Conserved Protein Domain Family
T7SS_mycosin

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TIGR03921: T7SS_mycosin 
type VII secretion-associated serine protease mycosin
Members of this family are subtilisin-related serine proteases, found strictly in the Actinobacteria and associated with type VII secretion operons. The designation mycosin is used for members from Mycobacterium. [Protein fate, Protein and peptide secretion and trafficking, Protein fate, Protein modification and repair]
Statistics
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PSSM-Id: 274856
Aligned: 21 rows
Threshold Bit Score: 280.365
Created: 9-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_003940739  76 LGFDSVWPITR-GAGQRIAVIDTGVS-R-H-PRLPSLD---GGGDYVG-----TSDGTD---DCDAHGTVVAGLIAAQ-- 138 Rhodococcus ery...
WP_011905335  69 LSPARVWPLTR-GEGQVVAVIDSGVE-A-V-PQLAGGRl--DQVEVVR-----GPSGVD---DCPGHGTFVAGLIAAR-- 132 Salinispora tro...
WP_010985999  48 MQAEQMWKTST-GKGITVAVIDTGIQ-D-NiPDLRGRVv--AGKDFSNh----PGDEHS---DYDGHGTSMAVLIAGTg- 114 Streptomyces av...
WP_011030423  46 MHAEEMWKVST-GRGITVAVIDTGVD-D-SlPDLKGQVl--KGKDYSDq----PGDERT---DHEGHGTGMAALIAGTg- 112 Streptomyces co...
WP_011030414  66 vlLDELWQGTRkGKGVRVAVIDTGVD-DdN-PQLTDAVdkaAGLDLLT-----KGKGGDpthDEVGHGTKVAGIIAAR-- 136 Streptomyces co...
WP_011904399  55 LTPQRVWPFST-GAGVRVAVVDSGSDgD-H-PQLNGQVa--NGFDALR-----GTSGGDi--DCVSHGTAVTSLIAAR-- 120 Salinispora
WP_012015506  67 LRASTAWRTST-GAGVVVAVIDSGVD-DtH-PDLAGRVl--PGLDLVE-----SSPTADp--DPVGHGTTVAGLIAGR-- 132 Salinispora tro...
WP_011075052  76 VSLDRAHRIAT-GHDVTVAVIDTGVS-P-H-PRLPGIH---PGGDLVGahqqeGIPGELi--DCDGHGTIVAGIIAMR-- 144 Corynebacterium...
WP_003977220  44 LHTQQAWRTTK-GAGITVAVLDTGVEaD-H-PDLAGNVl--TGKDLVGf----GASEGDr--SWARHGTAMAGIIAGHgh 112 Streptomyces
WP_011874743  49 LAPRSAWALNQ-GGSTLVGVVDTGVS-A-AaPALAGRVl--PGQDVLG-----SGPANN---DCAGRGTFMAGLIAAG-- 113 Saccharopolyspo...
WP_003940739 139 -QVEGSG---------FSGAAPDAQIISIRQSSAAFSvagqredpaVA-ENSSGYGNVDTMASAVRHAADMGASVINISE 207 Rhodococcus ery...
WP_011905335 133 -PVSGTG---------FSGVAPASTILPVRQT------------------GDGLDGTAATLAEAIRAATDRGADIINIS- 183 Salinispora tro...
WP_010985999 115 aKGRATG---------SYGLAPGAKILPIRIPDFIEQ---------SR-SDGNPDDYPTYMAKAIRYAADSDAQVINISL 175 Streptomyces av...
WP_011030423 113 kHGSKSG---------AYGLAPGVEILPIRMPEKI-E---------GL-DFTSGHNAARDFSKAIRFAADSDAKVINISM 172 Streptomyces co...
WP_011030414 137 -PAEGTG---------FVGLAPGATVIPVRQNDADSS---------GD-SDS--------MAAAIRHAVAKGADVVNISQ 188 Streptomyces co...
WP_011904399 121 -PQEGIG---------FHGLAPDATILPIRVSEQAGS---------GGgETPGESVSTEIFAQAIRRAVDDGADVVNMS- 180 Salinispora
WP_012015506 133 -HDDSSG---------AVGLAPDARILPVRVLDAENR-----------------YDDALIVANGVRWAVDNGARVINLSL 185 Salinispora tro...
WP_011075052 145 -PDHGSGwpydgtgdnHIGIAPAANLIAIKQTSAFVR----------H-SGDTGVGTLGTLADSIHRALDQGAHIINISV 212 Corynebacterium...
WP_003977220 113 gSGDAEG---------VMGIAPEAKILPVRVILEDGD---------PS-RAKARKTRGNALAEGIRWAADHGADIINLSL 173 Streptomyces
WP_011874743 114 -QTTGVG---------FAGIAPRARILPIRVAQNPNE------------------VDPGRLAAGIRAAVDGGAKVIAVS- 164 Saccharopolyspo...
WP_003940739 208 VACkP-AGD--GINDQRLGAAIEYAtIAKNVVVVAAAGNVGSGGCKnqnpppdpvdpladpwnsvTTIASPAWYdDYVLT 284 Rhodococcus ery...
WP_011905335 184 ------TAS--LFPDETLRRAVEYA-SSKDVLIVAAVANERGSGN---------------------TRPYPAAY-PEVLA 232 Salinispora tro...
WP_010985999 176 -------AS--TAHSPELTESVAYA-LSKGKLIFAGVGNTGGGLNK---------------------VEYPAAT-PGVVG 223 Streptomyces av...
WP_011030423 173 GQAeSgTKG--GVDTSELDAAVKYA-VDKGKLIFAAAGNEGDGANR---------------------PRFPAST-PGVVA 227 Streptomyces co...
WP_011030414 189 D---T-TKP--LAATSELAEAVREA-LAQGVVVVASAGNDGLDG-K-------------------TKDTYPAAF-EGVLA 240 Streptomyces co...
WP_011904399 181 ------VTL--YRPDPDVEGAIRYA-RERDVVLVAAAGNLHRNGEQs------------------DPVPYPAAY-DGVIG 232 Salinispora
WP_012015506 186 -------GG--GSASPALAAALDYA-FARDVVVVACTGNESAPSSS--------------------TVWYPARE-PGVIA 234 Salinispora tro...
WP_011075052 213 VSCiP-ATHehPGAIHPLDEALWRA-EHQGVVVVAAAGNVGQDCPE-------------------GSTVYPAHA-ETVLA 270 Corynebacterium...
WP_003977220 174 GD--D-SAS--AHPEPGEDEAIQYA-LKKGVVVVASAGNGGELGDH---------------------ISYPAAY-PGVIA 225 Streptomyces
WP_011874743 165 ------MGT--PSPAADLRAAVDYA-AGRDALVIAASDMNVQDGQT----------------------SYPAAF-PSVLP 212 Saccharopolyspo...
WP_003940739 285 VGSVDPNGAA-SS---FSLGGPWVDVAAPGTGITSLHPTSPGLTNGVygsdgavqsfnGTSFAAPFVAATAALVRSVHPE 360 Rhodococcus ery...
WP_011905335 233 VGAIGPDGAP-AD---FSGSGDFVDLAAPGSSIVSIGPRGGGHLTAT-----------GTSYAAPLVAGTAALVRAYHPQ 297 Salinispora tro...
WP_010985999 224 VGAIDRGVKA-TK---ESQHGPQVDLVAPGEEMVAACLGSTELCKTH-----------GTSDATAIASASAALIWSKHLD 288 Streptomyces av...
WP_011030423 228 VGSINEKVKR-SS---FSEWGPEIDVTAPGEDLVHACIGGTGVCRTS-----------GTSDATAIASASAALVWSKHPT 292 Streptomyces co...
WP_011030414 241 VASSDRNNER-AA---FSQPGDFVGVAAPGVDIVSTVPGG-GQCTDS-----------GTSFSAPFVAGVAVLLKEKYPD 304 Streptomyces co...
WP_011904399 233 VGAIDQQGAR-VE---QSQVGPYVDLVAPGGGVVAA-TRVNGHAIWS-----------GTSFATPLVSATAALIRAAEPE 296 Salinispora
WP_012015506 235 VSGLDRDSEKlWS---GAITGRETVLTAPATGLVGARPPDGYWQVQ------------GTSFATPLVSATAALIRARFPE 299 Salinispora tro...
WP_011075052 271 VSARFDSHTI-AS---YSVAADQQLLSAQGLIPTGLSPRGDGFVSGVltqsg-pspfeGTSFAAPVVSGTAALIRQRHPH 345 Corynebacterium...
WP_003977220 226 ATAVDRYGTR-AA---FSTRRWYATVSAPGVDVIIADPDHRYYEGW------------GTSAASAFVSGAAALVKAAHPD 289 Streptomyces
WP_011874743 213 VSGIDESGSP-ANrggSNAPAQAPALVAPSSNVVSIAPAGAGHITAS-----------GGGIGVAFVAGAAALVRSYHPD 280 Saccharopolyspo...
WP_003940739 361 LTALQVTQRIEATAHAPAQ--GWNPYVGHGVIDPLAAV--TG--ELaPGERVKVNH---QSVSIDPLPTPPTPDN----- 426 Rhodococcus ery...
WP_011905335 298 LTAEQVRRRLQLTADRPSGs-VPDPRLGWGVVNPYAAV--AS--ILpEATG--------GPPTASPVVVSAPTRP----- 359 Salinispora tro...
WP_010985999 289 WTNNQVLRVMVNTASKSKSgkERTDYLGYGAVRPRIAL--TDpgDPgPVDGYPLPDfeyAASRTPEVSASASSKQ----- 361 Streptomyces av...
WP_011030423 293 WTNNQVLRVLINTMKGNEEewTHNESFGYGIVRPRVAL--QNpgDPgPADEYPLPDlaaAAASKSPSPEASPSGD----- 365 Streptomyces co...
WP_011030414 305 WTPAQIVTRIEQTAERSVn--GHDDFVGWGVVDPVRAV--QE--AD--SGRPPSSP---TPDPGVRSAEAPDVAPfslae 373 Streptomyces co...
WP_011904399 297 LSATQVSRRLLATAD-PARg-GPGQGYGQGVLNPYRAV--TE--RL--STAAPVAP---APLPDPPYDAVALERA----- 360 Salinispora
WP_012015506 300 MPAGDVINRMLHTARDIGPa-GQDDSFGYGLVDPVAAL--TT--EVaPVGLNPLDD---QSSPGIVGFGPAPITA----- 366 Salinispora tro...
WP_011075052 346 ASPAEIRTRILASVD-PAR----------GAVDPYRAL--TM--EPaP-----------GPVPAREVHISAPAPP----- 394 Corynebacterium...
WP_003977220 290 LTPAQVKSVLEDTARNAPAg-GRDDSRGFGFVDPAAAIeaAG--RLkPEGLR-------AASYGDEYFGTGPDAP----- 354 Streptomyces
WP_011874743 281 LSAAQVRHRLEATADHPPAv-LPDPALGFGVVDPRAAL--AT--VLp--EESGDRP---TPAPAPDVRVPPVPAA----- 345 Saccharopolyspo...
WP_003940739 427 -RSRDt------------------ALV-----G-AGT--------VGTLALLTLLASMPLRR 455 Rhodococcus erythropolis
WP_011905335 360 -DDGMpgr--------------ivALL-----I-AAA--------ASTLVVVMLVARAVVPR 392 Salinispora tropica
WP_010985999 362 -EGAApaastns------gsgdssPPW-----IlLGV--------GSGVLISGAAFAGWCVR 403 Streptomyces avermitilis
WP_011030423 366 -AAENpaggtyqaaastseddsstSLW-----I-ALG--------VAAAVVVGAAITFAVLR 412 Streptomyces coelicolor
WP_011030414 374 tPEERdr---------------ryAVY-----G-LSV--------GAVLVVLISGTGVVlrd 406 Streptomyces coelicolor
WP_011904399 361 -QRWHvlg--------------rvALW-----G-GLS--------VAVLALAIGATVlllpr 393 Salinispora
WP_012015506 367 -SADTdrtgidfapsapsarsgswEPWdpwsaG-AGGsstsdqwwTGLAFPVALVAGGDRRV 426 Salinispora tropica
WP_011075052 395 -DDSArrn--------------avAV---------LA--------MVTAVVTAIAVTAGRWW 424 Corynebacterium efficiens
WP_003977220 355 -ASDDd-----------------tSAW-----A-APL--------AGGAGGVLVVAAVVLWR 384 Streptomyces
WP_011874743 346 --DDTpv---------------fiALA-----V-TAL--------TVSAASLGALAAALVTR 376 Saccharopolyspora erythraea
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