1ZJR,1V2X


Conserved Protein Domain Family
SpoU-like_TrmH
?
cd18092: SpoU-like_TrmH 
Click on image for an interactive view with Cn3D
SAM-dependent tRNA methylase related to TrmH
TrmH catalyzes the transfer of the methyl group from S-adenosyl-L-methionine (AdoMet) to the 2'-OH group of the ribose of the universally conserved guanosine 18 (G18) position in tRNA. It is part of the SpoU family of MTases, a subfamily of the SPOUT methyltransferase superfamily. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Links
?
Statistics
?
PSSM-Id: 349965
Aligned: 80 rows
Threshold Bit Score: 158.399
Created: 12-May-2009
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
 
SAM binding
Conserved site includes 14 residues -Click on image for an interactive view with Cn3D
Feature 1:SAM binding site [chemical binding site]
Evidence:
  • Structure:1V2X; Thermus thermophilus TrmH with bound SAM, contacts 4A
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1ZJR_A     10 KRLKRLREVLEKRqkdLIVFADNVKNEHNFSAIVRTCDAVGvLYLYYYHaegkkakinegitqGSHKWVFIEKVd----n 85  Aquifex aeolicus
1V2X_A      7 ARRRRIEEVLRRRqpdLTVLLENVHKPHNLSAILRTCDAVGvLEAHAVNptggvpt-fnetsgGSHKWVYLRVHp----d 81  Thermus thermophilus
ACY16928   32 ERAARIDSVLSARlsgLTVAIENLHDPHNGAAVVRSVEAVGlTSLHVAEpierfqf-spavaiGSEKWIRVLRHq----g 106 Haliangium ochrace...
EKX53506   99 TRAAKIEAMAARRqsgLIVVLEDASDAHNAGAVIRSCDAFGvTEIWFVHngik-------egtSMRPWVSARTFm----s 167 Guillardia theta C...
KIG16412   29 NRRARIETVLAGRlrsVAVAIENPYDPHNAAAVVRSAEAVGaWTVHVIAasqrilq-asgttkGTHHWIETRHHd----g 103 Enhygromyxa salina
CCB88504   26 ERKVRIDQVLEKRvkgVQVALEAPADIHNALAVTRTGEALGvYQFHLIDaqlvkgq-gkatmrGSSRWIHLYRHn----t 100 Simkania negevensis Z
CCB91762   30 ERKRKIDPVVKYRiqsIQTAAEAPSDIHNALAMVRTAEALGfTDAHLIGeprkgr--grqtmrGSDRWMNLHSHs----s 103 Waddlia chondrophi...
CDR33884   30 NRLEKIDQVLDARlhgLQVAIESPSDLHNASASTRSCEAFGvYQVHVISsevkkts-gksasqGAWKWTFVHKHk----n 104 Criblamydia sequan...
EHM96915   20 ERLFKIDKYAEESsdfVLPVLENIYQFRNAAAIIRSVEACGfHKIVALEeenvfnp-ntrvarGADTWMQVEKMp----k 94  Elizabethkingia an...
KFD39789   25 HKKNLFTTLIEYRtnhIAWLADNFYHEQNSSAIIRSADCFGyNTVFVIEdkyrfkv-neeiamGAQKWVNTVIFqvgnvd 103 Schleiferia thermo...

Feature 1                               # #                        ####  #             ## #   
1ZJR_A     86 PVQKLLEFKn---------rGFQIVATWLSKe----SVNFREvdy-tkPTVLVVGNELQGVSPEIVEiaDKKIVIPMYGM 151 Aquifex aeolicus
1V2X_A     82 LHEAFRFLKe---------rGFTVYATALREd----ARDFREvdy-tkPTAVLFGAEKWGVSEEALAlaDGAIKIPMLGM 147 Thermus thermophilus
ACY16928  107 FTACARILRg---------aGFRMYAACPDA-----EMSMDDidv-sqPSAVVFGNEHEGLSRRAIDacDAKVAIPMHGF 171 Haliangium ochrace...
EKX53506  168 TKEALEELKe---------mGYSNVCTCFTQs----SKSLYRcsllqdKLALWVGNEFAGLSDVAISaaDVELYIPMRGM 234 Guillardia theta C...
KIG16412  104 LEEFLSALEqpsgpgadnpsGMLLAGACVDA-----THMLEElpt-drPICLLFGNEHAGLSPEAQAacSVRFRIPIHGF 177 Enhygromyxa salina
CCB88504  101 LEVFRSKMK-----------GFILAGASLDG-----ELTLEElpk-drPLCLLFGNERKGLTSEAKAmcDLLYHIPMVGM 163 Simkania negevensis Z
CCB91762  104 LDTFQKSMK-----------GFVIYGATPHG-----NTPLHAlsl-drPCCFLFGNEKNGLTDAALNicTSHFTIPMYGF 166 Waddlia chondrophi...
CDR33884  105 TQDFISEMKr---------qGVLLAGASLKGklsleKIPVDK------PLCLLFGNEDRGLSEEALSscEYEFTIPMQGM 169 Criblamydia sequan...
EHM96915   95 TMASLQQIRd---------kGYKILAVSPEKn----AVSLPEyel-kePVALIFGTEMEGVSQEVLDfaDETLIIPMYGF 160 Elizabethkingia an...
KFD39789  104 YGQAIHAIKq---------sGYKLIAATPHId----GLSAENldi-rkPICIAMGSERHGHHPEILEeaDGFVAIPMEGF 169 Schleiferia thermo...

Feature 1       ## #  #            
1ZJR_A    152 aqSLNVSVATGIILYEAQRQR 172 Aquifex aeolicus
1V2X_A    148 vqSLNVSVAAAVILFEAQRQR 168 Thermus thermophilus
ACY16928  172 tqSLNLSVSVAVSIFQLAARR 192 Haliangium ochraceum DSM 14365
EKX53506  235 iqSLNLSVAAAICLSEICRQR 255 Guillardia theta CCMP2712
KIG16412  178 aeSYNLSVAAALSLYSQTTRR 198 Enhygromyxa salina
CCB88504  164 veSFNLSVSAGLSLYQMMRGK 184 Simkania negevensis Z
CCB91762  167 ceSFNLSVAAAITLHHAVTEK 187 Waddlia chondrophila 2032/99
CDR33884  170 meSLNLSVAVGISVYETAKRM 190 Criblamydia sequanensis CRIB-18
EHM96915  161 tqSFNVSVAAAICMYELKQKL 181 Elizabethkingia anophelis Ag1
KFD39789  170 seSLNVSVTAGVLMYTLKKRL 190 Schleiferia thermophila str. Yellowstone

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap