1IMQ,4QKO,4UHP,2GZF,1BXI,3GKL,1CEI,1GXH


Conserved Protein Domain Family
Col_Im_like

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cd16363: Col_Im_like 
Click on image for an interactive view with Cn3D
inhibitory immunity (Im) protein of colicin (Col) deoxyribonuclease (DNase) and pyocins
This family contains inhibitory immunity (Im) proteins that bind to colicin endonucleases (DNases) or pyocins with very high affinity and specificity; this is critical for the neutralization of endogenous DNase catalytic activity and for protection against exogenous DNase bacteriocins. The DNase colicin family (ColE2, ColE7, ColE8 and ColE9) in E. coli, and pyocin family (S1, S2, S3 and AP41) in P. aeruginosa, are potent bacteriocins where the immunity proteins (Ims) protect the colicin/pyocin producing (i.e. colicinogenic) bacteria by binding and inactivating colicin nucleases. The binding affinities between cognate and non-cognate nucleases by Im proteins can vary up to 10 orders of magnitude.
Statistics
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PSSM-Id: 319897
Aligned: 105 rows
Threshold Bit Score: 66.7665
Created: 28-Mar-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
heterodimer
Conserved site includes 17 residues -Click on image for an interactive view with Cn3D
Feature 1:heterodimer interface [polypeptide binding site]
Evidence:
  • Structure:1BXI: Escherichia coli immunity protein IM9 in complex with colicin E9 DNase domain; contacts at 4.0A
  • Structure:4UHP: Pseudomonas aeruginosa immunity protein ImAP41 in complex with pyocin AP41 DNase; contacts at 4.0A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                          ##          #  ##  ##  #      #### ####     #                
1IMQ_A        4 KHSiSDYTEAEFLQLVTTICNadt-----ssEEELVKLVTHFEEmTEHPSGSDLIYYPkegdDDSPSGIVNTVKQWRAAn 78  Escherichia coli
1BXI_A        4 KASiSDYTEAEFLQLVTTICNadt-----ssEEELVKLVTHFEEmTEHPSGSDLIYYPkegdDDSPSGIVNTVQQWRAAn 78  Escherichia coli
KUI97499      4 KNSiNEYSEDEFLRLLQKICKada-----ssESELDALVDHFEDiTEHPDGSDLIYYPddlaDATPERIVEIVKQWRMSq 78  Vibrio sp. MEBiC...
KRW86347      2 KDRiEEYTEAEFKKLVQDICSvnv-----asEDEHTQLVRLFCRlTQHPDGSDLIYYPddeaDATPERITEIVKNWRADq 76  Marinobacter sp....
KDM91482      9 KDTlSEYTRSDFIELLARICRada-----stEAELNKFVDHFEKiAQHPDGSDLIDYPessaDGTPERITEIVQQWRQSq 83  Photobacterium g...
KUI97529      2 EKNiTSYTQDEFLSLVRRISIddy-----ptEQEHIDAVLLFEKlTEHPDGSDLFYYPddpaDATPERIVEIVKQWRMSq 76  Vibrio sp. MEBiC...
EKX86409      4 KQKlEEYTEAEFVQLVGEFFEnrsglhgkafIDYQDYLSDEFERlTEHPAKSDLIYYPeeghSVTPQSIVNHVKEWRAAn 83  Pseudomonas puti...
ADW72592      4 KDKfEEYSEAEFVALVKDIFDvh------gsESYQDSLLENFSRvTGHPSGTDLIFYPegdnPVTPESVVTEIKQWRTSv 77  Rahnella sp. Y9602
KQT63251      2 ANEtPGYTEKYFSGLLERIFAanrn---gtpEVLLADMLDNFCElAEHPAGTDLIYWPedetQCTPESITATVKKWRTDh 78  Pseudomonas sp. ...
WP_036205216  3 SIRiEDMTRQEFLGLLKRIFDvt------dcEKVHDELIDQFEElSQHPDGSDLIFYPenpeDSTPERIAEIVEEWRARn 76  Marinobacter sp....
Feature 1             
1IMQ_A       79 GKSGFK 84  Escherichia coli
1BXI_A       79 GKSGFK 84  Escherichia coli
KUI97499     79 GLPCFK 84  Vibrio sp. MEBiC08052
KRW86347     77 GLPGFK 82  Marinobacter sp. LQ44
KDM91482     84 GLPCFK 89  Photobacterium galatheae
KUI97529     77 GLPCFK 82  Vibrio sp. MEBiC08052
EKX86409     84 GKPGFK 89  Pseudomonas putida CSV86
ADW72592     78 GKTLFR 83  Rahnella sp. Y9602
KQT63251     79 GPTEFK 84  Pseudomonas sp. Leaf434
WP_036205216 77 GLPGFN 82  Marinobacter sp. MCTG268

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