Conserved Protein Domain Family
GSCFA

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pfam08885: GSCFA 
GSCFA family
This family of proteins are functionally uncharacterized. They have been named GSCFA after a highly conserved N-terminal motif in the alignment. Distant similarity to the pfam00657 lipases suggests these proteins are likely to be enzymes.
Statistics
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PSSM-Id: 430286
Aligned: 105 rows
Threshold Bit Score: 158.861
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_012050181              41 KVATAGSCFAQHIARYLKRSGFAflVTetahpivpad-aaerhgyglFSArYGNIYTARQLLQLFDRAYGAFAPAEDVWD 119 Rhi...
WP_011758871              44 RISSAGSCFAQHIGNWLTQNDYSynRSqlns-------------devsSFaFGNIYTPRSLLQWFVCSDDELSEHSVYFE 110 She...
Q28TN8                    41 KVFTAGSCFAQHVGAALKGAGIGviDAeparrglppt-tarrfgygvYSArFGNIYTVKQFRQLVDEIGG-AAPALPVWE 118 Jan...
WP_015905944              46 PIASMGSCFAREIRKRLIKKGYNyiQEerdhpasv-----------hasaawerTYSIFSMRQIFEYTFGSFDPIIRWWI 114 Des...
WP_014810908              46 PVASMGSCFAREIKSVLLREGYSyvQEeaehpask-----------hasaawerLYNTFSMRQIFEYTFEDWNPEVRWWK 114 Des...
PRJNA212980:JCM7686_1535  50 KVFTIGSCFARNIEDFLQD--FDvpTTrfavda---------sewpsRPNgILNEYNPGTIAQRLNWSAQsastvgmset 118
WP_016389182              57 SVYTVGSCFARNVERSLLECGVDliGQdfsidsnyllesvgfmgnqvNNRsALNKYSTFSICEEFERVLLhkevldsgfi 136 Sim...
WP_020950165              50 PVFTIGSCFARNIESALKNRGYSvpAFeyrlpke------elygvtqQQSgFLNKYTPQSMLQEIAFAF---------GD 114 Par...
jgi:Dshi_1942             55 TVFALGSCFARNIEDALAAEGFRvlSRefdlge--------igasldDAAnFFNKYTIHSMLNELRWAFD---------R 117
Q121I3                    60 PLVAFGSCFASNISNYLHKRGYNvlTKreg--------------rsyVTSmGDGIVNTFAILQQFKWAWLNYVPEGTFWH 125 Pol...
WP_012050181             120 Aaegggrvvdpf---------rptieprgyaSEAELRADRAHHLAKVREMFEA---LDIFVFTLGLTEGWEST-DDGAV- 185 Rhi...
WP_011758871             111 Aqssryfdlll-----------pkvadagypSLDELLAFRTLVMEETRAQLAQ---SECFIFTLGLIETWVDR--NGIC- 173 She...
Q28TN8                   119 Kngrfwdaqr------------pgvepdglaSEALVHEMRAAHLSSVAQALKE---ADVIVFTLGLTEAWEHT-DTGTV- 181 Jan...
WP_015905944             115 Spetqtvqdp-------------frrvvlydNLKQARKDFKQHISFSRKALTK---ARVIILTLGMTEVWEDQ-EDQTVi 177 Des...
WP_014810908             115 Tpmsgkiqdp-------------yrrivlyeTQEQADSDFRHHRECSKRALQR---AEVLILTLGLTEVWEDM-HDGSVi 177 Des...
PRJNA212980:JCM7686_1535 119 lvg----------------paescadlllprSPDVTLQRARERRGEIDQLYAElpgSDFVIITLGLTECWYDD-HTGTF- 180
WP_016389182             137 rised------------gwidpqlasvlrplPFSELLKVRQSVDSLVGEVV-K---ADVIFITLGLNEVWFDN-HTKTY- 198 Sim...
WP_020950165             115 Tdgseylievqgg------widgqchsnkpvSLERALARRQEVRDLYRTAIKD---AGLVIITFGLIEAWWDR-ANQNY- 183 Par...
jgi:Dshi_1942            118 DsfpgadmlyplrdddtayrdlqlgsaklafPRDRILAFRHRFLDAVAQIA-E---ADVVVMTLGYVEGWRDT-RLDLA- 191
Q121I3                   126 G------------------------------YEAEEFGYDEEIRLETKALFDE---ADVFVITLGLSEIWYDEpTGEVF- 171 Pol...
WP_012050181             186 -FPVCPGvsggrfdpARHRFRNFRVAEVTADMAAFVARLRGVN-PG-ARIILTVSPVPlva-taSGNHVLAATTYSKSVL 261 Rhi...
WP_011758871             174 -YPSCPGvkfgeydpEKYQLKVFNYQEIFSDLSELFKQIKVVN-PD-IRFVLTVSPVPlta-taTDDHVLVANGYSKSVL 249 She...
Q28TN8                   182 -YPTAPGtiagsydpDLFHFANYGVADILDDFAALDDALAAFN-PK-LKWVLTVSPVPlaa-taSDHHVLTATTRSKATL 257 Jan...
WP_015905944             178 cVPAGPYvneg-gdmDRYRFRVTRYLENLENLERIHTLLHLHN-PE-CKILITVSPVQlwatfrTDLDVISASCNSKSTL 254 Des...
WP_014810908             178 cLPSGPYvneh-gdmNRYRFRVTRYAENLANLERIHEIMARHN-PQ-CQIVITVSPVHlwatfrTNADVISASCCSKATL 254 Des...
PRJNA212980:JCM7686_1535 181 -LNRMPPedvmraqkGRYVFVNLGFQDCVNLLTRAFEQVTA---PRgRHVILTVSPVPlqt-tfTGQDCYTANMRSKSVL 255
WP_016389182             199 -LNSSPPpsllrsddSRFTFAAPDIIEVYEKLSSTVDLISRMS-EKdPKFVVTVSPVPmst-twTSSDVVVANTISKSSL 275 Sim...
WP_020950165             184 -LNATPYpsmisahqERFDFEILDPIDAINCATKTVELIREHGgAD-TNIMVTVSPIPlqr-tfAPDDVLTANCYSKSVL 260 Par...
jgi:Dshi_1942            192 -LNTAPPpalcarepDRFAFEVLSYEDVLGGLRAFHALLTAHR-TKpLKMLLTVSPVPlls-tfRDMDVLVANSYSKAVQ 268
Q121I3                   172 -WRAVPQdry---daERHKFRISTVEENKRNLLEIHSLIRRFR-PD-AKIVITVSPIPlta-tfRPETCIAANAVSKAVL 244 Pol...
WP_012050181             262 RAAAQEIAEDHD----GVFYFPSYEMIT--GAPAAARYFAE-DLRN--VTEEGVAHVMSVF 313 Rhizorhabdus wittichii
WP_011758871             250 RAVAGAFCQGRD----DVSYFPSFELIT--TPLPGDFRYLE-NRRT--VSEKGVGYVMRHW 301 Shewanella amazonensis
Q28TN8                   258 RVACDMLSDSSD----RIDYFPSYELAT--SPAHPHSVFAD-DLRS--VRPEVVAQIMQTF 309 Jannaschia sp. CCS1
WP_015905944             255 RAVADVFASDHD----NVSYFPAYEMAIlhSVIMGKNPFAD-GKENfhVSKETVDHIMEQF 310 Desulforapulum autotro...
WP_014810908             255 RAVADQFAENHQ----NVHYFPAFEMATvyLPLLGRSIFSE-GRENfhVNQDTVDFIMEQF 310 Desulfomonile tiedjei
PRJNA212980:JCM7686_1535 256 RAVADEIVARFPg---KVDYFPSYEIVM----SGGTRAFGK-DNVH--VFPKVIGKVMDHl 306
WP_016389182             276 RVCAEKLTNDFG----NVDYFPSFEMVL---NSPRALAWGD-DELH--VRPQMVDFVIGNF 326 Simiduia agarivorans
WP_020950165             261 RVAAEAVVNKFD----RADYYPSYESIS---VSDPDATWED-DMVH--VKLGAVKENVErm 311 Paracoccus aminophilus
jgi:Dshi_1942            269 RAAVETFVAETP----GVDYFPSYECVT---LSDPAAIWTEgDFRH--VAPDLVTRIMSSv 320
Q121I3                   245 RVAVDEVMREVQptdsNIYYFPSYDVVM--YAFDNQ--WTE-DRRH--VYPHVLDFNMKVF 298 Polaromonas sp. JS666
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