Conserved Protein Domain Family
SF1-HH
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pfam16275: SF1-HH 
Splicing factor 1 helix-hairpin domain
This domain, approximately 100 residues in length, is mainly found in splicing factor 1 from yeast to human. It is a helix-hairpin domain, which forms a secondary, hydrophobic interface with U2AF65(UHM) to lock the orientation of the two subunits, which is essential for cooperative formation of the ternary SF1-U2AF65-RNA complex. In this domain, it contains a highly conserved SPSP motif in its C terminal and phophorylation of SPSP motif induces a disorder-to-order transition within a novel SF1/U2AF65 interface, indicating a phosphorylation-dependent control of pre-mRNA splicing factors.
Links
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Statistics
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PSSM-Id: 465080
Aligned: 82 rows
Threshold Bit Score: 100.376
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EER35712                       25 RETKWSGkprRYVQLGEQTFDTMITGHLTEEQLTAYQEYFRSEEITHLLNIARqqhrpvPEILPSakfessdpqlKYKRD 104
A0E4D7                        130 SHTRWGPdyeKTFQPP---SLNCIPPDLSIDDLEYIIRLYCLDDINQKLQQPIdsk----------------mddPDLRS 190 Paramecium tetraurelia...
WGS:AAGF:cds.TTHERM_00444570A 159 KFSRWGPeyeKTFHPP---PLNYIPQNINDDDLEYIIRLYRLDEIQNKMINKIqtl----------------eddSDCRS 219
EGR33369                      129 aPSRWGAeyeKTFHPP---LLNYIPLQISDDDFEYLIRLYRLDEINNKQLYKTkni----------------lddEDCRS 189
WGS:AAFB:cds.EHI_193510A       25 RVSRWDRkirDVLPN----IPVHIPPSLDEKYWDTLAIRIRYEELQYALGTHRlgl-----------------ntERDRT 83 
XP_001315055                   12 RKSKWGPedeKTVMSN---VANILPPNLPPDVLNAFLLRFQLEEVQYKMNHLQeerkniLyg------------eTLINN 76 
EAY11301                        5 THSKWSLignSTNIPN---YPTVLPPGMDSVTLQSVLLRAQFEEIQFKLAHLKteaprvIQF-------------DEVLS 68 
EGC38748                       47 RLSRWDStpsMDS-SPFSSIFKTLPPGLTDEQISALILRLRIDEITKKVTIGP------IEITDR----------DRDRS 109
Q54BM5                         60 RLSRWDTpltNDGVSPFSSIFKTLPPGLTDEQIAALILRLRVDEITKKITIGP------IEFTER----------DRERS 123 Dictyostelium discoideum...
EGG21812                       50 RKNKWDVdknPAVSLP--GIPKTIPPGLTDDQLSSLLIRVRIDEITKKLVTGP------IEYDTK-----------EDRS 110

EER35712                      105 PSPPPKYDRDGMKINTRDRVVREALEKERHEMVELAAGSIKGYMPPSNYT 154
A0E4D7                        191 PSPEPVYDQHGKRVNTREVRRKENFQRIKCSLTEECIKINKNFVPPHDFK 240 Paramecium tetraurelia
WGS:AAGF:cds.TTHERM_00444570A 220 PSPDPIYNEQGKRINTRDYREQESLQKEKYNLIEEAMRINPAFIPPHDFK 269
EGR33369                      190 PSPEPIYNESGKRINTRDIVEYETIQKEKHNLIEECMKINPTFVPPHDYK 239
WGS:AAFB:cds.EHI_193510A       84 PSPPKQYNENQQEI-TREMRREEKLKNERLYVVDRAIEIYPSFRIPAELa 132
XP_001315055                   77 MNP----DQRG--FIHPDVRARDALVKERSQILNAIEKIFPVFRPPLslk 120
EAY11301                       69 KKNTLVYDQNGYRKDPTQVRARDSLFQERKEVIHAIDSIYPLFRVPgsir 118
EGC38748                      110 PSPPPIYDSNGKRSNTREQRIKDKLQKERHHLIVTAQRISPTYKPPSDYQ 159
Q54BM5                        124 PSPPPTYDNNGKRSNTREQRIKEKLQKERHQLVVTAQQINPTYKPPSDYQ 173 Dictyostelium discoideum
EGG21812                      111 RSPSPVYDNTGKRTNTREQRTRDKLAKERHNLVTNAQQINPNFKPPSDYQ 160
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