5Z56


Conserved Protein Domain Family
Bud13
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pfam09736: Bud13 
Pre-mRNA-splicing factor of RES complex
This entry is characterized by proteins with alternating conserved and low-complexity regions. Bud13 together with Snu17p and a newly identified factor, Pml1p/Ylr016c, form a novel trimeric complex. called The RES complex, pre-mRNA retention and splicing complex. Subunits of this complex are not essential for viability of yeasts but they are required for efficient splicing in vitro and in vivo. Furthermore, inactivation of this complex causes pre-mRNA leakage from the nucleus. Bud13 contains a unique, phylogenetically conserved C-terminal region of unknown function.
Links
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Statistics
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PSSM-Id: 462867
Aligned: 133 rows
Threshold Bit Score: 106.895
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5Z56_Z       460 ETVFRD-KSGRKRNLKL-ER-LEQRR-----------------------KAEKDS--ERDELYAQWGKGLAQSRQQQQNV 511
Q6BGC8       108 EVIHRDvKTGQRITQSQrVEqEKQLNpkl-----------------kakEDKQTVlqANKQQIEMWSKGLVQIQEKQKKQ 170 Paramecium tetr...
EWS71241     195 QTIHRD-EFGRKIDIDKiIQeKLSKK-----------------------EQIEELkkKNQERIDQWGKGMKQKEQKLQQK 250
XP_004040201  84 ETVYRD-ALGRKVSARElLNqQKTKK-----------------------DKIEELkiQNQERIDQWGKGLKQKEDKQNQK 139
ESS31836     505 QVVYRD-RQGRIITEEEwLElQDQKRg----------------------KRRKKE--RSPPPELEWGKGLVQKEAREKQA 559
EDO05151      98 EVVYRD-KSGKRITRDQwLVlHAKRVv----------------------KAKRAE----PAQELAWGKGLVQKADLEAQA 150
Q4N3V7        78 DIVYRD-KFGKRITRDQwLLlNHREK-----------------------RGREEP-----KQELVWGKGLVQIKEKEEIL 128 Theileria parva
Q8I4W6       223 KTIYRD-KSGKIISREKwIEeQKKEMkykhg--------------kykdKKKKQE--EEKKRKLEWDGGLVQKDIRQKNI 285 Plasmodium falc...
CAQ42417     274 STVYRD-KGGKIISREEwISiQKMDMntkyrrggkk---gveeedpdvdKSKKKN---KDAKEIEWGSGLIQKEMRKKIL 346
EDL44264     330 STIYRD-KGGKIISREEwVSkQKIEMnatnrrrgktggegeedqeggekKKKKRS---KDSKELEWGSGLVQKEMRKKNL 405

5Z56_Z       512 EDAMKEMQ---KP-LARYIDDEDLDRMLREQEREGDPMANFIKknkaKEN--Knk-------kvRPR---YSG--PaPPP 573
Q6BGC8       171 EDAQQALA---TK---NEEQIKQIDMQLMGQQKFDDPMRKMIQe---EDDkqIt---------lKQSdflLKCkfP-PPI 231 Paramecium tetr...
EWS71241     251 QNEINAAKetyNG---DYTISKQADIELMKQEKFNDPMRLLIQk---EDQkiAsaql----nlqNKQfcrLKCrfP-GVT 319
XP_004040201 140 EAIKNAKNelyVG---EYAISKQTEIELMKQTRFNDPMQNLIDk---EDQkiTqak-----lnlGKNfcrLQCkfP-PVS 207
ESS31836     560 QEDAKVAQ---QP-LTRYDIDEEYDRNLQDRARWEDPMNQVPQk---ADEsrAtpavpeqskgkEHPkcpH----D-APR 627
EDO05151     151 QEELKISK---QP-LNRYDIDEDYDQQLKERTRWSDPINDTSSv---TNEdqPd----------NVPkcrF----T-GLP 208
Q4N3V7       129 KEEQKIIN---QS-FQNFDIDQDYDEELKEKKRWSDPIn--------TNSnqQs----------EEPrcrF----S-MVP 181 Theileria parva
Q8I4W6       286 EENEKLIK---KKnIINYEFDSDYDIELKMKKRKDDPMNIYLEa---KEEnqEn----------KKLtcrY----Q-SPY 344 Plasmodium falc...
CAQ42417     347 EENDKLVK---KKnIVNYEFDSDYDVELRKAKRKEDPMNKYLD-----HTkeQp----------QKAmcrY----Q-SPY 403
EDL44264     406 EQNDKLAK---KKnIINYEYDSDYDAQLRKMKRKEDPMNEYLD-----VTteQp----------AKAtcrY----Q-SPY 462

5Z56_Z       574 NRFNIWPGYRWDGVDRSNGFEQKRFARLA 602
Q6BGC8       232 NRFNILPGFRWDGVDRSNGYEMKLLNSIN 260 Paramecium tetraurelia
EWS71241     320 NRFDIPPGHMWDGVDRGNGAEKRYFNMVN 348
XP_004040201 208 NRFNILPGHMWDGVDRGNQFEARYFDMLN 236
ESS31836     628 NRFGILPGYRWDGVVRGNGYEDRRLKAIN 656
EDO05151     209 NRFNIQPGYRWDGVIRGNGYEERWFKARA 237
Q4N3V7       182 NRFNIEPGYRWDGVIRGNNYEQRWFEARA 210 Theileria parva
Q8I4W6       345 NRFNIQAGYRWDGVIRGNGFEERRLEAQK 373 Plasmodium falciparum 3D7
CAQ42417     404 NRFNILAGYRWDGVVRGNGFEKRRFEALK 432
EDL44264     463 NRFNILAGYRWDGVVRGNGFEKRRFEALK 491
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