1M0W


Conserved Protein Domain Family
GSH_synth_ATP

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pfam03917: GSH_synth_ATP 
Eukaryotic glutathione synthase, ATP binding domain
Statistics
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PSSM-Id: 461091
Aligned: 90 rows
Threshold Bit Score: 545.558
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1M0W_B         8 KDQLNELIQEVNQWAITNGLSMYPp-KFEEN------PSNASVSPVTIYPTPIPRKCFDEAV-QIQPVFNELYARITQDm 79  baker's yeast
XP_002144726  12 PDHLNSILTQIKDYQTTHGSLLKVigSETPH------SVHLQPISASVFPTLFPLRLFNEAAgELQLVYNQLYCKLAED- 84 
XP_007798163   8 DDEINAILSELEDYQLTHGSLLKI--PRGFAkdidspIAIARPIGISVIPTAFPRAQFQHAV-RIQGAFNELYAKVAED- 83 
XP_002340757  23 PDQIHSLLTQIKDYQSTHGSLLKVidSEIPH------SVHLQPVSVSVFPTVFPRRVFHEAIdELQLAYNELYGKIAED- 95 
P35669         8 PEQIEELGKGARDFAFAHGVVFTEl-SVSKEg-----RNIATQIPITLFPSVIPHGAFVEAV-SVQKAYNKLYAKIAND- 79  Schizosaccharom...
XP_002172601  11 SSEIDDLSYTARNYAVSNGLVFLNn-DEKSSe-----ATTLTQIPVTLFPTVIPREAFVEAL-SVQQAYNKLYAKVSND- 82 
EGG21840       9 KEKLIEIGEQAIDWALGKGIIFVK--RKTEQeavaiqQPIVTHIPLSILPSEFPKRLYEQAV-SLSKDYNLLVHHLSKN- 84 
EGC34001       7 KEKLNELKEQGIDWAFGNGFTMIK--RPTEEevk-kdIVTITHVPFSLYPSAMNKKLFEEAV-NLSQDYNILVHNVSKD- 81 
Q54E83         2 EEKLNDLKEQGIDWAFANGLIMIK--KPTEEeak-nnVVNVTHVPFSLYPSKMNKKLFNEAC-KLAEDYNLLVHNISKD- 76  Dictyostelium d...
XP_008912531  28 ntQLMDVKEQAIAYAAAHGLLVGWrdPSKPKd----pTPAFTHIPLCLLPVQFPRAQFEHGV-KLSPIYGRLVDRVSRD- 101 Phytophthora pa...
1M0W_B        80 aqPDsYLHKTTEALALS---DSeFTGKLWSLYLAT---LKSa-qY-KK-----QNFRLGIFRSDYLIDKKKG-------- 138 baker's yeast
XP_002144726  85 --VE-WLYAVTGPLRKT---EP-LVDALWSVYEEVqmrRQDegmQyIR-----QRVHAGVFRSDYMLHVQSEsaaesdd- 151
XP_007798163  84 --HA-WLEGILEELRRKttaDG-FVAKLWGIWERV---VREd-gGeEV-----QPWRCAVWRSDYMLQASREildfqnra 150
XP_002340757  96 --KE-WLYAVTGPLRKT---EP-LVDALWCVYEEV---QRQ---R-RKvqyieQNVHAGLFRSDYMLHVLSDsdnddd-- 159
P35669        80 --YE-FLRLHLQSITKY---DE-FMNKLWNLYQKH---REA---VaHLkenqfQPLSLGVFRSDYMVHQDDS-------- 138 Schizosaccharom...
XP_002172601  83 --HR-FLERCLKDMCGQ---DE-FISKLWKVYEES---RAH---FaTLkkpcqQPVSLGIFRSDYLVTDSKE-------- 141
EGG21840      85 --FN-FIQSTLKDVQ-----DP-FTQSLLKIHREI---ENE---G-KK-----QKIELGIFRSDYMVHHNDDs------- 136
EGC34001      82 --FD-FLQNTLKDVQ-----DD-FTQKLLEIHRQV---NKE---G-IK-----QKKSLGVFRSDYMLHDSDKt------- 133
Q54E83        77 --YD-FLQNTLKDVF-----DD-FTQMLLNIQRKV---VKE---G-IK-----QKISLGIFRSDYMFHNKIEg------- 128 Dictyostelium d...
XP_008912531 102 --VE-WLHSCVQSVVAE---DA-FTARLLELSRLV---QKE---G-VQ-----QKAYLGIHRSDYMLHEPQAdva----- 157 Phytophthora pa...
1M0W_B       139 ----------------TEQIKQVEFNTVSVSFAGLSEKVDRLHSY-LNRAnkydp-----------kgpiYND-----QN 185 baker's yeast
XP_002144726 152 ---------dgenwgqNLCLKQVEFNSFSCAGGCHADKVAHMHRF-LARRgvydfvytssesqdellintKMLp----SS 217
XP_007798163 151 dggnkggegdvrnvfrDAQLKQVEFNTFSCAGGSHATIVANAHRYlASRGahg--------------agrITR-----EK 211
XP_002340757 160 -----------edwiqSLCLKQVEFNSYSCAGGCHADKVADMHRF-LALRgvyncps------idekqdmRILp----SS 217
P35669       139 ----------------FIGCKQVEFNTISVSFGGVSKAVSNLHAY-CSQSgly--------------rkpLTT-----NY 182 Schizosaccharom...
XP_002172601 142 ----------------GPSCKQVEFNTISVSFGAASKVVKNMHNY-LSDYgly--------------hdrLTP-----NH 185
EGG21840     137 ---------------sKSELYQVELNTISSSFGCISAKVFDMHRYlIKDN--------------------HLQhtyplEN 181
EGC34001     134 ---------------qEPRIYQVELNTISSSLAVLSTKIFELHKHlIGRNdln--------------kegYNL-----EN 179
Q54E83       129 ---------------eEERIYQVELNTISSSLAVVSNRVFNLHKYlIGRNdln---------------dnGYDl----LN 174 Dictyostelium d...
XP_008912531 158 --------------gdSQRLLQVELNTISSSFACISSLVSGMHSflvsrlgae---------ipalekhyGIPsaeyaNA 214 Phytophthora pa...
1M0W_B       186 MVISDSGYLLSKALAKAVESYK--SQQSsstt-----------sdpIVAFIVQRNERNVFDQKVLELNLL-------E-K 244 baker's yeast
XP_002144726 218 LPRNNTINGIASLLVSAHKMYG--SKPYspta-----------shtAVLMVVQPNNFNIADERPIEYALWnwtdnngD-D 283
XP_007798163 212 LRSNDSLDSIVRLLEAAHRAYG--SPVShda------------kqtAIMMTVQGRNINICDERPVEYALS-------EcD 270
XP_002340757 218 LPLNNTIHGIASLLVLAHKRYG--STPYnsaa-----------shtAVLMVVQPNNFNIADERPIEYALWnw----aD-D 279
P35669       183 LTVNTSVSGICTGISNAVDAYR--DYVKnitskmni---asdntkpIVLFVVKGGERNITDQRTLEYELL-------N-R 249 Schizosaccharom...
XP_002172601 186 LTINTSTTGIVMGLNKAYCVYK--QQAEqllkeqnnelpdktaaqvIVLFIVDRNERNIMDQCALEIELN-------N-R 255
EGG21840     182 LPRNDSGANIARSIAQAHNLYTssTNNTakt-------------niVVMIVVQPDERNIWDQKAIEYTLS-------S-D 240
EGC34001     180 HPDNKSSYEIVEGLATAHQLYN--KADS------------------VVMMIIQDGEKNIFDQKGLEWILW-------D-K 231
Q54E83       175 HPTNQSDKEISDSIALAHKLYN--KEKSs-----------------VVLMIIQEGERNIYDQKGLEFQLW-------S-N 227 Dictyostelium d...
XP_008912531 215 LPQNDAIIELPNSLASAHKLYG--VKDA------------------VVMFVVQPNEANAIDQRWLEYNLW-------E-H 266 Phytophthora pa...
1M0W_B       245 FGTKSVRLTFDDVNDKL-FId-DKTGKLFIr--------dTE-QEIAVVYYRTGYTTTDYTSE-K--DWEARLFLEKSFA 310 baker's yeast
XP_002144726 284 NPIPIYRIEWQLVIQYT-KLt-QTGELLFFppenggsrevQP-VEISVIYHRAGYEPHEYSEDiD--GKEIRIRLELSRA 358
XP_007798163 271 PPILLYRVEFGEKTMQS-CKfgANRELLFLpp------sgGPpLEISVVYHRAGYSEGEYDDK----GIEARYMLECSRA 339
XP_002340757 280 NPIPTYRIEWQDVLHRT-QLt-ETGELLFFppes---ggrTP-VEISVIYHRAGYEPQEYSDEiK--GKDIRIRLELSRA 351
P35669       250 FHVISKRIDIAELN-SL-IHd-KSSNKLYMkt------sfTT-YEVAVVYYRVGYALDDYPSQ-E--AWDMRLTIENTLA 316 Schizosaccharom...
XP_002172601 256 FKVPSARIYFDELDKSA-TLd-NKTNKLFVkv------kgKV-YEVAVAYYRTAYALSEYTSE-A--DWNARLTVEKSLA 323
EGG21840     241 YSIKMIRRTLLELDTRG-KId-PSNHSLQI----------DG-YEISVSYYRAGYTPNDYPSE-N--EWNGRLLVERSLA 304
EGC34001     232 YKIKLIRRTLKEINERA-VVn-NSDFTLSI----------DG-YEISVSYYRSGYTPNDYPSE-V--EWSGRLLVERSSS 295
Q54E83       228 HSIKLIRRTMKEINQCA-KLdeENGSVLIV----------DG-MEISVAYYRAGYTPNDYTSS-GgdEWKARLLIERSLA 294 Dictyostelium d...
XP_008912531 267 HGIRVLRRTMAEVDARGkLVerDGKRTLVI----------DE-HEVSVAYFRSAYTPNDYPTE-Q--EWAGRTLIERSYA 332 Phytophthora pa...
1M0W_B       311 IKAPDLLTQLSGSKKIQQLLTDEGVLGKYISDAEk-KSSLLKTFVKIYPLD-----DTKLGRe-gKRLAls--epSKYVL 381 baker's yeast
XP_002144726 359 IKCPSILGHITTIKKVQEALTVPGTLERWLTTER--ADSIRRTFVEIRSLEhfissKNPVRN---AELA------ENYIL 427
XP_007798163 340 IKCPTILSQISGFKKVQQELARPGVLERFLTPDK--SALLRQVFMPMYPLD-----DSPEGQh-aREIAlsedmaADYIL 411
XP_002340757 352 IKCPSILGHITTIKKVQQALTVPGTLGRWLTSDK--ADRIRGTFVEIYSLN-----EFDF-----SEKIhdekltENYIL 419
P35669       317 IKCPSISTHLAGSKKIQQVLAESNALERFLEGDE--LQAVRSTFADMYPLD-----DTPRGKe-gIKLAfe--kpEDFVL 386 Schizosaccharom...
XP_002172601 324 IKCPSIAFHLAGSKKIQQELAVEGVLENYLSGNE--LKAIRYTFADMYPLD-----ESEAGLk-gRKLAle--spEHYVL 393
EGG21840     305 IKCPSIANHLVGAKKIQQAIAKKGVLEELLQDQEs-IKRMRRSFTGLYSLS-----KEDIDQe-aVQKAka--npQLYVM 375
EGC34001     296 IKCPTIAHHLVGVKKIQQVLAKPGVLEKFITNKEs-FDRLKRSFTGLYSLS-----KEDIDQe-vVKKAia--npNLYVM 366
Q54E83       295 IKCPTIAHHLVGVKKIQQVLAQPGVLEKFINNDKesLQRVKRSFTGLYSLS-----KEDIDMs-vVKEAie--spQNYVM 366 Dictyostelium d...
XP_008912531 333 IKCPSIAYHLAGTKKVQQVLAQPAVLRRFMAEEE--AKELETSFAGLYGLE-----KDSATIedvKKMAva--npRSYVL 403 Phytophthora pa...
1M0W_B       382 KPQR-EGGGNNVYKENIPNFLKGIE--ERhWDA-YILMELIEPELnENNIILR-DNKSYNEPIISELGIYGCVLF----- 451 baker's yeast
XP_002144726 428 KPASlEGGGNNIYGADIYAFLKTLSaeATeKSA-YILMQRIRSPMdVYGMLMSsSRGVVVDEVVSELGIFGGCLW----- 501
XP_007798163 412 KPNM-EGGGNNIHGCNIPDFLLALP--PErWSD-YILMRRIEPPL-VHGVLVSpKFG-YQGPTISELGILGTCMW----- 480
XP_002340757 420 KPASlEGGGHNIYGSDIPSILQTLL--ENeKSRaYILMQKIRSPQnIYGMLMSsSRGVVVDEVVSELGVFGGCIW----- 492
P35669       387 KPQR-EGGGNNTYGKDIPGLLSKMP--QEeWDS-YILMRYINAVP-SQNYILKgERP-EKFDVVDEIGILGTIVWn---i 457 Schizosaccharom...
XP_002172601 394 KPQR-EGGGNNVYGADIPKFLEKTE--KKnWSS-YILMRHIDAIP-STNYILKgKKA-VKFETVDELGILGTLVYn---s 464
EGG21840     376 KPQR-EGGGNNIYGDQVRESLASMN--ADeLGS-YILMDRIVPKA-FNTTIIR-ESKVIDIEALYELGIFGLYIGh---- 445
EGC34001     367 KPQR-EGGGNNIYNEDVAKELQSMT--PDqLSS-YILMDKIVSTS-FKTHVVR-DRQLLEIDALYELGIYSVFISdesdn 440
Q54E83       367 KPQR-EGGGNNIYNDQVAIALKSMS--SEeLSS-YILMDKIMSKS-FKTHVVR-DRQLLEIEGLYELGIYSVFISn---- 436 Dictyostelium d...
XP_008912531 404 KPQR-EGGGNNLYGDEVAAAIQKMS--PAeLES-YILMERIFPKE-NPAVLMR-NSLTSSGPTISELGMFITSLFd---- 473 Phytophthora pa...
1M0W_B       452 NDEQ---------VLSNEFSGSLLRSKFNTSNEGGVAAGFGCLDSIIL 490 baker's yeast
XP_002144726 502 ERKEsssegercqVIENRVVGWSFKTKEVSVDEMSVVKGYGCFDAPFL 549
XP_007798163 481 ARNDlggg--sldIGIDSHGGWTFKTKPSHVEEMSVVMGYGCFDSPCL 526
XP_002340757 493 EKNEsss---gldMIENRVVGWSFKSKERSLDEMSVVKGFGCFDTPLL 537
P35669       458 KTDE---------VVQNGQSGFICRTKPKKTNEGGVATGYASLSSIEL 496 Schizosaccharomyces pombe 972h-
XP_002172601 465 KTGE---------ELQNTQVGYICRTKPINVSEGGVATGYASLSSVHL 503
EGG21840     446 DDQG---------VLLNEEGGILLRTKTSNSDEGGVAAGFAVIDSLIL 484
EGC34001     441 SKDQ---------VVVNKNAGILLRTKTSHSNEVGVAAGFGLLDSPIL 479
Q54E83       437 GDDD---------IVLNKQAGILLRTKTANSDEVGVAAGFGLLDSPIL 475 Dictyostelium discoideum
XP_008912531 474 GDEK---------EIVNKHAGHLLRTKLSGTDEGGVATGFSVVSSPLL 512 Phytophthora parasitica INRA-310
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