Conserved Protein Domain Family
Top1

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COG3569: Top1 
DNA topoisomerase IB [Replication, recombination and repair]
Statistics
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PSSM-Id: 442790
Aligned: 210 rows
Threshold Bit Score: 288.225
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_013593974   1 MYlpadpsarsrdagprpapPER-LPGG--LRY-------------------VHpDT----------L-P-GLTR-VL-R 44 
WP_012921599   1 ---------------------------mkaLRP------------------------------------P-GLHR-VR-I 14 
WP_041248100   1 ------------------------------MRK-------------------INacgl-----ggkmE-N-FIIR-KP-F 22 
WP_014397278   1 MT----------------------QLER--LRQ----------------------------------D---GHRR-LG-T 17 
WP_104022608   1 MRagar-----------igrQSTrRGPGfaLTSr------------------AM-AE----------R---WILR-KGsK 36 
WP_047857505   1 MT----------------------HIER--LRQ----------------------------------D---GIRR-RG-S 17 
WP_085017711   1 MS----------------------------IRS------------------------------------P-SAARwCRsS 15 
WP_095981447   1 MT----------------------HIER--MQR----------------------------------E---GIRR-RG-S 17 
WP_106418281   1 ------------------------------MSR----------------------ST------------PrRVTR-HR-C 14 
WP_120761579   1 MCgkq-------------dqEYSgRALR--LSSaswscrghhvgarrrddegVTtPSllpeasrhvpRpP-GFHR-VT-- 61 
WP_013593974  45 -G-K--HFRFRTPDGQWVTDEEEIARIRKLAIPPAYTNVWICPLPEGHLQATGLDARGRRQYRYHPEWRQQRDEAKFERM 120
WP_012921599  15 -E-G--RLVWYDEAGRPVEDAGELARLAELAVPPAWREVWAAADPQAAVQATGVDARGRTQYRYLPAVLQAHAEDKFGAL 90 
WP_041248100  23 -G-D--TFTYQYPSGKTVKNKGIRRWVKSLAIPPAWQEVQIDLDRSAKVFAVGRDAQNRKQYIYNPKWTERANEQKFERI 98 
WP_014397278  18 mK-R--GFRYVDAQGRAVS-QAERERIDALRLPPAWTDVAISPKASARLQAVGRDGAGRWQYRYSEAHTQKQRDAKYQRI 93 
WP_104022608  37 -R-S--GFRYVTEAGAPVRAAATLARADALRIPPAWTDVHVAASPTSAIQAWGFDAKGRKQYRYHDREVARGQLRKYYRV 112
WP_047857505  18 pQ-R--GFQYVLTNGKPVP-AKERERIGALKLPPAWTDVLISPSATSKLQAMGKDSAGRWQYRYHESFTKRREVEKYKRV 93 
WP_085017711  16 -GlHrvEMRWFDDLGRPVQDDAILHRLRSLAIPPGWHDVWADADPEARVQATGVDARGRTQYRYSAAAEAEATARKFADL 94 
WP_095981447  18 pQ-R--GFRYLRPDGQRVS-AKESQRIAAMKLPPAWKDVFISGSPGAKLQALGKDSAGRWQYRYHPSFTRRQEEAKFQRI 93 
WP_106418281  15 -G-K--GFTYRTPDGTTLKDKRWREWIAGLAIPPAWREVEIFLDKRNRIHATGRDSAGRKQYVYNDAWRERRELEKFDRM 90 
WP_120761579  62 -A-S--NASWVQEDGHPVTS-SERTRLAALRVPPGWTHVWASYDPAAALQATGVDSRGRTQYRYSADAVDRASRDKFEHM 136
WP_013593974 121 QAFGRALPRIRARVARDLQPrrgePA-LSRAVVLATIVRLLDTTFLRVGNEEYAAANRSYGLTTLRNRHAGVRGSTLTLR 199
WP_012921599  91 AAFGRALPSLRRTVADHVSEpl-gDH-PDRRPVLAAMTRLLDRGFFRVGSSRYLRDNHTYGLTTLRRDQVTITGSVLHFD 168
WP_041248100  99 LRFAKALSTMRRVTGQHITQ----RP-IDEKVVLACMTRMLDDAFFRPGNPTYTKDNETYGLTTLRVKHMNISGNHVEFD 173
WP_014397278  94 VGFAQALPKMRRQVSKDLRK----RG-LGRERVLAGMLRILGTCFIRPGSERYAEEHGSFGLATLRARHVKVHGDTVVFD 168
WP_104022608 113 RRLAHDLPGIRAALDRDLRK----RT-LDRCHVAAGVVRLISEGFFRVGNERYAAENATFGIATLRKEHVVLHDDRAVFH 187
WP_047857505  94 VDFARALPKLRRRVAADLRQ----PG-LGRDKVMACLLRILGTCFIRAGSQQYADENKSFGLATLRAKHVKVKGDTVIFD 168
WP_085017711  95 LQFGGSLPTLRTHVERHLTEgvgeDSpSRVRRATAAAVRLLDRGLFRVGSPRYARDNHTYGLTTLTREHVRLDGDEIEFE 174
WP_095981447  94 VDFARALPKLRRRVAEDLRQ----RG-LGRNRVMACLLRILGTCFIRPGSQQYADENQSFGLATLRARHVKLKGDTVIFD 168
WP_106418281  91 VEFAGRLTRMRRVTGQHLTL----DG-MPREKVLACMVRLIDSAYFRPGSERYRQENDSYGLTTMRSRHLTIDGDELIFD 165
WP_120761579 137 LAFATSLPVLRKRVSEDLEG----EH-LEASTVTATVVRLLDKGLFRVGNERYRRDNHTFGLTTLRRSQVALDGVSARFD 211
WP_013593974 200 FRGKSGVEQQATVDDPRVARVVRRCQQLP---GQELFQYEDEDGTRHTVGSGDVNDYLHEIAGTDdsapgggmrFTAKDF 276
WP_012921599 169 YVAKEHLHRITDVDDADSARVVVALLAMPgtpDQPLFRAATHPRPPGPVSSATVNAYLHGLIGLP---------ATAKAF 239
WP_041248100 174 YVGKSHQQQHREVDDKHVAKVLTQLEKMT---GYELFDIKLPEGERKKVTSQDLNQYIAQVMGEN---------FSAKDF 241
WP_014397278 169 YPGKSGVRQHRELKDRRVATLVRQLLKVP---GRDVFKFVVDDGAVVDVRRRHINEYIQQVMGPG---------YSAKDF 236
WP_104022608 188 YVGKKSIEQHQTVCEPALVEFVRALALTP---GYRLFRWVDDDGEWHDLTARDVNEYLHELLGVP---------YTAKDF 255
WP_047857505 169 FPGKSGKQQHRELKDRQVARVVRECLKLP---GRDVFKFVLDDGFVVDVRRRHINEYIQEVMGAR---------YSAKDF 236
WP_085017711 175 FIGKEHRPWHVTVRDGQVAEVIRMLVASSssaTAPLFSVRTPEGE-HAITSAVVNAYVHGATSAP---------ATAKTF 244
WP_095981447 169 FPGKSGQRQHRELKDRQVARVVRECLRVP---GRDIFKFILDDGLVVDVRRRHINEYIREVMGER---------YSAKDF 236
WP_106418281 166 YQGKSGQQQHRVVEDARLAAIVAELDDIP---GYEIFKYFDDAGDKTRIDSHDLNDYIHEVMGER---------FSAKDF 233
WP_120761579 212 FVGKEHKEHSVSVADSGATRVLRALLTQAedaSSPLFMITTATAS-RLIDSVTVNAYIHTHADTA---------SSAKTF 281
WP_013593974 277 RTWHGTAQALE-LTRIACTQ-PE-------G--APVATAKHILAEVARQLGNTPAVCKKSYIHPAVLELGSRlasdaGpG 345
WP_012921599 240 RTWSGTVVAAAaRAGAVLPGlAT-------R--ASPDSPRVAVVSAAALLGNTPAVARTSYVHPAVLAGDPA-----P-E 304
WP_041248100 242 RTWAGTVLMAVaLEQIGPAN-DQ-------K--LSQSNVLAAVKKVASELGNTPAVCRANYIHPNVIFHYES-----G-R 305
WP_014397278 237 RTWAGTLICACaLARARERV-KEdgdggpvKktVLKKSMVAAVREASEQLGNTPAVAKASYIYPSVLVLFER-----G-Q 309
WP_104022608 256 RTWGGTLRVATiLADLGEPA-SD-------R--DAKKNVVTAVRLVAAELGNTPTVCRASYVHPLVIARYLDa----G-T 320
WP_047857505 237 RTWGGTLICACaLARAKERV-REeaakdgkK--LTKKTMVAAVKEVSEHLGNTPAVARDSYIYPSVLAMFEK-----G-Q 307
WP_085017711 245 RTWGGTAAAAAvAGGATAPF-AA----------RSTRPDLVAVEVAAYLLGNTRDVARRSYVHPLALEAGRS-----P-A 307
WP_095981447 237 RTWGGTLICACaLARAQGRA-CDga---glR--AVKKTMVAAVKEAATQLGNTPTVARDSYIYPSVLAMFKQ-----G-R 304
WP_106418281 234 RTWAGTSIAALaLDELGLGK-DD-------Q--SSEKNVREAVTRVAERLGNTPSIAKASYIDPRVVESYLD-----G-R 297
WP_120761579 282 RTWGASVAAAAvSAGATVIA-SD-------G--ARHSPERLPLIAAAQLLGNTPAVAKQSYVHPAAIAVGRT-----A-S 345
WP_013593974 346 MQ-AVWERIGERa-AGARGL-SAVERRLMAFLQDT--ARAR 381
WP_012921599 305 VArAVDAVAEREghRDLRLV-WTDAGVQAAVAHQL--EEVN 342
WP_041248100 306 TLaYFRKQLKR---TKTKYF-SPDEKATLKLLEYLvdtn-- 340
WP_014397278 310 VVdRYFKSVDELaaSSGEGM-HCSEKALLHMLGKT--KLSA 347
WP_104022608 321 TIaPFLPng---isPARDAH-RPEERALIRFLDKFfpERRR 357
WP_047857505 308 VVeRYFESVDELvrHEKPAL-HCAEKALLDMLEEG--KRPA 345
WP_085017711 308 VVeAIAAAARASgsSDVREL-LRADAVVLALAAEL--ARIT 345
WP_095981447 305 VVgRYFETVEELaqQEKPGL-HRAEKALLEMLESP--GLAA 342
WP_106418281 298 TLsHFRQLVETEi-EQDETLtSPDERAILELLRSR--LKRE 335
WP_120761579 346 VRrALNDAAARAktDDVRVI-HADPSLQEAIVSEL--ALVR 383
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