3LM9,3OHR,1XC3


Conserved Protein Domain Family
ASKHA_NBD_ROK_BsFRK-like
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cd24067: ASKHA_NBD_ROK_BsFRK-like 
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins
Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Links
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Statistics
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PSSM-Id: 466917
Aligned: 57 rows
Threshold Bit Score: 262.48
Created: 13-Dec-2022
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1: catalytic site [active site], 1 residue position
Conserved feature residue pattern:DClick to see conserved feature residue pattern help
Evidence:
  • Comment:the catalytic Asp acts as a catalytic base.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                        
3LM9_A         5 LGGIEAGGTKFVCAVGREd-GTIIDRIEFPTk---xPDETIEKVIQYFSQFs-----lQAIGIGSFGPVDNDkts----q 71  Bacillus subtilis
XP_005535953  65 FAAIELGGTSARAAIAVGrpDQFIERFQVPTs---tPRETLTLLTAWLAERhet-hpiTALGVATFGPILLPsvassaas 140 Cyanidioschyzon...
KYQ92109       7 YGGIEAGGTGFSLAIAIGepSNITERISVPTt---tPQETKDRVLQWFKERge----iHSFGIASFGPVDLDkls----p 75  Tieghemostelium...
WP_148623485   3 LGGIEGGHQKFIVAVSNQa-FGIIARKEIATd---vPSVTMQAIFDFFDQYpe----lVAIGIGAFGPIDTRpls----y 70  Weissella muntiaci
CEO99088       7 FGGIEAGGTTFVASLAVGdpTNVVDYKRFPTts--sPEETYQTALDWFAQTgk---piGALGIATFGPVCLNras----a 77  Plasmodiophora ...
WP_011470432   6 IAAIEAGGTKINISVGYTv-DEPLMATRIPTh---tPSDTLPACVDFLQTAqnklgaiKALGIASFGPVDIDkqs----a 77  Saccharophagus ...
OHT11651       6 VAAIELGGTSASVAITNElgNFLYKKKGINTapprdAAEAVKEIAEALKEPni---pfEAIGIASFGPIDIK-------- 74  Tritrichomonas ...
POM61654       4 FAGVEVGGTTWVAAIAEDhpENILEKFEVDTt---tPDETIGAVVDWLKERk-----fDSIGIASFGPVDLNkks----p 71  Phytophthora pa...
OQS02671     128 ECSIELGGTTWALAIAHDspLNIVARTRIDTt---tPEETFEKALAWLLSQt-----fDAIGIASFGPVDLNkqs----a 195 Thraustotheca c...
CCI41496      33 FAGIELGGTTWLIAIAEGdvTNIVAKVKIITt---tPEETLKNAINWLKTQr-----fDAIGIASFGPVDLNpds----e 100 Albugo candida

Feature 1                                                            #                           
3LM9_A        72 tYGTITATPKAGWrh----------------yPFLQTVKNEXk--IPVGFSTDVNAAALGEFLfgea----kglDSCLYI 129 Bacillus subtilis
XP_005535953 141 hQVRFGKTPKKAWqglalleelqqlwerdeqrPASQELAKAIgtrIPVLVDTDVNAPALAELAarrsptdpggpLVLAYV 220 Cyanidioschyzon...
KYQ92109      76 tYGYITTTPKPGWqn----------------tNILGWIKEQYp-nTPVGFDTDVNGAAISETKhgkhe--rgaiDSCAYI 136 Tieghemostelium...
WP_148623485  71 tYGQVLTTPVAGWsg---------------yqFLAGMQKWRDd--LAYYWTSNINAAAWAEYLngsg----qraNTMLYL 129 Weissella muntiaci
CEO99088      78 sYGQIGATPKKGWrq----------------yNILSFLSSKLp-nVPIGIDTDVNAAALAELQygtgr--ganlHSLAYI 138 Plasmodiophora ...
WP_011470432  78 sYGTILNSPKLAWc-----------------dQNILEAFNVFd--CPIALDTDVNAAAYAEHQrle-----ksnCNSVYI 133 Saccharophagus ...
OHT11651      75 -NGKIANTPKPNWrq----------------fPFISELRKYFgndIPIIFETDVNAPAYSEYLalhke--dpsiSSVAYL 135 Tritrichomonas ...
POM61654      72 tYGYITSTPKPNWgn----------------tDVVGVFKRAFp-dVPIGFDTDVNAPALYEVAyggh----gdiSSAVYI 130 Phytophthora pa...
OQS02671     196 tYGFITTTPKPHWan----------------tDIVGKFKLAFp-gIPVNFETDVNAPALFEAEfggh----gdvSTLCYI 254 Thraustotheca c...
CCI41496     101 tYGYITKTPKPGWsn----------------tEIVGVFRRAFp-gKPIKFDTDVNAPALYEVTqggh----gniSSACYI 159 Albugo candida

Feature 1                                                                                        
3LM9_A       130 TIGTGIGAGAIVEGRLLqGLSHPEXGHIYIrrhpdd---vyqgkCPYHGDCFEGLASGPAIEARWGKKAAdls---diaQ 203 Bacillus subtilis
XP_005535953 221 TVGTGVGVGVAIQDEPLhGRLHPEAGHIRVvrypad---sysgsCIWHQDCLEGLCCAGALAERAKVDASqladladdhP 297 Cyanidioschyzon...
KYQ92109     137 TVGTGIGVGVVINNQPVhGLVHPEGGHTLVkmqkgd--egfqgtCPFHGNCVEGLVSTGAISKRVNLNADqiptlsdqdP 214 Tieghemostelium...
WP_148623485 130 NVGNDVGMSIVHNGKLYaGAGMPQGGHVLVttrqdd--syegycPFHGNRCLEGLVAGPAVKARYGIEAVdla---ddhP 204 Weissella muntiaci
CEO99088     139 TVGTGVGVGLCVDGKSLiGMSHAEAGHIRVprhesdpkdtfqgvCPSHGDCVEGLASATAIAARLSIHESalpavpdsdP 218 Plasmodiophora ...
WP_011470432 134 TVGTGVGVGVVINGATLtGELHPELGHCYSerlai----epkgvCIRHGDCVEGLISGPALKQRWKILPEeae---sdhI 206 Saccharophagus ...
OHT11651     136 TIGTGVGLGAFLDDRMVhGRLHPEFGHTLIaprkdd---hfegtCPFHGPCIEGLIATGALAKRLNISHEelvdvpvddP 212 Tritrichomonas ...
POM61654     131 TVGTGVGVGVCTNGNAIhGFMHPEGGHIIVppaqqdvetgfkgvCPFHGDCIEGMVASGSIAARTGVDRRdlatitdddP 210 Phytophthora pa...
OQS02671     255 TVGTGIGVGVCIEGKPVhGLMHPEAGHMLVpiaeedlaigfkgtCPYHGNCAEGMAASGAIAARMSKERRelqnlsdddP 334 Thraustotheca c...
CCI41496     160 TVGTGVGVGVAVGSVPVhGLMHPEGGHIRVpispqdiesgfqgvCPFHSDCVEGMVGNRSIAARTGIDRHnlhtihdsdP 239 Albugo candida

Feature 1                                                                                        
3LM9_A       204 VWELEGYYIAQALAQYILILaPXXIILGGGVXQQk---qVFSYIYQYVPKIXNSYldfse-lsddISDYIVPPRLgsNAG 279 Bacillus subtilis
XP_005535953 298 VWKLAAHYLAQLCWNLSCVLaPHWIVLGGGVMQRk---sLLKKIQSKFVELDRDYlgi----etpVEKYIVSSAYgpHAG 370 Cyanidioschyzon...
KYQ92109     215 VWKVIAHYLAELCANLIMSLsPKIIVLGGGVLNRe---cLYPLIRQETLTILNGYikspyltpenIHKYIVQSPYksSAG 291 Tieghemostelium...
WP_148623485 205 AWELIADYVSQALISATVLLrPNCIVLGGGILQRp---hLVARIKDQYQLLSNHFleq----gsiIDQYILRGEYqeEAD 277 Weissella muntiaci
CEO99088     219 VWDLVGYYLGQLCASICLMVsPERIVLGGGVPQRa---cLLASVEKHFVASINGYvd-------vPSGYIRKSALsvGPG 288 Plasmodiophora ...
WP_011470432 207 MWESVGFHLARLCYTATLAYsPNNIILGGGVLQNt---fIIPMVHKYFAHLAGGYlpaka-vpqnLDSFIKASSYstGAG 282 Saccharophagus ...
OHT11651     213 IWDLFAYYVAETAAAAAYAYaIDVLVVGGGIMTGdnrgyLYDLANEHLKKIINGYi---------EPPVIRRPYYnkDAG 283 Tritrichomonas ...
POM61654     211 VWDTIAHYLANLCINVTFLTsPDVIVIGGGIARRe---kLFDLIREKFVARVNKYgqq-----ppVEKYIRASFHp-AIG 281 Phytophthora pa...
OQS02671     335 VWNTVAYYLALVCVNLTLTVsPQVIVIGGGISKRn---gLFEKIHTAFEKALNGYvkt-----pdMKKYIRPSFHs-DIG 405 Thraustotheca c...
CCI41496     240 IWPTLAHYLAHLCANLLFTVsPEVIVIGGGLSKRp---iLLQLIREKFEQIVNHYvqy-----ppVEQYIVSSFHk-HVG 310 Albugo candida

Feature 1               
3LM9_A       280 IIGTLVL 286 Bacillus subtilis
XP_005535953 371 LVGACTL 377 Cyanidioschyzon merolae strain 10D
KYQ92109     292 LVGSLEL 298 Tieghemostelium lacteum
WP_148623485 278 ILGALAL 284 Weissella muntiaci
CEO99088     289 VVGSQEV 295 Plasmodiophora brassicae
WP_011470432 283 LAGAFLL 289 Saccharophagus degradans
OHT11651     284 LVGASAC 290 Tritrichomonas foetus
POM61654     282 LVSSLHL 288 Phytophthora palmivora var. palmivora
OQS02671     406 LVSSLEL 412 Thraustotheca clavata
CCI41496     311 LIGSLEL 317 Albugo candida

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