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Vmh family MBL fold metallo-hydrolase Members of this family are zinc-binding enzymes with a metallo-beta-lactamase fold. The founding member, Vmh from Vibrio vulnificus (AAO08273.1), was described as having actual beta-lactamase activity. Because the search for beta-lactamases in known and potential pathogens has been so intense for so long, the potential zinc-binding motifs differ so greatly from those of the well-characterized metallo-beta-lactamases, and reports of beta-lactamase activity have not been widespread throughout this family, the question of whether the beta-lactamase activity seen for Vmh is essential or incidental is not yet answered. |
Jiyao W et al.(2023). "The conserved domain database in 2023.",