6PCM


Conserved Protein Domain Family
TopA

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COG0550: TopA 
DNA topoisomerase IA [Replication, recombination and repair]
Statistics
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PSSM-Id: 440316
Aligned: 723 rows
Threshold Bit Score: 293.925
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6PCM_A        18 RRLVIVESPTKARKIAGYL-G-----------SNY-VVESSRGHIRDLPrnaadvpakfKSEpwarlgvNVD--Q-N--- 78 
WP_099514151   8 RTLFFFEKPSAMRQLKRFFk-----------sPST-ICVSAEGHLLAAE----------EPGt-----vRDEw-K-Swrf 58 
WP_043751848   1 --MFFFEKPSAMRQLQRFFk-----------aPTT-ICVSAEGHLLAAQ----------EPAa-----iRPAw-K-Awrf 49 
WP_013380222   2 KDLILAEKPTVAVNIAKAV-GmtsrkdgyfenSQY-VITFAVGHLLELY----------DVKd-----yHPEygE-Kwei 63 
WP_055329711   1 MKLILAEKPSVAKTIASFL-GaktkhdgyfegNNY-IVTYAVGHLVSLY----------DVKd-----yDKAy-AgSwks 62 
YP_001088916   1 MKLVLAEKPSVAKTIASFL-GaktrqdgyfegNDY-IITYAVGHLVSLY----------DMKd-----yDKDkySgSwkm 63 
WP_012863576   1 MKLIIAEKRNVATAIATAIdGaqetkdgyvkkGDY-YITWASGHLLSLK----------EPEd-----yDPKf-Q-Kwni 62 
WP_059399051   2 aTLIITEKSSQAKDLRAAL-Gd-----------RYgRILPAEGHLLRLA----------EPDe-----vNPDw-K-Rwap 52 
WP_075799474   3 EQIVIAEKTSQAKDIRAAV-Gq-----------RYgAVLPAEGHLFDLV----------EPEe-----aNPAw-K-Rwsp 53 
WP_015769197   2 KKLIIAEKPSLARNIASAL-DirvnkegymenEKY-IVSWAFGHLFKLR----------DVDg-----yVGEk-R-Kwse 62 
6PCM_A        79 ----FEP-----LYI-VS----PE--KKSTVTELKGLLKDV--DELYLATDGDREGEAIAWHLLETLKpRVPVKRMVFHE 140
WP_099514151  59 dtlpIVLeripvTYG--TsrsgQS--HKPKVEAIKQALQGV--ERVIIATDPGREGSMIAWEVLEHLGyRGRVDRLKLGA 132
WP_043751848  50 ddlpIALdeipvAYA--RnrsgAS--HAGRIEAIRGALQGV--DRVIIATDPGREGSMIAWEVLEHLGyRGRVERLRLGA 123
WP_013380222  64 shypFVPdt--fKYK-IA----ES--TRKQFKIVKDLILSDeiQEIISATDNDREGQLIADLIFRYLGvKKPIRRLITNE 134
WP_055329711  63 enfpFIPdk--fRFK-VD----SS--KTKQFNIVKSLIHRDdvDEIINATDNDREGELIAFLIFLTAKnKKPIKRILVNE 133
YP_001088916  64 nnfpFVPed-kfKFK-ID----SS--KTKQFNTVKKLLNRKdvEYVINATDNDREGELIAFLIFLLAKnKKPVKRILVNE 135
WP_012863576  63 pdlpFNFpn--wELKpIN----AG--SKKQLNIIKDLLKEC--SGVIHACDPDDEGQLIGDEILLYHDyKKPVERMLIND 132
WP_059399051  53 --tlLKPd---gLYP-TKpdsgGN--KTAKLAAIKAALKGC--DQVILATDCDREGQLIGQEILEHLGfRGRVQRALFTA 122
WP_075799474  54 --vlLRPe---sLYG-TRpatgGN--KASKLQAIRAALRSA--KRVWLATDCDREGQLIGQEILEHYGyRGTVMRVMFTA 123
WP_015769197  63 vklpFFPke--fEFE-LK----NDlgIKKQYKILKNLINSKevDEIVNAGDADREGQIIVDIIINAIKtDKKIKRLWLPE 135
6PCM_A       141 ITEPAIRNAAENPRD------LDIALVDAQETRRILDRLYGYEVSPVLWKKVAP-K-----LSAGRVQSVATRIIVQRER 208
WP_099514151 133 LDEISIRRAFAVMAKepdsgeRDYAAYLEALCRQYEDYHLGLNGTRAISLRLRPpAfr-epWRFGGVQTPTLAILADLEQ 211
WP_043751848 124 LDEVSIRRAFAALARepdsgeRDYAAYLEALCRRYEDWHLGLNGTRAVSLRLRPpAfr-epWRFGGVQTPTLAILADLER 202
WP_013380222 135 WTTDAIRYGLKNTVPn----kSKQSLFYAGLVRQQMDWLLGINLTSVATLKLLKnGtgkdtLHIGRVILPTLKLVYDREM 210
WP_055329711 134 WTPEDIKRGLSNLKTd----eQMRNLQAAGYTRLVTDWLIGINFTSMTTLKYGNgk----lLNIGRVILPTVKLVYDRDM 205
YP_001088916 136 WTPEDITRGIKNLKDe----dEMRNLQAAGYTRLITDWLIGINFTSVATLKYGNgk----lLNIGRVILPTVKLVYDRDM 207
WP_012863576 133 NNTEYIRKLFTKLEDn----rKYESLGISAAARRIADAIIGINLSRFYSCKSSKt------LHVGRVKAPTLGLVVNRDY 202
WP_059399051 123 QDPKTIRDAFAKLKPn----nELRPLYEAAVARQQADQIFNLSLTRTATKTLLApGtr-gvIGIGRVKTPTLSIVCLREL 197
WP_075799474 124 QDPQTIRDAFAHARPn----aEHARLYAAAVARRQADQIYNLSLTRTATVTLAK-Gar-avIGVGRVKTPTLAIVCRREI 197
WP_015769197 136 QTEETIRKAINNLEDn----fKYRNLHNEGLARTYMDWLMGINLTRYISLKANMl------FPVGRVLIPVIKYIYDRDL 205
6PCM_A       209 ERMAFHSASYWDVTAELDASvsdpsaspPK--FTAKLNTV------DGR--RVatgrdfdslgqlkrpdevlvLDEASAG 278
WP_099514151 212 RIREFVPQDYSKIALLVTTEt------gAE--LTLWHAP--------KD--KI--------------------LDKQVAE 253
WP_043751848 203 RIRDFVPRDFFKVAMPVETEt------gAA--LTLWHAP--------KE--RI--------------------FDRAEAD 244
WP_013380222 211 NVKNFKSIPIYYLNAYVKDVs------gEE--IIFRYIEg------DEKiyKF--------------------DHDSHLV 256
WP_055329711 206 EISNFIPKTYFEIEGNFKCDn-------GN--YKGKYIKg------KES--KF--------------------DSIDDAN 248
YP_001088916 208 EILNFVPKTYYEIEGHFKAEa-------GE--YKGKYVKg------KES--KF--------------------DTLEDAN 250
WP_012863576 203 AIENHIKQLHYILRIIANNNd-------KDnnITFTFQKNantpvnEDKl--I--------------------IDLDYIE 253
WP_059399051 198 EIRNFKPEDYFEVVATATAAg-------GS--FLMRHAPp------PKD--RI--------------------KDRARAE 240
WP_075799474 198 EIRDFVPQSYFEVVATAAVEa-------GR--LRMRHAP--------KE--RI--------------------LKREEAE 238
WP_015769197 206 TIKNFSPEKYFTIESETMCNg-------TL--LKLICd--------KKY--NL--------------------LELEKAK 246
6PCM_A       279 ALASGLRG-AQLAVTSVEQKPYTRRPYAPFMTSTLQQEAARKL-RFSSERTMSIAQRLYE---N-GYITYMRTDSTTLSE 352
WP_099514151 254 TIQQAAADw-Sg-PLGVEQKDVRRSPPRLFSKDTLARRCAKRF-GWDPQHTAKLAQDLYD---Q-GYLTYPRTESEHLPE 326
WP_043751848 245 AIREAAAGw-Sg-PLSVVQKDVRRPPPRLFSKDTLARRCAKRF-GWDPQRTAATAQDLYD---S-GFLSYPRTESEHLPE 317
WP_013380222 257 QILRLINT-ETAVVVGYECSEKKMNPQRLFSLPTLQGHITTKYeGWSSDKVLKIAQKLYE---N-KLITYPRTDSVYLDE 331
WP_055329711 249 KVIESITS-DKGVIKEKKVSNSKEYAPKLFSLTSLQGYITSKHaNFTSDKVLKVCQSLYEgkgKgGFITYPRTDSIYLEE 327
YP_001088916 251 KIIASITS-ETGKILDKKVTMSKEYAPKLFSLTSLQGYITSKYsNFTSDKVLNVCQSLYEgngKgGYITYPRTDSIFLEE 329
WP_012863576 254 KVQAEIADiKDy-KVNVTSKILTKNPPLVFNIDKLQAYCNNKF-SYTAQEVLEITQVLQA---ThQIITYNRSDSQYLNE 328
WP_059399051 241 AIARAADG-HGg-PLSVTVEDRRQAPPKLYDLPALQKTCGQRW-GWTADRTLEVAQELYDgegK-KLITYPRAEARYLSE 316
WP_075799474 239 AIAALAEG-FQg-PLAVKVEEKRQSPPRLHDLPSLQRLCGSRF-GWSAARTLEVAQELYDgegK-KVITYPRAETRYLPE 314
WP_015769197 247 NYSYELNR-NKGIVKDITEKEIILNPPKLFSLSKLQSKLSKEK-KISFAKSLETIQKLYE---K-GFITYPRTNTEYLAE 320
6PCM_A       353 SAINAARTQARQLYG--EEY----VHP--------SPR--QYTrkvKNAQ--EAHEAIRPAgDVFQT-----PGQLhsal 409
WP_099514151 327 SQTGDASTVIESVVGilTDLas-lVPAtgdlvfrkGSKghY-----VKDP--GEHHAIVPL-RKVPQ-----PGSA---- 388
WP_043751848 318 SQSGDAAAILAAIAGclDDVae-lVPAgeaivvrrGPRghY-----VKDP--GEHHAIVPL-RKVPR-----RGEL---- 379
WP_013380222 332 TLKENMSMVLNIHKIe-SQYae-mLQfk------dTKR--IFN---SEKV--ESHSAITIT-KEK-------PRGL---- 384
WP_055329711 328 SLAGKAAQTLEKLKVg-LPYenki-------kfakTKR--VFD---SSKV--DSHSAIIPT-YIV-------PNKL---- 380
YP_001088916 330 SLASKASQTLDKLKVg-LEYenki-------kfskTKR--VFD---SSKV--DSHSAIIPT-YII-------PKSL---- 382
WP_012863576 329 EHFQEAPQLIEIIKEn-LNLs---LDNidt---nrKSK--VFD---SSKV--TAHHGIIPT-HTRFD-----LSKL---- 384
WP_059399051 317 NQIADVPAITGALTRl-RGFahldISRpvi--rrgKSG--HFC---DKALegVSHHAIVPN-VNVLDdlesrLNRL---- 383
WP_075799474 315 SLIPDVPRIVAALQEg-RAWsgipVPQpplv-rrgASG--AFH---DKGLagASHHAVIPN-VNTVErlreaWPRL---- 382
WP_015769197 321 EEKDKVRELIKLY----SDYrle---------fkdSKK--IFD---SSKI--ESHSAVMPT-LKIPD-----MNSL---- 370
6PCM_A       410 DTDEFRLYELIWQRTVASQ-MADARGTTLSLRIggsasSG----EQ----V----VFNASGRTITFPGFLKAYVESIDEl 476
WP_099514151 389 SGDHLCLWELVAKSFLAAH-LPDGIDARTTVAV-----QVptpfGP----K----RFSISGSVIKSPGWRAVYGAEADEe 454
WP_043751848 380 GPEAWRLWELVAKSYLAAH-LPDGIDARTTVAA-----EVatppGP----K----RFAVTGSVVRAPGWRAVYGSEAEDe 445
WP_013380222 385 SQDEHIVYEAIRNRFLEQF-MPLAIDEEVEVTL-----AF----EGkvpsEdgafLFSAKSIVERSPGWRLIENRNA--- 451
WP_055329711 381 TSDEEIVYNAIKDRFIANF-MPPAEYENTEIHT-----YV----ND----H----KFLTKGKVLKVKGFLEVYNKEE--- 439
YP_001088916 383 SKDEQLVYDAIKDRFVANF-MPPAEYENTEIKT-----EV----DN----C----TFLTKGKVLKSKGYLEVYNKEE--- 441
WP_012863576 385 TEKERNVYQVIAEFYLVQF-MPPEKLKETTGIF-----KV----KD----Y----DFKTTDRTVQDLGYKKFLNSINEEk 446
WP_059399051 384 TDDEKRLYALICRSYLAAV-MPDYEYRQTTVLM-----DVp--vDGk--pV----VFRAVGRIPLKLGWKAAFGSAETDg 449
WP_075799474 383 SADERKLFDVIARAYLAAM-MPDFRYRQTTATI-----DV----KGpgslH----VFRAVGRQPLEMGWRAAFPEwVPAe 448
WP_015769197 371 NLEEKIIFETIRNRFISNFlKEQAIINQTEIKI-----AV----GN----E----IFNLKGKSVKQEGFLKYENQ----- 428
6PCM_A       477 ag-------gesDDAESRLPNLTQG--QRVDAADLSADGHQTSPPARYTEASLIKALEEL-------------------- 527
WP_099514151 455 teavpgkakpdeEPTTGRLPLVRDN--EPGKAADARIETAKTEPPRRITRGELPVVMGRLvdqvedpalkaa--lenpan 530
WP_043751848 446 dpvpg-karrddEPTTGRLPPLRDG--AAARATDATVETAVTEPPRRITRGELPVVMGRLidqvedpvlrra--lenpan 520
WP_013380222 452 ------------TKKETLLTRMREN--ESVTIDRVMVNKGETKPNPLHTEETLIKAMLQCgkkyktede-------lets 510
WP_055329711 440 --------------KDDLLPFVNKD--DIVDVVKMDILNKQTTPPKSYTEDTLLKAMKNCgknvsddd----------ta 493
YP_001088916 442 --------------KNDLLPLVNKD--DVVDVLEIKPLTKQTTPPKPYTEDTLLKAMKNCgknvpeed----------tt 495
WP_012863576 447 -----------eEEEKSNISKFEDRlyDFVNFAt-PIDTRETKPPKPYTEATLISDMTSIakyiknpeikeillrkdkdk 514
WP_059399051 450 kp--------deKEEEQTLPPLADG--EPARLSDSRVEAKRTQAPPRYNEGTLVDAMQNAwrfvedpal--------rdr 511
WP_075799474 449 e----------kGEDAQLLPALRNG--EATTLSEAKVEAKETRPPPRYNEGTLIEAMQNAwrfvedeal--------qdr 508
WP_015769197 429 -------------KVDNKLPYFEIS--QEIDI-DFKVVDKLTVSPKKVTEENLSNYLKNPfrkekkqededd--tqeyre 490
6PCM_A       528 -----GIGRPSTYSSIIKTIQDRGYVQK-KGS--ALVPSWVAFAVVGLLEQHFGRLVDYDFTAAMEDELDEIANGQEQ-- 597
WP_099514151 531 pnepkGLGTAATRDTILPKLQKSQYVDLlKGKdpPIQVTEVGLAFIAAVRRVFPSYGDPVGRAMFEADLAEIGRAATRse 610
WP_043751848 521 pneprGLGTAATRDAVLPKLEKSHYVVLaKGKdpAITVTEAGLAFIDAVRRVFPAYGDPVGRAVFEADLAEIGRAPSRae 600
WP_013380222 511 ilsgfTIGASSSRAAVIKKLFDSDYVIK-KGK--SLVTTDRGKSLIQAFPV--KSLFNVETTGKMEMRLKDIEEGKAD-- 583
WP_055329711 494 vlsgySIGTSATRAEVLKKIAEVGYVHK-KGK--SYYITDLGKNLVEIFPL--KDLLDVDYTGKLEKSLSDIQRGEFT-- 566
YP_001088916 496 vlsgySIGTSATRADVLKKISQVGYVKK-KGK--SYSITELGKNLVEIFPV--KDLFDVDYTGKLEKSLSDIQKGKYT-- 568
WP_012863576 515 egakgSIGTPATRASTVEELINDGYLER-KGK--QIRATEKGKNFYNNVLP--DEIKTADLTALWWVIQEDIIAGTKT-- 587
WP_059399051 512 lkeakGIGTPATRAEIIKGLRRQNLLGA-DGK--WLVPTPAGLQLFETLRGAAPTLVDPGTTALWEMRLDEVVVGRAD-- 586
WP_075799474 509 lkeakGIGTPATRAEIIRGLKAQDFLRI-DGK--HIVPTERGLQLFAVLEQADPALVDPGVTAQLERLLDEVLVGQQE-- 583
WP_015769197 491 imkgvEIGTEATRTGIIENAKKYGYITS-EKQ--NFSITEKGIKLIELLDLLHINLYA-EKTVEFSMLQKDIYNNRKN-- 564
6PCM_A       598 ----RTNWLNNFYFGGEHGVE 614
WP_099514151 611 agrrAASYQERTRARVQELIG 631
WP_043751848 601 avrrAEEFRQRTRARLDALIA 621
WP_013380222 584 ----PRAYLEDVKIKTKEYVQ 600
WP_055329711 567 ----RSQYLTNIMSFIVNGVE 583
YP_001088916 569 ----RKEYLTNIISFIYQNVN 585
WP_012863576 588 ----ITDLTDSVFKSVIQAME 604
WP_059399051 587 ----FRTVIDGIADEAGRLIG 603
WP_075799474 584 ----MMGAIDAVCAQASRIIA 600
WP_015769197 565 ----ISDIIEKTENELQNIIN 581
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