Conserved Protein Domain Family
7TM_GPCR_Srbc

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pfam10316: 7TM_GPCR_Srbc 
Serpentine type 7TM GPCR chemoreceptor Srbc
Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srbc is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.
Statistics
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PSSM-Id: 402093
Aligned: 59 rows
Threshold Bit Score: 198.526
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5F4V3         1 MKTAV-LLVCFTGMVCASIEVLLNTNLVWKIV-------------LRKS-QRKCEMGLFYYRFALDLCFGLALLSYISFI 65  Caenorhabditis ...
O44692         1 MLSVS-VVISSIGVTSSIVSCVVNTYMFVTVE------------------RRKNDMTLFYFRFLLDVILSVLVAAFLTSD 61  Caenorhabditis ...
O16943         1 MLHIT-VIISLIGIASSMVSCSVNTYMLVTVE------------------RRKKDMVLFYFRFLLDGIISILIAAFLSCG 61  Caenorhabditis ...
Q9N4Q8         7 MNVSA-LIVTAIGVFSSLFAFAMNIYILKNFE------------------RKKNDMALFRFRFFLDVVLGSTTAVYLASM 67  Caenorhabditis ...
O44694         7 LKTSA-VVITCFGVFFSIFNCVGNVAIIKKMG------------------RRKNDMVLFYFRFLLDVIFGATSTIYLLSI 67  Caenorhabditis ...
O44695         7 LDISA-EITTFFGIFFAIFSSLMNIFNLKKIE-------------K----KKKNDMVLFYSRFIFDAFYGITVTIFLSLM 68  Caenorhabditis ...
O44696         2 FSYLE-IIINLIGVFFAIFSCFINIFNLKKLE------------------KKKEDMVLFYFRFFLDAFFGATILFFFASS 62  Caenorhabditis ...
O44697         2 FSYHA-IVINFIGVFFAIFSCFINIFNLKKLE------------------KKKEDMVLFYFRFILDAFFGATILFFFAIT 62  Caenorhabditis ...
1_pfamImport   1 MNVTTpVIISMIGLLPSIFTCVLNISLLKQIErlfkfsalklfstFKSIfRKKKHLILFKFRFFFDVILGASVVAHLGFY 80 
Q5F4U4         1 MNITTpIIVSFIGLFPSVFTCVVNLFSLKKID------------------RKKNDLVLFKIRFFLDVVLGASVVAHLGFV 62  Caenorhabditis ...
Q5F4V3        66 LIFSEKSEFMi-eHRNLLTYLGLFWSNTASCRSILALAIAAERATAVCLPILYRTVNLKIPNLLILLVAIAYGLFEDVVL 144 Caenorhabditis ...
O44692        62 IIYFTFSEKMdsqLIVVIFYIPLLASNVAAVRSIVILFISVERVVASYFPIFFHNHRKFRFKVFIMILAVFYGLTEDIVL 141 Caenorhabditis ...
O16943        62 ISYSMFPEQFs-qTQNLIFYLSLPASNFSAIRSIVALFISVERVVAAYFPIQYHNYHQSFPKIPIMITAIIYGFNEDIVL 140 Caenorhabditis ...
Q9N4Q8        68 GISAVYIKESt-eFANFVFHIGFFTSNIGVSRSLITLAISIERFVAVYFPILFLQKHPFFPNSVIPIIAIGYGVFEYPVL 146 Caenorhabditis ...
O44694        68 IIFNLNYLKLs-dLRVFIFFLGFLISNVRATRALLTMAISIDRVVAVYTPIWFLNYRSLVANSAVLGLTAAFGLSEYPVL 146 Caenorhabditis ...
O44695        69 IAANFNNLET---INHFTLLSGLLVWNVGISQAVVALMISIERNMAIFTPIFYRNHRSLVTNSVILCLIFGYAIFQYSFI 145 Caenorhabditis ...
O44696        63 IASNFSAEEI---VIKLIYLSGLLGTLVGRARAAVTLMITVERILAVFTPIFYRNYRPLISNLAILSLIVGYGLFDYLIM 139 Caenorhabditis ...
O44697        63 ISSNFSGEKI---FNSIIFLSGFFSSLVGRARVAVTLMISVERVMAVFTPVFYRHYRPLISNSAILSLIIGYGLFDYLIM 139 Caenorhabditis ...
1_pfamImport  81 IILTSFHDEFl-pWRNMIFYFSLVSWNIGAARSLTALTISVERVMAVYVPITYRNYRPYFPTFVIPIFAIGFGASDIFVL 159
Q5F4U4        63 LILATFHEELi-pWKNVILYLSLFSWNIGSARSVTVLAISVERVVAVFAPISYHNYRPYFPTFLIPIAAISFGASDIFIL 141 Caenorhabditis ...
Q5F4V3       145 FKFCEFNVnSIPDTCKQFGCAINKCFFSYFMLHRCIVFSINICVSIVLSVKLL--FWNRkqshqHKNNNNNKLSKANRLA 222 Caenorhabditis ...
O44692       142 YVFCDFQL-KLVPNCVAFGCTINACYHQYWITHRMTVFALMFLFSIFLASKLF--MLRK-----SKNVGKNEQFRMNRLA 213 Caenorhabditis ...
O16943       141 YVFCDFQL-NIPKNCTALGCAINECFYQYWTTHKSIVFALIFLSSLALCFQLF--MLNK-----REKKGKNELTKLNRLA 212 Caenorhabditis ...
Q9N4Q8       147 YSFCNFEL-NIPYGCVTLSCSLNLCFYQYWTTYKTIVYILTFLSTIVLTCKLLlkIHES---------QSNNLTRANRLA 216 Caenorhabditis ...
O44694       147 YIFCEFEV-DIPPKCVSINCALNDCFLQYWTTYKMIIFACTFIFTILLSLKLIskIFKD---------DNKDLNRANRLT 216 Caenorhabditis ...
O44695       146 YYFCNFEL-TFPRNCLTIGCSINACSSRFWTKSKLVIFVLTFSFAALLSSKLLwkVFKK---------DNKDFNKANLLA 215 Caenorhabditis ...
O44696       140 RFLCDFKF-VIPTNCITAGCSMNLCSSQYWATSKTVIIAFTFLFAIMLSLKLLwkVIKE---------KNKDFNNANRLA 209 Caenorhabditis ...
O44697       140 YFFCDFEF-VIPTSCVTLTCSMNLCSSQYWATSKSVIIWLTFFFAIILSMKLLwkVIKE---------KNKDLNKANRLA 209 Caenorhabditis ...
1_pfamImport 160 FNICDYQV-NVPKECAALGCCINACFNKYYSINKGTAYILTVMFAILLSTKLF--FLNK------DSTEQKTLSKANLLA 230
Q5F4U4       142 FGICEYEI-DVPEGCAALGCCINACFTKYYSINKGITYISTFTFTLLLSTKLL--YLKN------YNAEKKSLSRANILT 212 Caenorhabditis ...
Q5F4V3       223 LLDTCTVFLFDFIPVLCGNMWp--QYFSGENLGPFTVVMKVTGCAIESIVVSCLLKFGK 279 Caenorhabditis elegans
O44692       214 LIDIGNVTLFEFFPIFLANQLs--KYFNFKSLGPYGISIKMLGCAVEAVLMLYILKGKK 270 Caenorhabditis elegans
O16943       213 LIDGVRVLLADFLPNLVANQLsrgGFSIFQSLGPYEVVAKKFGCATEAILVLYTLRHRT 271 Caenorhabditis elegans
Q9N4Q8       217 LIDCIVIFLFDFFPILFEKLVtqkNIFTPRNLGSYSTVTKLSGCAVEAFLVYRTVIRKQ 275 Caenorhabditis elegans
O44694       217 LIDSTIIFATDFLPTMLC-LMgheDLFNTQNMGPFGAVLKQVGCAFEALLVLQTITRRN 274 Caenorhabditis elegans
O44695       216 LIDAAIIFLFDFLSIVFFNFTdrvETFSIHNIGPFATSLKQVGCTIEALLVYRTITKKN 274 Caenorhabditis elegans
O44696       210 LIDAAIIFLFDISSSIISYYV-----IKINNGGPITAALKQFGCVIEALLVFRTITRKT 263 Caenorhabditis elegans
O44697       210 LIDTAIIFLFDILSNIVIHYVsreDVFNLQNGGPILAVLRQLGCVVDALLVFRTITRKV 268 Caenorhabditis elegans
1_pfamImport 231 LIDAANVIIFHFSPILFAFLFk--HWFTAQNIGPIGVVSKMWGCALEALLVFGTLRKKS 287
Q5F4U4       213 LIDAANVIIFDFSPVLISFLFq--QWFSLQDFGPIGVVSKMWGCATEALLVFGTFRKPS 269 Caenorhabditis elegans
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