3FHK


Conserved Protein Domain Family
Disulph_isomer
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pfam06491: Disulph_isomer 
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Disulphide isomerase
This family of proteins has disulphide isomerase activity, EC:5.3.4.1. It has a similar fold to thioredoxin, with an alpha-beta-alpha-beta-alpha-beta-beta-alpha topology. It has a conserved CGC motif in the loop immediately downstream of the first beta strand. This motif is essential for activity.
Links
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Statistics
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PSSM-Id: 428976
Aligned: 69 rows
Threshold Bit Score: 190.427
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3FHK_F                 11 YMRQLVVPMRRELTGAGFEELTTAEEVENFMEKA-EGTTLVVVNSVCGCAAGLARPAATQAVLQ-NdKTPDNTVTVFAGQ 88  Bacill...
INMI:Cabys_2856        12 YSEEMVKPLREEVTSAGVEEWRTAEEIDHALQQP--GITLVFINSVCGCAARSARPALKLALGH-D-KLPDRIGTCFAGV 87 
WP_014265644            3 YSPLLVKPFRDEVTEVDVQELLTSQDVDNFFNNQ-TGSALLFINSVCGCAAGTARPALRQAKANgNgKTPDRWVSVFAGQ 81  Granul...
PRJNA194094:J421_2070   2 YPEMLVAPMRQELTRLGVTELRTPEAVDAALRDA-QGTTLVVVNSVCGCGARAARPAVAMALQH-E-VKPDQLTTVFAGQ 78 
WP_015894875            2 YPENMLIPMRQELTRLGVEELRTAEDVDARIGGN-TGTMLVVVNSVCGCAARNARPAIATALAH-A-VTPDASTTVFAGQ 78  Gemmat...
Q2S2G5                  3 YPKQMVEPMRKELTQLGVEELRTPDEVDAAFDQAeDETMLLVINSVCGCAAGNARPAVAKAKDA-TdHHPDRYLTVFAGQ 81  Salini...
Q2S5Z3                  3 YPKSMVEPMRKELTRLGIDELKSPDDVDAAFGAAeDETLLLIINSVCGCAAGGARPAVAQALE--TgPTPDHAVTVFAGQ 80  Salini...
Q1IQG9                  2 YPEIMLVPMREELTRIGIEETRTADAVDDAVRGT-EGTLMVVVNSVCGCAAGKMRPGIRRAFDH-A-TKPARSITVFAGQ 78  Candid...
WP_012680670            2 YPEIMVIPMREELTRVGIKEARTAADVDAALAAP--GTTMVVVNSICGCAAGKMRPGVRLALQN-A-VVPDQSITVFAGQ 77  Acidob...
WP_014786700            2 YPEIMVIPMREELTRAGISEARTAAEVDQALAQS--GTTLVVVNSICGCAAGKMRPGVRMAMEH-T-QKPDHAITVFAGQ 77  Terrig...

3FHK_F                 89 DKEATAKMRE-YFTGAAPSSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC 147 Bacillus subtilis
INMI:Cabys_2856        88 DLDAVESVRK-RIKNYPASSPSIALFKDGEPIYFMPRHHIEGSPAEEIAEDLKEIFDVYC 146
WP_014265644           82 DLEATARARG-YFPDIPPSSPSIALFKDGELVYFVPKHRIEGRDANGLANDLTSAFSEvl 140 Granulicella mallensis
PRJNA194094:J421_2070  79 DVAATERARS-YFVGYPPSSPSIALLKDGQLVHMIERWQIEGRPAQAIAQDLVAAFERHC 137
WP_015894875           79 DSAATERARG-YFTGYRPSSPSIALMKGAEVVFMLERHQIEGRSSAEIAADLTNAFDQYC 137 Gemmatimonas aurantiaca
Q2S2G5                 82 DLEATERTRE-YLAGIPPSSPFFALFRDGQPVYVVERKHIEGRNADVIARDLVEAFEAYC 140 Salinibacter ruber DSM 13855
Q2S5Z3                 81 DVAATDYVRDtHLPGIPPSSPFMALFRNGQPVYVIERKHIEGREPAAISADLVEALQAYC 140 Salinibacter ruber DSM 13855
Q1IQG9                 79 DGEATDRARG-YFTGYPPSSPSIGFLREGQLVHMIQRSDIETRTADQIEALLTQAFDQYC 137 Candidatus Koribacter vers...
WP_012680670           78 DREATDRARS-YFEGHPPSSPAIAILRDGKLIYLMQRAIIETNTAQAIGQELARAFNEYC 136 Acidobacterium capsulatum
WP_014786700           78 DREATDKARG-YFGGHPPTSPAIAILRDGQLVYLMQRSAIEGANAPAIAQELARAFDAYC 136 Terriglobus roseus
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