Conserved Protein Domain Family
Response_reg_2

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pfam19192: Response_reg_2 
Response receiver domain
This is a receiver domain (REC) commonly found in the same gene-neighbourhood of its cognate HK. Together they comprise a Two-Component System (TCS). There is a high degree of specificity among REC and DHp domains in a cognate pair. This domain is related to the Response_reg (pfam00072) domain. We found that pfam19191 and this domain show high degree of linkage in the same gene-neighbourhoods across several bacterial lineages. This implies that they comprise a TCS.
Statistics
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PSSM-Id: 437036
Aligned: 42 rows
Threshold Bit Score: 92.111
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence trees and CD hierarchy information associated with this CD can not be displayed.

This model has been replaced with 497839.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q1NVW9        15 YLQSVVFVDDKIYFNQSP---VDLdD---LAAGAfsglkpqftEEQAGGdm-dSAveeeqisigelmpatsaegkgedai 87  delta proteobac...
RVU13187      17 PIRSVLIVDDDYPTFEEM---LSDgEslgKDWRN---------------------------------------------- 47 
KKO49437      15 PLRSVLIVDDQYPTWEEI---LNShLdddAKDADdytrshkklWRT---------------------------------- 57 
PRH85455      21 AIRTAVLIDDQFPDYLQI---GTEdVgafK-------------------------------------------------- 47 
CUW01263      18 AIRSVVMIDDDFLTYSESiraLNNeVdldYNKID---------------------------------------------- 51 
PIJ48226      18 AIRSVVMIDDDFITYSDSikaLNReIeldPAKID---------------------------------------------- 51 
WP_006843704  17 SIKSAIFIDDMIPGLFSS---EED-------------------------------------------------------- 37  Dysgonomonas mo...
ROS87496      14 SISNAICIDDEFCAPYDT---EGR-------------------------------------------------------- 34 
WP_055279200  14 SIKSAVCIDDQYAEPYQK---APK-------------------------------------------------------- 34  Bacteroides fin...
OXM86264      16 YFKDILYVDDAIKKPTDL---KNViElanNESAAasetvnsvqEQPVTRrpvtYSvdtqvnqttseqqmesnqsvleane 92 
Q1NVW9        88 dggGGYHPRELLESFARKGIVCAL-YEPRE---GFDSDS-TsdLFRLCERADVVILDWDLHGDD----GDGVSQLLAELI 158 delta proteobac...
RVU13187      48 ---QTDRVRKIIRGFRARNLLVDI-----HdgrNVGLDD-EirEAEHLHQSDLLVLDYQLDKTRag-dGSIAINIIRKLM 117
KKO49437      58 ---KAQGPFQVIKKFRERKPGFVIdIHDAVvnaSPEGET-PsqLANHLHQSDLLVLDYNLEGADsglrGKKAREILYSVL 133
PRH85455      48 ---ETARAKSIYQFIHRRGLICDV-----LnwrEVGEARl--eLIDKVRKSDLIVLDYKLDGDN----PEPALQILRRLA 113
CUW01263      52 ---SSKRAATLESFFQSKNMICDV-----------DNGS-VnfDVDRIRKSDLIIVDYHLDNNA----PDKTLKLLQDLK 112
PIJ48226      52 ---SSKRAATLEGYFQSKNMICDI-----------DNGS-VnfDVDRIRKSDLVIMDYHLDNNA----PDKTISILKELK 112
WP_006843704  38 ---KEAICQPMYESFQANQ--CSLdFFKFTkdwATKSKL-------IFERKDLVVLDWELENEVp--kYRSTLEIIDGAV 103 Dysgonomonas mo...
ROS87496      35 ---NLDAPKSMRDSFRNQH-QCNL-----EiyrYTNFGDiKtlLPVLFKNRDLLILDWELNPSEqi-kYQDTLKIIEAGV 104
WP_055279200  35 ---NGKDAEILYHSFRQQG-KCDL-----DiynYNNLEDfIkaREYLFCNKELLILDWELSPSAqn-vYEDSLKILEDAI 104 Bacteroides fin...
OXM86264      93 ileDYFDAFEIIYNLNSNGNKVSP-FFFEG---DHQVET----VVSLIEQSHLTILDWELDQTG----GETTLNILESVF 160
Q1NVW9       159 KKSeadlpHHVRLCALYTDRPSLQP--ILLRLLEKLEE-----QGCEVDMGEGKLQLIAGATRIAIFGKPHTAG 225 delta proteobacterium...
RVU13187     118 ANT------HFNLVVVHTSE-NLDA--VFQNVILALLP-----YELYELTQDDLFLVDEALEELRSRIGDLDSR 177
KKO49437     134 SNQ------HFNLIIVHTGEDDLEE--VAQECVISLMTsctskFAVQEVQNIASLDEAITDLEDDESFNRATLR 199
PRH85455     114 NTD------HFNMVVLYTADVTAP---VAVAVAAAMRG-------VSPPDQRAMLKPAEEEAAHDFLEDPVNAE 171
CUW01263     113 DSD------HLNMIVIYTRE-NLET--VWMQISSTLKGal-diNSLIIDYDNEDVQSYWEDVVLPNLNDNGNKA 176
PIJ48226     113 SSD------HLNMIVIYTRE-ELET--VWMQIASSLKGtv-kiNDRIVDTNNDDLIDYWENTILPDLAQIGDRS 176
WP_006843704 104 RTD------NLHFVCIYSLTPNATQe-IHYKILAYYCGnektkAIADITSFKEYVENELGENTDDILPRLKDLL 170 Dysgonomonas mossii
ROS87496     105 DSK------TLRYIVIYTQNTDTEN--ICKVILRAFSKyr-qdFSDIEKNILENLDEFCAENELDFDGDKVWSL 169
WP_055279200 105 NNS------YIQFITIYTQAPSFNE--IVYRIFSYFYFns-meNNSLRKEKYKNLTEEIEDALSEINSDLSSDD 169 Bacteroides finegoldii
OXM86264     161 RNT-----GRLKLLVVYTKNPLQASkmIRDKFTSKIVD-----YTQIKVEESTIDIFDLHDAFVLVCKKRELPS 224
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