGFFTNADVTISFHPQAEGMGISFQRtd---lkStgPvQARI--ENVIR---KE--RRTAISqgGVTV 76 
jgi:Plabr_1978   6 QRTIQGVSELSGFGLFTNSEVHLRFFPAPEHHGIVFERtd---lpGcpQvPATV--AYLAP---EE--RRTKLVcgEATV 75 
jgi:Isop_0750   11 QRTIVGPVEVRGVGFLTGAEVTLRFEPAPVDTGARFVRvd---lpNqpSiAATI--EHVVP---RQ--RRTAIQsgDTVV 80 
jgi:Sinac_5597   8 QRTIAREAEVRGVGFIQGADVAVRFRPAEADQGVVFIRtd---lpGrpAvPAHI--RHVIP---RQ--RRTTLQqgEATV 77 
FDU:OP10G_1812   6 rHTVRQPFTVAGLGLHTGVPVSVTVHP--GDQGIGFRYggt-------rvLAHP--ANVTD---TT--RSTKLG----EV 65 
3U1Y_A          74 DTVEHLLSAMAGLGIDNAYVELSASEVPIMDG-SAGPFVFLIQSAGLQEQEAAKK---FIRIKREVSV----E--EGD-- 141 Pseudomonas a...
WP_015756737    72 EHTEHLLAAVIGLGIDNIKVCLDGPHIPVVSNfSSLNFVEALQQAKIIEQDKPKK---HFVVNQPQWVfdsfRynGREye 148 Desulfofarcim...
WP_014435966    73 ETCEHVLSAVAGWSIDNLIIDLDAAEVPGVDG-SALPFYEAIASAGVREQAAARR---YLVVEEPVTI----V--QDE-- 140 Phycisphaera ...
Q7UGZ2          77 EMVEHLMAALAGLEIDNCRVEITAEELPGLDG-SSLAYVDALQEAGLVIQAATSQ---PLVIRESFRI----E--HSG-- 144 Pirellula sp.
WP_012912116    72 EMVEHILAALMGLSIDNCEVWVDAAEMPGCDG-SSKAFVDALQSVGTEKLKQPRA---RLVVPEITRV----G--NDD-- 139 Pirellula sta...
jgi:Plim_0919   77 ELIEHVMAALAGLQIDNCLVRLNAPEPPGCDG-SSLDFVQCLLDGGIVEQNAYRD---LIVVTQPQAI----VteNDS-- 146
jgi:Plabr_1978  76 EMTEHLMAAFAGLQIDNCLVQIDAPELPGCDG-SALPYAEALLRADSIEQSAERD---LFCLDRSLLL----D--DET-- 143
jgi:Isop_0750   81 ELVEHVMSALSGLRIDNVRILLDAVETPGMDG-SSRSFVEALERAGVKEQEADRL---AVVLDQPLAV----S--EGN-- 148
jgi:Sinac_5597  78 EMVEHVMAALSGLRIDNCLVEIDAAETPGCDG-SSQAFVEALNGAGIVELDRERE---TLVIERPITV----R--EGK-- 145
FDU:OP10G_1812  66 GTVEHLMSAFAGLEITDAEVELDAPELPGLDG-SAGGYIDAIMGVGIEQIGDREFpslYTR----LFL----Q--EDGgp 134
3U1Y_A         142 KRAVFVPF---D--G----FKVSFEIDFDH--PVFRGrtQQASVD-FSSTSFVKEVSRARTF--GFMRDIEYLRSQNLAL 207 Pseudomonas a...
WP_015756737   149 SILLALPS---Te------LKVTYLLDY----PGRQVptQAAHFR-LNNRQFAEQLAPARSYimDFEYDL-----VAALI 209 Desulfofarcim...
WP_014435966   141 AELVALPS---HdpG----LDLTYQLDYSPqnALIGR--QLQQFR-THGDDYRDQIAPSRTF--SLEAEAKAALAQGLFA 208 Phycisphaera ...
Q7UGZ2         145 GYVDVSPS---TnnE----STFEYSLDYGPd-STIRE--QKFRCV-QTPLTFARQVASARTF--VTAEQAQQLRASGVAS 211 Pirellula sp.
WP_012912116   140 AWVEARPS---SsgN----LSIKYRLDYGPs-TPIGR--QTIEMT-VTPETFTDELSSARTF--ILKDEADWLRSRGLGT 206 Pirellula sta...
jgi:Plim_0919  147 VALSASPI---SrhG----LVITYELDYGPr-SPIKP--QSFSLE-VTPETFITLVAFARTF--VAEEEVKYLQSQGYGQ 213
jgi:Plabr_1978 144 AVLNGMP----SetG----YRISYELNYGAn-SPIPV--QMADFT-ITPETFITKIAPARTF--VQEQEIDFLRSRGYGK 209
jgi:Isop_0750  149 ASVVALPPvhpQdnA----LAVTYTLDY-GlnAPIPR--QTYSLPrLDPDSYRRELAPCRTF--LLQREAEELRKTGVGS 219
jgi:Sinac_5597 146 AILTAHPG---TddG----LVLSYHLDYGRq-TPIGS--QSLFVD-VSPETFREELAPSRTF--LLESEAKALRAAGIGS 212
FDU:OP10G_1812 135 KMAIG---------KgngqWRFVFATDD----RWPGE--QAFELE-DAVGGYVEHIARARTF--AFAEEVPMIIQLGLGR 196
3U1Y_A         208 GGSVENAIVVD-ENRVLNEDGLRYEDEFVKHKILDAIGDLYLLGNSLIG-EFRGFKSGHALNNQLLRTLIA 276 Pseudomonas aeruginosa
WP_015756737   210 GQSIKDCLVIGqSE--IN---LKWGNEPARHKLLDLMGDLATLGSPIKG-HFIGIRTGHKVNIKMSQKLqg 274 Desulfofarcimen acetox...
WP_014435966   209 HLSPSEVLVIG-EDGPLGGNAFRFADEPVRHKILDLLGDLALVGSPIRG-RVIARRSGHPLNHELARALVT 277 Phycisphaera mikurensis
Q7UGZ2         212 HVTHQDLLVIG-DNGPV-DNQYRFRNECARHKTLDLIGDLSLAGVGLIG-QFSSVRGGHQLNGMVAVRLAq 279 Pirellula sp.
WP_012912116   207 RVTNQDILVFG-DEGPID-NELRFTDECVRHKALDLVGDLALSGCDLVG-HFTAHRSGHRLNAELVRALLv 274 Pirellula staleyi
jgi:Plim_0919  214 RVTEKDLLIFG-PDGPIG-NALRTRDECVRHKILDCIGDFALIGCDLHG-HFRAFRTGHHHNHQIIERIKQ 281
jgi:Plabr_1978 210 HVTFQDLVVYG-ADGPIE-NTLRAQNECARHKLLDCLGDLALTGCDLQG-HIRAFRSGHRHNHELARQIDa 277
jgi:Isop_0750  220 QTKISDLVIYG-PDGPID-NTLRFPDECARHKALDLVGDLALLGMDLVG-QVVGHRSGHALNARLVRAIRQ 287
jgi:Sinac_5597 213 RTTEADLLIFG-PDGVIG-NQLRYRDECVRHKILDMVGDLALLDKDLSG-HVVAHRSGHQLNAALVRKLWE 280
FDU:OP10G_1812 197 GLDENSALILG-IEGY--KNEPRYPDEPARHKLLDLMGDLYLAGVPVRAlNVVSERSGHRANVKAAAMLAq 264
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