Conserved Protein Domain Family
ABC1_ADCK3-like

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cd05121: ABC1_ADCK3-like 
Activator of bc1 complex (ABC1) kinases (also called aarF domain containing kinase 3) and similar proteins
This family is composed of the atypical yeast protein kinase Abc1p, its human homolog ADCK3 (also called CABC1), and similar proteins. Abc1p (also called Coq8p) is required for the biosynthesis of Coenzyme Q (ubiquinone or Q), which is an essential lipid component in respiratory electron and proton transport. It is necessary for the formation of a multi-subunit Q-biosynthetic complex and may also function in the regulation of Q synthesis. Human ADCK3 is able to rescue defects in Q synthesis and the phosphorylation state of Coq proteins in yeast Abc1 (or Coq8) mutants. Mutations in ADCK3 cause progressive cerebellar ataxia and atrophy due to Q10 deficiency. Eukaryotes contain at least two more ABC1/ADCK3-like proteins: in humans, these are the putative atypical protein kinases named ADCK1 and ADCK2. In algae and higher plants, ABC1 kinases have proliferated to more than 15 subfamilies, most of which are located in plastids or mitochondria. Eight of these plant ABC1 kinase subfamilies (ABC1K1-8) are specific for photosynthetic organisms. ABC1 kinases are not related to the ATP-binding cassette (ABC) membrane transporter family.
Statistics
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PSSM-Id: 270691
Aligned: 295 rows
Threshold Bit Score: 146.486
Created: 20-Mar-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative ATP
Feature 1:putative ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                          ####   # #         # #     
NP_064632 299 RVRQSADFMPLKQMMKtln---ndLGPNWRDKLEyfeeRPFAAASIGqvHLARMKGG---REVAMKIqyPGVAQSINSDV 372 human
NP_969171 285 GLENSVRPVPWSQVEKlln---seNGNYKFTYFEr---KALGVGTMAqvHRAKVIIDgqrRDVVVRFikPGIADRVEEDK 358 Bdellovibrio bacte...
EGJ34370  121 RLQYEAIGFPMAIVRStie---seLGAPMEKIFQdfdeTPLAAASIGqvHRATLRSKrknVPVIVKIqrPNLAEAFKRDL 197 Lyngbya majuscula 3L
CBD77728  105 RLQNRAHGFPAHYARSiie---eeLGAPIDSIFVefddRPLAAASVGqaHRARLKDNg--VEVVVKVqrPNAKASFEKDF 179 Chondromyces crocatus
AGC46600  103 DLHDRATAFPPGVARRyle---eaFGRPLESVFSefspVPVAAASIGqcHIARLRQGg--HLVAVKLqrPDAPSMFWRDL 177 Myxococcus stipita...
CBD77730  112 LTRDRAMPVPMGVLRKvideelqkRGATVDQVFDelheRPMNARAFSqfHLGRLKEGg--HQVVVRVrpPDAVQRAKTDW 189 Chondromyces crocatus
EFH01375  134 HLQHRAIGFPPEVARRvie---teLGASVDDIFSefdpLPFAAASLSqvHAARLSNG---REVVVKVlrPGIRKKFERDL 207 Methylosinus trich...
CCE88383  229 KLLDAVLPFPSSEAVKave---raTGKPIAETFLlfdpTPIGSASIAcvYQAVLKNG---DKVAVKVrrPGIGTVFATDL 302 Sorangium cellulosum
ACY13734   75 KLLDASKPFPLELAIQtie---asLGRPVSEIFAeiepEPIGSASIAcvWSATLLNG---ERVAVKVrrPKVERGFIADI 148 Haliangium ochrace...
ACY13735  116 RLEDKQPAMPLAKAVDefe---rhLDKTLTQIFEvfdpVALRSSSLDciYQASLHGG---RKVIVRImrPEAPLRIHAEQ 189 Haliangium ochrace...
Feature 1                                                                          #          
NP_064632 373 NNLMAVlnmsnm-----lpeglfPEHLIDVLRRELALECDyqr----eaACARKFRDLl-------KGHPFFYVPEivde 436 human
NP_969171 359 RILMDVaeildsnpefrktgapkLTPVVQDITDTVLAELSqedtvarqkLAATRYEKMafmntpdyKNEIQFHVPKiydg 438 Bdellovibrio bacte...
EGJ34370  198 DLIKVVakvlisf---nfmsylrLDEAVSELDKIFNEELDyry----eaSNTRNMRKT--------LKQHKIYVPKiynk 262 Lyngbya majuscula 3L
CBD77728  180 VLLRRLvrfltfi---rfspesrWSEMYTEVESAILEELDyrq----eaTSLRRMRKN--------LRDHKIYVPKvfls 244 Chondromyces crocatus
AGC46600  178 DLFQSLlgplsll---psselfnWEDALWELQDIVKEELDyry----eaAALATFRKKl-------RKHENIYVPQvfte 243 Myxococcus stipita...
CBD77730  190 AHMQFFlglferf---gilphlrWKALMFEVKKATDDQLDfrt----eeAEVRRISKI--------LRSRRIYVPRlhrr 254 Chondromyces crocatus
EFH01375  208 AVLRYLancldrl---prlrilrLRDAVAELEQIFLEETDyry----eaANAKQLRKN--------INSRKIKIPKvygr 272 Methylosinus trich...
CCE88383  303 RAIGWVmrvmetl---aivrpglMQNFVREFASTIMEELDfrmeayhqaIFLRESRKNn------lGKKRFFTAPKlyye 373 Sorangium cellulosum
ACY13734  149 ELVAKFtrmleti---svirpgfLENLRNEMRDMFMDELDfvq----eaNYQIMFRRMak-----kAKLRWVSVPKvyve 216 Haliangium ochrace...
ACY13735  190 IALKRLvkllawl---fpsyeerLVALGDELPFIEKEIVDfvt----iaRLHRLLKKNlk----ewKVSNKFYVEKvfle 258 Haliangium ochrace...
Feature 1             ####                                                      #   ## #      
NP_064632 437 LCSPHVLTTELVSGFpldqaeg--------------lsqeirnEICYNILVLCLRELFef-hFMQTDPNWSNFFYDp--q 499 human
NP_969171 439 KKGSKFMVQELVIGKkldkevamy----------keiapdmkrVIIEQMARVWAQEVMfgggFYHSDLHQGNFMIQvtep 508 Bdellovibrio bacte...
EGJ34370  263 YSKRRVLVMEYIDGVlasdyikvlardpvrasqwqdendfdpkKAGETMFISLLRQVFed-nLYHGDLHPGNIIFLr--- 338 Lyngbya majuscula 3L
CBD77728  245 FCTDRVLVMEMVHGVymseyiqtvvanpdrarawlkenqisasRLGKRLWFSYLRQLFed-nLYHCDLHPGNILVMr--- 320 Chondromyces crocatus
AGC46600  244 WCRPNVIVLEYIPGVfmsellhvketdpekvlrwqrdnnvdleVVGRTLLQSLYRQMFee-hLFHGDLHPGNIVLLk--- 319 Myxococcus stipita...
CBD77730  255 YTGERLLVSEYIRGVsvedldvalrqdregvalwmqqnginppRICRRLFQARLELLFeh-nMFYTELLPRNVLLLr--- 330 Chondromyces crocatus
EFH01375  273 YTTANVIVLERIHGVlmsdlirvrekdpervrawleengvdrkRVGTRLLISFMRQLFqd-nFFHADLHPGNIILLr--- 348 Methylosinus trich...
CCE88383  374 LSNEEVIVEEFAGGMwmweilaavesndpvafarmrelnidpqVVAKRLLWVQFWSLLvs-pMFHADPHPANIVVQq--- 449 Sorangium cellulosum
ACY13734  217 YSSEIVLTSQFVTGYlatdvlkaleendlemlrelksknidieKIGKRVLALGYWSRLes-fFFHSDLHPGNVFILp--- 292 Haliangium ochrace...
ACY13735  259 YCSTNVIVSEYVETYwlsevlcayesndrealeklharnidpkKCAARMFEFGLWSMLen-sFSLVSPRVGQFAVMn--- 334 Haliangium ochrace...
Feature 1           ##                                                 
NP_064632 500 QHKVALLDFGATREYDRSftdl---------------yiqiIRAAADRDRETVRAKS 541 human
NP_969171 509 KIIVNILDYGMGGVITRDmqtqvmllgagtellnseimsraFWNIADKEKSTVTQSR 565 Bdellovibrio bacteriovorus HD100
EGJ34370  339 RSKVAFIDMGSVGSLDRElrvt---------------yneyTNALSDGDFAKAANYI 380 Lyngbya majuscula 3L
CBD77728  321 KGRITLIDFGSVATSDRSqlek---------------frllYKAMGDKDFRKVAEMF 362 Chondromyces crocatus
AGC46600  320 DSQVCLIDFGSVGRLDIDflds---------------fhgyMKALAERDFETAILNM 361 Myxococcus stipitatus DSM 14675
CBD77730  331 RNRIALLTLNTIGTLETTvvrq---------------yqmlCQALVAEDYTKVCDSF 372 Chondromyces crocatus
EFH01375  349 DSRVALIDLGSIGSLDREfltl---------------yrglQRALAEQDFGKAADLQ 390 Methylosinus trichosporium OB3b
CCE88383  450 DSKLVFIDFGACGTLSVGkrel---------------frdvNVYQIQKDIVGVVRAT 491 Sorangium cellulosum
ACY13734  293 GSKIALIDFGSCGVNYSFmaea---------------efegTRRMLMDDIPGAINAS 334 Haliangium ochraceum DSM 14365
ACY13735  335 HSKIMITQLGTVGTVGRYrrrm---------------yttlFQKLLAHDFEGMAELL 376 Haliangium ochraceum DSM 14365

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