Conserved Protein Domain Family
matur_PanM
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NF033213: matur_PanM 
aspartate 1-decarboxylase autocleavage activator PanM
Members of this family, called PanM (or PanZ), although related to the GNAT family N-acetyltransferases, have a different function. Then enzyme PanD, aspartate 1-decarboxylase, has an active site modified Ser residue, created by cleavage of a precursor form. PanM promotes the maturation of the CoA biosynthesis enzyme PanD, but also inhibits its activity in the presence of CoA. Figure 6 in PMID:26276430 identifies residues considered critical to interaction with PanD; seed alignment sequences and cutoff scores were chosen to separate proposed PanM from functionally distinct relatives.
Links
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Statistics
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PSSM-Id: 411104
Aligned: 42 rows
Threshold Bit Score: 195.477
Created: 24-Apr-2023
Updated: 3-May-2023
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_014657531   1 MKLTIIPLVNPTEQQYLDLYKIWPDQ------KPDQLAHQCQS--EQKIYAARFNDRLLAAAKIHREqHKGTIYDFLVRE 72  Providencia
WP_004391344   1 MKLTIERLTNLTHQDLIDLAKIWPEQ------QQTYWLQWIND--GKPLFAARFNERLLGAVKVIVDgQQAELEDLCVRE 72  Yersinia kriste...
WP_005187951   1 MKLTIERLTTLTHQDLIDLAKIWPEQ------QPTLWQQWIND--SKPLFGARFNERLLGAVKITVNgQQAEFQDLYVRE 72  Yersinia
WP_004703951   1 MKLTIERLTILTHQDLIDLAKIWPEQhfpgqlREATWQRWINE--GKPLFAARFNDRLLGAVKVVVHgQRAELVDLCVRE 78  Yersinia aldovae
WP_002211507   1 MKLTIERLITLTHQDVIDLAKIWPNQ------QPAAWQQWITE--GRPLFAARFNERLLGAVKVAVYdQQAELQDLCVRE 72  Yersinia pestis
WP_006317231   1 MKLTIERLTTLSPQDLIDLGKIWPQQ------QPQQWQSWLDG--DKALFAARFNERLLGAVKIVLDgDNAQLQDLLVRE 72  Serratia inhibens
WP_015344180   1 MKLTIERLTALSAQDLIDLGKIWPHQ------TPEQWQSWLSD--GRALFGARFNERLLGAVKVSLDgDTAQLHDLLVRD 72  Serratia
WP_006708561   1 MKLTIERLIALSTQDLIDLGKIWPHQ------QPEQWQRWLNGsdGKALFAARFNERLLGAVKIVLRdDHAELQDLRVRE 74  Serratia symbio...
WP_005290603   1 MKLTIERLETLSADDLRDLQKIWPQQ------TPACWQQWLDN--GGALFAARFNERLLAAVKVTLDnGIATLRDLMVRE 72  Edwardsiella tarda
WP_015699085   1 MKLTIKKLTSLSAQDLICLAKIWPEQ------TESDWQASLQN--NRALFAAVFNERILGAVKITLDgNQGELHDLRVRE 72  Rahnella aquatilis

WP_014657531  73 VTRRRGVGLYLLDEICRQEPQITHWYFSLEGVLDADKIVMEQFLLACRFtpTQESHRWEK 132 Providencia
WP_004391344  73 VTRRRGVGLYLIEETLRQLAEVKHWQLKDDQVASTNRKAVDGFMHACGF--SRGTQNWQR 130 Yersinia kristensenii
WP_005187951  73 VTRRRGVGLYLIEETQRQLPTVQHWQLKDEQVIAEQYEAMDSFMHACGF--SRGTQGWHK 130 Yersinia
WP_004703951  79 VTRRRGVGLYLMEETLRQLPEVKHWYLAHEQVSAINRAEMGAFMRACGF--SDVTQGWQR 136 Yersinia aldovae
WP_002211507  73 VTRRRGVGLYLIEETLRQLPEIKHWYLNGGDLTAAERPQMNSFMLACGF--SHEAQGWRR 130 Yersinia pestis
WP_006317231  73 VTRRRGVGLYLVQDAQRQLPQIAHWQLSIAGLAPRERGEVDNFMRACGF--TQQGDLWHK 130 Serratia inhibens
WP_015344180  73 VTRRRGVGLYLVQDMQRQLPQATRWQLSTADLAARERGEVENFMRACGF--SAQGDIWQK 130 Serratia
WP_006708561  75 VTRRRGVGLYLVQDTQHQLPQAAYWHLSTARLAPCESGAVGNFMRACGF--VPQGELWQK 132 Serratia symbiotica
WP_005290603  73 VTRRRGVGLYLIEDTLRQLPAIHAWQLPLSDIPATQQATMDHFMVACGF--SRRAQGWSR 130 Edwardsiella tarda
WP_015699085  73 VTRRRGVGLYLIEDLQAQLPQVKSWTMK-----ADDDAVTAAFMQTCGF--TREGNVWKK 125 Rahnella aquatilis
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