Conserved Protein Domain Family
Patched

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pfam02460: Patched 
Patched family
The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Statistics
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PSSM-Id: 308203
Aligned: 8 rows
Threshold Bit Score: 975.296
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q09938        52 LTLLDARKLYTPVSAP-SWKEEQVFSELWPVKSYEFLPERTFQWNRY--LYLVVHGRPYengtypNILEGSYLNDIAKIE 128  Caenorhabditis...
Q18129        47 QTTNDPQYVFSPANAP-WRYERAVLTEHWPLDEEKFWPGKSYDLHGY--VDVIASGRIHpdygrpNILNIRYLDEVARIN 123  Caenorhabditis...
Q19945        49 LRVDDPSYVFTPSDAR-WRREISVFNENWPLDENKFLPGKSFEAKRFvnILIRAKDGGS-------IMRDNVLHEIEILN 120  Caenorhabditis...
O61894        44 IFSFGILNMRTEDDLR-FLYSPEHSLSREEYQVHKDFSGDSKNNSFV--SITIQTSSEDk-----NLLKKDLAQKLIQLN 115  Caenorhabditis...
O44978        31 VLSSGLVHIRLEPDIRkAFSPDDSDAGYETRVWLEYYGLDIYPERAF--CIFTAKRENS------SILQEGALADIYTVD 102  Caenorhabditis...
1_pfamImport   1 VLSLKIPFTRMQNDIS-DFTPFGARSRVELEKYRKFFNNHGEPKAIY--AFITSKVGDN-------MLGISQLNDTVHVL 70  
Q21883        44 FCSSKICFTKQEDDIKtGYTPVGARSLDEIEVFSDFFASTGDPIAVF--LFITAKDNSS-------MADYNTMKEVVDIM 114  Caenorhabditis...
P91129        47 NPLSDAVYLFTPLGAQ-SKMERMSIHEKWPLTDNNYIPGRAVTQSRE--IQVTALARNDs-----NILDPKFANAVYQLD 118  Caenorhabditis...
Q09938       129 EELVTNVsfpreaalednpalmrkrhlnetEIEENRn---ITITFKDVCMNW-YGDCYREKNVI---------------- 188  Caenorhabditis...
Q18129       124 DYIIHNL-----------------------TVPVDIngkhYDIAYTDLCMRY-DWACYLNDHITmlmpktrwgnfsgpfa 179  Caenorhabditis...
Q19945       121 QWIMNNI-----------------------SIPTDDl--kFNLTYQDLCLSY-DWVCGANEHIQm--------------- 159  Caenorhabditis...
O61894       116 KYVLEKM-----------------------EIQVDGk---IINFGKEVCSRMkQCELSNTIATIfld-----------tf 158  Caenorhabditis...
O44978       103 NRLSAAV-----------------------GYQDGD------G--RKNCDPLcDLNSPFHLLAN---------------- 135  Caenorhabditis...
1_pfamImport  71 DTISRDF-----------------------YLKTSQ----GPKNFEEYCSGFcLLNEPVKHFYSg--------------- 108 
Q21883       115 DYVGSN-------------------------LTHKG------ESFYTLCTDFcQINEPVRQYYNgl-------------a 150  Caenorhabditis...
P91129       119 KYIQTRV-----------------------RVLHNG----HYYSYKNLCLQYkNGGCPSNKHV----------------- 154  Caenorhabditis...
Q09938       189 ELLKRRHElnkRGISVTFPQVNQEGTPIYIAFVIGGVDTYP-----------------------NDTIKYARAMRLWYFL 245  Caenorhabditis...
Q18129       180 ELASDIIN---TQVNITYPIGWRGTEPIYFGALVGAPNLVDe----------------------EGHFDYASAIRLTYNT 234  Caenorhabditis...
Q19945       160 lLRRNDVN---QILDLHFPRGGTKDTPVYLGGIFGDVQFFQ-----------------------NGTLSDAKLTQLFYFL 213  Caenorhabditis...
O61894       159 WSEKLRKD---PRIKIEYPTMKFFDNKFFLPTHFYGVQPGGp----------------------LGIESIDMVHFVYQIP 213  Caenorhabditis...
O44978       136 -LTRRNNG---TTSVFTYPDMPYSGLDIFLGLHLSNADFEP-----------------------PTERISSKSLVLWYFS 188  Caenorhabditis...
1_pfamImport 109 MLISGQHGtdfSHLDLGYPITTVLGTKLYMDPNFFGVKVTTsnnkvesiadgntklfgdhtkqePNNIREVSLVVLQFRS 188 
Q21883       151 MKQQNLSEv-gSRFQLTFPMMQVLGKELDLSPNFFGVKTDE-----------------------DGNVEYVKIIMLQIRA 206  Caenorhabditis...
P91129       155 HILSDLHN---HGFNITYPYFRFGSEGGYIGSSLGGVTVMKge-------------------neTDILASAKAWFMIYHL 212  Caenorhabditis...
Q09938       246 KfdDEEQEQLAKFWEDTAEKFVRETYADHp-TIQCHIKHSRIVDQGLTRNANRLKPYFNVTIAVLVLFTAFYSVkwYFRM 324  Caenorhabditis...
Q18129       235 R--EGKVDQYGIEWRRKLSMWLTDKENPVseLLEFGVNHNMTLPEGLQDVADTLAPKFVGTCAILFTFSFLVSV--VLRK 310  Caenorhabditis...
Q19945       214 KqdQKMVEEYSSKFSYALETFLNQVYSSD--VITLSFAHYQSLEDGLDENAKAFVPNFVVSFFVLAMYALVSSF--TLKS 289  Caenorhabditis...
O61894       214 AynEHTSEEMSKIFEQSLTALLENQTTFD-----TSMFSLSILKDEMQKNSTYTMPFISLTILLLLCFTVASCM--TDNW 286  Caenorhabditis...
O44978       189 RsdTPEGKLAFKDAIDELFQLSKNSSAFE--HVQFTIFSDQVANREMIRGAIEATTLMTIGFFLLLTQVIIVIV--RLSS 264  Caenorhabditis...
1_pfamImport 189 ElgDEVTPEDLRNYEHQILDYIHDEYQSE--HINVYILTDSYITEEIVRAGLTLLPFLVIGFTIMAVFSSITFV--VSAY 264 
Q21883       207 NipNDWKKEDAAEYERMISQYFHFKYDST--HVTPLAMSLTYTGDEVVRTGLTIFPFIGVGFIIMTTFSIITIY--YSSS 282  Caenorhabditis...
P91129       213 KfhPEEMSYISGEWELELGRMLTQYPEDP--YISITYFHSQTLADELKRNADTLIPRFIISITLLIVFSTLCSL--SFID 288  Caenorhabditis...
Q09938       325 dhswpLHIDWLRSKPMLALGGVLSSVLAILSGIGLLLWFGMFFAEITLIAPFLVLSIGVDDMFIAVAAWHNTEMKYPgrs 404  Caenorhabditis...
Q18129       311 hrtgqVMPDWVRSKPLVAAAGLMTPIMATVTSFGLILWCGFLYNAIVNVSPFLILCIGIDDLFIMCAEWHRTNPQHS--- 387  Caenorhabditis...
Q19945       290 ss--aTKIDWISSKPWLAAAGMFSTVLSIISAFGFLFILGVRYNVINTIIPFLIIAIGIDDMFLMNACWDQTSKSLS--- 364  Caenorhabditis...
O61894       287 ----------VTSKPIEAMIGILVSSMAIVSAGGLLFALGVPFINQVTVMPFIALAIGVDDVYVMLGAWQDTRRTLD--- 353  Caenorhabditis...
O44978       265 ----------VKMAFYLVATSLLTPMAATVASFGAICWMGFPSFSIQCVTPFLVLgIGVDDAFILLHRWKHHIAITD--- 331  Caenorhabditis...
1_pfamImport 265 -----YTKQLNFYKPILAVMACVCPFMACGASLGAMFFIGFRFGSILCVTPFLVLAIGVDDSYLMANAWQRITCHRRkha 339 
Q21883       283 -----RLDQWSVHKVSEAILACVCPLLATSSALGTLFWFGFRFGTILCVTPFLILAIGVDDAYLQVHACMRLTAEDSsm- 356  Caenorhabditis...
P91129       289 g---sFSIDWVLSKPILSILGVVSAGIAILTGVGFLSLMGMPYNDIVGVMPFLVLAVGVDNMFLMVAAVRRTSRTHT--- 362  Caenorhabditis...
Q09938       405 -----pkvMKKRMIEAMSESAVAIFITSFTDVLSFGAGTITDIIAVQGFCAMTAACMFFTFLYQITFFAALMVISAKAQM 479  Caenorhabditis...
Q18129       388 --------PEKRIGKTLSEAAVAISITSLTDIATFAMGCYTTLPGVQMFCMYTCVQCFFCYVYQIIFLGPVLAYAAEMEQ 459  Caenorhabditis...
Q19945       365 --------VPERMSKTLSHAGVAVTITNVTDVMSFAIGCITDLPGIQFFCIYACVSVAFSYFYQLTFFSGAMAIMGEVER 436  Caenorhabditis...
O61894       354 --------AKKRMGLALEEAGSAITVTSLTSVLSFGIGTYSTTPAIAIFCKFIALAIMFDWFYQLTFFAAVMAMGAKREA 425  Caenorhabditis...
O44978       332 --------TPRRLEQVIVDVGPSITITSLTNIIAFGIGFLTPTPQMSLFCLTASLALLLDYIFTYTILAPIVFLCNDPDY 403  Caenorhabditis...
1_pfamImport 340 rfesvnveLKNRITEMFIETGPSITITTITNALAFGIGATTPAAEIQLFSIGNALAVITDFVFTITFYGALMAVVGRYEI 419 
Q21883       357 -------tKREKIARMLVEVGPSIAITSMTNLFAFLVGIYTPTPEISLFCAGNAVAILFDFIYQITMYTAILSICENLEM 429  Caenorhabditis...
P91129       363 --------VHERMGECLADAAVSILITSSTDVLSFGVGAITTIPAVQIFCVYTGVAIFFAFIYQITFFAACLALAMKHEA 434  Caenorhabditis...
Q09938       480 SGRNSCMPC-------IT-------Ag----------DIYTIEDGSLQPnlkkkksksrkdakaekekkdeakndknmei 535  Caenorhabditis...
Q18129       460 NGQHVLLIRka---vdPDkte--spVklwllsgsvnrQDQEARRRNSRKvapvekegekkskfg---------------- 518  Caenorhabditis...
Q19945       437 EKRHCLFFYrtfqlvdISkmneeadS-----------KLQQIKSRSASPapfnylsssnssfssdsdsfss----kktip 501  Caenorhabditis...
O61894       426 AGYHCVFVW------------------------------KRCDREEIAK------------------------------- 444  Caenorhabditis...
O44978       404 KS---------------------------------------IANET-EP------------------------------- 412  Caenorhabditis...
1_pfamImport 420 EQELKTQKP-------LPese----------------spSETSSTGSMR------------------------------- 445 
Q21883       430 RKN-------------ATk---------------------RKDSGLSFK------------------------------- 444  Caenorhabditis...
P91129       435 SGRNSLFLIea---vsAEkkt--slS-----------TFQRLFNLGSVPd------------------------------ 468  Caenorhabditis...
Q09938       536 eenaenaekssydsspDPSQIHIP--VKSrgamgHFFRDYYVPWLLNWKTKLFMFVTFIIYLGISVYGICVMEQGLDYDK 613  Caenorhabditis...
Q18129       519 -evveklehtlekhddDPGHNSEEt-LVS-----KVFREIIGPFILQKSTQVCALLLYLVYISLAIGGCLNIKEGLDPKL 591  Caenorhabditis...
Q19945       502 aefawkeqqspnsslsKKSKDREEkdRIV-----HFIGKIYGPFILSNSVRIFSGLIFVVYLAIAMYGCYNFREGLNPGN 576  Caenorhabditis...
O61894       445 ----------------AKNENAIS--PTR-----YFFENIFAPFICRPSVRFCMLNLYVVYIAIAFYGCSQLTPNLTPSQ 501  Caenorhabditis...
O44978       413 --------------------KISR----A-----DTWLSKYSSFVCSVKGRVACIMVLLGMYALTTYGVVTMKTTFEPAK 463  Caenorhabditis...
1_pfamImport 446 ------------------SSELDD--CKF-----RRMIANVCKFLTNTWVCSVVLGLLAVYWYICIVGTVNIKSELSPNK 500 
Q21883       445 ---------------------NEQ----F-----TVMLDSYCDWVANAYTHLLVLFCFIVYIFVSIRGALNINIILSPDK 494  Caenorhabditis...
P91129       469 ---------------hSASHDVKQp-LTS-----RFFGEWYAPVLMHPVVRGIAMVWFVIYLLGASYGCSRIKEGLEPVN 527  Caenorhabditis...
Q09938       614 LLLHSDPLVEALK-REIELFHGGDQIEIAIQNCPNITI-AESRDRIELVAQEFENISYSLGGKGTSFWMREYKK-Ysn-- 688  Caenorhabditis...
Q18129       592 LVRESFYLSKFYEiIDETFWREGLQMQVVVNNPPDLFT-PETRKGFDEMMAEFENTQYTMHPNATMIWLRAYEHhLe--- 667  Caenorhabditis...
Q19945       577 LVTNDHYIAKYFSdI-KHFWRIGAQLHVAVLNPPNLTI-SENRNELLKVVSAFENTQYTLGREGTVFFLLEYLNyLse-- 652  Caenorhabditis...
O61894       502 LVVDDSPLVPYLNlAEKKIWAEGLIGRIYVNNAPDFSKnPEMVDRMLQMVNELESTPYSMGPNSTNFWLNEFN--Ny--- 576  Caenorhabditis...
O44978       464 AFPSNSKLVDSLSnI-KPVFNRYFPITVIVNNPPNIEI-KAEYDSFNNMMDRLEHVPGIRGDNRSLIFLPQYVNfDkt-- 539  Caenorhabditis...
1_pfamImport 501 LFLAESNIVEIFKqRKSHIIPYYSACWVLVENPGDINN-PNQRAKLEELIESFEALPSANGRYSTKFWLRDYEDfLkqse 579 
Q21883       495 LVIGDSPLLQVNYlRDQFVLPNYTTVNIFVQNPGNLTI-QSNLDYMNSLFDSFESYPECLGKKFSHYFVRDYESfRess- 572  Caenorhabditis...
P91129       528 LLVEDSYAIPHYRlLEKYFWKYGQQVQIVINNAPDLRN-HTSRDRVHAMVLDFATSKHAIGMESVQFWLFEMER-Yy--- 602  Caenorhabditis...
Q09938       689 ---lTGSYLNDNRE----------------SW-IVGVYEWSQLFAFYKL-WSQDFVWAne--sdYDTLELKSYRFRIG-- 743  Caenorhabditis...
Q18129       668 ---tEVHELNIEKPns------------tvEW-YTRCRDWLIVAGGRRL-WQMDMVWAnt--tfEETPRITAFRFQLG-- 726  Caenorhabditis...
Q19945       653 ---lNAEVEDTER-----------------LW--KTKLNSWLKYTGGSTqWASNLKIN------KTDGSFQAFRFQIA-- 702  Caenorhabditis...
O61894       577 ---rQFFFQEDAK--------------------FYETLKSFLKVSFNSH-WETDLVWDtpdkssKGGTKVEKFVFTTA-- 630  Caenorhabditis...
O44978       540 ---mNILSTLVGEK----------------YRpSYDNLPTWMDAIGNPP-LVKYHMGD------DNKTIVTAFRLTLL-- 591  Caenorhabditis...
1_pfamImport 580 eidlPMEEEEDEELaiqftvngsqvvtpsqPFgQGNELRQFLEWPEFSF-WKGFIQVN------ESTYQMSKFLVTTAyh 652 
Q21883       573 --leEMEMMEDEEGdtnk---------talEPfSKAAMSEFLAWPEFQH-WNGFVKFD-------KNGMLSKYWATVSyh 633  Caenorhabditis...
P91129       603 ---qKELEVQIID-----------------SS-FYGLLHHFLASKTNNP-LAEDIYWGpmp-ddDNGTMVKSFRFILG-- 657  Caenorhabditis...
Q09938       744 VHRLSTPTDLVLITEELRGVADRHPD--LNIVTYQQSRAIADQLNVILSSTITNDTLAMFCMFCVALIFIPNPICALFIT 821  Caenorhabditis...
Q18129       727 LRNYRTPTDHTHSCKLMRSIADKYSM--FNVTTFHEYYPFADQYLELTPSLFQNMISDLCTIFAVSWVMIPELICAVAIV 804  Caenorhabditis...
Q19945       703 LKNFVEPNDHKHAAQLLRDIAD-HQP--FNVVVYHEAFPFADQYLIILPATIQNVVISLLCMAVVSFLLVPSLPSGFVIF 779  Caenorhabditis...
O61894       631 -FKISNWNIRTSLLLTWRNITSSYPE--FDALVFDENNFYSDQMLELQSTILSSLGTAIILLSAICIMFIAESYIVFWVV 707  Caenorhabditis...
O44978       592 GKGMSEWAERARAMQHIRTILHEESQ--FNATLFDCDSAILSIILTVGTDLIGSIAVTVVCMAIVCFVFIANFNAVAVIT 669  Caenorhabditis...
1_pfamImport 653 GSDLVDWSNRAKLLNEWRSVADQDKFksLNVTVYEEDAKFLDLIETMSPVAIQSALWTFASMFLVAALFISHPPTLFVAT 732 
Q21883       634 GEGLGDFQVRRRMLNRWRATADQFAP--LNVSIFDDYAPFVDTLETILPATISTSVCTLICMMIVCFLFMYNVFTVFVAT 711  Caenorhabditis...
P91129       658 MKDLVTTMDQTDATMSFREVAARWPE--FNVTTFMPIWMFTDQYIIIIPNTVQNIIIALLVMIVIAVLFIPQPMCSLWVA 735  Caenorhabditis...
Q09938       822 FAMVTIDIGVIGFLSLWSVKLDPISMITIIMSIGFSIEFSAHITHGFVSNDSn---lSAFDRCVDAMEKLAWPVVHGSLS 898  Caenorhabditis...
Q18129       805 LSIASINVGVLGFMSFWGVNLDSVSIITVIMCIGFSVDLSAHIAYAFSQSYG-----NSHARAVAALETLGWPVFLGASS 879  Caenorhabditis...
Q19945       780 VSIVSINIGVFGYMTLWGVNLDAVSMISIIMSIGFAVDLSAHIIYAFVTSHG-----DTKQRVIGALETLGWPIFQGASS 854  Caenorhabditis...
O61894       708 CTLISMDIGTAGLLSLWGADLDPMTVVNILMSIGQCIDFATHVGIRIYRSEYs----DPDERIRDAMGAIGWPVVQAGTS 783  Caenorhabditis...
O44978       670 SVIASICYVLVGGLSLWGADLDPVIQVDVLLATGFSVDYTAHVAYNFFRARG-----TPQERVYSSLAEMAMPMCEAGLS 744  Caenorhabditis...
1_pfamImport 733 FSILSTSLGVFGIMSWWGADLDPIMMSATVMSIGFSVDIPSHVSYHFYQTAKdt--sDIRRRLQMTIEAVGFPIFEASLS 810 
Q21883       712 LAITSICIGVFGFLSMWGIDLDPISMACLIMSIGFSVDFPAHITFHYFREGLhdpqsTPAKRVARSLAAIGFPLLQCGLS 791  Caenorhabditis...
P91129       736 LACASIDFGVIGYMTLWGVNLDAISMITIIMSIGFSVDYSAHIAYGYVVSREd----TAAGRVKEALSALGWPLSQGAMS 811  Caenorhabditis...
Q09938       899 TILGVFVLAFIDSYMVLVFFKTISLVLIIGAWHALMLLPILLSMCIP 945  Caenorhabditis elegans
Q18129       880 TVLGILLLTLVDSYIVQIFFKTVFLVINFSILHGLIFLPIFLMKVVR 926  Caenorhabditis elegans
Q19945       855 TIAGISILYTVDAYIILVFFKTIWLTMLIGAIHGLFFIPIFLSLFPV 901  Caenorhabditis elegans
O61894       784 TLLAIVVMLMVPSSAVRMFARTSVLVVGTGFFHGLIILPIIVRSFAT 830  Caenorhabditis elegans
O44978       745 TFLCMLPLIFVPTYAIVCFAKTVFLVVAIGLLHGLFILPVILALFSK 791  Caenorhabditis elegans
1_pfamImport 811 TSLCVMSLFFVDLNMAQIFAKCMLLVVVIGMVHGMLVMPVIFALLDT 857 
Q21883       792 TILFVLCLLFVPTYMGEVFVKTMILVVTLGLIHGLFIVPAFLCAFTA 838  Caenorhabditis elegans
P91129       812 TIIAVSVLADIPAYMIVTFFKTVVLSISLGLLHGLVFLPVLLSIFVR 858  Caenorhabditis elegans
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