1M3S,1JEO,1VIM


Conserved Protein Domain Family
SIS_PHI
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cd05005: SIS_PHI 
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Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.
Links
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Statistics
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PSSM-Id: 240138
Aligned: 54 rows
Threshold Bit Score: 188.938
Created: 23-Mar-2007
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitetetramer
Conserved site includes 4 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1JEO: Methanocaldococcus jannaschii Hypothetical protein Mj1247 binds citric acid, contacts calulated at 3.5A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                               #                        
1M3S_A         5 TEYVAEILNELHNsaay------isnEEADQLADHIlss------hqIFTAGAGRSGLMAKSFAMRLMHMGfnAHIVGEI 72  Bacillus subtilis
1JEO_A         4 LEELDIVSNNILIlkkfyt--ndewkNKLDSLIDRIika------kkIFIFGVGRSGYIGRCFAMRLMHLGfkSYFVGET 75  Methanocaldococ...
NP_108570     13 LDELSGVLARVDDsq---------idAACKLLAEARq----------IVVYGCGREALQVKGFAMRLYHLGlpVSVVGDM 73  Mesorhizobium l...
AAM62627      10 ANLSSQICNQISSvftkp---tspypPPLDLLVTELtaisrnrnnsrIFLYGVGREGLMLKAFAMRLFHLGlpTHLVFDM 86  thale cress
YP_426455     11 LDDLRAVFATLDEta---------tdRAVEEFVKARq----------IALYGVGREGLQIKGLAMRLHHLGlrVAMVGDM 71  Rhodospirillum ...
CAI78192      23 AAARRTILREIEAlltr------areDQAQELMQAVyga------qrIMVLGAGRSKLAVDAFAMRLMHLGltAHVSTDV 90  Streptomyces am...
CAJ75414      19 KPTTKIILNEIHSvldk------ineQSFAQLFSSIlda------knIFVTGQGRSGLVSRTFAMRLTHIGlnAYCVGDA 86  Candidatus Kuen...
CAJ35239     189 QRYYKQIDHFASNaallk----nieaGHLGDWIERLlnr-----rgnYIVDGVGRSGFVAKAFGMRLTHLGrnVFMRDGP 259 uncultured meth...
NP_001053590   4 GGDAAAICAQIAAvfsgdpaarpvlvAELAAAAARGg---------rVFVHGVGREGLMMRALCMRLAHLGlpAHCVGDV 74  Japanese rice
EDO61786       5 LDLCETIIEEHRRvfhk------ldlTELSQFLNELika------nsVFIAGIGREGISMRSFAMRLAHLGkkVYWVWDD 72  Clostridium lep...

Feature 1                      ###                                                               
1M3S_A        73 LTPplaeGDLVIIGSGSGetKSLIHTAAKAKSlhgIVAALTinpes------sigkqADLIIRMpgspkdqsn------- 139 Bacillus subtilis
1JEO_A        76 TTPsyekDDLLILISGSGrtESVLTVAKKAKNinnNIIAIVxexgn-------vvefADLTIPLevkks----------- 137 Methanocaldococ...
NP_108570     74 TAPplgpGDVFLASSGPGetSTVLTLMRVAREagaTNLLLTaqagg------saakrADTTLLIpaqtmandqg------ 141 Mesorhizobium l...
AAM62627      87 TTPpissSDLLIASAGPGgfSTVDALCSVAKSngaKVILITaepaig-----scvkhATDVCYVpaqtrasdngggd--s 159 thale cress
YP_426455     72 TTPplaaGDLLVVSAGPGafSTVSALMGVAKAagaRSLLVTaqpag------dcarlADVVLPIpaqtmaddq------- 138 Rhodospirillum ...
CAI78192      91 TCPaiaeGDLLVACSGSGhtPTVVQRTEAAKQagaRIAVVTanqes------plaalADIRVHLaeysqdfe-------- 156 Streptomyces am...
CAJ75414      87 TTPnidkGDLLIACSSSGntHITCYIAELAKKsfaTVAAITsqkns------plteyADIIVDLpvqeirthn------- 153 Candidatus Kuen...
CAJ35239     260 TTPaflrGDAYIPISGSGntREIIEGVVKAKLhgaDVFPIMinidsrlsslmdswgySKNAMYIpvsledislyweqdms 339 uncultured meth...
NP_001053590  75 TAPpaspGDLLLASAGPGafSTVDAICGVARGagaHVVLLTakpegd-----fprrqADVVAHLpaqtmaddeeat---t 146 Japanese rice
EDO61786      73 TTVallpGDLFIVADGSAniPSLEHMLQKGKKagaKIVLITsdpkg------shkkyADYILHIhataylsrnl------ 140 Clostridium lep...

Feature 1                                                      
1M3S_A       140 --gsyktiqpmGSLFEQTLLLFYDAVILKLmekkgldsetMFTHHA 183 Bacillus subtilis
1JEO_A       138 ------kylpmGTTFEETALIFLDLVIAEImkrlnldeseIIKRHX 177 Methanocaldococcus jannaschii
NP_108570    142 --pqktsvlpmGSVFEGALFLLFEVMVLKLksligaspeaMRARHT 185 Mesorhizobium loti MAFF303099
AAM62627     160 vemgerrllpmGSVYEGALFVLFEMVVYKLgevlgessesVRARHT 205 thale cress
YP_426455    139 --hpsasilpmGSVFEGAEFILFEALVLALrdrlavspeaMRARHT 182 Rhodospirillum rubrum ATCC 11170
CAI78192     157 ---pdastqfvGTLFEQGALVFFDCLILALqrtqhvdpseMYARHT 199 Streptomyces ambofaciens ATCC 23877
CAJ75414     154 --kingsiqfrSTLFEQACLVYLDGVIHLLvtelrsseqeMNRRHS 197 Candidatus Kuenenia stuttgartiensis
CAJ35239     340 kimatksvqtrPSISEINSYVFTNAIVAQAmemlgvseqyLKRIHV 385 uncultured methanogenic archaeon RC-I
NP_001053590 147 esspakaklpmGSLYEGAMFVLFEMVVLELarvlgqspaqMRARHT 192 Japanese rice
EDO61786     141 --ecvptiqimGNQFEQHLYMLADIIIMLYmdevgltpsdLEKRHR 184 Clostridium leptum DSM 753

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