Conserved Protein Domain Family
CDK2AP

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pfam09806: CDK2AP 
Cyclin-dependent kinase 2-associated protein
Members of this family of proteins are cell-growth suppressors, associating with and influencing the biological activities of important cell cycle regulators in the S phase including monomeric non-phosphorylated cyclin-dependent kinase 2 (CDK2) and DNA polymerase alpha/primase. An association between mutations in the gene coding for this protein and oral cancer has been described.
Statistics
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PSSM-Id: 430840
Aligned: 8 rows
Threshold Bit Score: 144.653
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9VZ27         1 MDIMDIQAVESKLSDVTVTPIP--------RSQVQNFYNYQQQREQREQQPQIQISAIHHSRGSVgggggs--------- 63  fruit fly
XP_001992100   1 MDIMDIQAVESKLSDVTVTPIP--------RSQVQNFYNYQQQREQREQQPQIQISAIHHSRGSNnstnsgsntgnnsni 72 
XP_001961697   1 MDYVDIESFRSKYSDITVTAVPtrskrleeAPVEPE----TKASVTKQQEPRVEITRVPGAPGSS--------------- 61 
Q9VJC8         1 MDYLDIESFRSRYSDITVTAVPsrpkadeePAMDTN-----QELAIKTHVPQVEITRVSGAASAG--------------- 60  fruit fly
XP_001989255   1 MEFTDLETFRSKYSDLTVTAVPakrqkldaQ---PENLD-AAKHVEKSPTALVEIIPIIASNAAA--------------- 61 
XP_002003465   1 MDYLDLDSFRSRYSDITVTAVPakpqaveeQETLPDCCDVAGGGAEMMPADRVEIFPISMSSAPG--------------- 65 
XP_002052701   1 MDYLDLDSFRSRYSDITVTAVPakrqktdgQDEPPEAWD-AAGSSEKAPAARVEIIPITLPNGAA--------------- 64 
XP_002066313   1 MDFLDIESFRSKYSDITVTAVPsggnsstnCNVQKDGDPSMDEPLLVEEPPRVEITRVEVVGGSN--------------- 65 
Q9VZ27        64 --------nssnaaTDYSTSS----------GGKRERDRSSasdysssSSKQSSAAAANAaaaAAAVAALQYSpQFLQAQ 125 fruit fly
XP_001992100  73 nnnnnsnnnnnmvaTDYATNSssssglggggGGGSKRDRNS-------VTQSSAAATAAA---AAAVAALQYSpQFLQAQ 142
XP_001961697  62 --------------SSGTPTS----------TAMMQRSKQQ----------QNAAALAYAneyKEVMAKLEYT-RYMQAK 106
Q9VJC8        61 --------------SSSTANA-----------AMMLRNRQQ----------TNSAALAYAneyKEVMAKLEYT-KYMQAQ 104 fruit fly
XP_001989255  62 --------------STFQQSS----------KRITKQEQQQlqfqqqqQLQQAEDDVAYSneyRQVLAKLEYT-KYAQAQ 116
XP_002003465  66 -------------------NS----------MVMQQQHPHQle---eqQLKLNQEAAAYSneyQQVLAKLEYT-KYVQAQ 112
XP_002052701  65 ---------------PTEQCS----------KSMQQQQQHQqk---qqQQQFTQDALAYSneyQQVLAKLEYT-KYVQAQ 115
XP_002066313  66 --------------GGGHGSV----------PPPQTSNEMD----------LKNAATAYAmeyKQVMDKLEHT-RYLQAQ 110
Q9VZ27       126 LALLQQQSntTATP--------AAVAAAALSLANmcsSNGGqRNSgagvsstssgsngqsmglnls----------ssql 187 fruit fly
XP_001992100 143 LALLQKQSntTATPssasasaaAAAAAAALSLANiaaASNGgRSSininsinninnsnssnintnssssnlglnltqsql 222
XP_001961697 107 IQLMAMASgvGSGAgagmdgslYGMMPTAITVDA---------------------------------------------- 140
Q9VJC8       105 LQIMSAAN--GGGGgfgidsdlFG---TSIGLDE---------------------------------------------- 133 fruit fly
XP_001989255 117 LQLMSASN---------------GIAGNSYDSNDiggNSYD-SNG----------------------------------- 145
XP_002003465 113 LQLMSNNNgfg--------elfYGLPGNQIQVPS---NEADnSGN----------------------------------- 146
XP_002052701 116 LQLMSSNN---ALGscafgellYGLPGSNMQLPS---AE---SNG----------------------------------- 151
XP_002066313 111 LQLLTLAN-----GgrvldnglFDLIPSGIANDP---------------------------------------------- 139
Q9VZ27       188 kypppstspvvvttqtSANIttpltstas---lpsvgpgngLTKYAQLLAVIEEMGRDIRPTYTGSRSSTERLKRGIVHA 264 fruit fly
XP_001992100 223 kypppstspaivttqtSANIttpltstanlptvgslsvgngLTKYAQLLAVIEEMGRDIRPTYTGSRSSTERLKRGIVHA 302
XP_001961697 141 ----------------NANI---------------------EDKYSDLLRLLAEMQPNLAPTMMGLRAPKERLQRDIAHA 183
Q9VJC8       134 ----------------NANI---------------------VDKYSDLLNVLGEMRTNVPTTMAGLRAPKERMQRDIAHA 176 fruit fly
XP_001989255 146 ----------------TSNI---------------------VDVYDNLLSVIAEMQSCLGPTAMGLRAPKERLLRDIGHA 188
XP_002003465 147 ----------------SGNI---------------------VDTYDNLLRVIAEMHRNLGPTAIGLRAPKERLLRDIAHA 189
XP_002052701 152 ----------------TTNI---------------------VDTYDNLLAVIGEMQSNLGPTAIGLRAPKERLLRDIAHA 194
XP_002066313 140 ----------------TANI---------------------VDKYSNILATLASMKMEISPTLMGARGPRERLLRDIAHA 182
Q9VZ27       265 RILVRECLMETERAAR 280 fruit fly
XP_001992100 303 RILVRECLMETERAAR 318
XP_001961697 184 RVIVRECLLILERDQQ 199
Q9VJC8       177 RLKVRQCLQLLQQAEE 192 fruit fly
XP_001989255 189 RVLVRECILmlmhnq- 203
XP_002003465 190 RVLVRECILMLMRDHR 205
XP_002052701 195 RVLVRECILMLMRDhq 210
XP_002066313 183 RILVRECIMLIERDQQ 198
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