Conserved Protein Domain Family
CYP709

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cd20641: CYP709 
cytochrome P450 family 709
Cytochrome P450 family 709 (CYP709) belongs to the plant CYP72 clan, which is generally associated with the metabolism of a diversity of fairly hydrophobic compounds including fatty acids and isoprenoids, with the catabolism of hormones (brassinosteroids and gibberellin, GA) and with the biosynthesis of cytokinins. Arabidopsis thaliana CYP709B3 is involved in abscisic acid (ABA) and salt stress response. CYP709 belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410734
Aligned: 7 rows
Threshold Bit Score: 688.415
Created: 31-Jul-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                          #   #      
F4IK45    139 LPHLQQWKSQyGETFLYWQGtdPRLCISDHELAKQILSNKFVffsksktkPEILKLSG-NGLIFVNGLDWVRHRRILNPA 217 thale cress
AAC34228   84 LPHLQQWKSQyGETFLYWQGtdPRLCISDHELAKQILSNKFVffsksktkPEILKLSG-NGLIFVNGLDWVRHRRILNPA 162 thale cress
AAG46147   80 VPHFVAWKELyGTPFLYWFGpqPRICVSDYNLVKQILSKKYGhfvkndahPAILSMIG-KGLVLVEGADWVRHRRVLTPA 158 Japanese rice
ACN29332    5 LPPFHRWVVEyGRTFLYWIGptPAIFSVDLELIKEVLTDRTGlfgkdfmiPVFKVLLG-NGLILANGDDWKRHRKVVLPA 83  maize
AAK73105   83 MPQYRAWVSLyGKVFLTWSGstPALFVGSHDMVKRVLFDKAGlygktdpgPTILSLMG-RGLVFTDGDDWSRHRRVVHPA 161 maize
Q9ASR3     82 LPHYQKWMSQyGETFLYWNGtePRICISDPELAKTMLSNKLGffvkskarPEAVKLVGsKGLVFIEGADWVRHRRILNPA 161 thale cress
Q9T093     84 FPQYHQWMSQyGDTFLFWTGtkPTIYISNHELAKQVLSSKFGftiipvkrPEVFILFG-KGLSFIQGDDWIRHRRILNPA 162 thale cress
Feature 1     #                                                    #                          
F4IK45    218 FsmdkLKLMTQLMVDCTFRMFLEWKKQrngvete---qfvlisrEFKRLTADIIATAAFGSsyaeGIEVFKSQLELQKCc 294 thale cress
AAC34228  163 FsmdkLKLMTQLMVDCTFRMFLEWKKQrngvete---qfvlisrEFKRLTADIIATAAFGSsyaeGIEVFKSQLELQKCc 239 thale cress
AAG46147  159 FtmdkLKVMTKTMASCAECLIQGWLDHasnsksie--ievefskQFQDLTADVICRTAFGSnsekGKEVFHAQKQLQAIa 236 Japanese rice
ACN29332   84 FnherIKSMSAVTAEATEQMAQRWCEQlilhsgarqaaeiqvdrAICDLTAEIIGRAAFGTslqeAGEVLLLMHEMQKMg 163 maize
AAK73105  162 FamdkLKSMTGAMAACAAEVIRGWEARaaasgdrg-evtvevgqQFTELTADVISHTAFGSsyrqGKEVFLAQRELQFIa 240 maize
Q9ASR3    162 FsidrLKIMTTVMVDCTLKMLEEWRKEstkeetehpkikkemneEFQRLTADIIATSAFGSsyveGIEVFRSQMELKRCy 241 thale cress
Q9T093    163 FsmdrLKAMTQPMGDCTLRIFEEWRKQrrngevl---ikieiskEFHKLTADIIATTAFGSsyaeGIELCRSQTELEKYy 239 thale cress
Feature 1                                                                                     
F4IK45    295 aaaltd-lyfpgiqYLPTPSNLQIWKLDMKVNSSIKRIIDARltse--skdYGNDLLGIMLTAAssnes----------- 360 thale cress
AAC34228  240 aaaltd-lyfpgiqYLPTPSNLQIWKLDMKVNSSIKRIIDARltse--skdYGNDLLGIMLTAAssnes----------- 305 thale cress
AAG46147  237 iatiln-lqlpgfkYLPTKRNRCKWKLENKLRNTLMQIIQSRitse--gngYGDDLLGVMLNACfsteqgek-------r 306 Japanese rice
ACN29332  164 aaamv---dapilwYLPTRRNLTVRRLDKLLRAKITAMMAARvaan-cgggYGDDLLGLLLEAWspepgrrhagsddegt 239 maize
AAK73105  241 fasinsgmrvpgtqYAPTKANVRRWQLERTVRGTLMAIIDERlaaakeakgYGSDLLGLMLEANagdgggk--------r 312 maize
Q9ASR3    242 ttslnq-vsipgtqYLPTPSNIRVWKLERKMDNSIKRIISSRlqs---ksdYGDDLLGILLKAYntegk----------- 306 thale cress
Q9T093    240 issltn-vfipgtqYLPTPTNLKLWELHKKVKNSIKRIIDSRlkskcktygYGDDLLGVMLTAAksney----------- 307 thale cress
Feature 1                    ##  ##  ##  #                                                   #
F4IK45    361 -ekkmsIDEIIEECKTFFFAGHETTANLLTWSTMLLSLHQDWQEKLREEVFNECGkdkipd-aetcsKLKLMNTVFMESL 438 thale cress
AAC34228  306 -ekkmsIDEIIEECKTFFFAGHETTANLLTWSTMLLSLHQDWQEKLREEVFNECGkdkipd-aetcsKLKLMNTVFMESL 383 thale cress
AAG46147  307 delilcVDEIIDECKTFFFAGHETTSHLLTWTMFLLSVYPEWQDRLREEVLRECRkenpn--admlsKLKEMTMVLLETL 384 Japanese rice
ACN29332  240 ttttltTGEVIDECKTFFGAGQETTATLLVWTMFLLSTHPQWQDKVREEVLREFRgdvpt--tdtlsRLKLLHMVLLETL 317 maize
AAK73105  313 qqqamsMDEIIDECKTFFFAGHDTTSHLLTWAMFLLGTHPEWQQRLREEVVRECGgaevplsgdalnKLKLVTMVLYETL 392 maize
Q9ASR3    307 -erkmsIEEIIHECRTFFFGGHETTSNLLAWTTMLLSLHQDWQEKLREEIFKECGkektpd-setfsKLKLMNMVIMESL 384 thale cress
Q9T093    308 -erkmrMDEIIEECKNFYYAGQGTTSILLTWTTMLLSLHQGWQEKLREEVFNECGkdkipd-tdtfsKLKLMNMVLMESL 385 thale cress
Feature 1             # #                       #                                     ###   ##
F4IK45    439 RLYGPvLNLLRLASEDMKLGn-LEIPKGTTIILPIAKMHRDKavWGSDADKFNPMRFANGlsraanhPNALLAFSMGPRA 517 thale cress
AAC34228  384 RLYGPvLNLLRLASEDMKLGn-LEIPKGTTIILPIAKMHRDKavWGSDADKFNPMRFANGlsraanhPNALLAFSMGPRA 462 thale cress
AAG46147  385 RLYPPvIFMFRKPITDMQLGr-LHLPRGTAIVIPIPILHRDKevWGDDADEFNPLRFANGvtraakiPHAHLGFSIGPRS 463 Japanese rice
ACN29332  318 RLYPPiVYIQRRTASDVVLRgmLQVPEGTVVSIPIGLLQRDRevWGSDADEFNPLRFSNGvaraatdPHALLSFSLGPRA 397 maize
AAK73105  393 RLYGAvPLIARRATAGADLCg-VKVPKGTLLLIPIAMLHRDEevWGADAGAFNPLRFRDGmgraathPNALLSFSLGPRS 471 maize
Q9ASR3    385 RLYGPvSALAREASVNIKLGd-LEIPKGTTVVIPLLKMHSDKtlWGSDADKFNPMRFANGvsraanhPNALLAFSVGPRA 463 thale cress
Q9T093    386 RLYGPvIKISREATQDMKVGh-LEIPKGTSIIIPLLKMHRDKaiWGEDAEQFNPLRFENGisqatihPNALLPFSIGPRA 464 thale cress
Feature 1     ###  ##                                         
F4IK45    518 CIGQNFAIMEAKTVLAMILQRFRl-nLSADYKHAPAdhlTLQPQYDLP 564 thale cress
AAC34228  463 CIGQNFAIMEAKTVLAMILQRFRl-nLSADYKHAPAdhlTLQPQYDLP 509 thale cress
AAG46147  464 CIGQNFAMLEAKLVMAMILQKFSf-aLSPKYVHAPAdliTLQPKFGLP 510 Japanese rice
ACN29332  398 CTGKSFGIIEAQIVMAVILRNFSf-sLSPTYVHKPKyvvSLTPKCGMP 444 maize
AAK73105  472 CIGQDFAMLEAKATLALILRRFAf-rVAPEYVHAPAdflTLQPSKGLP 518 maize
Q9ASR3    464 CIGQNFVMIEAKTVLTMILQRFRfisLCDEYKHTPVdnvTIQPQYGLP 511 thale cress
Q9T093    465 CIAKNFAMVEAKTVLTMILQQFQl-sLSPEYKHTPVdhfDLFPQYGLP 511 thale cress

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