Conserved Protein Domain Family
LPLAT_AGPAT-like
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cd07989: LPLAT_AGPAT-like 
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.
Links
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Statistics
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PSSM-Id: 153251
Aligned: 332 rows
Threshold Bit Score: 67.296
Created: 5-Oct-2009
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative
Feature 1:putative acyl-acceptor binding pocket
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                             #  #  #                 ###
YP_356073     41 AKVSLrl--------------agVRLVVEGrenlp--------aegaVVFMPNHQSNF-DILALfaal--srqFRWLAKE 95   Pelobacter car...
ZP_03225303   14 VKTVLsctrtf------lesrstITIEQNDtidl----------kppYIILSNHVTNW-DPFYIncyv--nepICFVASD 74   Bacillus coahu...
ZP_01907765   15 NKVWIervtqralgpsraalmgvAPLSWSGretl---------pdepVLILSNHVSLF-DPWFTitaa--gkpIHYLATA 82   Plesiocystis p...
ZP_01905520   36 YRGTWlais-----------pliGLLRLRGqghrdi------prrgpMLLLPNHCTMI-DPFMVgwlp--lrpSRFMASA 95   Plesiocystis p...
ZP_01091703    5 LRFLLrf---------------rYRVQLHGleelr-------svqgpILVLPNHPAYV-DPPLVlshlrfgrsLRPLVFA 61   Blastopirellul...
ZP_02736225   13 LRALLsl---------------rYKLTLVGtedvl-------krpgpYLFMPNHPAYA-DPPNLlvrlwprfkVRPLLLE 69   Gemmata obscur...
ZP_03312568  440 VRILLsrmllgcg---rcllslrYRVRLEGldilqaevararergrgVLVLPNHPAFM-DPALLcthl-aafdLRPLADS 514  Desulfovibrio ...
YP_008235      1 MRHLLglvllyfm---rftlwfrYRVTIKGienvnpk---vlnkpggVLFLPNHPTVFvDPTLVtlaiwkkylIRPLIVE 74   Candidatus Pro...
ZP_01313362   10 LRTLLrl---------------rYRIDIKGldrirr------dgkvgMLFLPNHPALV-DPLIVnvalqqhfsVRPLADR 67   Desulfuromonas...
NP_225116     18 VGALLkl---------------rYRMQVEGwdtlni------npkqgCLFLANHVAEV-DPIILeylfwsrfhVRPMAVE 75   Chlamydophila ...

Feature 1        #                                                                      ###      
YP_356073     96 Elf----hiPLFGLtmr---------ragYIPVDRsnrk--------ksveSMRHAIERISDGtSVVIFPEGTRSpd-gh 153  Pelobacter car...
ZP_03225303   75 SlfrkpllkPLLHYv-------------nAIPKTKfks----------dtrTIRGMVNAKKENrVIGLFPEGNRNwd-gq 130  Bacillus coahu...
ZP_01907765   83 Aam----qqPVMGFvlr---------twgSVPKRKftv----------dagAIRALKKWADLGaSVGSYPEGERSwd-ge 138  Plesiocystis p...
ZP_01905520   96 Qpl----tkPLLGPwlk---------algAFPKHKfvk----------draAMEELQRLYDDGhMIVIFPEGSRSwn-gr 151  Plesiocystis p...
ZP_01091703   62 DtfrswifyPFCKAs-------------hAFEVPNlkshsrd--ahrqtteMIDRVVAGVEAGnDFLIYPSGRLKr---- 122  Blastopirellul...
ZP_02736225   70 Snf----kgPLFAPiawllrgikmpdivkASVEDRrra-----------eeAVGEVIATLRGGgNVILWPSGRLSr---- 130  Gemmata obscur...
ZP_03312568  515 Hqi----rrPWLRPlaal-------tgciSLPDLRraglsa----rdrvreALDSCAAALARGeNVLLYPSGGLSrdggt 579  Desulfovibrio ...
YP_008235     75 Ymy----ytPIVHGfmk---------fmrAIPIPNfvsssnsl-kkkkvdqVIETVINDLRKKeNFLIYPAGKVKnq-ak 139  Candidatus Pro...
ZP_01313362   68 Aqa----dhPVTGFlln---------kmqALLIPDlsqqsnqg-ergdvaeALQLMERSLEQGeHLLVYPAGRIYrgpne 133  Desulfuromonas...
NP_225116     76 Ylf----hsRVVQWfln---------svrSIPIPQlvpgkeskrslermnvCYEEASRALNRGeSLLLYPSGRLSrtgke 142  Chlamydophila ...

Feature 1                                                                                        
YP_356073    154 LKEFKAGSFTLAIqa-----qvPIVPIAITGsrdvmpkh------------------------srwirggRVTVTIMppv 204  Pelobacter car...
ZP_03225303  131 TEPIPLAVSKLVKml-----tiPVVVAKIKGghlshprw------------------------aqsfrkgPISISFEkil 181  Bacillus coahu...
ZP_01907765  139 LLPLLPGIEALVRll-----klPVVPVRILNadrvlprw------------------------asvrrhgRVEIQFGear 189  Plesiocystis p...
ZP_01905520  152 TLEVREGIGRLVNri-----daEVVIARMVTahylwprw------------------------aryprfvPTHIEYEgpl 202  Plesiocystis p...
ZP_01091703  123 QGTEVIGGARMAYelltrcpnlQVILVRTEGmwgsrfgcaq--------------------tggvpdlagAARLALGsll 182  Blastopirellul...
ZP_02736225  131 DGTERLGGARTAAdvlaavpnaTVVLVRTRGlwgsmfswadgkpsltrgv--trgvglwvanlfvlaprrRVTLTLEaft 208  Gemmata obscur...
ZP_03312568  580 HLGGNSGAYRLLQavp----dcGLVLVRTRGlwgssfswasgepvlgral--lrglvsllchglfflprrEVRITCAlps 653  Desulfovibrio ...
YP_008235    140 EIIAASGVHRIIQavp----eaNIVLVRTTGlwgssfsraltgksppmfktifegvkiafknlifftprrEVIIEFMpap 215  Candidatus Pro...
ZP_01313362  134 ELRGSSAVDRLVKavp----eaRVVLVRTSGlwgsrfsrahgdkphffkt-llamlpkllvnglvfmpkrTVTVEFIeea 208  Desulfuromonas...
NP_225116    143 EIVNQYSAYVLLHrvm----ecNVVLVRVSGlwgsafsrykqns--------------tpklgpafkeafRALLRRGiff 204  Chlamydophila ...

Feature 1                                             
YP_356073    205 stad-------------------ravkernELMQEVR 222  Pelobacter carbinolicus DSM 2380
ZP_03225303  182 dpnq-------------------iedlstdQVLQVIR 199  Bacillus coahuilensis m4-4
ZP_01907765  190 kfp---------------------rkappaEVRAWLE 205  Plesiocystis pacifica SIR-1
ZP_01905520  203 ryp---------------------astspeAITEDIR 218  Plesiocystis pacifica SIR-1
ZP_01091703  183 ssllffvpkrkvsltaqaidrsqlplaskeSLNRFLE 219  Blastopirellula marina DSM 3645
ZP_02736225  209 pdqr--------------------pepkreLVNKWLE 225  Gemmata obscuriglobus UQM 2246
ZP_03312568  654 rrpma-----------------gegarpynALLEAFY 673  Desulfovibrio piger ATCC 29098
YP_008235    216 adfp--------------------yqasrlELNRYLE 232  Candidatus Protochlamydia amoebophila UWE25
ZP_01313362  209 dfp---------------------rqgsrqEINGYLE 224  Desulfuromonas acetoxidans DSM 684
NP_225116    205 mpkrfvkitlc-----qvdhlflkqfptkqDLNTFLA 236  Chlamydophila pneumoniae CWL029

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