Conserved Protein Domain Family
PseudoU_synth_ScPus3
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cd02569: PseudoU_synth_ScPus3 
Pseudouridine synthase, Saccharomyces cerevisiae Pus3 like.
This group consists of eukaryotic pseudouridine synthases similar to S. cerevisiae Pus3p, mouse Pus3p and, human PUS2. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). No cofactors are required. S. cerevisiae Pus3p makes psi38 and psi39 in tRNAs. Mouse Pus3p has been shown to makes psi38 and, possibly also psi 39, in tRNAs. Psi38 and psi39 are highly conserved in tRNAs from eubacteria, archea and eukarya.
Links
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Statistics
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PSSM-Id: 211336
Aligned: 17 rows
Threshold Bit Score: 366.996
Created: 3-Mar-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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probable active
Feature 1:probable active site [active site]
Evidence:
  • Comment:D of active site is key conserved residue
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                  ####               
P31115     96 LRFAYLGWNYNGLAVQKEytp-----lpTVEGTILEAMNKCKLvpsmv----lqdykFSRCGRTDKGVSAMNQVISLEVR 166 baker's yeast
CAD21201  144 LKFAYLGKNYNGFEYQSSakm-----psIEEELWKALVKSCLIfperpdevdfgpweYSKCGRTDRGVSAFGQVIGIRVR 218 Neurospora crassa
XP_393954  76 LKFYYLGWDYNGFVVQESid-------nTIEEHLFEALIKSCCiesr------etsnYHRCGRTDKGVSSFSQVISLDIR 142 honey bee
CAG78377   88 IRFSYLGWNYGGLAVQHEdtp-----lpTIEGTILSAMQRCRLipesas---lfdldFSRCGRTDRGVSAFSQVIALKVR 159 Yarrowia lipolytic...
CAB61771   96 FKFAYCGWNYNGLAYQLEptp-----lpTVEGKVFEALLRAHLitdp------sscsFSRCGRTDKGVSAMGQVISLNVR 164 fission yeast
EAL62978   89 FKLSYVGWPFFGFAAQDCse-------eTIENYLIKAFLKTSLipdi------ktanYFKSGRTDKGVSAYGQVISLYVR 155 Dictyostelium disc...
EAL19370   77 LLISYHGWPYSGLALQAPatpdg-ppvpTVEAELLAALEKTRLiaegkg---wegcgFGRCGRTDRGVSGEGQVVNLWVR 152 Cryptococcus neofo...
EAK85418  133 LRFSYDGAGYSGLAAQNTtvpgsgsslpTVEGVLWDALCTARLvdpalg---mdgagFSRCGRTDRGVSAAGQVVALWVR 209 Ustilago maydis 521
Q09524     34 IQFFYLGWEHDGLVQQPHtq-------nTVENHIMQALIKTHLiedw------tkcdFSRCGRTDKGVSAFKQTAAMVVR 100 nematode
AAX81000   29 LRLAYHGHIYCGLVRQAEtp-------nTVEAYLVAALERLRFveps------gpkdFSRCGRTDKGVSALGNVVSFTSR 95  Trypanosoma brucei

Feature 1                                                                                     
P31115    167 SNltdeeqrdp----------------------------------------tndsreipyVHVLNQLLPDDIRISAVCLR 206 baker's yeast
CAD21201  219 SNkplpkeepeqtgneeddvvmveaaqqq----akdsekaaaevdhqkpewdpiadeipyCRVLNRLLPPDIRIMAWAPD 294 Neurospora crassa
XP_393954 143 SKlnpedqyk-------------------------------------------ledelpyCKILNRLLPSNIRCIAWCPV 179 honey bee
CAG78377  160 SKlspeeqqda----------------------------------------andnkelnyIHILNQLLPPDIRIYSVALR 199 Yarrowia lipolytic...
CAB61771  165 HSerrp---------------------------------------------------iiyCDVLNRLLPADIRITGYAFP 193 fission yeast
EAL62978  156 SNlkegegiippkdqsggpisnrtksnkt----eltknndnekarkgnkksieddeelpyIKMLNGVLPPEIRILAWAPV 231 Dictyostelium disc...
EAL19370  153 SSrkrgdgggelgdgwrdavepevekmektvivqedeekgvkekkskviqpprqpsefpyPKLLNSVLPPSIRILAWSPI 232 Cryptococcus neofo...
EAK85418  210 SKklnqwpdrlehqeqfsplassllsk---------pspqewddlqekrnaklegtelpyVQILNRILPSSIRIQAWSPV 280 Ustilago maydis 521
Q09524    101 SLcpgdsgvfwsdstqe----------------------------hqkvdykasgeelpyVKMLNGVLPKTIRVFAWAPV 152 nematode
AAX81000   96 ASswatdeq--------------------------------------------qqppldyCEKLNNVLPPTIRIVGWSYV 131 Trypanosoma brucei

Feature 1                                                                                     
P31115    207 PpPNFDARFSCVHRHYKYIFNgk-------------------------------nLNIEKMSKAASYFVGERDFRNFCKL 255 baker's yeast
CAD21201  295 LpPNFSARFSCRERQYRYFFTqpafapmpstlepp------lassghksggkqgwLDIDMMRKAAKMFEGVHDFRNFCKI 368 Neurospora crassa
XP_393954 180 P-NDFSARFNCKFRTYKYFFPrg-------------------------------nLNIDAMNKAVKYIIGEHDFRNICKM 227 honey bee
CAG78377  200 LpEGFDSRFSCEYRHYRYFFHkg-------------------------------dLDIDLMRQAAKLYLGEHDYRNFCKV 248 Yarrowia lipolytic...
CAB61771  194 P-EGFDARFSCKQRHYKYLFTkdyp---------------------------ggsLDIDRMNEAAALYLGEHDFRNFCKI 245 fission yeast
EAL62978  232 P-FHFNARFSTLSRTYKYFFNpn-------------------------------gLDLNLMKEASKLYLGEHNYINFCKI 279 Dictyostelium disc...
EAL19370  233 P-ASFDSRFSCTYRHYRYAFHtrptp-------------------------tspeLDLELMRQGAQLLLGEHDYRNFCKL 286 Cryptococcus neofo...
EAK85418  281 R-SNFSSRFDCVYRHYKYFFPagpprlfyprsktingedgvafsvgggqdagatrLDIALMRDAARRLLGEHDFRNLCKI 359 Ustilago maydis 521
Q09524    153 A-QTFNARFDCNRRTYKYSFAka-------------------------------dLNLEKMRQGAELLVGEHDFSNFCQI 200 nematode
AAX81000  132 N-ADFDARFSCTGRTYRYYFCnr-------------------------------gLNLEAMRKAVGYLKGVHNFRNFCKT 179 Trypanosoma brucei

Feature 1                                                                       #             
P31115    256 Dgskq--itnFKRTIISSKILPls------------------------etFYCFDLVGSAFLWHQVRCMMAILFLVGQSL 309 baker's yeast
CAD21201  369 Dpgkq--itnFSRRVFESDIVEvkdlesdlpylglpefqppagsdgphpkVYYFHVRGSAFLWHQIRHMVAVLFLVGQGL 446 Neurospora crassa
XP_393954 228 Dvang--vinYIRKVINAEVRMyrqdfr----------------nisgydMYQLIITSQAFLWHQIRCLMGVLFLIGEGK 289 honey bee
CAG78377  249 Dgskq--lahHNRVMLEAEIEQls------------------------ddIYYFNLKGRAFLWHQVRCMMAILFLVGQKL 302 Yarrowia lipolytic...
CAB61771  246 Daskq--itnYHRRILSSKVICidp----------------------stgLYAFDLQGTAFLWHQVRCMMAILFLIGQKL 301 fission yeast
EAL62978  280 Dvnv----ksFMRVILQFDIEKven-----------------------seLYVATIKGFAFLWHQIRCMMAVLFLIGQKK 332 Dictyostelium disc...
EAL19370  287 Dgskq--ienHTRGVLKAWFEGgesqg-------------------vgdgMMVFNLIGTAFLWHQVRHIIAVLFLVGAKL 345 Cryptococcus neofo...
EAK85418  360 Daskq--itnYRRRIDGVSIDRvsshwpskndgv----edddggeegeehMYVLNLRGTAFLYHQVRNIMAILFLVGARL 433 Ustilago maydis 521
Q09524    201 DmnekrllqsYVRKVYEVKVEQvsthpe-----------------ndmysMVELTVSGSGFLWHMIRYIVTILQEIGREN 263 nematode
AAX81000  180 Dvvn---vnnYERHVRHADIVGsdml---------------------pdlVSYFEIEANSFLYNQIRCTMEVLFLVGRCL 235 Trypanosoma brucei

Feature 1                                                                                     
P31115    310 EVPEIVLRLTDIEKTpqrpvy----------------------------------------------------------- 330 baker's yeast
CAD21201  447 EPPSIVQQLLDVEKNprkpny----------------------------------------------------------- 467 Neurospora crassa
XP_393954 290 EEAEIMLELLDIENCpkkpqy----------------------------------------------------------- 310 honey bee
CAG78377  303 EKPSVITDLLNPEKYpgrpvy----------------------------------------------------------- 323 Yarrowia lipolytic...
CAB61771  302 EPASLINDLLDIKKVptkpiy----------------------------------------------------------- 322 fission yeast
EAL62978  333 ANISLITQLLDTNKTitkppy----------------------------------------------------------- 353 Dictyostelium disc...
EAL19370  346 EPPSIVSDLLDVKRFpskpny----------------------------------------------------------- 366 Cryptococcus neofo...
EAK85418  434 EPPSVIEELMNTESGriaadrvkmqlatqrvaratanseqdheaikwwlpvnatscsasssqstpedvpmwmhsslysss 513 Ustilago maydis 521
Q09524    264 EQPSLISQLLDLKKYpsrpqy----------------------------------------------------------- 284 nematode
AAX81000  236 EEPEVVKQLLDCGDRkpvyp------------------------------------------------------------ 255 Trypanosoma brucei

Feature 1                                  
P31115    331 --------------emandiPLLLYDCKF 345 baker's yeast
CAD21201  468 --------------vmadevPLVLWDCIF 482 Neurospora crassa
XP_393954 311 --------------nlaheiPLNLWYCEY 325 honey bee
CAG78377  324 --------------dmahdvPLVLYDCTF 338 Yarrowia lipolytica CLIB99
CAB61771  323 --------------dmaseyPLILYDCDF 337 fission yeast
EAL62978  354 --------------emasevPLVLFDCGY 368 Dictyostelium discoideum
EAL19370  367 --------------tmghplPLTLHHCGY 381 Cryptococcus neoformans var. neoformans B-3501A
EAK85418  514 addelevyatkpnyemaadrPLVLWECGF 542 Ustilago maydis 521
Q09524    285 --------------tlasdtPLCLFDCGY 299 nematode
AAX81000  256 ---------------ladatPLVLWECHF 269 Trypanosoma brucei

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