Conserved Protein Domain Family
PRX_like1
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cd02969: PRX_like1 
Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic cysteine found in PRXs, which aligns to the second cysteine in the CXXC motif of TRX. In addition, these proteins do not contain the other two conserved residues of the catalytic triad of PRX. PRXs confer a protective antioxidant role in cells through their peroxidase activity in which hydrogen peroxide, peroxynitrate, and organic hydroperoxides are reduced and detoxified using reducing equivalents derived from either thioredoxin, glutathione, trypanothione and AhpF.
Links
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Statistics
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PSSM-Id: 239267
Aligned: 39 rows
Threshold Bit Score: 166.26
Created: 8-Dec-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Conserved Features/SitesClick to see Conserved Features Help
 
putative
Feature 1:putative catalytic residue [active site]
Evidence:
  • Comment:This conserved cysteine aligns with the first cysteine in the CXXC motif of thioredoxin, in contrast to the peroxidatic cysteine of peroxiredoxin which aligns to the second cysteine of the CXXC motif.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                               #                                       
NP_973876    71 GARAPNFELPEPLTg--nLWKLEDfe-lYPSLLVMFICNHCPFVIHLKKDIVKLCNFYmk--kGLAVVAISSNsvvt-hp 144 thale cress
BAC91905     30 GQPAPSFTAADTNGk---SHALTDf--kGKYVVLEWTNYDCPFVVKQYSTQAMQEMQKmaagkGVVWLSVNSSaagk-qg 103 Gloeobacter viol...
BAB73163     12 GGYAPDFELPGIDNq---VHHLSRyldnFRAVGVVSLGNYCSYVNLYLDRLKGIQGEFgt--dGFILIGINASdite-ps 85  Nostoc sp. PCC 7120
ZP_00243785  40 GEAAPDFELKDTHGk---TVKLADf--kGRHVVLEWTNPGCPFVQKHYSSQNMQSLQKefvgrNVAWLSISSTarga-td 113 Rubrivivax gelat...
ZP_00310336  15 GDEIKNFSMLNVTNq--tVLSLTDyn-dQKVVVIIFTNNNCAYAKLYEQRIANLAKQYnt--sGVAFLLVNPSvsns-dk 88  Cytophaga hutchi...
NP_868073    57 GDPAPEWSELPTTEd--tTSSLNDls-dSKVVVLAFTCNSCPYAIDAEERLIALTKDYae--kTVTVIAVNVNrie---- 127 Rhodopirellula b...
NP_419039    24 ARPAPDFTAIDADGk---TRSLSEf--rGKTVVLEWTNEGCPYVRKHYSGNMQGLQQAar-adGVVWLTIASSapgkqgh 97  Caulobacter cres...
NP_969109    20 AEKLTNLSGIDVLTnetkTFTMEN----HKATVIVFLSAKCPCSASHENLLKDLAQQYk----DFQFVGIHSNsd----- 86  Bdellovibrio bac...
ZP_00315628  32 GEAAPDFTEVDASGk---TQALKDy--kGEWLVLEWFNKDCPYVKKHYGSENMQSLQQkyaakGVKWLTVISSakgk-qg 105 Microbulbifer de...
CAD78645     46 TSNADGLKGLDLDGr---LIRLGQsn-eTKAVAVVFLSTHCPISNGYLPLLNGYASEYgt--qGIELIGVISDp------ 113 Rhodopirellula b...

Feature 1                                                                                       
NP_973876   145 qdGPEFMAEDAKVFKYp--FPYLYDESQEVAREFGAVCTPEFFLYKkdgrrpFELVYHGQFDDSRpss---nspVTGRDL 219 thale cress
BAC91905    104 nyPAEKWNTLVKEKGAa-pKAILLDGDGKIGQLYGAKTTPHMYIINp----eGKLIYNGAIDDKPttda--atkPQTNYV 176 Gloeobacter viol...
BAB73163     86 wsSLEKMKAFAQNHELn--FPYLWDSTQEVSRSFGATKTPIAFLIDs----hGILRYRGQIDNHPqep----ssVGEDYL 155 Nostoc sp. PCC 7120
ZP_00243785 114 ylEPAALQAKYQGWGAa-pTALLMDDAGGVGKAYGAKTTPHMYVIDp----gGKLIYAGGIDDKRsadp-advkGARNFV 187 Rubrivivax gelat...
ZP_00310336  89 feTIEAMRKKIQNDKSl--YPYLADTTQSLAISFGVQRLPDAFVLKkme-tsFRLVYKGSIDDNPqsa----edVSNRFL 161 Cytophaga hutchi...
NP_868073   128 edAMPAMKEKAKEEQFp--FAYLYDESQQIARDYGAKYTPQFFVLDa----dRNIAYMGAMDDSPdg-----rnVSKPYL 196 Rhodopirellula b...
NP_419039    98 faDGAAAKAWMNARGAk-pTALLLDADNKVATLYKAKTTPHMFVIDk----tGAVVYEGAIDDKPtnkv-ediqGSKNLV 171 Caulobacter cres...
NP_969109    87 -eTLEETQKHFREAHLl--LPVIRDSRSQWANKLGALKTPHAFVLSp----tGEMLYHGGVTDSHvg-----psAKKHFL 154 Bdellovibrio bac...
ZP_00315628 106 ylEPKQALEEALSHNLnasAALVLDADGSMGKAYGAKTTPHMFIINp----eGKVVYAGAIDDNDsanp-avikTSKNYV 180 Microbulbifer de...
CAD78645    114 --SVTRSDAKKHSVDYrveFPVLFDGSGELRLALSPTHTPQAMLIRp----tGEMLYNGAIDDRHvqvgrkkdhAANSYL 187 Rhodopirellula b...

Feature 1                                  
NP_973876   220 SLAIDLSLSCQPIPSNQKPSVGCSIKW 246 thale cress
BAC91905    177 AAALTEAMAGKPVTVATTRPYGCSVKY 203 Gloeobacter violaceus PCC 7421
BAB73163    156 RNAIAALFKGEEILVPETEPVGTSLIW 182 Nostoc sp. PCC 7120
ZP_00243785 188 KAALTESLAGKAVSTGTATPYGCSVKY 214 Rubrivivax gelatinosus PM1
ZP_00310336 162 SDAISAMVLNRSIKVADTRAVGCLLKP 188 Cytophaga hutchinsonii
NP_868073   197 RDAIDDVLAGKPVTVSETVPVGCRIRM 223 Rhodopirellula baltica SH 1
NP_419039   172 AAALGDLKAGRKVATPFVTPYGCSVKY 198 Caulobacter crescentus CB15
NP_969109   155 KEVLEDLHAGKPPRHKEGRALGCYIQR 181 Bdellovibrio bacteriovorus HD100
ZP_00315628 181 AAALDEVLAGKPVTVASSRAYGCSVKY 207 Microbulbifer degradans 2-40
CAD78645    188 RDAIRAVIARRAVDVPRTKPIGCLLED 214 Rhodopirellula baltica SH 1

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