Conserved Protein Domain Family
DNA2

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COG1112: DNA2 
Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
Statistics
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PSSM-Id: 440729
Aligned: 654 rows
Threshold Bit Score: 134.485
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_046011117  576 REVKEnririsarLENDfeeylhelsqtipaletsannvglirriralrictvsfsddgpdratdllrwlehnqssvtee 655 
NP_603846     951 qkigkgtgkntvlyKKH--------------------------------------------------------------- 967 
WP_011416729 1045 DKRQT--------LLSE--------------------------------------------------------------- 1053
WP_013174279 1039 KRAPQ--------LRVE--------------------------------------------------------------- 1047
WP_014186541 1101 KRVPR--------FLAE--------------------------------------------------------------- 1109
WP_080585397 1099 RYAAR--------HIKE--------------------------------------------------------------- 1107
WP_023359061  959 RTAAA--------WQAH--------------------------------------------------------------- 967 
WP_096055575 1042 VRDAE--------NRAA--------------------------------------------------------------- 1050
WP_120177213 1152 KKVAE--------YRRE--------------------------------------------------------------- 1160
WP_083427741  933 RDAKE--------LKAK--------------------------------------------------------------- 941 
WP_046011117  656 tsdllkniaketlptqqqlrnieflrnrlldqhlsdcrlpelknklDTKafklisqlesslessiqqhkqgvasvleela 735 
NP_603846     968 ----------------------------------------------AKEk------------------------------ 971 
WP_011416729 1054 ----------------------------------------------SRKl------------------------------ 1057
WP_013174279 1048 ----------------------------------------------ASRr------------------------------ 1051
WP_014186541 1110 ----------------------------------------------ARKl------------------------------ 1113
WP_080585397 1108 ----------------------------------------------AKAc------------------------------ 1111
WP_023359061  968 ----------------------------------------------AQRa------------------------------ 971 
WP_096055575 1051 ----------------------------------------------ARRe------------------------------ 1054
WP_120177213 1161 ----------------------------------------------ANRl------------------------------ 1164
WP_083427741  942 ----------------------------------------------ADDl------------------------------ 945 
WP_046011117  736 nsivmdrkaALDTVEEYAmVIGATCQqaagnKMASlKSVadlestEISFETVIVDEAARANPlDLFIPMSMAtRRIILVG 815 
NP_603846     972 ---------MLLCQKVVP-AWIMPLN-----KVFDtLNp-----vENKFDIVIVDEASQSDI-SSLILLYMA-KKIIVVG 1029
WP_011416729 1058 ---------MKKCADAVP-VWIMPIS-----ILAEsFDp-----rATRFDVVIIDEASQADL-NALIPLYLG-KQVIVVG 1115
WP_013174279 1052 ---------LRDAREAVP-VWIMPIA-----RAVEqFDp-----sSTRFDVVIVDEASQCDI-LGLAVLYLG-KSTIVVG 1109
WP_014186541 1114 ---------MPICQSAVP-VWIMPLN-----RVIDnFNp-----kTNRFDVVIVDEASQADA-MALTTLYLG-SQVVIVG 1171
WP_080585397 1112 ---------MLEAQGAVP-AWIMPLS-----RVWQnVSp-----dSPKFDIILIDEASQADI-TALPLLYLG-RRVIIVG 1169
WP_023359061  972 ---------MESAVEAVP-VWVMSVD-----RAIEqFAGg----aH--FDVVIVDEASQADL-FALPVLSLA-ERAVVVG 1028
WP_096055575 1055 ---------MAVAKDAVP-VWIMPLA-----EVAEtFDp-----rTARFDVVIVDEASQCDP-TSLFALYLG-RQTIIVG 1112
WP_120177213 1165 ---------LPDCQTAVP-VWIMMLQ-----DALLnFNg------AGRFDIVIVDEASQADL-LALPVLYMA-DKVIVVG 1221
WP_083427741  946 ---------LREAQGYVP-CWIMTID-----DCIDnVa------lKQYFDLTIVDEASQADI-LSLPIVYTS-PKIIAIG 1002
WP_046011117  816 DDKQLPHMLEPAiEDElleehqltelhleAF------------RLSLFERLRLQLenlpyapsKPRIIMLDTQFRMHPVL 883 
NP_603846    1030 DDKQVSPSDVGVnIDKinmf------rrkYIkgnvanddlygvRASLYSIVSTTF----------QPISLREHFRSVPEI 1093
WP_011416729 1116 DHEQVTPLGVGKkQTIlenl------rksMLqdipns-flfdnLFSIYDIGRESF--------GD-AIRLVEHFRSVPEI 1179
WP_013174279 1110 DHEQVSPEGVGQeLERitsl------iseYLsdipna-alydgRRSVYDIAREAF--------GG-VIMLVEHFRCVPEI 1173
WP_014186541 1172 DHEQVSPVGVGQnQDEiqkl------ideHLpgipns-qlydgLFSIYNLGMTTF--------DP--ICLREHFRCVSPI 1234
WP_080585397 1170 DDKQVSPAAVGVtAAEithl------qstTIegviqhaslytmDTSLYDIAQMNF--------A-A-RMLTEHFRCVPEI 1233
WP_023359061 1029 DDQQIGPQLGFV--GSvsgl------ihsHLddvpsa-ehfdpESSLYDHAVRRS--------P-ERILLTEHFRCVPQI 1090
WP_096055575 1113 DDEQVTPIAIGThSEDvskl------vsiFLdgvphk-elydgETSVYELAQIAF--------GG-VIRLTEHFRCAPDI 1176
WP_120177213 1222 DDKQVTPLAVGTnLDTvdal------arrFLagrvkepklynaQISLYDVIKTMG--------F-PTHMLREHFRCVPEI 1286
WP_083427741 1003 DDKQTTPLYANIgLERvknl------raaSLsedfpnyhlmdlTTSLYDILKASF--------PS--FLLKEQFRSVPEI 1066
WP_046011117  884 GDFISKQFYEntGMakVKSGRPESDfafhndfltelgSNRevyEnkVCRWIDIPqdeGKTIKR----GTSWVRESESDRI 959 
NP_603846    1094 IGYSNKTSYD--NQ--ILPLRDSNS------------SILk--P--AIVEYKVD---GKRDE------KNKVNKVEAETI 1144
WP_011416729 1180 IAFSNLLSYE--GK--IRPLRESNS------------TDIk--P--ACVGCRVd---GVREG--------DINKAEARRI 1228
WP_013174279 1174 IQFSNSLCYN--GR--IRPLRESSN------------VALk--P--HVVPYRVRe--AYAEK--------KINKKEALEL 1223
WP_014186541 1235 IQFSNFLSYN--GK--IKPLRDESE------------VNLk--P--FTVAYRVEg--GTSR--------GKTNEKEAQTI 1284
WP_080585397 1234 IGFSNQLAYD--GR--IRPLRESGR------------S-Lq--P---WVQVKVSg--IRE-------PGKKQNLMEAEYI 1282
WP_023359061 1091 IEFSSRHYYD--GK--IQPLRADRP------------LST------PVRPVFIAd--GVRQPLp---PYGDVNVAEADAL 1143
WP_096055575 1177 IGFSNHLSYK--GE--IQPLRESSA------------VPLr--P--HVVPLHVPe--GRARA-------GETNDAEAQTI 1227
WP_120177213 1287 IGYCNRLSYE--GS--IRPLRDGSS------------TNLk--P--AIVPFRVEn--PEAIDEatdaSETRANRAEAEAV 1344
WP_083427741 1067 IEYSNKLSYD--GK--ILPLRDTND------------TTIk--P--ALKLVHVe---GVREG--------DTNQIEADKI 1115
WP_046011117  960 AEEVKRLLIA-AgnsL------SIGIITFY--AAQR--DLIMNKLAATyiddipimiktengfephelfkwalkekndgt 1028
NP_603846    1145 VTLIEACLDMkEyknS------SFGVISLLg-DEQA--ELIQNLIVKRipai---------------------------- 1187
WP_011416729 1229 IDTIKAMIRHpRytgK------TIGIISMLg-GAQA--LLIQSMLHKEisgf---------------------------- 1271
WP_013174279 1224 ASLLLAAVQHpAykgK------TFGVVSLVg-EDQA--RLIDSFLRTYlser---------------------------- 1266
WP_014186541 1285 VSLILACTENpLykdA------SLGVISLVg-EEQA--MLIDRLLQTNlsps---------------------------- 1327
WP_080585397 1283 VATLQACLEEpAykgK------RFGAISLLg-EDQS--KLIRELAAKEigit---------------------------- 1325
WP_023359061 1144 VAQVAAIVADpDyrgK------TLGVISLLstSGQA--NYLLQALREAiged---------------------------- 1187
WP_096055575 1228 ASLICAAHELpEfakNdrgtpvSFGVVSLVg-DKQA--VKIDALLRRHltpa---------------------------- 1276
WP_120177213 1345 VRLMQAMIADpAyerK------TFGVISMRs-GSQSqiRLLKNLIYAAfdpr---------------------------- 1389
WP_083427741 1116 LETIKEILADpAydgK------TIGVISLLg-DAQA--KLIDDMMIEQidii---------------------------- 1158
WP_046011117 1029 lekEEGLRVGSVDAFQGKEFDIVFLSSVRTwnssnskfnrnsnkihD---SAEskelnekqmnrQFGFL---RLPNRMNV 1102
NP_603846    1188 eieNHKILCGNPASFQGDERDVMFISLVDS----------------S---EENkn-------lrLVGEGvegATRKRYNV 1241
WP_011416729 1272 eiaKRRIQAGISGEFQGDERDIMFLSMVDS----------------S---SDEgq-------lrTTGEGafeLIKKRYNV 1325
WP_013174279 1267 eykERRILCGTAAQFQGDERDVMFLSLVDA----------------P---AGGp-----------LPMReddRFRQRFNV 1316
WP_014186541 1328 eyiRRRIQCGNPANFQGDERDVIFLSVVDA----------------P---TGQgp-------ltLRREGahdMYKKRFNV 1381
WP_080585397 1326 sleACDFLCGSPADFQGDERDVVFLSLVDS----------------RdslEAGkq-------mrLVGEGhagDTAKRYNV 1382
WP_023359061 1188 emeARRLRVGDAYTFQGDERDVVLVSMVVS----------------D---NDg-----------RLAAFtkrEYHRRVNV 1237
WP_096055575 1277 aykQRQILCGDAAQFQGDERDVMFLSVVDG----------------P---PANpp-------laIRQEGpkkVFKKRFNV 1330
WP_120177213 1390 eieRRRILCGSSAEFQGDERDVILLSLVDS----------------A---APGkm-------lrKMGDGnddLQKKRWNV 1443
WP_083427741 1159 dydNRKLMAGTPVDFQGDERDIIFLSMVDS----------------P---QDKpl--------rLMSEGgedLNKKRYNV 1211
WP_046011117 1103 AMSRQRQMLICVGDSGLV-TNELSeqgIPAFHAFYklcG 1140
NP_603846    1242 AISRAKDQLWLVHSIDKNslkegdlrkelfeyinsvken 1280
WP_011416729 1326 AASRARDQMWVMHSFDPDlhlkssdirlkllqhvrdpla 1364
WP_013174279 1317 AASRARDQMWVVYSLDLHvDLKPGd-lRRRLIeyaldpn 1354
WP_014186541 1382 AASRARDQLWVVYSLD------Pdldlkagdirrdlikh 1414
WP_080585397 1383 AVSRARDQLWIFHSMERddlkegdlrrnlleydgssqmn 1421
WP_023359061 1238 AASRARDQLWIFHSVRPQ-SLLADd-aRALLLNYA---Q 1271
WP_096055575 1331 AASRARNQMWVVHSLAHEtDLQPGd-yRRRLIEHAldpq 1368
WP_120177213 1444 AVSRARDQLWIVHSFD------Pqsqlkhddlryglfaw 1476
WP_083427741 1212 AFSRARDQEILVTSLRQK-Dlktgdlrqftieyfeeahe 1249
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