6Z3A


Conserved Protein Domain Family
LCD1

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pfam09798: LCD1 
DNA damage checkpoint protein
This is a family of proteins which regulate checkpoint kinases. In Schizosaccharomyces pombe this protein is called Rad26 and in Saccharomyces cerevisiae it is called LCD1.
Statistics
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PSSM-Id: 462906
Aligned: 27 rows
Threshold Bit Score: 247.231
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6Z3A_D        77 MLRDKINFLNIEREKEKNIQAVKVNELQVKHLQELAKLKQELQKLEDEKKFLQMEARGKSKRevitnvkppsttlstntn 156 Saccharomyces c...
EMG49723      74 tLRAQLLQLQNQKQQEITELKQTYDTLKQTSEEQMLNLKNTVQRLEDEKKFLNNELISTTA------------------- 134
XP_002549810  70 tLRAQLLQLQNQKQKEVADLKDTFNTFKQSTEDQVASLKNTVQRLEDEKRFLSNELITTND------------------- 130
XP_001528384 127 tLQAQLLQLQNQKRDELNDLRQAYEALKKSKDAETEALKEAVHKLEDDRKFLKNELITSNA------------------- 187
CCE43149      86 tLKAQLISLQNAKRDELNTLRQSYDAFKKSKEEEAAALRDVVLKLEDDRKFLKNELVTTNA------------------- 146
ABN64347      36 ILRAQLEQLQKQNQKEIHQLRDQKDQLYRQNEDQVNVLKHAVQKLEDEKKFLNNELKTTTH------------------- 96 
CCE87077      70 ILRAQLDLLQRQKHDEIKQLVDAQEASRLRDEEKMQALKFTIQRLEDEKRFLNNEVRNLAS------------------- 130
EDK39210      63 ILRAQLEQLQNSSRDELAKLRETLALEKHNKDGQVESLRAAVQSLEDERKFLNNELRATSVA------------------ 124
Q6BPF5        66 ILRAQLQQLQNQKQEDLNKLKESHNISKVQNDEQLKALKFTVQKLEDERKFLNNELRGATA------------------- 126 Debaryomyces ha...
EEQ38026      37 ILRAQLEALQSSKNAEAERLRRDLEAARSAARGHIDALKSSVDKLEDEKRFLDNEIRALS-------------------- 96 
6Z3A_D       157 titpdsssvaieakpqspqSKKRKI--SDNL------------------------------------------------- 185 Saccharomyces c...
EMG49723     135 -------------------VKRRKV--TTTdtpntttfveshstppppapvpaqappqpqqpptpnqteptqlttqydyk 193
XP_002549810 131 -------------------LKRRKIvqnkvtppvvsnsphnedsiiee---------pvisvqpnneisivssepeitvk 182
XP_001528384 188 -------------------LKKRKIvlTQEDgllatmgttngnttvnasg-----------maetpptsvatdvevirek 237
CCE43149     147 -------------------LKKRKI--NGNDntnssqqtrpqvstemdq--------------svfeaslesegtsipsq 191
ABN64347      97 -------------------NKRRKL--TPPVierqppshstplspsq-----------------lsmegsassvelphkh 138
CCE87077     131 -------------------FKRRRV--DSGRsedlstttespvskvsrs--------------sgtqshsetsenssrsv 175
EDK39210     125 -------------------LKRRKV--GESQtanitfsgtmgattlatpstqskspaiskqknssnsgqyrvpesdtrpl 183
Q6BPF5       127 -------------------LKRRKL---PSRaddsmmdidvmpildtqqang--------tryqheraesiepetelrpi 176 Debaryomyces ha...
EEQ38026      97 -------------------AKRRKV--EAAEsrpqsrpaklssae----------------------sspaeqpevdvrp 133
6Z3A_D       186 LKKNMVPLNPnriipdETSLFLESILLHQIIGADLSTIEILNRLKLdyITEFKF--KNF---VIAKGAPIGKSIVSLLLR 260 Saccharomyces c...
EMG49723     194 PVQKIIKLQN------DSSLLIDQLWNNSIIGSSRTSFEYLSKICL--DFDLELn-SGL---VILKQTSISSSIVEFLMI 261
XP_002549810 183 PIQKIIKLQN------DSSLLIDQLWNHSIIGSKRTSFEYLSKICI--DMDLTLs-SGL---KIVKRTSLSSGIVEFLMI 250
XP_001528384 238 VVQKIVRVEN------DTVVFIDHLRKYIMLGTNRSSFSFLNKICF--DSDLDFnfETMsktQIKKQQAISPVLLDAIMN 309
CCE43149     192 TIQKVIRVQH------ETSALIDQIWRYCIPGSKRSTIEYLSKICF--NFDI----DTLygyKLEKKTAIASFISNVLMS 259
ABN64347     139 LAQQIFQQQQ------TSALYTDHIWNHCIVGSNRTSLSYLGKISI--HFDVVV--GDL---SLVKREPLSRSIVDYMML 205
CCE87077     176 LAQRVIKIQN------DSSLFTDHIWSHCINGSRRSTLKYLSKICL--DDDIQF--DGF---KVNAKMPVSTAITEYLML 242
EDK39210     184 VPQKVIKIDN------DASLLEDHLWNHCINGTKRTTVSYLSKIYL--DRDVRI--RDF---VLHKKQPISTAVTEFLMV 250
Q6BPF5       177 LPQKIIKIQN------DASLFTDHIWNHCINGSKRSTLNYLSKIYV--DIDILV--HDF---KTHAKMPLSTAITEYLML 243 Debaryomyces ha...
EEQ38026     134 GDGVVIRVQD------EWSQFCDYLHGYTINGSSRTCMGFLATICV--EESVGSsgFGRr-lRLAPRVPVSSAVWEYLLE 204
6Z3A_D       261 CKKTlTLDRFIDTLLEDIAVLIKEIS-VHPNESKLAVPFLVALMYQIVQFRPSATHNLALKDCFLFICDLIRIYHHVLKV 339 Saccharomyces c...
EMG49723     262 NKNN-RLDKLIEIFTLSLIQLVERLL---KQKSILSIPFLLSLIHCSISFRPAALTKALITQLLKRVSKITEGLSFLLNS 337
XP_002549810 251 NKNN-RLDKLVENFTLSLIQLIEKLL---KSKSILSVPFLISLIHCSINFRPAALTKSLISQLLKRVSKIAEGWAFLLDS 326
XP_001528384 310 LREN-RLDDMIDKVNTLLMNIIEKSI---QNDLILPVPFLVSLMHCSLTFKSAAVTERLIKKLVVWLSDFAAKYVYLLSP 385
CCE43149     260 MKAA-RLDELIEKLSLLVLDIIRQVV---AQKATLSVPFLLSLIYCTISFRPVAVTKPVIIKLIHDCCELAMSYTFLLNP 335
ABN64347     206 KKSL-RLDELVEDFCLSIAEVVDILL---EKKAILAIPFLLSLVHCSIAFRPAAITPNLIVKLLQRFSRISNNLSFLLSS 281
CCE87077     243 KKSL-RLDDLISDFCVTLCTFVEILV---SRKSVLAVPFVISLIHGALSFRSSAVSRDLIKKLLTSLCTIVSDSVFLLDS 318
EDK39210     251 KKAL-RLDSLIHEFSLTMCELVEDII---AHQILTSVPFLLSLVYASLIFRSSALNKETIQLLVPKICSIAVDFAFLLDS 326
Q6BPF5       244 KKNL-RLDELVAEFTQTLSDLVDILL---EKKLILSIPFLLALIHASLNFRSSAVSQTSIKSLLESICKLALNFTFLLDS 319 Debaryomyces ha...
EEQ38026     205 VRHL-RLDMLVENVCGELMALVEALLaVPQQRAFLAVPFLVCLVHASVTFKYSAVGEKLALQLVQQACALSRRFVALLVS 283
6Z3A_D       340 PIH-------ESNMNLH-VEpqiFQYELIDYLIISYSFDLLEGILRVLQSHpkqtymeffDENILKSFE-F--VYKLALT 408 Saccharomyces c...
EMG49723     338 NLDe------dDLANYHdVP---YQIMVLEKFIFTSCLDLVERLVTLSTIFd--------EPQFVKKIW-QnhILSESLI 399
XP_002549810 327 NLDe------dDLANYHeVP---YQVMVLEKFIFTCCLDLIERLVTVSTIF---------EPDFIKAIW-QkqILSQTLV 387
XP_001528384 386 DLEe-----eSRIGIHSeKP---LQVTALEKFLLIQLVDTLEKVVILASGF---------GAKFLTSVWk--iSLMVSLV 446
CCE43149     336 NLEe-----eADFGNYHdVP---DQVIAIERFILICCLELIEKLTVISSIY---------DADFIRQVWtDqtVIPKALV 398
ABN64347     282 NLNe------eDYVNYHdVP---NQVMILEKFIFICCLDIIEKLTSVSSLH---------GSNFIKSVW-KddVLSIELL 342
CCE87077     319 TQDe------nDIVHYHdVP---RQVMVLEKFALICALDTVEKLMVIASQF---------DQSFIKSLW-DedYLSLNLL 379
EDK39210     327 SQDq------dDIINYHnVP---LQVMVLQKFSLICCFDILERILYVATVF---------DTEFSSGLW-Qe-PQMVQLF 386
Q6BPF5       320 SQDe------eDFINYHdVP---NQVMVLEKFALICCLDIIEKLMSLSSLF---------GAKFIETIW-KenYVRVELF 380 Debaryomyces ha...
EEQ38026     284 ADGadsfveqRGT----------YQQRVLENFTLVACLDLVEAVVVVATQF---------GAAFVRRLW-H--TMDFDLL 341
6Z3A_D       409 ISYKPM----------VNVIFSAVEVvniitsiilnmdnssdlksLISGSW---WRDCITRLYALLEKEIKSG--DVYNe 473 Saccharomyces c...
EMG49723     400 TSCLPEnserfkntaqINAVFNIVEM-------------------LIASVSettFGFNETKT----DESIISSllKIFLi 456
XP_002549810 388 KSCLPEnserfkntvqINAVFNIVEM-------------------LGASITedtFAFNETKL----DESIISSllKVFLi 444
XP_001528384 447 NTLLPQnterfksiaqINTVTSIVGL-------------------TASSVAeegFTFNSVKT----ETSIVSAliKVLTf 503
CCE43149     399 TSCLPQnverfkstaqINLVFNVVEI-------------------LLASITedtFGFNEAVS----DFNMISSlmRIFLi 455
ABN64347     343 NRCLPEnterfknsaqINVVYNIVEM-------------------LISSTTddtFAFSDVANAKVSDSSIFNSllKIFLi 403
CCE87077     380 RSCLPEnterfknvsqINVIFNFIEI-------------------LASSLTesgFAYNNVKS-KASNESIINSllKIFLi 439
EDK39210     387 KFCLPEnserfmnttqSNLVYSVVEM-------------------LISSITesgFAFDNQPV---KNDAIVSSllKVFLi 444
Q6BPF5       381 RKCLPEnterfknlaqINLIYNFVEI-------------------LMSSISettFAYNDTPN-KILDESIINSllKVFLi 440 Debaryomyces ha...
EEQ38026     342 TAVFPEnserfkasaqINLVYNYVEM--------------------LSASLeggFAAGDQAQ----NARIVQSliKAFLi 397
6Z3A_D       474 nvdtttLHMSKYHDFFGLIRNIGDNELGGLISKLIYT------DRLQSVPRVISKEDIGMds---------------dkF 532 Saccharomyces c...
EMG49723     457 -----eIPLRQDFMFYGLNRILGNNHDFIKVDSVIPVqhdylnNYLVSIPQPIPYNITEP-------------------- 511
XP_002549810 445 -----dIPLRQDFMFYGLNRILGNNLDFLKINSMIPVdrdhlnNYLVVLPQPIPFNMAIP-------------------- 499
XP_001528384 504 -----dLLVKNGFHFYGLNRILGNNSDMQKIELAVPRehdrlnNYLVTIPPPIHLNLFSQd-----------------pQ 561
CCE43149     456 -----dVPIKDGFRFYGLNRFNGNNYDLKVIDLTIPIkhdnlhNYLVSIPQPVYKNLDSD-------------------L 511
ABN64347     404 -----eLPIKDDFMFYGLNRVIGNNIDFRKIDATIPQtadilnNFNILIPQPIPFNLIKEnqs--------------neS 464
CCE87077     440 -----eLPIKEDFMFYGLNRVVGNNFDFDKIESIIPAtetilkHSMISIPGPIADDVLEEkgfmrqdttggsenpssesH 514
EDK39210     445 -----dIPIKEDFKFYGLNRVLGNNSDLSKVEATVPEsetllqESMVLIPCPIPQTMQQE-------------------- 499
Q6BPF5       441 -----eLPVKDDFMFYGLNRIMGNNIDFNKIDSIIPTsetllnHSMISRPCPIPYEYLQErmvpikkesnltskdsqmnQ 515 Debaryomyces ha...
EEQ38026     398 -----dISVKDDFMFFGLNRALGNNGDLVKICEAVPQenp-lnTPLVSVAFPVKHTPPSP-------------------Q 452
6Z3A_D       533 TAPIIGYKMEKWLLKLKDEVLNIFENLLMIYGDDATIVNGEMLIHSSKFLSREQALMIEryvGQDSPNLDLRCHLIEHTL 612 Saccharomyces c...
EMG49723     512 SQFEINMNHEYHLLTLRIKVAELLLSLIITKQTVDFLYSKDHFKSLIRVIGFEQNYIAR---SPRSKHIYLRLQIIAILV 588
XP_002549810 500 SKFGIDMNHEYHLFTLRIKVAQLLLGLIITKQTFDFLYKKEHFKSMIRVIGFEQNYIAR---NPRSKHVHLRLQLIAILV 576
XP_001528384 562 TFGFSHEKYETHLLHLRIQVAHLFLTWIITKQSVSMLRDRDHFKSLFRVIGIHQSYVAN---NVRSKHVGLRIQLIALLV 638
CCE43149     512 NQKEIQLHHEAHLLNLKIKVCELFQSLIISKQTIDFLIDKEHFKSFVRIIHFEQTYMAN---DPRSPTLHSRVHLIGQIV 588
ABN64347     465 IRFELLSNHEFHLLNLRIKVADLLESYIVAKQSVEFLMSREHVKSIMRIINFEQMYIMR---SPRSKYIHLRIQIVSKLV 541
CCE87077     515 LCFELSKLHEIHLLHLRLKVTSLLESYVMTHLSTKVLESKECLKSIIRTIGLEQNFIMK---LPRSDTVPMRIQIIASLV 591
EDK39210     500 SAVTVETNHELHLLYLRLRVATMIEGHIVTKGSTQLFQDKEYLKSIVRYIGLEQGLIMN---SPRAPTVHIRVRIISTLV 576
Q6BPF5       516 LAFEVQSNHEYHVLDLRLKVATLLESFIVTKSSTQIFELKEYIKSIVRTIGFEQVFIMR---SPRSKTIYLRIQIIAVLV 592 Debaryomyces ha...
EEQ38026     453 ESFAVLQNHESHLLSLRLKMVSLLEALIVN-GNMQLVNSKENIKSIVRIIGFEQNFIMH---QPRSKVVHMRLSIISSLL 528
6Z3A_D       613 TIIYRLWkDHFKQLREEQIKQVESQLIMSLWRFLVCQTeTvtanerEMRDHRHLVDSLHDLTIKDQASYYEDAFEDLPEY 692 Saccharomyces c...
EMG49723     589 KIVDYLT-QDLREISELMYGELMYEIFVIFSRIAFGSD-S------LSIDAHKLLVKIRAGGLT---PVFNKWCESRARE 657
XP_002549810 577 RIIDYLT-QDLRDASELIYGEQMYEIFVVFSRIAFGAD-S------LSIEAHNLLIKIRSQPKFVDFPVFNKWCENRALE 648
XP_001528384 639 KVINYIT-QDLHEASDLIYSETMYEMFVVLLRIAFGAD-S------LSSDAFKLLVKIRSRGLS-KLTVFNEWCEMRARE 709
CCE43149     589 KIMNYLT-QDLHEASDLIYSETMYEMFVALSRIAFGAD-S------LSLDAHKLLVKIRTQGHF-DITIFNKSCEVRARQ 659
ABN64347     542 KILNYLI-QNAVEYGAFIYPETMYELYVALSRIAFSSD-S------LSDHAHKLLIQVRNKGLK--EPIFNAWCENKARE 611
CCE87077     592 RLVSYIC-SESRGITGLIYPETLYEIYIVFSRIAFGSN-S------LSVEAHNFLRRIRNNGFY--HPVFNASCEKKARE 661
EDK39210     577 RVLHHIA-TEAKTITNVVYPETMYEVFVILSRIAFGSD-S------LSVDAYQLSSHARQMNYT--GTIYNYWCEQRARQ 646
Q6BPF5       593 RILNYIS-SEVRGLNNLIYPETLYEIFVILLRIAFGSN-S------LSAEAHSLLLEIRSKHKY-DKLVFNDDCERKARE 663 Debaryomyces ha...
EEQ38026     529 RVLFYII-DENKNINTLIYPETLHEIFVILMRVAFSSD-S------LSTDAHQFLSEIRGKGLV-DIGVFNKACEWRSRE 599
6Z3A_D       693 IEE------------ELKMQLNKRTGRIMQVKYDEKFQEMARTILESksfdLTTLEEADSLYISM 745 Saccharomyces cerevisiae S288C
EMG49723     658 LNHivpsn--nhergSEIADIESDFANGLEFPYESETVELARDILNR----FVDHDEAENLYFSM 716
XP_002549810 649 LNHitpq----tsngETIANIESDFANGLEFPYESDTVELARDILNR----FVDHDEADNLYFNM 705
XP_001528384 710 VNHvgllq--kdisgRSLATIESDYANGLEFPYEAETVELARDILNR----FVNHEEADNLYFNM 768
CCE43149     660 LNHltakdfisknggKLVANVESDYANGLEFPYEAETVELSREILNR----FVNHEEADNLYFNM 720
ABN64347     612 LNHltse----dlqgKFLADIESDFANGLEVAYEADTVEIAREILNT----FVTHDDADNLYFTM 668
CCE87077     662 INHvtysd--pkvlgNSLADIESDFPNGLEFSYENETVEIAREILDS----CLTREEADNLYFNM 720
EDK39210     647 LGHsd--------gvEEMADVESEFANGLEFPYEPEIIELAREILEP----CVTHEEADNLYFNM 699
Q6BPF5       664 INHitfsn--lhtdgKLVADIESELANGLEFPYETDTIEVAREILDL----CVTHEEADNLYFNM 722 Debaryomyces hansenii
EEQ38026     600 VAHfnifda-rpnkyAELSNIECDFANGVEFPYDSETIEIAREMLSV----CVNHDEADNLYYNM 659
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