4BTA


Conserved Protein Domain Family
P4Ha_N
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pfam08336: P4Ha_N 
Prolyl 4-Hydroxylase alpha-subunit, N-terminal region
The members of this family are eukaryotic proteins, and include all three isoforms of the prolyl 4-hydroxylase alpha subunit. This enzyme (EC:1.14.11.2) is important in the post-translational modification of collagen, as it catalyzes the formation of 4-hydroxyproline. In vertebrates, the complete enzyme is an alpha2-beta2 tetramer; the beta-subunit is identical to protein disulphide isomerase. The function of the N-terminal region featured in this family does not seem to be known.
Links
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Statistics
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PSSM-Id: 462433
Aligned: 165 rows
Threshold Bit Score: 78.4696
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4BTA_A               14 SIGQMTDLIHTEKDLVTSLKDYIKAEEDKLEQIKKWAEKLDRLt--ST--ATKDPEG----FVGHPVNAFKLMKRLNTEW 85 
1_pfamImport          1 SLRHLKEAYQKEADLLNYLKEYNSEFQRHLDKIKKDIRKIKSEh--EI--AEKDVDN----YFRNPFNSFHIIKRIFVDY 72 
XP_002037364         28 SVDSMQDLAQVEEELLNATRSYVESQQKQLDFYRRYVEQIRQEh------EWATSQLklddYLGHPLHAFRLIKRLVQDW 101
XP_001964707         29 SADAMQDLVQVEREILNATRSYLEEQQKQLDFYRKFLEQIKEEhdwVV--EQTDLNE----YLGHPLHAFRLIKRLVQDW 102
WGS:AAPP:GF22908-PA  29 SIDSMQDLVKVEENLINATRLYLEAQQKQLYIYSRFIQQIKQEq--KSarTLPNLDE----YLEHPLHSFRFLKRFVYDW 102
XP_001237637         30 SVEQMRKLLKLEESLVTSLGQYIKLHEQKIEFLHRQRDLLEKEl--KK--GLKDDIE----YSSNPVSAFLMVNRLVNDW 101
XP_001842645         32 SIQNMELLLKSELAILDRLDKIIRLSEARVSELKRQRDSLRQDl--EG--VDS--LE----YVSNPVSAFLMTKRLLKDY 101
EDS45525             31 SVVNMELLLKSELAILDRLDRLILLSEEKVAFLKRERDRLRADi--EG--AEESPLV----YVSNPVSAFLMTKRLVKDY 102
EDS45527             35 STVGMERLLQSELAILDRLDTIIAKSEAEITLLKRERDRLRAEv--AG--AKQNPIA----YVSNPIRAFLMTKRLLVEY 106
EDS45526             30 SVMNMELLLSSELAILDRLDFFIRKSQEKIKLLKRERDRLRNDv--QG--VES--IA----YVSNPISAFLMTKRLLMDY 99 

4BTA_A               86 -SEL--ENLVLKDMSDGfISNLtiQRQY----FPNDEDQVGAAKALLRLQDTYNLDTDTISKGNLPG 145
1_pfamImport         73 -KEF--HQEISENKIFEnfkheanKIIIte-eYPTDEDLLSSAMSIARIQETYNIQTSELASGLIAG 135
XP_002037364        102 dALIf-EPILANNAREEfRAFVevLSRDlg--yPDQSELQGAIKGLARLQKVYNLATSDLADGIIGG 165
XP_001964707        103 -DELvfDPIVSNAPREElREFVd--SVVnelgYPNPSELHGAVKGIARLQKVYNLTTTDVADGLIDG 166
WGS:AAPP:GF22908-PA 103 -DTLilGPIVNNNPREEfQHSVndLFENl--gYPNSSEVQGAVKGLARLQKVYNLTASHLADGAIHG 166
XP_001237637        102 -ERL--RAFMDMDVGAK-LQNTt--------eMPTHEDLIGVVEGLARLQDMYELNAKEMASGKLLD 156
XP_001842645        102 -QDI--DALIRKELDVMlIDDTt--------vIPATVDLLGVAEGLSRLQDLYLLEVEDMADGYMYG 157
EDS45525            103 -QDI--DELIRKGVGIDlIDGTt--------vLPTEEDLQGIAEGLSRLQDLYMMEATDLAKGNVYG 158
EDS45527            107 -RDI--DARVRRGVGVElIDAWt--------aLPRVDDLQGVAEGLSRLQEVYKMKAAELAKGNLNG 162
EDS45526            100 -RDI--DALIRDGIGVEiINHAt--------vLPTENDLQGVAGGLSRLQDIYRMEASELAQGNVYG 155
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